NCI Drug Dictionary

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The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.

tetradecanoylphorbol acetate
A phorbol ester with potential antineoplastic effects. Tetradecanoylphorbol acetate (TPA) induces maturation and differentiation of hematopoietic cell lines, including leukemic cells. This agent may induce gene expression and protein kinase C (PKC) activity. In addition to potential antineoplastic effects, TPA may exhibit tumor promoting activity. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonyms:Lonomycin
Phorbol Myristate Acetate
Abbreviations:PMA
TPA
Chemical structure:12-O-tetradecanoylphorbol-13-acetate