NCI Drug Dictionary

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The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.

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thioguanine
Patient Information
A synthetic guanosine analogue antimetabolite. Phosphorylated by hypoxanthine-guanine phosphoribosyltransferase, thioguanine incorporates into DNA and RNA, resulting in inhibition of DNA and RNA syntheses and cell death. This agent also inhibits glutamine-5-phosphoribosylpyrophosphate amidotransferase, thereby inhibiting purine synthesis. Check for active clinical trials using this agent. (NCI Thesaurus)

Synonym:tioguanin
tioguanine
US brand name:Tabloid
Tabloid
Foreign brand name:Lanvis
Abbreviation:6-TG
TG
Code name:BW 5071
Wellcome U3B
WR-1141
X 27
Chemical structure:
  • 2-amino 6MP
  • 2-amino-1,7-dihydro-6H-purine-6-thione
  • 2-amino-6-mercaptopurine
  • 2-amino-6-purinethiol
  • 2-aminopurin-6-thiol
  • 2-aminopurine-6(1H)-thione
  • 2-aminopurine-6-thiol
  • 6 mercaptoguanine
  • 6 thioguanine
  • 6H-purine-6-thione, 2-amino-1,7-dihydro- (9CI)
  • 6-mercapto-2-aminopurine
  • 6-mercaptoguanine
  • 6-thioguanine