NCI Drug Dictionary
The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.
A synthetic guanosine analogue antimetabolite. Phosphorylated by hypoxanthine-guanine phosphoribosyltransferase, thioguanine incorporates into DNA and RNA, resulting in inhibition of DNA and RNA syntheses and cell death. This agent also inhibits glutamine-5-phosphoribosylpyrophosphate amidotransferase, thereby inhibiting purine synthesis. Check for active clinical trials using this agent. (NCI Thesaurus)
US brand names: Tabloid
Foreign brand name: Lanvis Abbreviations: 6-TG
Code names: BW 5071
Chemical structures: 2-amino 6MP
6H-purine-6-thione, 2-amino-1,7-dihydro- (9CI)