NCI Drug Dictionary

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The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.

thioguanine
A synthetic guanosine analogue antimetabolite. Phosphorylated by hypoxanthine-guanine phosphoribosyltransferase, thioguanine incorporates into DNA and RNA, resulting in inhibition of DNA and RNA syntheses and cell death. This agent also inhibits glutamine-5-phosphoribosylpyrophosphate amidotransferase, thereby inhibiting purine synthesis. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonyms:tioguanin
tioguanine
US brand names:Tabloid
Tabloid
Foreign brand name:Lanvis
Abbreviations:6-TG
TG
Code names:BW 5071
Wellcome U3B
WR-1141
X 27
Chemical structures:2-amino 6MP
2-amino-1,7-dihydro-6H-purine-6-thione
2-amino-6-mercaptopurine
2-amino-6-purinethiol
2-aminopurin-6-thiol
2-aminopurine-6(1H)-thione
2-aminopurine-6-thiol
6 mercaptoguanine
6 thioguanine
6H-purine-6-thione, 2-amino-1,7-dihydro- (9CI)
6-mercapto-2-aminopurine
6-mercaptoguanine
6-thioguanine