NCI Drug Dictionary
The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.
- dapsone gel, 5%
A gel containing 5% (w/w) dapsone, a synthetic derivative of diamino-sulfone with anti-infective properties. A structural analog of p-aminobenzoic acid (PABA), dapsone inhibits dihydropteroate synthase (DHPS), an enzyme important in folate synthesis, resulting in a depletion of the folate pool and a reduction in the amount of thymidylate available for DNA synthesis. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
US brand name: Aczone Gel