NCI Drug Dictionary

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The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.

fluoxymesterone
A halogenated derivative of 17-alpha-methyltestosterone. Similar to testosterone, fluoxymesterone binds to and activates specific nuclear receptors, resulting in an increase in protein anabolism, a decrease in amino acid catabolism, and retention of nitrogen, potassium, and phosphorus. This agent also may competitively inhibit prolactin receptors and estrogen receptors, thereby inhibiting the growth of hormone-dependent tumor lines. Fluoxymesterone is approximately five times more potent than methyltestosterone. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonyms:Androfluorene
Androsterolo
US brand names:Android-F
Halodrin
Halotestin
Ora-Testryl
Ultandren
Foreign brand names:Oratestin
Stenox
Testoral
Abbreviation:FXM
Chemical structures:(11Beta,17beta)-9-fluoro-11,17-dihydroxy-17-methylandrost-4-en-3-one
11Beta,17beta-dihydroxy-9alpha-fluoro-17alpha-methyl-4-androsten-3-one
9Alpha-fluoro-11beta-hydroxy-17alpha-methyltestosterone