NCI Drug Dictionary

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The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.

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fluoxymesterone
A halogenated derivative of 17-alpha-methyltestosterone. Similar to testosterone, fluoxymesterone binds to and activates specific nuclear receptors, resulting in an increase in protein anabolism, a decrease in amino acid catabolism, and retention of nitrogen, potassium, and phosphorus. This agent also may competitively inhibit prolactin receptors and estrogen receptors, thereby inhibiting the growth of hormone-dependent tumor lines. Fluoxymesterone is approximately five times more potent than methyltestosterone. Check for active clinical trials using this agent. (NCI Thesaurus)

Synonym:Androfluorene
Androsterolo
US brand name:Android-F
Halodrin
Halotestin
Ora-Testryl
Ultandren
Foreign brand name:Oratestin
Stenox
Testoral
Abbreviation:FXM
Chemical structure:
  • (11Beta,17beta)-9-fluoro-11,17-dihydroxy-17-methylandrost-4-en-3-one
  • 11Beta,17beta-dihydroxy-9alpha-fluoro-17alpha-methyl-4-androsten-3-one
  • 9Alpha-fluoro-11beta-hydroxy-17alpha-methyltestosterone