NCI Drug Dictionary
The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.
- betulinic acid
A pentacyclic lupane-type triterpene derivative of betulin (isolated from the bark of Betula alba, the common white birch) with antiinflammatory, anti-HIV and antineoplastic activities. Betulinic acid induces apoptosis
through induction of changes in mitochondrial membrane potential, production of reactive oxygen
species, and opening of mitochondrial permeability transition pores, resulting in the release of mitochondrial
apogenic factors, activation of caspases, and DNA fragmentation. Although originally thought to exhibit specific cytotoxicity against melanoma cells, this agent has been found to be cytotoxic against non-melanoma tumor cell types including neuroectodermal.and brain tumor cells. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonym: Mairin Acronym: BA Code name: ALS-357 Chemical structure: (3beta)-3-Hydroxy-lup-20(29)-en-28-oic Acid