NCI Drug Dictionary

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The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.

ciclopirox olamine lotion
A lotion preparation of the olamine salt of ciclopirox, a synthetic hydroxypyridone derivative with broad-spectrum antifungal and anti-inflammatory activities. Although its mechanism of action is not well understood, ciclopirox may chelate trivalent cations, such as Fe3+ and Al3+, thereby inhibiting the availability of essential metal co-factors for enzymes, which may result in a loss of enzyme activities that are essential for cellular metabolism, organization of cell wall structure, and other crucial cell functions in a wide variety of fungal species. This agent may also disrupt DNA repair, cell division signals and mitotic spindles as well as some elements of intracellular transport in susceptible fungi. Ciclopirox exhibits anti-inflammatory activity by inhibiting 5-lipoxygenase and cyclooxygenase (COX). Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
US brand name:Loprox Lotion
Chemical structure:6-cyclohexyl-1-hydroxy-4-methylpyridin-2(1H)-one