NCI Drug Dictionary

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The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.

S-adenosyl-L-methionine disulfate p-toluene-sulfonate
The disulfate salt of the stable p-toluene-sulfonate complex of s-adenosyl-L-methionine (SAMe) with chemopreventive activity. SAMe disulfate p-toluene-sulfonate undergoes hydrolytic conversion to its active compound SAMe within cells. Although the mechanism of action is largely unknown, SAMe attenuates experimental liver damage and prevents experimental hepatocarcinogenesis. In addition, SAMe may reduce mitochondrial cytochrome C release, caspase 3 activation, and poly(ADP-ribose) polymerase cleavage, and attenuate okadaic acid-mediated hepatocyte apoptosis in a dose-dependent manner. SAMe is an essential compound in cellular transmethylation reactions and a precursor of polyamine and glutathione synthesis in the liver; SAMe deficiency is associated with chronic liver disease-associated decreases in the activity of methionine adenosyltransferase 1A (MAT1A), the enzyme that catalyzes the production of SAMe as the first step in methionine catabolism. Check for active clinical trials using this agent. (NCI Thesaurus)
Synonyms:S-adenosyl-L-methionine disulfate p-toluenesulfonate
S-adenosyl-L-methionine disulfate tosilate
S-adenosyl-L-methionine disulfate tosylate
S-adenosylmethionine tosylate disulfate
US brand name:SAM-e Complete
Abbreviation:SAMe disulfate p-toluene-sulfonate
Chemical structure:(3S)-5'-((3-amino-3-carboxypropyl)methylsulfonio)-5'-deoxyadenosine, disulfate-methylbenzenesulfonate