NCI Drug Dictionary

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The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.

indoximod
A methylated tryptophan with anti-immunosuppressive activity. Indoximod inhibits the enzyme indoleamine 2,3-dioxygenase (IDO), which degrades the essential amino acid tryptophan, and may increase or maintain tryptophan levels important to T cell function. Tryptophan depletion is associated with immunosuppression involving T cell arrest and anergy. Check for active clinical trials or closed clinical trials using this agent.
Synonyms:1-methyl-d-tryptophan
D-(+)-1-methyltryptophan
Abbreviation:1-MT