NCI Drug Dictionary
The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.
- gadoxetate disodium
A paramagnetic contrast agent consisting of the disodium salt of the gadolinium ion chelated with the lipophilic moiety ethoxybenzyl (EOB) bound to diethylenetriamine pentaacetic acid (DTPA). When placed in a magnetic field, gadolinium produces a large magnetic moment and so a large local magnetic field, which can enhance the relaxation rate of nearby protons; as a result, the signal intensity of tissue images observed with magnetic resonance imaging (MRI) may be enhanced. Because this agent is preferentially taken up by normal functioning hepatocytes, normal hepatic tissue is enhanced with MRI while tumor tissue is unenhanced. In addition, because this agent is excreted in the bile, it may be used to visualize the biliary system using MRI. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonym: gadoxetic acid, disodium US brand name: Eovist Foreign brand names: EOB Primavist
Abbreviation: Gd-EOB-DTPA Chemical structure: (4S)-4-(4-ththoxylmethyl)-3,6,9-tris(carboxylatomethyl)-3,6,9-triazaundecanedoic acid, gadolinium complex, disodium salt