NCI Drug Dictionary

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The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.

synthetic human secretin
A synthetic human therapeutic agent which is chemically identical or similar to endogenous secretin, a peptide hormone found in the mucosal S-cells of the proximal small intestine. Secretin stimulates the pancreatic acinar cells and ductal epithelial cells to emit bicarbonate rich digestive fluids, thereby increases duodenal bicarbonate level. Bicarbonate neutralizes acidity of the intestines, consequently increasing the pH and facilitating the action of intestinal digestive enzymes. In addition, secretin stimulates the stomach and the liver to produce pepsin and bile, respectively. Both pepsin and bile aide the digestive action of the duodenum, which resulting in the prevention of gastric inflammation. Check for active clinical trials using this agent.
Synonym:secretin human
US brand name:ChiRhoStim
Abbreviation:SHS
Code name:RG1068