NCI Drug Dictionary

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The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.

dexpanthenol mouthwash
A mouthwash containing 5% dexpanthenol, the alcoholic analogue of the dextrorotatory isomer of pantothenic acid with potential antimucositis activity. Although the exact mechanism remains to be elucidated, upon rinsing with this solution dexpanthenol is converted to pantothenic acid (vitamin B5) which is required for coenzyme A synthesis as well as for the metabolism of proteins, carbohydrates, and fats. Coenzyme A is involved in fatty acids and sphingolipids synthesis crucial for cell membrane integrity. This mouthwash may have a protective and healing effect on the oral mucosa, may improve hydration and may potentially prevent or reduce radiation/chemotherapy-induced mucositis. Check for active clinical trials using this agent.
Synonym:5% dexpanthenol mouthwash