NCI Drug Dictionary

  • Resize font
  • Print
  • Email
  • Facebook
  • Twitter
  • Google+
  • Pinterest

The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.

mepivacaine hydrochloride
The hydrochloride salt form of mepivacaine, an amide-type local anesthetic agent. At the injection site, mepivacaine binds to specific voltage-gated sodium ion channels in neuronal cell membranes, which inhibits both sodium influx and membrane depolarization. This leads to a blockage of nerve impulse initiation and conduction and results in a reversible loss of sensation. Compared to other local anesthetics, this agent has a more rapid onset and moderate duration of action. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
US brand names:Carbocaine
Polocaine
Chemical structure:1-methyl-2',6'-pipecoloxylidide hydrochloride (SY), (1-methyl-DL-piperidine-2-carboxylic acid)-2,6-dimethylanilide hydrochloride