NCI Drug Dictionary

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The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.

cyclobenzaprine hydrochloride
A centrally acting muscle relaxant, chemically similar to amitriptyline hydrochloride with antidepressant activity. The exact mechanism of action of cyclobenzaprine hydrochloride has not been fully determined. However, it primarily acts at the brain stem to reduce tonic somatic motor activity, influencing both gamma and alpha motor neurons. This leads to a reduction in muscle spasms. Check for active clinical trials or closed clinical trials using this agent.
Synonyms:cloben
Novo-Cycloprine
US brand names:Cycloflex
Flexeril
Flexiban
Code name:FR2100873
Chemical structures:10,11delta-amitriptyline hydrochloride
1-propanamine, 3-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-N,N-dimethyl-, hydrochloride
3-(5H-dibenzo(a,d)cyclohepten-5-ylidene)propyl(dimethyl)ammonium chloride