iodine I 131 iopofosine
A radioconjugate composed of iopofosine, a phospholipid ether analog, labeled with the radioactive isotope iodine I 131, with potential antineoplastic activity. Upon administration, iodine I 131 iopofosine selectively accumulates in and retains within tumor cells for a prolonged period of time due to the decreased activity of a phospholipase D (PLD) in tumor cells compared to normal cells, thereby delivering cytotoxic radiation specifically to tumor cells. PLD is an enzyme found in the cell membrane of normal cells that degrades phospholipids.
| Synonym: | 131I-CLR1404 131I-NM-404 CLR 1404 I-131 CLR-1404 I-131 CLR131 I-131 PLE analogue CLR1404 iopofosine I 131 NM-404 I-131 PDC CLR 131 phospholipid ether-drug conjugate CLR 131 |
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| Abbreviation: | I-131-CLR1404 |
| Code name: | CLR 131 |