NCI Dictionary of Cancer Terms

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The NCI Dictionary of Cancer Terms features 7,780 terms related to cancer and medicine.

Browse the dictionary by selecting a letter of the alphabet or by entering a cancer-related word or phrase in the search box.

c-kit
A protein found on the surface of many different types of cells. It binds to a substance called stem cell factor (SCF), which causes certain types of blood cells to grow. C-kit may also be found in higher than normal amounts, or in a changed form, on some types of cancer cells, including gastrointestinal stromal tumors and melanoma. Measuring the amount of c-kit in tumor tissue may help diagnose cancer and plan treatment. C-kit is a type of receptor tyrosine kinase and a type of tumor marker. Also called CD117 and stem cell factor receptor.