NCI Dictionary of Cancer Terms

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The NCI Dictionary of Cancer Terms features 7,777 terms related to cancer and medicine.

Browse the dictionary by selecting a letter of the alphabet or by entering a cancer-related word or phrase in the search box.

glucarpidase
(gloo-KAR-pih-dayz)
A drug used to treat toxic levels of methotrexate (an anticancer drug) in the blood of patients with kidney problems. It is a bacterial enzyme that breaks down proteins and other substances, such as methotrexate. Glucarpidase may also help certain drugs kill cancer cells. It is a type of chemoprotective agent and a type of prodrug activator. Also called carboxypeptidase-G2 and Voraxaze.