NCI Dictionary of Cancer Terms

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The NCI Dictionary of Cancer Terms features 7,926 terms related to cancer and medicine.

Browse the dictionary by selecting a letter of the alphabet or by entering a cancer-related word or phrase in the search box.

poly (ADP-ribose) polymerase
(PAH-lee (... RY-bose) puh-LIH-meh-rays)
A type of enzyme involved in many functions of the cell, including the repair of DNA damage. DNA damage may be caused by normal cell actions, UV light, some anticancer drugs, and radiation used to treat cancer. Inhibitors of one enzyme, poly (ADP-ribose) polymerase-1, are being studied in the treatment of cancer. Also called PARP.