NCI Dictionary of Cancer Terms

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The NCI Dictionary of Cancer Terms features 7,855 terms related to cancer and medicine.

Browse the dictionary by selecting a letter of the alphabet or by entering a cancer-related word or phrase in the search box.

stage I esophageal squamous cell carcinoma
(... ee-SAH-fuh-JEE-ul SKWAY-mus sel KAR-sih-NOH-muh)
Stage I is divided into stages IA and IB, depending on where the cancer is found. In stage IA, cancer has formed in the mucosa or submucosa layer of the esophagus wall. The cancer cells are grade 1. Grade 1 cancer cells look more like normal cells under a microscope and grow and spread more slowly than grade 2 and 3 cancer cells. In stage IB, cancer has formed (1) in the mucosa or submucosa layer of the esophagus wall, and the cancer cells are grade 2 and 3. Grade 2 and 3 cancer cells look more abnormal under a microscope and grow and spread more quickly than grade 1 cancer cells; or (2) in the mucosa or submucosa layer and spread into the muscle layer or the connective tissue layer of the esophagus wall, and the cancer cells are grade 1. The tumor is in the lower esophagus or it is not known where the tumor is.