NCI Dictionary of Cancer Terms

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The NCI Dictionary of Cancer Terms features 7,790 terms related to cancer and medicine.

Browse the dictionary by selecting a letter of the alphabet or by entering a cancer-related word or phrase in the search box.

stage II esophageal adenocarcinoma
(... ee-SAH-fuh-JEE-ul A-deh-noh-KAR-sih-NOH-muh)
Stage II is divided into stages IIA and IIB, depending on where the cancer has spread. In stage IIA, cancer has spread into the muscle layer of the esophagus wall. The cancer cells are grade 3. Grade 3 cancer cells look more abnormal under a microscope and grow and spread more quickly than grade 1 and 2 cancer cells. In stage IIB, cancer (1) has spread into the connective tissue layer of the esophagus wall; or (2) is in the mucosa or submucosa layer and may have spread into the muscle layer of the esophagus wall. Cancer is found in 1 or 2 lymph nodes near the tumor.

EnlargeStage IIA adenocarcinoma of the esophagus; drawing shows the esophagus and stomach. An inset shows cancer in the mucosa, submucosa, and muscle layers of the esophagus wall. Also shown is the connective tissue layer of the esophagus wall and lymph nodes.

Stage IIA adenocarcinoma of the esophagus. Cancer has spread into the muscle layer of the esophagus wall. The cancer cells are grade 3. Grade 3 cancer cells look more abnormal under a microscope and grow and spread more quickly than grade 1 or 2 cancer cells.

EnlargeStage IIB adenocarcinoma of the esophagus; drawing shows the esophagus and stomach. A two-panel inset shows the layers of the esophagus wall: the mucosa, submucosa, muscle, and connective tissue layers. The left panel shows cancer in the mucosa, submucosa, muscle, and connective tissue layers. The right panel shows cancer in the mucosa, submucosa, and muscle layers and in 1 lymph node.

Stage IIB adenocarcinoma of the esophagus. Cancer has spread into the connective tissue layer of the esophagus wall; OR cancer is in the mucosa or submucosa layer and may have spread into the muscle layer of the esophagus wall, and cancer is found in 1 or 2 lymph nodes near the tumor.