NCI Dictionary of Cancer Terms

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The NCI Dictionary of Cancer Terms features 7,863 terms related to cancer and medicine.

Browse the dictionary by selecting a letter of the alphabet or by entering a cancer-related word or phrase in the search box.

aseptic necrosis
(ay-SEP-tik neh-KROH-sis)
A condition in which there is a loss of blood flow to bone tissue, which causes the bone to die. It is most common in the hips, knees, shoulders, and ankles. It may be caused by long-term use of steroid medicines, alcohol abuse, joint injuries, and certain diseases, such as cancer and arthritis. It may also occur at some point in time after cancer treatment that included methotrexate, bisphosphonates, or corticosteroids. Also called avascular necrosis, ischemic necrosis, and osteonecrosis.