NCI Dictionary of Cancer Terms

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The NCI Dictionary of Cancer Terms features 7,863 terms related to cancer and medicine.

Browse the dictionary by selecting a letter of the alphabet or by entering a cancer-related word or phrase in the search box.

ponatinib hydrochloride
(poh-NA-tih-nib HY-droh-KLOR-ide)
A drug used to treat chronic myelogenous leukemia (CML) and Philadelphia chromosome-positive acute lymphoblastic leukemia. It is used in patients who are not able to take or have not gotten better after treatment with other anticancer drugs. It is also being studied in the treatment of other types of cancer. Ponatinib hydrochloride blocks BCR-ABL and other proteins, which may help keep cancer cells from growing and may kill them. It may also prevent the growth of new blood vessels that tumors need to grow. It is a type of tyrosine kinase inhibitor and a type of angiogenesis inhibitor. Also called Iclusig.