NCI Dictionary of Cancer Terms

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The NCI Dictionary of Cancer Terms features 7,894 terms related to cancer and medicine.

Browse the dictionary by selecting a letter of the alphabet or by entering a cancer-related word or phrase in the search box.

progressive familial intrahepatic cholestasis
(pruh-GREH-siv fuh-MIH-lee-ul IN-truh-heh-PA-tik koh-leh-STAY-sis)
A rare, inherited disorder marked by a buildup in the liver of bile (fluid that helps digest fat). This can lead to liver disease and liver failure. It may also increase the risk of liver cancer. Progressive familial intrahepatic cholestasis is caused by mutations (changes) in certain genes that make proteins needed to help the liver work the way it should. It usually occurs in infants and children. Also called PFIC.