NCI Dictionary of Cancer Terms

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The NCI Dictionary of Cancer Terms features 7,791 terms related to cancer and medicine.

Browse the dictionary by selecting a letter of the alphabet or by entering a cancer-related word or phrase in the search box.

dihydrofolate reductase inhibitor
(dy-HY-droh-FOH-layt ree-DUK-tays in-HIH-bih-ter)
A substance that can build up in cancer cells and block them from using folate. Folate is a nutrient that rapidly dividing cells need to make DNA. Blocking folate use helps keep cancer cells from growing and may kill them. Some dihydrofolate reductase inhibitors are used to treat cancer. A dihydrofolate reductase inhibitor is a type of antifolate. Also called DHFR inhibitor.