Surgery with or without Docetaxel and Leuprolide Acetate or Goserelin Acetate in Treating Patients with High-Risk Localized Prostate Cancer

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Basic Trial Information

PhaseTypeAgeTrial IDs
Phase IIIBiomarker/Laboratory analysis, Treatment18 and overCALGB 90203
NCI-2009-00496, CDR0000526353, NCT00430183

Trial Description

Summary

This randomized phase III trial studies docetaxel and leuprolide acetate or goserelin acetate to see how well they work when given before surgery compared with surgery alone in treating patients with high-risk localized prostate cancer. Drugs used in chemotherapy, such as docetaxel, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Androgens can cause the growth of prostate cancer cells. Antihormone therapy, such as goserelin acetate and leuprolide acetate, may stop the adrenal glands from making androgens. Giving docetaxel and leuprolide acetate or goserelin acetate before surgery may make the tumor smaller and reduce the amount of normal tissue that needs to be removed. It is not yet known whether giving docetaxel and leuprolide acetate or goserelin acetate before surgery is more effective than surgery alone in treating patients with prostate cancer.

Further Study Information

PRIMARY OBJECTIVES:

I. To determine whether treatment with neoadjuvant docetaxel and androgen deprivation therapy prior to radical prostatectomy will increase the rate of 3-year biochemical progression-free survival (bPFS) compared to treatment with immediate radical prostatectomy alone for high-risk prostate cancer patients.

SECONDARY OBJECTIVES:

I. To compare the 5-year bPFS rate, bPFS, disease progression, disease-free survival, and overall survival of patients randomized to the two arms of this trial.

II. To determine the safety and tolerability of neoadjuvant docetaxel and androgen deprivation therapy prior to surgery for high-risk patients undergoing radical prostatectomy.

III. To compare the impact of neoadjuvant docetaxel and androgen deprivation therapy on time to clinically apparent local disease recurrence and metastatic disease in high-risk patients undergoing radical prostatectomy for clinically localized prostate cancer.

IV. To compare the impact of neoadjuvant docetaxel and androgen deprivation therapy relative to radical prostatectomy (RP) on pathologic tumor stage, frequency of lymph node metastases and positive margin rates for high-risk patients undergoing radical prostatectomy for clinically localized prostate cancer.

V. To determine if changes in serum testosterone levels will predict bPFS in these patients.

VI. To determine, prospectively, whether prostate-specific antigen doubling time (PSADT) is a surrogate endpoint for time to clinical metastases and overall survival in these patients.

TERTIARY OBJECTIVES:

I. To evaluate associations between post-diagnosis diet and lifestyle, change in food group intake, and risk of prostate cancer recurrence, independent of treatment.

OUTLINE: Patients are randomized to 1 of 2 treatment arms.

ARM I: Patients receive goserelin acetate subcutaneously or leuprolide acetate intramuscularly once every 4 or 12 weeks for 18-24 weeks (measured from the date of starting docetaxel). They also receive docetaxel IV over 1 hour on day 1. Treatment with docetaxel repeats every 3 weeks for up to 6 courses. Within 60 days after completion of chemohormonal therapy, patients undergo radical prostatectomy with staging pelvic lymphadenectomy.

ARM II: Within 60 days after randomization, patients undergo radical prostatectomy with staging pelvic lymphadenectomy.

After completion of study therapy, patients are followed up at 1 and 3 months and then periodically for up to 15 years.

Eligibility Criteria

Inclusion Criteria:

Histologic documentation of prostatic adenocarcinoma; patients with small cell, neuroendocrine, or transitional cell carcinomas are not eligible; all eligible patients must have a known Gleason sum based on biopsy or transurethral resection of the prostate (TURP) at the time of registration

Patients must have clinical stage T1-T3a and no radiographic evidence of metastatic disease as demonstrated by:

EITHER computed tomography (CT) or magnetic resonance imaging (MRI) of the abdomen and pelvis, OR endorectal MRI of the pelvis that demonstrate no nodes > 1.5 cm

If one or more pelvic lymph node(s) measures > 1.5 cm, a negative biopsy is required; if more than one lymph node is > 1.5 cm, the largest or most accessible node should be biopsied; AND

Negative bone scan (with plain films and/or MRI and/or CT scan confirmation, if necessary)

Positive positron emission tomography (PET) and ProstaScint scans are not considered proof of metastatic disease

Patients must have either:

A Kattan nomogram predicted probability of being free from biochemical progression at 5 years after surgery of < 60%; please note that for the purposes of the nomogram calculation, the pre-biopsy prostate specific antigen (PSA) value must be used OR

Prostate biopsy Gleason sum >= 8

(NOTE: the Kattan nomogram probability must be calculated for all patients, including those eligible based on Gleason sum >= 8 only)

Eastern Cooperative Oncology Group (ECOG) performance status: 0-2

Patients must be appropriate candidates for radical prostatectomy with an estimated life expectancy > 10 years as determined by a urologist; evidence of underlying cardiac disease should be evaluated prior to enrollment to ensure that patients are not at high risk of cardiac complications

Absolute neutrophil count (ANC) >= 1,500/uL

Platelet count >= 150,000/uL

Creatinine =< 2.0 mg/dL

No prior treatment for prostate cancer including prior surgery (excluding TURP), pelvic lymph node dissection, radiation therapy, or chemotherapy; patients may have received up to 4 months of androgen deprivation therapy (luteinizing hormone releasing hormone [LHRH] agonists, antiandrogens, or both) prior to being enrolled on the study

Pre-registration serum PSA level =< 100 ng/mL

Bilirubin =< upper limit of normal (ULN); for patients with Gilbert’s disease, =< 2.5 x ULN is allowed

Aspartate aminotransferase (AST)/alanine aminotransferase (ALT) =< 1.5 x ULN

Patients with a history of deep venous thrombosis, pulmonary embolism, and/or cerebrovascular accident or currently requiring systemic anticoagulation are eligible provided they are determined to be candidates for radical prostatectomy

Trial Contact Information

Trial Lead Organizations / Sponsors / Collaborators

Alliance for Clinical Trials in Oncology

  • National Cancer Institute
  • Eastern Cooperative Oncology Group
  • NCIC-Clinical Trials Group
James Andrew Eastham, Principal Investigator

Trial Sites

U.S.A.

Alaska
Anchorage

Alaska Breast Care and Surgery LLC

Keith S. Lanier
Ph: 503-215-6412

Keith S. Lanier
Principal Investigator

Alaska Women's Cancer Care

Keith S. Lanier
Ph: 503-215-6412

Keith S. Lanier
Principal Investigator

Anchorage Oncology Centre

Keith S. Lanier
Ph: 503-215-6412

Keith S. Lanier
Principal Investigator

Katmai Oncology Group

Keith S. Lanier
Ph: 503-215-6412

Keith S. Lanier
Principal Investigator

Providence Alaska Medical Center

Keith S. Lanier
Ph: 503-215-6412

Keith S. Lanier
Principal Investigator

Fairbanks

Fairbanks Memorial Hospital

Yoshio Inoue
Ph: 253-403-2394

Yoshio Inoue
Principal Investigator

California
Auburn

Sutter Auburn Faith Hospital

Elizabeth Min Hui Kim
Ph: 415-209-2686
Email: bernicl@sutterhealth.org

Elizabeth Min Hui Kim
Principal Investigator

Sutter Cancer Centers Radiation Oncology Services-Auburn

Elizabeth Min Hui Kim
Ph: 415-209-2686
Email: bernicl@sutterhealth.org

Elizabeth Min Hui Kim
Principal Investigator

Berkeley

Alta Bates Summit Medical Center-Herrick Campus

Elizabeth Min Hui Kim
Ph: 415-209-2686
Email: bernicl@sutterhealth.org

Elizabeth Min Hui Kim
Principal Investigator

Burlingame

Mills - Peninsula Hospitals

Elizabeth Min Hui Kim
Ph: 415-209-2686
Email: bernicl@sutterhealth.org

Elizabeth Min Hui Kim
Principal Investigator

Cameron Park

Sutter Cancer Centers Radiation Oncology Services-Cameron Park

Elizabeth Min Hui Kim
Ph: 415-209-2686
Email: bernicl@sutterhealth.org

Elizabeth Min Hui Kim
Principal Investigator

Davis

Sutter Davis Hospital

Elizabeth Min Hui Kim
Ph: 415-209-2686
Email: bernicl@sutterhealth.org

Elizabeth Min Hui Kim
Principal Investigator

Duarte

City of Hope Comprehensive Cancer Center

James Andrew Eastham

James Andrew Eastham
Principal Investigator

La Jolla

UC San Diego Moores Cancer Center

James Andrew Eastham

James Andrew Eastham
Principal Investigator

Los Angeles

Los Angeles County-USC Medical Center

David Ian Quinn
Ph: 323-865-0451

David Ian Quinn
Principal Investigator

USC / Norris Comprehensive Cancer Center

David Ian Quinn
Ph: 323-865-0451

David Ian Quinn
Principal Investigator

Modesto

Memorial Medical Center

Elizabeth Min Hui Kim
Ph: 415-209-2686
Email: bernicl@sutterhealth.org

Elizabeth Min Hui Kim
Principal Investigator

Mountain View

Palo Alto Medical Foundation-Camino Division

Elizabeth Min Hui Kim
Ph: 415-209-2686
Email: bernicl@sutterhealth.org

Elizabeth Min Hui Kim
Principal Investigator

Palo Alto Medical Foundation-Gynecologic Oncology

Elizabeth Min Hui Kim
Ph: 415-209-2686
Email: bernicl@sutterhealth.org

Elizabeth Min Hui Kim
Principal Investigator

Novato

Sutter Cancer Research Consortium

Elizabeth Min Hui Kim
Ph: 415-209-2686
Email: bernicl@sutterhealth.org

Elizabeth Min Hui Kim
Principal Investigator

Orange

UC Irvine Health/Chao Family Comprehensive Cancer Center

Edward M. Uchio
Ph: 877-827-8839
Email: ucstudy@uci.edu

Edward M. Uchio
Principal Investigator

Palo Alto

Palo Alto Medical Foundation Health Care

Elizabeth Min Hui Kim
Ph: 415-209-2686
Email: bernicl@sutterhealth.org

Elizabeth Min Hui Kim
Principal Investigator

Pismo Beach

Palchak David MD

John Allan Ellerton
Ph: 702-384-0013

John Allan Ellerton
Principal Investigator

Roseville

Sutter Cancer Centers Radiation Oncology Services-Roseville

Elizabeth Min Hui Kim
Ph: 415-209-2686
Email: bernicl@sutterhealth.org

Elizabeth Min Hui Kim
Principal Investigator

Sutter Roseville Medical Center

Elizabeth Min Hui Kim
Ph: 415-209-2686
Email: bernicl@sutterhealth.org

Elizabeth Min Hui Kim
Principal Investigator

Sacramento

Sutter General Hospital

Elizabeth Min Hui Kim
Ph: 415-209-2686
Email: bernicl@sutterhealth.org

Elizabeth Min Hui Kim
Principal Investigator

University of California Davis Comprehensive Cancer Center

Primo Nery Lara
Ph: 916-734-3089

Primo Nery Lara
Principal Investigator

Saint Helena

Saint Helena Hospital

Gregory B. Smith
Ph: 707-967-3698

Gregory B. Smith
Principal Investigator

San Diego

Naval Medical Center -San Diego

Preston S. Gable
Ph: 619-532-8712

Preston S. Gable
Principal Investigator

University of California San Diego

Frederick Edward Millard
Ph: 858-822-5354
Email: cancercto@ucsd.edu

Frederick Edward Millard
Principal Investigator

San Francisco

California Pacific Medical Center-Pacific Campus

Elizabeth Min Hui Kim
Ph: 415-209-2686
Email: bernicl@sutterhealth.org

Elizabeth Min Hui Kim
Principal Investigator

Santa Cruz

Palo Alto Medical Foundation-Santa Cruz

Elizabeth Min Hui Kim
Ph: 415-209-2686
Email: bernicl@sutterhealth.org

Elizabeth Min Hui Kim
Principal Investigator

Santa Rosa

Sutter Pacific Medical Foundation

Elizabeth Min Hui Kim
Ph: 415-209-2686
Email: bernicl@sutterhealth.org

Elizabeth Min Hui Kim
Principal Investigator

Sunnyvale

Palo Atlo Medical Foundation-Sunnyvale

Elizabeth Min Hui Kim
Ph: 415-209-2686
Email: bernicl@sutterhealth.org

Elizabeth Min Hui Kim
Principal Investigator

Vacaville

Sutter Cancer Centers Radiation Oncology Services-Vacaville

Elizabeth Min Hui Kim
Ph: 415-209-2686
Email: bernicl@sutterhealth.org

Elizabeth Min Hui Kim
Principal Investigator

Vallejo

Sutter Solano Medical Center/Cancer Center

Elizabeth Min Hui Kim
Ph: 415-209-2686
Email: bernicl@sutterhealth.org

Elizabeth Min Hui Kim
Principal Investigator

Colorado
Aurora

University of Colorado Cancer Center - Anschutz Cancer Pavilion

Paul Daniel Maroni
Ph: 720-848-0650

Paul Daniel Maroni
Principal Investigator

Denver

Denver Veterans Administration Medical Center

Paul Daniel Maroni
Ph: 720-848-0650

Paul Daniel Maroni
Principal Investigator

University of Colorado

James Andrew Eastham

James Andrew Eastham
Principal Investigator

Edwards

The Shaw Regional Cancer Center

Alexander Terry Urquhart
Ph: 970-569-7429

Alexander Terry Urquhart
Principal Investigator

Glenwood Springs

Valley View Hospital Cancer Center

Paul Daniel Maroni
Ph: 720-848-0650

Paul Daniel Maroni
Principal Investigator

Connecticut
Hartford

Hartford Hospital

Jeffrey M. Kamradt
Ph: 888-823-5923
Email: ctsucontact@westat.com

Jeffrey M. Kamradt
Principal Investigator

Saint Francis Hospital and Medical Center

Philip J. Stella
Ph: 734-712-4673

Philip J. Stella
Principal Investigator

Meriden

Midstate Medical Center

Jeffrey M. Kamradt
Ph: 888-823-5923
Email: ctsucontact@westat.com

Jeffrey M. Kamradt
Principal Investigator

New Haven

Yale University

John W. Colberg
Ph: 203-785-5702

John W. Colberg
Principal Investigator

Norwich

Eastern Connecticut Hematology and Oncology Associates

Dennis E. Slater
Ph: 860-886-8362

Dennis E. Slater
Principal Investigator

West Haven

Veterans Affairs Connecticut Healthcare System-West Haven Campus

Charles Nathan Walker
Ph: 203-937-3421ext2832

Charles Nathan Walker
Principal Investigator

Delaware
Lewes

Beebe Medical Center

Stephen Scott Grubbs
Ph: 302-733-6227

Stephen Scott Grubbs
Principal Investigator

Newark

Christiana Care Health System-Christiana Hospital

Stephen Scott Grubbs
Ph: 302-733-6227

Stephen Scott Grubbs
Principal Investigator

Christiana Gynecologic Oncology LLC

Stephen Scott Grubbs
Ph: 302-733-6227

Stephen Scott Grubbs
Principal Investigator

Delaware Clinical and Laboratory Physicians PA

Stephen Scott Grubbs
Ph: 302-733-6227

Stephen Scott Grubbs
Principal Investigator

Helen F Graham Cancer Center

Stephen Scott Grubbs
Ph: 302-733-6227

Stephen Scott Grubbs
Principal Investigator

Medical Oncology Hematology Consultants PA

Stephen Scott Grubbs
Ph: 302-733-6227

Stephen Scott Grubbs
Principal Investigator

Regional Hematology and Oncology PA

Stephen Scott Grubbs
Ph: 302-733-6227

Stephen Scott Grubbs
Principal Investigator

Rehoboth Beach

Beebe Health Campus

Stephen Scott Grubbs
Ph: 302-733-6227

Stephen Scott Grubbs
Principal Investigator

Seaford

Nanticoke Memorial Hospital

Stephen Scott Grubbs
Ph: 302-733-6227

Stephen Scott Grubbs
Principal Investigator

Wilmington

Christiana Care Health System-Wilmington Hospital

Stephen Scott Grubbs
Ph: 302-733-6227

Stephen Scott Grubbs
Principal Investigator

District of Columbia
Washington

MedStar Georgetown University Hospital

Nancy Ann Dawson
Ph: 202-444-0381

Nancy Ann Dawson
Principal Investigator

Florida
Altamonte Springs

Florida Hospital Cancer Institute Altamonte

Lee M. Zehngebot
Ph: 407-303-5623

Lee M. Zehngebot
Principal Investigator

Kissimmee

Florida Hospital Kissimmee

Lee M. Zehngebot
Ph: 407-303-5623

Lee M. Zehngebot
Principal Investigator

Miami Beach

Mount Sinai Medical Center

Michael A. Schwartz
Ph: 305-674-2625
Email: info@msccop.com

Michael A. Schwartz
Principal Investigator

Orlando

Florida Hospital East Orlando

Lee M. Zehngebot
Ph: 407-303-5623

Lee M. Zehngebot
Principal Investigator

Florida Hospital Orlando

Lee M. Zehngebot
Ph: 407-303-5623

Lee M. Zehngebot
Principal Investigator

Florida Urology Associates-Orlando

Lee M. Zehngebot
Ph: 407-303-5623

Lee M. Zehngebot
Principal Investigator

Weston

Cleveland Clinic-Weston

Nicolas Andre Muruve
Ph: 954-659-5705

Nicolas Andre Muruve
Principal Investigator

Winter Park

Florida Hospital Cancer Institute Winter Park

Lee M. Zehngebot
Ph: 407-303-5623

Lee M. Zehngebot
Principal Investigator

Georgia
Columbus

John B Amos Cancer Center

Andrew W. Pippas
Ph: 706-660-6404

Andrew W. Pippas
Principal Investigator

Idaho
Boise

Saint Alphonsus Cancer Care Center-Boise

Philip J. Stella
Ph: 734-712-4673

Philip J. Stella
Principal Investigator

Lewiston

Saint Joseph Regional Medical Center

Yoshio Inoue
Ph: 800-351-7955

Yoshio Inoue
Principal Investigator

Illinois
Bloomington

Illinois CancerCare-Bloomington

James Lloyd Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

James Lloyd Wade
Principal Investigator

Saint Joseph Medical Center

James Lloyd Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

James Lloyd Wade
Principal Investigator

Canton

Illinois CancerCare-Canton

James Lloyd Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

James Lloyd Wade
Principal Investigator

Carbondale

Memorial Hospital of Carbondale

James Lloyd Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

James Lloyd Wade
Principal Investigator

Carthage

Illinois CancerCare-Carthage

James Lloyd Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

James Lloyd Wade
Principal Investigator

Centralia

Centralia Oncology Clinic

James Lloyd Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

James Lloyd Wade
Principal Investigator

Chicago

University of Chicago Comprehensive Cancer Center

David VanderWeele
Ph: 773-834-7424

David VanderWeele
Principal Investigator

Decatur

Cancer Care Center of Decatur

James Lloyd Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

James Lloyd Wade
Principal Investigator

Decatur Memorial Hospital

James Lloyd Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

James Lloyd Wade
Principal Investigator

Effingham

Crossroads Cancer Center

James Lloyd Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

James Lloyd Wade
Principal Investigator

Eureka

Illinois CancerCare-Eureka

James Lloyd Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

James Lloyd Wade
Principal Investigator

Galesburg

Illinois CancerCare Galesburg

James Lloyd Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

James Lloyd Wade
Principal Investigator

Western Illinois Cancer Treatment Center

James Lloyd Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

James Lloyd Wade
Principal Investigator

Kewanee

Illinois CancerCare-Kewanee Clinic

James Lloyd Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

James Lloyd Wade
Principal Investigator

Macomb

Illinois CancerCare-Macomb

James Lloyd Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

James Lloyd Wade
Principal Investigator

Maywood

Loyola University Medical Center

Ellen R. Gaynor
Ph: 708-226-4357

Ellen R. Gaynor
Principal Investigator

Ottawa

Illinois CancerCare-Ottawa Clinic

James Lloyd Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

James Lloyd Wade
Principal Investigator

Radiation Oncology of Northern Illinois

James Lloyd Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

James Lloyd Wade
Principal Investigator

Pekin

Illinois CancerCare-Pekin

James Lloyd Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

James Lloyd Wade
Principal Investigator

Pekin Cancer Treatment Center

James Lloyd Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

James Lloyd Wade
Principal Investigator

Peoria

Illinois CancerCare-Peoria

James Lloyd Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

James Lloyd Wade
Principal Investigator

Methodist Medical Center of Illinois

James Lloyd Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

James Lloyd Wade
Principal Investigator

OSF Saint Francis Medical Center

James Lloyd Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

James Lloyd Wade
Principal Investigator

OSF Saint Francis Medical Center Radiation Oncology Service at the Central Illinois Comprehensive CC

James Lloyd Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

James Lloyd Wade
Principal Investigator

Peru

Illinois CancerCare-Peru

James Lloyd Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

James Lloyd Wade
Principal Investigator

Valley Radiation Oncology

James Lloyd Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

James Lloyd Wade
Principal Investigator

Princeton

Illinois CancerCare-Princeton

James Lloyd Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

James Lloyd Wade
Principal Investigator

Springfield

Central Illinois Hematology Oncology Center

James Lloyd Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

James Lloyd Wade
Principal Investigator

Memorial Medical Center

James Lloyd Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

James Lloyd Wade
Principal Investigator

Southern Illinois University School of Medicine

James Lloyd Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

James Lloyd Wade
Principal Investigator

Springfield Clinic

James Lloyd Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

James Lloyd Wade
Principal Investigator

Swansea

Cancer Care Specialists of Illinois-Swansea

James Lloyd Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

James Lloyd Wade
Principal Investigator

Indiana
Crown Point

Michiana Hematology Oncology PC-Crown Point

Rafat H. Ansari
Ph: 574-234-5123

Rafat H. Ansari
Principal Investigator

Elkhart

Michiana Hematology Oncology PC-Elkhart

Rafat H. Ansari
Ph: 574-234-5123

Rafat H. Ansari
Principal Investigator

Mishawaka

Memorial Regional Cancer Center Day Road

Thomas Joseph Reid
Ph: 800-284-7370

Thomas Joseph Reid
Principal Investigator

Michiana Hematology Oncology PC-Mishawaka

Rafat H. Ansari
Ph: 574-234-5123

Rafat H. Ansari
Principal Investigator

Saint Joseph Regional Medical Center-Mishawaka

Rafat H. Ansari
Ph: 574-234-5123

Rafat H. Ansari
Principal Investigator

Plymouth

Michiana Hematology Oncology PC-Plymouth

Rafat H. Ansari
Ph: 574-234-5123

Rafat H. Ansari
Principal Investigator

South Bend

Memorial Hospital of South Bend

Thomas Joseph Reid
Ph: 800-284-7370

Thomas Joseph Reid
Principal Investigator

Michiana Hematology Oncology PC-South Bend

Rafat H. Ansari
Ph: 574-234-5123

Rafat H. Ansari
Principal Investigator

Northern Indiana Cancer Research Consortium CCOP

Rafat H. Ansari
Ph: 574-234-5123

Rafat H. Ansari
Principal Investigator

Westville

Michiana Hematology Oncology PC-Westville

Rafat H. Ansari
Ph: 574-234-5123

Rafat H. Ansari
Principal Investigator

Iowa
Davenport

Genesis Medical Center - East Campus

George Kovach
Ph: 800-446-6088
Email: werners@genesishealth.com

George Kovach
Principal Investigator

Iowa City

University of Iowa/Holden Comprehensive Cancer Center

Daniel Alberto Vaena
Ph: 800-237-1225

Daniel Alberto Vaena
Principal Investigator

Kansas
Emporia

Newman Regional Health

Peter J. Van Veldhuizen
Ph: 800-525-1483

Peter J. Van Veldhuizen
Principal Investigator

Garden City

Saint Catherine Hospital

Peter J. Van Veldhuizen
Ph: 800-525-1483

Peter J. Van Veldhuizen
Principal Investigator

Great Bend

Saint Rose Ambulatory and Surgery Center

Peter J. Van Veldhuizen
Ph: 800-525-1483

Peter J. Van Veldhuizen
Principal Investigator

Hays

Hays Medical Center

Peter J. Van Veldhuizen
Ph: 800-525-1483

Peter J. Van Veldhuizen
Principal Investigator

Kansas City

Kansas City Cancer Center-West

Peter J. Van Veldhuizen
Ph: 800-525-1483

Peter J. Van Veldhuizen
Principal Investigator

University of Kansas Cancer Center

Peter J. Van Veldhuizen
Ph: 800-525-1483

Peter J. Van Veldhuizen
Principal Investigator

Olathe

Olathe Medical Center

Peter J. Van Veldhuizen
Ph: 800-525-1483

Peter J. Van Veldhuizen
Principal Investigator

Overland Park

Kansas City Cancer Centers-Southwest

Peter J. Van Veldhuizen
Ph: 800-525-1483

Peter J. Van Veldhuizen
Principal Investigator

Pittsburg

Via Christi Hospital-Pittsburg

Peter J. Van Veldhuizen
Ph: 800-525-1483

Peter J. Van Veldhuizen
Principal Investigator

Salina

Salina Regional Health Center

Peter J. Van Veldhuizen
Ph: 800-525-1483

Peter J. Van Veldhuizen
Principal Investigator

Topeka

Saint Francis Hospital and Medical Center - Topeka

Peter J. Van Veldhuizen
Ph: 800-525-1483

Peter J. Van Veldhuizen
Principal Investigator

Louisiana
Baton Rouge

Louisiana Hematology Oncology Associates LLC

Augusto C. Ochoa
Ph: 504-568-2428
Email: emede1@lsuhsc.edu

Augusto C. Ochoa
Principal Investigator

Mary Bird Perkins Cancer Center

Augusto C. Ochoa
Ph: 504-568-2428
Email: emede1@lsuhsc.edu

Augusto C. Ochoa
Principal Investigator

Medical Oncology LLC

Augusto C. Ochoa
Ph: 504-568-2428
Email: emede1@lsuhsc.edu

Augusto C. Ochoa
Principal Investigator

Houma

Mary Bird Perkins Cancer Center/Terrebonne General Medical Center

Augusto C. Ochoa
Ph: 504-568-2428
Email: emede1@lsuhsc.edu

Augusto C. Ochoa
Principal Investigator

Metairie

East Jefferson General Hospital

Augusto C. Ochoa
Ph: 504-568-2428
Email: emede1@lsuhsc.edu

Augusto C. Ochoa
Principal Investigator

Robert Veith MD LLC

Augusto C. Ochoa
Ph: 504-568-2428
Email: emede1@lsuhsc.edu

Augusto C. Ochoa
Principal Investigator

New Orleans

Interim LSU Public Hospital

Augusto C. Ochoa
Ph: 504-568-2428
Email: emede1@lsuhsc.edu

Augusto C. Ochoa
Principal Investigator

Louisiana State University Health Science Center

Augusto C. Ochoa
Ph: 504-568-2428
Email: emede1@lsuhsc.edu

Augusto C. Ochoa
Principal Investigator

Tulane University Health Sciences Center

Hana F. Safah
Ph: 504-988-6121

Hana F. Safah
Principal Investigator

Shreveport

Louisiana State University Health Sciences Center Shreveport

James Andrew Eastham

James Andrew Eastham
Principal Investigator

Maine
Scarborough

Maine Center for Cancer Medicine-Scarborough

Frederick Rupp Aronson
Email: research@newecs.org

Frederick Rupp Aronson
Principal Investigator

Maryland
Bethesda

Walter Reed National Military Medical Center

David C. Van Echo
Ph: 301-319-2100

David C. Van Echo
Principal Investigator

Salisbury

Peninsula Regional Medical Center

Paul E. Zorsky
Ph: 410-543-7017
Email: sandra.heineken@peninsula.org

Paul E. Zorsky
Principal Investigator

Massachusetts
Boston

Tufts Medical Center

Paul Mathew
Ph: 617-636-5000
Email: ContactUsCancerCenter@TuftsMedicalCenter.org

Paul Mathew
Principal Investigator

Pittsfield

Berkshire Hematology Oncology PC

Harvey Zimbler
Ph: 413-496-8205
Email: ggero@bhs1.org

Harvey Zimbler
Principal Investigator

Michigan
Ann Arbor

Saint Joseph Mercy Hospital

Philip J. Stella
Ph: 734-712-4673

Philip J. Stella
Principal Investigator

Battle Creek

Bronson Battle Creek

Gilbert D.A. Padula
Ph: 616-685-5225
Email: connie.szczepanek@grcop.org

Gilbert D.A. Padula
Principal Investigator

Dearborn

Oakwood Hospital and Medical Center

Philip J. Stella
Ph: 734-712-4673

Philip J. Stella
Principal Investigator

Detroit

Saint John Hospital and Medical Center

Philip J. Stella
Ph: 734-712-4673

Philip J. Stella
Principal Investigator

Flint

Genesys Hurley Cancer Institute

Philip J. Stella
Ph: 734-712-4673

Philip J. Stella
Principal Investigator

Hurley Medical Center

Philip J. Stella
Ph: 734-712-4673

Philip J. Stella
Principal Investigator

Grand Rapids

Mercy Health Saint Mary's

Gilbert D.A. Padula
Ph: 616-685-5225
Email: connie.szczepanek@grcop.org

Gilbert D.A. Padula
Principal Investigator

Spectrum Health at Butterworth Campus

Gilbert D.A. Padula
Ph: 616-685-5225
Email: connie.szczepanek@grcop.org

Gilbert D.A. Padula
Principal Investigator

Jackson

Allegiance Health

Philip J. Stella
Ph: 734-712-4673

Philip J. Stella
Principal Investigator

Lansing

Sparrow Hospital

Philip J. Stella
Ph: 734-712-4673

Philip J. Stella
Principal Investigator

Livonia

Saint Mary Mercy Hospital

Philip J. Stella
Ph: 734-712-4673

Philip J. Stella
Principal Investigator

Muskegon

Mercy Health Mercy Campus

Gilbert D.A. Padula
Ph: 616-685-5225
Email: connie.szczepanek@grcop.org

Gilbert D.A. Padula
Principal Investigator

Niles

Lakeland Community Hospital

Rafat H. Ansari
Ph: 574-234-5123

Rafat H. Ansari
Principal Investigator

Pontiac

Saint Joseph Mercy Oakland

Philip J. Stella
Ph: 734-712-4673

Philip J. Stella
Principal Investigator

Port Huron

Saint Joseph Mercy Port Huron

Philip J. Stella
Ph: 734-712-4673

Philip J. Stella
Principal Investigator

Reed City

Spectrum Health Reed City Hospital

Gilbert D.A. Padula
Ph: 616-685-5225
Email: connie.szczepanek@grcop.org

Gilbert D.A. Padula
Principal Investigator

Saginaw

Saint Mary's of Michigan

Philip J. Stella
Ph: 734-712-4673

Philip J. Stella
Principal Investigator

Saint Joseph

Marie Yeager Cancer Center

Rafat H. Ansari
Ph: 574-234-5123

Rafat H. Ansari
Principal Investigator

St. Joseph

Lakeland Hospital

Rafat H. Ansari
Ph: 574-234-5123

Rafat H. Ansari
Principal Investigator

Traverse City

Munson Medical Center

Gilbert D.A. Padula
Ph: 616-685-5225
Email: connie.szczepanek@grcop.org

Gilbert D.A. Padula
Principal Investigator

Warren

Saint John Macomb-Oakland Hospital

Philip J. Stella
Ph: 734-712-4673

Philip J. Stella
Principal Investigator

Minnesota
Burnsville

Fairview Ridges Hospital

Patrick James Flynn
Ph: 952-993-1517
Email: MMCCOP@parknicollet.com

Patrick James Flynn
Principal Investigator

Coon Rapids

Mercy Hospital

Patrick James Flynn
Ph: 952-993-1517
Email: MMCCOP@parknicollet.com

Patrick James Flynn
Principal Investigator

Edina

Fairview-Southdale Hospital

Patrick James Flynn
Ph: 952-993-1517
Email: MMCCOP@parknicollet.com

Patrick James Flynn
Principal Investigator

Fridley

Unity Hospital

Patrick James Flynn
Ph: 952-993-1517
Email: MMCCOP@parknicollet.com

Patrick James Flynn
Principal Investigator

Hutchinson

Hutchinson Area Health Care

Patrick James Flynn
Ph: 952-993-1517
Email: MMCCOP@parknicollet.com

Patrick James Flynn
Principal Investigator

Maplewood

Minnesota Oncology Hematology PA-Maplewood

Patrick James Flynn
Ph: 952-993-1517
Email: MMCCOP@parknicollet.com

Patrick James Flynn
Principal Investigator

Saint John's Hospital - Healtheast

Patrick James Flynn
Ph: 952-993-1517
Email: MMCCOP@parknicollet.com

Patrick James Flynn
Principal Investigator

Minneapolis

Abbott-Northwestern Hospital

Patrick James Flynn
Ph: 952-993-1517
Email: MMCCOP@parknicollet.com

Patrick James Flynn
Principal Investigator

Health Partners Inc

Patrick James Flynn
Ph: 952-993-1517
Email: MMCCOP@parknicollet.com

Patrick James Flynn
Principal Investigator

Hennepin County Medical Center

Patrick James Flynn
Ph: 952-993-1517
Email: MMCCOP@parknicollet.com

Patrick James Flynn
Principal Investigator

University of Minnesota Medical Center-Fairview

Bruce Attree Peterson
Ph: 612-624-2620

Bruce Attree Peterson
Principal Investigator

New Ulm

New Ulm Medical Center

Patrick James Flynn
Ph: 952-993-1517
Email: MMCCOP@parknicollet.com

Patrick James Flynn
Principal Investigator

Robbinsdale

North Memorial Medical Health Center

Patrick James Flynn
Ph: 952-993-1517
Email: MMCCOP@parknicollet.com

Patrick James Flynn
Principal Investigator

Saint Cloud

Coborn Cancer Center at Saint Cloud Hospital

Donald James Jurgens
Ph: 877-229-4907
Email: coborncancercenter@centracare.com

Donald James Jurgens
Principal Investigator

Saint Cloud Hospital

Donald James Jurgens
Ph: 877-229-4907
Email: coborncancercenter@centracare.com

Donald James Jurgens
Principal Investigator

Saint Louis Park

Park Nicollet Clinic - Saint Louis Park

Patrick James Flynn
Ph: 952-993-1517
Email: MMCCOP@parknicollet.com

Patrick James Flynn
Principal Investigator

Saint Paul

Regions Hospital

Patrick James Flynn
Ph: 952-993-1517
Email: MMCCOP@parknicollet.com

Patrick James Flynn
Principal Investigator

United Hospital

Patrick James Flynn
Ph: 952-993-1517
Email: MMCCOP@parknicollet.com

Patrick James Flynn
Principal Investigator

Shakopee

Saint Francis Regional Medical Center

Patrick James Flynn
Ph: 952-993-1517
Email: MMCCOP@parknicollet.com

Patrick James Flynn
Principal Investigator

Stillwater

Lakeview Hospital

Patrick James Flynn
Ph: 952-993-1517
Email: MMCCOP@parknicollet.com

Patrick James Flynn
Principal Investigator

Waconia

Ridgeview Medical Center

Patrick James Flynn
Ph: 952-993-1517
Email: MMCCOP@parknicollet.com

Patrick James Flynn
Principal Investigator

Willmar

Rice Memorial Hospital

Patrick James Flynn
Ph: 952-993-1517
Email: MMCCOP@parknicollet.com

Patrick James Flynn
Principal Investigator

Woodbury

Minnesota Oncology and Hematology PA-Woodbury

Patrick James Flynn
Ph: 952-993-1517
Email: MMCCOP@parknicollet.com

Patrick James Flynn
Principal Investigator

Mississippi
Hattiesburg

Forest General Hospital

Augusto C. Ochoa
Ph: 504-568-2428
Email: emede1@lsuhsc.edu

Augusto C. Ochoa
Principal Investigator

Hattiesburg Clinic

Augusto C. Ochoa
Ph: 504-568-2428
Email: emede1@lsuhsc.edu

Augusto C. Ochoa
Principal Investigator

Jackson

University of Mississippi Medical Center

Robert Darryl Hamilton
Ph: 601-815-6700

Robert Darryl Hamilton
Principal Investigator

Missouri
Bonne Terre

Parkland Health Center-Bonne Terre

James Lloyd Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

James Lloyd Wade
Principal Investigator

Cape Girardeau

Saint Francis Medical Center

James Lloyd Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

James Lloyd Wade
Principal Investigator

Southeast Cancer Center

James Lloyd Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

James Lloyd Wade
Principal Investigator

Jefferson City

Capital Region Medical Center-Goldschmidt Cancer Center

James Lloyd Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

James Lloyd Wade
Principal Investigator

Kansas City

Kansas City Cancer Center - South

Peter J. Van Veldhuizen
Ph: 800-525-1483

Peter J. Van Veldhuizen
Principal Investigator

Kansas City Cancer Centers - North

Peter J. Van Veldhuizen
Ph: 800-525-1483

Peter J. Van Veldhuizen
Principal Investigator

Truman Medical Center

Peter J. Van Veldhuizen
Ph: 800-525-1483

Peter J. Van Veldhuizen
Principal Investigator

Lee's Summit

Kansas City Cancer Center-Lee's Summit

Peter J. Van Veldhuizen
Ph: 800-525-1483

Peter J. Van Veldhuizen
Principal Investigator

Saint Louis

Missouri Baptist Medical Center

James Lloyd Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

James Lloyd Wade
Principal Investigator

Washington University School of Medicine

Joel Picus
Ph: 800-600-3606
Email: info@siteman.wustl.edu

Joel Picus
Principal Investigator

Sainte Genevieve

Sainte Genevieve County Memorial Hospital

James Lloyd Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

James Lloyd Wade
Principal Investigator

Sullivan

Missouri Baptist Sullivan Hospital

James Lloyd Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

James Lloyd Wade
Principal Investigator

Sunset Hills

Missouri Baptist Outpatient Center-Sunset Hills

James Lloyd Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

James Lloyd Wade
Principal Investigator

Montana
Billings

Billings Clinic Cancer Center

Benjamin T. Marchello
Ph: 800-648-6274

Benjamin T. Marchello
Principal Investigator

Montana Cancer Consortium CCOP

Benjamin T. Marchello
Ph: 800-648-6274

Benjamin T. Marchello
Principal Investigator

Saint Vincent Healthcare

Benjamin T. Marchello
Ph: 800-648-6274

Benjamin T. Marchello
Principal Investigator

Bozeman

Bozeman Deaconess Hospital

Benjamin T. Marchello
Ph: 800-648-6274

Benjamin T. Marchello
Principal Investigator

Butte

Saint James Community Hospital and Cancer Treatment Center

Benjamin T. Marchello
Ph: 800-648-6274

Benjamin T. Marchello
Principal Investigator

Great Falls

Benefis Healthcare- Sletten Cancer Institute

Benjamin T. Marchello
Ph: 800-648-6274

Benjamin T. Marchello
Principal Investigator

Helena

Saint Peter's Community Hospital

Benjamin T. Marchello
Ph: 800-648-6274

Benjamin T. Marchello
Principal Investigator

Kalispell

Kalispell Regional Medical Center

Benjamin T. Marchello
Ph: 800-648-6274

Benjamin T. Marchello
Principal Investigator

Missoula

Saint Patrick Hospital - Community Hospital

Benjamin T. Marchello
Ph: 800-648-6274

Benjamin T. Marchello
Principal Investigator

Nebraska
Lincoln

Nebraska Cancer Research Center

Gamini S. Soori
Ph: 402-991-8070
Email: mwilwerding@mvcc.cc

Gamini S. Soori
Principal Investigator

Nebraska Hematology and Oncology

Gamini S. Soori
Ph: 402-991-8070
Email: mwilwerding@mvcc.cc

Gamini S. Soori
Principal Investigator

Southeast Nebraska Cancer Center

Gamini S. Soori
Ph: 402-991-8070
Email: mwilwerding@mvcc.cc

Gamini S. Soori
Principal Investigator

Norfolk

Faith Regional Medical Offices West

Gamini S. Soori
Ph: 402-991-8070
Email: mwilwerding@mvcc.cc

Gamini S. Soori
Principal Investigator

North Platte

Great Plains Regional Medical Center

Gamini S. Soori
Ph: 402-991-8070
Email: mwilwerding@mvcc.cc

Gamini S. Soori
Principal Investigator

Omaha

Missouri Valley Cancer Consortium

Gamini S. Soori
Ph: 402-991-8070ext202
Email: mwilwerding@mvcc.cc

Gamini S. Soori
Principal Investigator

Oncology Hematology West

Gamini S. Soori
Ph: 402-991-8070
Email: mwilwerding@mvcc.cc

Gamini S. Soori
Principal Investigator

Oncology Hematology West PC

Gamini S. Soori
Ph: 402-991-8070
Email: mwilwerding@mvcc.cc

Gamini S. Soori
Principal Investigator

Scottsbluff

Regional West Medical Center

Gamini S. Soori
Ph: 402-991-8070
Email: mwilwerding@mvcc.cc

Gamini S. Soori
Principal Investigator

Nevada
Henderson

21st Century Oncology - Henderson

John Allan Ellerton
Ph: 702-384-0013

John Allan Ellerton
Principal Investigator

Cancer and Blood Specialists-Henderson

John Allan Ellerton
Ph: 702-384-0013

John Allan Ellerton
Principal Investigator

Comprehensive Cancer Centers of Nevada - Henderson

John Allan Ellerton
Ph: 702-384-0013

John Allan Ellerton
Principal Investigator

Comprehensive Cancer Centers of Nevada-Southeast Henderson

John Allan Ellerton
Ph: 702-384-0013

John Allan Ellerton
Principal Investigator

Las Vegas Cancer Center-Henderson

John Allan Ellerton
Ph: 702-384-0013

John Allan Ellerton
Principal Investigator

Las Vegas

21st Century Oncology

John Allan Ellerton
Ph: 702-384-0013

John Allan Ellerton
Principal Investigator

21st Century Oncology - Fort Apache

John Allan Ellerton
Ph: 702-384-0013

John Allan Ellerton
Principal Investigator

21st Century Oncology - Vegas Tenaya

John Allan Ellerton
Ph: 702-384-0013

John Allan Ellerton
Principal Investigator

Cancer and Blood Specialists-Fort Apache

John Allan Ellerton
Ph: 702-384-0013

John Allan Ellerton
Principal Investigator

Cancer and Blood Specialists-Shadow

John Allan Ellerton
Ph: 702-384-0013

John Allan Ellerton
Principal Investigator

Cancer and Blood Specialists-Tenaya

John Allan Ellerton
Ph: 702-384-0013

John Allan Ellerton
Principal Investigator

Cancer Therapy and Integrative Medicine

John Allan Ellerton
Ph: 702-384-0013

John Allan Ellerton
Principal Investigator

Comprehensive Cancer Centers of Nevada

John Allan Ellerton
Ph: 702-384-0013

John Allan Ellerton
Principal Investigator

Comprehensive Cancer Centers of Nevada - Central Valley

John Allan Ellerton
Ph: 702-384-0013

John Allan Ellerton
Principal Investigator

Comprehensive Cancer Centers of Nevada - Northwest

John Allan Ellerton
Ph: 702-384-0013

John Allan Ellerton
Principal Investigator

Comprehensive Cancer Centers of Nevada-Summerlin

John Allan Ellerton
Ph: 702-384-0013

John Allan Ellerton
Principal Investigator

HealthCare Partners Medical Group Oncology/Hematology-Centennial Hills

John Allan Ellerton
Ph: 702-384-0013

John Allan Ellerton
Principal Investigator

HealthCare Partners Medical Group Oncology/Hematology-Maryland Parkway

John Allan Ellerton
Ph: 702-384-0013

John Allan Ellerton
Principal Investigator

HealthCare Partners Medical Group Oncology/Hematology-San Martin

John Allan Ellerton
Ph: 702-384-0013

John Allan Ellerton
Principal Investigator

HealthCare Partners Medical Group Oncology/Hematology-Tenaya

John Allan Ellerton
Ph: 702-384-0013

John Allan Ellerton
Principal Investigator

Las Vegas Cancer Center-Medical Center

John Allan Ellerton
Ph: 702-384-0013

John Allan Ellerton
Principal Investigator

Nevada Cancer Research Foundation CCOP

John Allan Ellerton
Ph: 702-384-0013

John Allan Ellerton
Principal Investigator

Radiation Oncology Centers of Nevada Central

John Allan Ellerton
Ph: 702-384-0013

John Allan Ellerton
Principal Investigator

Radiation Oncology Centers of Nevada Southeast

John Allan Ellerton
Ph: 702-384-0013

John Allan Ellerton
Principal Investigator

Summerlin Hospital Medical Center

John Allan Ellerton
Ph: 702-384-0013

John Allan Ellerton
Principal Investigator

University Medical Center of Southern Nevada

John Allan Ellerton
Ph: 702-384-0013

John Allan Ellerton
Principal Investigator

New Hampshire
Concord

New Hampshire Oncology Hematology PA-Concord

Douglas J. Weckstein
Ph: 603-224-2556

Douglas J. Weckstein
Principal Investigator

Derry

Parkland Medical Center

Lata Chandi Thatai
Ph: 781-744-8027

Lata Chandi Thatai
Principal Investigator

Exeter

Exeter Hospital

Michael S. Buff
Ph: 800-339-6484

Michael S. Buff
Principal Investigator

Hooksett

New Hampshire Oncology Hematology PA-Hooksett

Douglas J. Weckstein
Ph: 603-224-2556

Douglas J. Weckstein
Principal Investigator

Lebanon

Dartmouth Hitchcock Medical Center

John D. Seigne
Ph: 800-639-6918
Email: cancer.research.nurse@dartmouth.edu

John D. Seigne
Principal Investigator

New Jersey
Basking Ridge

Memorial Sloan Kettering Cancer Center at Basking Ridge

James Andrew Eastham
Ph: 212-639-7202

James Andrew Eastham
Principal Investigator

Camden

Cooper Hospital University Medical Center

Robert A. Somer
Ph: 856-325-6757

Robert A. Somer
Principal Investigator

Morristown

Morristown Medical Center

Stacey Bucholtz Leibowitz
Ph: 973-971-5900

Stacey Bucholtz Leibowitz
Principal Investigator

Somerville

Robert Wood Johnson University Hospital Somerset

Steven Eugene Young
Ph: 908-685-2481

Steven Eugene Young
Principal Investigator

Sparta

Sparta Cancer Treatment Center

Edouard John Trabulsi
Ph: 215-955-6084

Edouard John Trabulsi
Principal Investigator

Summit

Overlook Hospital

Stacey Bucholtz Leibowitz
Ph: 973-971-5900

Stacey Bucholtz Leibowitz
Principal Investigator

Voorhees

MD Anderson Cancer Center at Cooper-Voorhees

Robert A. Somer
Ph: 856-325-6757

Robert A. Somer
Principal Investigator

New Mexico
Albuquerque

Hematology Oncology Associates

Richard C. Lauer
Ph: 505-272-6972

Richard C. Lauer
Principal Investigator

Lovelace Medical Center-Downtown

Richard C. Lauer
Ph: 505-272-6972

Richard C. Lauer
Principal Investigator

Presbyterian Kaseman Hospital

Richard C. Lauer
Ph: 505-272-6972

Richard C. Lauer
Principal Investigator

University of New Mexico

James Andrew Eastham

James Andrew Eastham
Principal Investigator

University of New Mexico Cancer Center

Richard C. Lauer
Ph: 505-272-6972

Richard C. Lauer
Principal Investigator

New York
Buffalo

Roswell Park Cancer Institute

James L. Mohler
Ph: 877-275-7724

James L. Mohler
Principal Investigator

Commack

Memorial Sloan Kettering Cancer Center Commack

James Andrew Eastham
Ph: 212-639-7202

James Andrew Eastham
Principal Investigator

New York

Memorial Sloan-Kettering Cancer Center

James Andrew Eastham
Ph: 212-639-7202

James Andrew Eastham
Principal Investigator

Rochester

University of Rochester

Jonathan Willmann Friedberg
Ph: 585-275-5830

Jonathan Willmann Friedberg
Principal Investigator

Syracuse

State University of New York Upstate Medical University

Bernard J. Poiesz
Ph: 315-464-5476

Bernard J. Poiesz
Principal Investigator

West Harrison

Memorial Sloan-Kettering Cancer Center West Harrison

James Andrew Eastham
Ph: 212-639-7202

James Andrew Eastham
Principal Investigator

North Carolina
Charlotte

Carolinas Medical Center/Levine Cancer Institute

John F. Mahoney
Ph: 704-355-2884

John F. Mahoney
Principal Investigator

Carolinas Medical Center/Levine Cancer Institute-Pineville

John F. Mahoney
Ph: 704-355-2884

John F. Mahoney
Principal Investigator

Carolinas Medical Center/Levine Cancer Institute-University

John F. Mahoney
Ph: 704-355-2884

John F. Mahoney
Principal Investigator

Levine Cancer Institute-Ballantyne

John F. Mahoney
Ph: 704-355-2884

John F. Mahoney
Principal Investigator

Levine Cancer Institute-Tryon

John F. Mahoney
Ph: 704-355-2884

John F. Mahoney
Principal Investigator

Mecklenburg Medical Group-South Park

John F. Mahoney
Ph: 704-355-2884

John F. Mahoney
Principal Investigator

Durham

Duke University Medical Center

Jeffrey Crawford
Ph: 888-275-3853

Jeffrey Crawford
Principal Investigator

Hendersonville

Park Ridge Hospital Breast Health Center

Charles E. Bowers
Ph: 800-486-5941

Charles E. Bowers
Principal Investigator

Kernersville

Novant Health Oncology Specialists-Kernersville

Judith Owen Hopkins
Ph: 336-277-8887

Judith Owen Hopkins
Principal Investigator

Kinston

Kinston Medical Specialists PA

Peter Robins Watson
Ph: 252-559-2200

Peter Robins Watson
Principal Investigator

Lexington

Novant Health Oncology Specialists-Davidson County

Judith Owen Hopkins
Ph: 336-277-8887

Judith Owen Hopkins
Principal Investigator

Monroe

Carolinas HealthCare System Union

John F. Mahoney
Ph: 704-355-2884

John F. Mahoney
Principal Investigator

Mount Airy

Novant Health Oncology Specialists-Mount Airy

Judith Owen Hopkins
Ph: 336-277-8887

Judith Owen Hopkins
Principal Investigator

Raleigh

Duke Raleigh Hospital

Jeffrey Crawford
Ph: 888-275-3853

Jeffrey Crawford
Principal Investigator

Shelby

Cleveland Regional Medical Center

John F. Mahoney
Ph: 704-355-2884

John F. Mahoney
Principal Investigator

Stateville

Novant Health Oncology Specialists-Statesville

Judith Owen Hopkins
Ph: 336-277-8887

Judith Owen Hopkins
Principal Investigator

Wilkesboro

Novant Health Oncology Specialists-Wilkesboro

Judith Owen Hopkins
Ph: 336-277-8887

Judith Owen Hopkins
Principal Investigator

Winston-Salem

Novant Health Forsyth Medical Center

Judith Owen Hopkins
Ph: 336-277-8887

Judith Owen Hopkins
Principal Investigator

Novant Health Oncology Specialists

Judith Owen Hopkins
Ph: 336-277-8887

Judith Owen Hopkins
Principal Investigator

Wake Forest University Health Sciences

Ashok K. Hemal
Ph: 888-823-5923
Email: ctsucontact@westat.com

Ashok K. Hemal
Principal Investigator

Winston-Salem Health Care

Judith Owen Hopkins
Ph: 336-277-8887

Judith Owen Hopkins
Principal Investigator

Ohio
Cleveland

Cleveland Clinic Cancer Center/Fairview Hospital

Anjali S. Advani
Ph: 866-223-8100

Anjali S. Advani
Principal Investigator

MetroHealth Medical Center

Bruce J. Averbook
Ph: 216-778-8526
Email: kbauchens@metrohealth.org

Bruce J. Averbook
Principal Investigator

Columbus

Ohio State University Comprehensive Cancer Center

James Andrew Eastham

James Andrew Eastham
Principal Investigator

Independence

Cleveland Clinic Cancer Center Independence

Anjali S. Advani
Ph: 866-223-8100

Anjali S. Advani
Principal Investigator

Lima

Saint Rita's Medical Center

Henry Gerad
Ph: 419-226-9617

Henry Gerad
Principal Investigator

Mansfield

Cleveland Clinic Cancer Center Mansfield

Anjali S. Advani
Ph: 866-223-8100

Anjali S. Advani
Principal Investigator

Mayfield Heights

Hillcrest Hospital Cancer Center

Anjali S. Advani
Ph: 866-223-8100

Anjali S. Advani
Principal Investigator

Sandusky

North Coast Cancer Care

Anjali S. Advani
Ph: 866-223-8100

Anjali S. Advani
Principal Investigator

Strongsville

Cleveland Clinic Cancer Center Strongsville

Anjali S. Advani
Ph: 866-223-8100

Anjali S. Advani
Principal Investigator

Sylvania

Flower Hospital

Jeffrey Henry Muler
Ph: 419-824-1842

Jeffrey Henry Muler
Principal Investigator

Warrensville Heights

South Pointe Hospital

Anjali S. Advani
Ph: 866-223-8100

Anjali S. Advani
Principal Investigator

Wooster

Cleveland Clinic Wooster Specialty Center

Anjali S. Advani
Ph: 866-223-8100

Anjali S. Advani
Principal Investigator

Oklahoma
Oklahoma City

University of Oklahoma Health Sciences Center

Sindhu Singh
Ph: 405-271-4272
Email: julie-traylor@ouhsc.edu

Sindhu Singh
Principal Investigator

Tulsa

Tulsa Cancer Institute

Sindhu Singh
Ph: 405-271-4272
Email: julie-traylor@ouhsc.edu

Sindhu Singh
Principal Investigator

Oregon
Clackamas

Clackamas Radiation Oncology Center

Keith S. Lanier
Ph: 503-215-6412

Keith S. Lanier
Principal Investigator

Providence Oncology and Hematology Care Southeast

Keith S. Lanier
Ph: 503-215-6412

Keith S. Lanier
Principal Investigator

Coos Bay

Bay Area Hospital

Bret Alan Cook
Ph: 541-269-8392
Email: cherie.cox@bayareahospital.org

Bret Alan Cook
Principal Investigator

Newberg

Providence Newberg Medical Center

Keith S. Lanier
Ph: 503-215-6412

Keith S. Lanier
Principal Investigator

Oregon City

Providence Willamette Falls Medical Center

Keith S. Lanier
Ph: 503-215-6412

Keith S. Lanier
Principal Investigator

Portland

Kaiser Permanente

Nagendra Ranganatha Tirumali
Ph: 503-335-2400

Nagendra Ranganatha Tirumali
Principal Investigator

Oregon Health and Science University

Christopher W. Ryan
Ph: 503-494-1080
Email: trials@ohsu.edu

Christopher W. Ryan
Principal Investigator

Providence Portland Medical Center

Keith S. Lanier
Ph: 503-215-6412

Keith S. Lanier
Principal Investigator

Providence Saint Vincent Medical Center

Keith S. Lanier
Ph: 503-215-6412

Keith S. Lanier
Principal Investigator

Pennsylvania
Darby

Mercy Fitzgerald Hospital

Edouard John Trabulsi
Ph: 215-955-6084

Edouard John Trabulsi
Principal Investigator

Philadelphia

Fox Chase Cancer Center

Rosalia Viterbo
Ph: 215-728-4790

Rosalia Viterbo
Principal Investigator

Thomas Jefferson University Hospital

Edouard John Trabulsi
Ph: 215-955-6084

Edouard John Trabulsi
Principal Investigator

South Carolina
Anderson

AnMed Health Cancer Center

Charles E. Bowers
Ph: 800-486-5941

Charles E. Bowers
Principal Investigator

AnMed Health Hospital

Charles E. Bowers
Ph: 800-486-5941

Charles E. Bowers
Principal Investigator

Charleston

Charleston Hematology Oncology Associates PA-St. Francis

James Michael Orcutt
Ph: 843-720-8386
Email: elizabeth.strojny@roperstfrancis.com

James Michael Orcutt
Principal Investigator

Charleston Hematology Oncology Associates-Roper

James Michael Orcutt
Ph: 843-720-8386
Email: elizabeth.strojny@roperstfrancis.com

James Michael Orcutt
Principal Investigator

Lowcountry Hematology Oncology PA-Charleston

James Michael Orcutt
Ph: 843-720-8386
Email: elizabeth.strojny@roperstfrancis.com

James Michael Orcutt
Principal Investigator

Lowcountry Hematology Oncology PA-West Ashley

James Michael Orcutt
Ph: 843-720-8386
Email: elizabeth.strojny@roperstfrancis.com

James Michael Orcutt
Principal Investigator

Roper Hospital

James Michael Orcutt
Ph: 843-720-8386
Email: elizabeth.strojny@roperstfrancis.com

James Michael Orcutt
Principal Investigator

Greenville

Greenville Health System Cancer Institute-Eastside

Jeffrey K. Giguere
Ph: 864-241-6251

Jeffrey K. Giguere
Principal Investigator

Saint Francis Hospital

Charles E. Bowers
Ph: 800-486-5941

Charles E. Bowers
Principal Investigator

Greer

Gibbs Cancer Center-Pelham

Charles E. Bowers
Ph: 800-486-5941

Charles E. Bowers
Principal Investigator

Lancaster

Carolina Blood and Cancer Care Associates PA-Lancaster

Charles E. Bowers
Ph: 800-486-5941

Charles E. Bowers
Principal Investigator

Mount Pleasant

Lowcountry Hematology Oncology PA-Mount Pleasant

James Michael Orcutt
Ph: 843-720-8386
Email: elizabeth.strojny@roperstfrancis.com

James Michael Orcutt
Principal Investigator

Rock Hill

Carolina Blood and Cancer Care Associates PA

Charles E. Bowers
Ph: 800-486-5941

Charles E. Bowers
Principal Investigator

Spartanburg

Spartanburg Medical Center

Charles E. Bowers
Ph: 800-486-5941

Charles E. Bowers
Principal Investigator

Tennessee
Bristol

Wellmont Bristol Regional Medical Center

Asheesh Shipstone
Ph: 423-578-8538

Asheesh Shipstone
Principal Investigator

Wellmont Medical Associates Oncology and Hematology-Bristol

Asheesh Shipstone
Ph: 423-578-8538

Asheesh Shipstone
Principal Investigator

Kingsport

Wellmont Holston Valley Hospital and Medical Center

Asheesh Shipstone
Ph: 423-578-8538

Asheesh Shipstone
Principal Investigator

Wellmont Medical Associates Oncology and Hematology-Kingsport

Asheesh Shipstone
Ph: 423-578-8538

Asheesh Shipstone
Principal Investigator

Nashville

Meharry Medical College

Philip Edward Lammers
Ph: 615-327-5724
Email: jmurray@mmc.edu

Philip Edward Lammers
Principal Investigator

Texas
Austin

Texas Oncology - Central Austin Cancer Center

Beth Ann Hellerstedt
Ph: 512-341-8724

Beth Ann Hellerstedt
Principal Investigator

Texas Oncology - South Austin Cancer Center

Beth Ann Hellerstedt
Ph: 512-341-8724

Beth Ann Hellerstedt
Principal Investigator

Texas Oncology-Austin Midtown

Beth Ann Hellerstedt
Ph: 512-341-8724

Beth Ann Hellerstedt
Principal Investigator

Texas Oncology-Austin North

Beth Ann Hellerstedt
Ph: 512-341-8724

Beth Ann Hellerstedt
Principal Investigator

Cedar Park

Texas Oncology-Cedar Park

Beth Ann Hellerstedt
Ph: 512-341-8724

Beth Ann Hellerstedt
Principal Investigator

Round Rock

Texas Oncology - Round Rock Cancer Center

Beth Ann Hellerstedt
Ph: 512-341-8724

Beth Ann Hellerstedt
Principal Investigator

Texas Oncology-Seton Williamson

Beth Ann Hellerstedt
Ph: 512-341-8724

Beth Ann Hellerstedt
Principal Investigator

San Marcos

Texas Oncology- San Marcos

Beth Ann Hellerstedt
Ph: 512-341-8724

Beth Ann Hellerstedt
Principal Investigator

Vermont
Berlin

Central Vermont Medical Center/National Life Cancer Treatment

Steven Ades
Ph: 802-656-4101

Steven Ades
Principal Investigator

Burlington

University of Vermont College of Medicine

Steven Ades
Ph: 802-656-4101

Steven Ades
Principal Investigator

Virginia
Norton

Southwest VA Regional Cancer Center

Asheesh Shipstone
Ph: 423-578-8538

Asheesh Shipstone
Principal Investigator

Washington
Auburn

MultiCare Auburn Medical Center

Yoshio Inoue
Ph: 253-403-2394

Yoshio Inoue
Principal Investigator

Bainbridge Island

Virginia Mason Bainbridge Island Medical Center

Yoshio Inoue
Ph: 253-403-2394

Yoshio Inoue
Principal Investigator

Bellevue

Overlake Hospital Medical Center

Yoshio Inoue
Ph: 253-403-2394

Yoshio Inoue
Principal Investigator

Centralia

Providence Regional Cancer System-Centralia

Yoshio Inoue
Ph: 800-351-7955

Yoshio Inoue
Principal Investigator

Everett

Providence Regional Cancer Partnership

Yoshio Inoue
Ph: 800-351-7955

Yoshio Inoue
Principal Investigator

Federal Way

Virginia Mason Federal Way Medical Center

Yoshio Inoue
Ph: 253-403-2394

Yoshio Inoue
Principal Investigator

Gig Harbor

MultiCare Gig Harbor Medical Park

Yoshio Inoue
Ph: 253-403-2394

Yoshio Inoue
Principal Investigator

Tacoma/Valley Radiation Oncology Centers-Gig Harbor

Yoshio Inoue
Ph: 253-403-2394

Yoshio Inoue
Principal Investigator

Kennewick

Northwest Cancer Clinic

Yoshio Inoue
Ph: 253-403-2394

Yoshio Inoue
Principal Investigator

Lacey

Providence Regional Cancer System-Lacey

Yoshio Inoue
Ph: 800-351-7955

Yoshio Inoue
Principal Investigator

Longview

Saint John Medical Center

Keith S. Lanier
Ph: 503-215-6412

Keith S. Lanier
Principal Investigator

Lynnwood

Virginia Mason Lynnwood Medical Center

Yoshio Inoue
Ph: 253-403-2394

Yoshio Inoue
Principal Investigator

Poulsbo

Peninsula Cancer Center

Yoshio Inoue
Ph: 253-403-2394

Yoshio Inoue
Principal Investigator

Puyallup

MultiCare Good Samaritan Hospital

Yoshio Inoue
Ph: 253-403-2394

Yoshio Inoue
Principal Investigator

Tacoma/Valley Radiation Oncology Centers-Puyallup

Yoshio Inoue
Ph: 253-403-2394

Yoshio Inoue
Principal Investigator

Seattle

Pacific Medical Center-First Hill

Craig R. Nichols
Ph: 503-215-6412
Email: vmmc.cancer_clinical_research@VirginiaMason.org

Craig R. Nichols
Principal Investigator

Virginia Mason CCOP

Craig R. Nichols
Ph: 503-215-6412
Email: vmmc.cancer_clinical_research@VirginiaMason.org

Craig R. Nichols
Principal Investigator

Virginia Mason Medical Center

Yoshio Inoue
Ph: 253-403-2394

Yoshio Inoue
Principal Investigator

Tacoma

Madigan Army Medical Center

Timothy Charles Brand
Ph: 253-968-0129
Email: mamcdci@amedd.army.mil

Timothy Charles Brand
Principal Investigator

Multicare Health System

Yoshio Inoue
Ph: 253-403-2394

Yoshio Inoue
Principal Investigator

Northwest Medical Specialties PLLC

Yoshio Inoue
Ph: 800-351-7955

Yoshio Inoue
Principal Investigator

Tacoma/Valley Radiation Oncology Centers-Jackson Hall

Yoshio Inoue
Ph: 253-403-2394

Yoshio Inoue
Principal Investigator

Tacoma/Valley Radiation Oncology Centers-Saint Joe's

Yoshio Inoue
Ph: 253-403-2394

Yoshio Inoue
Principal Investigator

Vancouver

PeaceHealth Southwest Medical Center

Keith S. Lanier
Ph: 503-215-6412

Keith S. Lanier
Principal Investigator

West Virginia
Charleston

West Virginia University Charleston

Steven James Jubelirer
Ph: 304-344-3457

Steven James Jubelirer
Principal Investigator

Huntington

Edwards Comprehensive Cancer Center

Maria Rosalia B. Tria Tirona
Ph: 304-399-6617

Maria Rosalia B. Tria Tirona
Principal Investigator

Wisconsin
Burlington

Aurora Cancer Care-Burlington

Dhimant R. Patel
Ph: 800-252-2990

Dhimant R. Patel
Principal Investigator

Elkhorn

Aurora Cancer Care-Southern Lakes

Dhimant R. Patel
Ph: 800-252-2990

Dhimant R. Patel
Principal Investigator

Fond Du Lac

Aurora Health Center-Fond du Lac

Dhimant R. Patel
Ph: 800-252-2990

Dhimant R. Patel
Principal Investigator

Grafton

Aurora Cancer Care-Grafton

Dhimant R. Patel
Ph: 800-252-2990

Dhimant R. Patel
Principal Investigator

Green Bay

Aurora BayCare Medical Center

Dhimant R. Patel
Ph: 800-252-2990

Dhimant R. Patel
Principal Investigator

Kenosha

Aurora Cancer Care-Kenosha South

Dhimant R. Patel
Ph: 800-252-2990

Dhimant R. Patel
Principal Investigator

La Crosse

Gundersen Lutheran Medical Center

Kurt Oettel
Ph: 608-775-2385
Email: cancerctr@gundluth.org

Kurt Oettel
Principal Investigator

Marinette

Vince Lombardi Cancer Clinic-Marinette

Dhimant R. Patel
Ph: 800-252-2990

Dhimant R. Patel
Principal Investigator

Menomonee Falls

Aurora Advanced Healthcare Inc-Menomonee Falls

Dhimant R. Patel
Ph: 800-252-2990

Dhimant R. Patel
Principal Investigator

Milwaukee

Aurora Cancer Care-Milwaukee

Dhimant R. Patel
Ph: 800-252-2990

Dhimant R. Patel
Principal Investigator

Aurora Cancer Care-Milwaukee South

Dhimant R. Patel
Ph: 800-252-2990

Dhimant R. Patel
Principal Investigator

Aurora Saint Luke's Medical Center

Dhimant R. Patel
Ph: 800-252-2990

Dhimant R. Patel
Principal Investigator

Aurora Sinai Medical Center

Dhimant R. Patel
Ph: 800-252-2990

Dhimant R. Patel
Principal Investigator

New Richmond

Cancer Center of Western Wisconsin

Patrick James Flynn
Ph: 952-993-1517
Email: MMCCOP@parknicollet.com

Patrick James Flynn
Principal Investigator

Oshkosh

Vince Lombardi Cancer Clinic - Oshkosh

Dhimant R. Patel
Ph: 800-252-2990

Dhimant R. Patel
Principal Investigator

Racine

Aurora Cancer Care-Racine

Dhimant R. Patel
Ph: 800-252-2990

Dhimant R. Patel
Principal Investigator

Sheboygan

Vince Lombardi Cancer Clinic-Sheboygan

Dhimant R. Patel
Ph: 800-252-2990

Dhimant R. Patel
Principal Investigator

Summit

Aurora Medical Center in Summit

Dhimant R. Patel
Ph: 800-252-2990

Dhimant R. Patel
Principal Investigator

Two Rivers

Vince Lombardi Cancer Clinic

Dhimant R. Patel
Ph: 800-252-2990

Dhimant R. Patel
Principal Investigator

Waukesha

Aurora Cancer Care-Waukesha

Dhimant R. Patel
Ph: 800-252-2990

Dhimant R. Patel
Principal Investigator

Wauwatosa

Aurora Cancer Care-Milwaukee West

Dhimant R. Patel
Ph: 800-252-2990

Dhimant R. Patel
Principal Investigator

West Allis

Aurora West Allis Medical Center

Dhimant R. Patel
Ph: 800-252-2990

Dhimant R. Patel
Principal Investigator

Wyoming
Sheridan

Welch Cancer Center

Benjamin T. Marchello
Ph: 800-648-6274

Benjamin T. Marchello
Principal Investigator

Canada

Alberta
Calgary

Tom Baker Cancer Centre

Joseph Dean Ruether
Ph: 403-521-3433

Joseph Dean Ruether
Principal Investigator

Edmonton

Cross Cancer Institute

Naveen S. Basappa
Ph: 780-432-8500

Naveen S. Basappa
Principal Investigator

British Columbia
Vancouver

Clinical Research Unit at Vancouver Coastal Health Authority

Martin Edwin Gleave
Ph: 888-939-3333

Martin Edwin Gleave
Principal Investigator

Manitoba
Winnipeg

CancerCare Manitoba

Darrel Edmund Drachenberg
Ph: 866-561-1026
Email: CIO_Web@cancercare.mb.ca

Darrel Edmund Drachenberg
Principal Investigator

Ontario
London

London Regional Cancer Program

Joseph L. Chin
Ph: 519-685-8600

Joseph L. Chin
Principal Investigator

Toronto

University Health Network-Princess Margaret Hospital

Alexandre R. Zlotta
Ph: 416-946-4501
Email: clinical.trials@uhn.on.ca

Alexandre R. Zlotta
Principal Investigator

Quebec
Montreal

CHUM - Hopital Notre-Dame

Fred Saad
Ph: 514-890-8000ext12725
Email: info.cr.chum@ssss.gouv.qc.ca

Fred Saad
Principal Investigator

Link to the current ClinicalTrials.gov record.
NLM Identifer NCT00430183

Note: Information about participating sites on pharmaceutical industry trials may be incomplete. Please visit the ClinicalTrials.gov record via the link above for more information about participating sites.