Comparison of Different Types of Surgery in Treating Patients with Stage IA Non-Small Cell Lung Cancer

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Basic Trial Information

PhaseTypeAgeTrial IDs
Phase IIITreatment18 and overCALGB 140503
NCI-2009-00447, CDR0000555324, ECOG-40503, NCT00499330

Trial Description

Summary

This randomized phase III trial is studying different types of surgery to compare how well they work in treating patients with stage IA non-small cell lung cancer. Wedge resection or segmentectomy may be less invasive types of surgery than lobectomy for non-small cell lung cancer and may have fewer side effects and improve recovery. It is not yet known whether wedge resection or segmentectomy are more effective than lobectomy in treating stage IA non-small cell lung cancer.

Further Study Information

PRIMARY OBJECTIVES:

I. To determine whether disease-free survival (DFS) after sublobar resection (segmentectomy or wedge) is non-inferior to that after lobectomy in patients with small peripheral (=< 2 cm) non-small cell lung cancer (NSCLC).

SECONDARY OBJECTIVES:

I. To determine whether overall survival (OS) (after sublobar resection) is non-inferior to that after lobectomy.

II. To determine the rates of loco-regional and systemic recurrence (exclusive of second primaries) after lobar and sublobar resection.

III. To determine the difference between the two arms of the study in pulmonary function as determined by expiratory flow rates measured at 6 months post-operatively.

IV. To explore the relationship between characteristics of the primary lung cancer, as revealed by pre-operative computed tomography (CT) and positron emission tomography (PET) imaging, and outcomes.

V. Determine the false-negative rate of preoperative PET scan for identification of involved hilar and mediastinal lymph nodes.

VI. Assess the utility of annual follow-up CT imaging after surgical resection of small stage IA NSCLC.

OUTLINE: Patients are randomized to 1 of 2 treatment arms.

ARM I: Patients undergo lobectomy by open thoracotomy or video-assisted thoracoscopic surgery (VATS).

ARM II: Patients undergo a wedge resection or anatomical segmentectomy by open thoracotomy or VATS.

After completion of study treatment, patients are followed up every 6 months for 2 years and then annually for 5 years.

Eligibility Criteria

Inclusion Criteria:

Histologic confirmation of NSCLC (if not already obtained)

No prior chemotherapy or radiotherapy for this malignancy

No prior malignancy within 3 years other than non-melanoma skin cancer, superficial bladder cancer, or carcinoma in situ (CIS) of the cervix

Eastern Cooperative Oncology Group (ECOG) performance status of 0-2

The tumor location must be suitable for either lobar or sublobar resection (wedge or segment)

Peripheral lung nodule =< 2 cm on preoperative CT scan and presumed to be lung cancer; the center of the tumor, as seen on CT, must be located in the outer third of the lung in either the transverse, coronal or sagittal plane; patients with pure ground glass opacities or pathologically confirmed N1 or N2 disease are not eligible

No evidence of locally advanced or metastatic disease

Confirmation of N0 status by frozen section examination; right sided tumors require that node levels 4, 7, and 10 be sampled and diagnosed as negative on frozen section; left sided tumors require that node levels 5 or 6, 7 and 10 be sampled and diagnosed as negative on frozen section; levels 4 and 7 nodes may be sampled by mediastinoscopy, endobronchial ultrasound (EBUS) and/or endoscopic ultrasound (EUS), or at the time of thoracotomy or VATS exploration; nodes previously sampled by mediastinoscopy (or EBUS and/or EUS) either immediately prior to or within 6 weeks of the definitive surgical procedure (thoracotomy or VATS) do not need to be resampled

Trial Contact Information

Trial Lead Organizations / Sponsors / Collaborators

Alliance for Clinical Trials in Oncology

  • National Cancer Institute
  • Southwest Oncology Group (SWOG) Research Base
  • Radiation Therapy Oncology Group
  • American College of Surgeons Oncology Group
Nasser K. Altorki, Principal Investigator

Trial Sites

U.S.A.

Alaska
Anchorage

Alaska Breast Care and Surgery LLC

Keith S. Lanier
Ph: 503-215-6412

Keith S. Lanier
Principal Investigator

Alaska Oncology and Hematology LLC

Keith S. Lanier
Ph: 503-215-6412

Keith S. Lanier
Principal Investigator

Alaska Regional Hospital

Keith S. Lanier
Ph: 503-215-6412

Keith S. Lanier
Principal Investigator

Alaska Women's Cancer Care

Keith S. Lanier
Ph: 503-215-6412

Keith S. Lanier
Principal Investigator

Anchorage Oncology Centre

Keith S. Lanier
Ph: 503-215-6412

Keith S. Lanier
Principal Investigator

Anchorage Radiation Therapy Center

Keith S. Lanier
Ph: 503-215-6412

Keith S. Lanier
Principal Investigator

Katmai Oncology Group

Keith S. Lanier
Ph: 503-215-6412

Keith S. Lanier
Principal Investigator

Providence Alaska Medical Center

Keith S. Lanier
Ph: 503-215-6412

Keith S. Lanier
Principal Investigator

Arizona
Tucson

The University of Arizona Medical Center-University Campus

Samuel S. Kim
Ph: 520-626-9008

Samuel S. Kim
Principal Investigator

Arkansas
Little Rock

University of Arkansas for Medical Sciences

Rangaswamy Govindarajan
Ph: 501-686-8274

Rangaswamy Govindarajan
Principal Investigator

California
Burbank

Providence Saint Joseph Medical Center/Disney Family Cancer Center

Keith S. Lanier
Ph: 503-215-6412

Keith S. Lanier
Principal Investigator

Loma Linda

Loma Linda University Medical Center

Jason Morgan Wallen
Ph: 800-741-8387

Jason Morgan Wallen
Principal Investigator

Veterans Affairs Loma Linda Healthcare System

Mark Evan Reeves
Ph: 909-558-3375

Mark Evan Reeves
Principal Investigator

Long Beach

Veterans Administration Long Beach Medical Center

Amir Abolhoda
Ph: 562-826-8000

Amir Abolhoda
Principal Investigator

Pasadena

Huntington Memorial Hospital

Robbin Gerald Cohen
Ph: 626-535-2420

Robbin Gerald Cohen
Principal Investigator

Riverside

Kaiser Permanente-Riverside

Gregory Marrujo
Ph: 626-564-3455

Gregory Marrujo
Principal Investigator

Sacramento

University of California Davis Comprehensive Cancer Center

David Tom Cooke
Ph: 916-734-3089

David Tom Cooke
Principal Investigator

Saint Helena

Saint Helena Hospital

Gregory B. Smith
Ph: 707-967-3698

Gregory B. Smith
Principal Investigator

Colorado
Aurora

University of Colorado Cancer Center - Anschutz Cancer Pavilion

John Douglas Mitchell
Ph: 720-848-0650

John Douglas Mitchell
Principal Investigator

Colorado Springs

Memorial Hospital Colorado Springs

Matthew Garret Blum
Ph: 719-365-2406

Matthew Garret Blum
Principal Investigator

Denver

University of Colorado

Nasser K. Altorki
Ph: 212-746-5156
Email: nkaltork@med.cornell.edu

Nasser K. Altorki
Principal Investigator

Connecticut
Bridgeport

Saint Vincent's Medical Center

Albert Christopher DiMeo
Ph: 203-576-6329
Email: twhite@stvincents.org

Albert Christopher DiMeo
Principal Investigator

Hartford

Saint Francis Hospital and Medical Center

Philip J. Stella
Ph: 734-712-4673

Philip J. Stella
Principal Investigator

New Haven

Yale University

Daniel Joseph Boffa
Ph: 203-785-5702

Daniel Joseph Boffa
Principal Investigator

Delaware
Lewes

Beebe Medical Center

Thomas Lee Bauer
Ph: 302-733-6227

Thomas Lee Bauer
Principal Investigator

Newark

Christiana Care Health System-Christiana Hospital

Thomas Lee Bauer
Ph: 302-733-6227

Thomas Lee Bauer
Principal Investigator

Christiana Gynecologic Oncology LLC

Thomas Lee Bauer
Ph: 302-733-6227

Thomas Lee Bauer
Principal Investigator

Delaware Clinical and Laboratory Physicians PA

Thomas Lee Bauer
Ph: 302-733-6227

Thomas Lee Bauer
Principal Investigator

Helen F Graham Cancer Center

Thomas Lee Bauer
Ph: 302-733-6227

Thomas Lee Bauer
Principal Investigator

Medical Oncology Hematology Consultants PA

Thomas Lee Bauer
Ph: 302-733-6227

Thomas Lee Bauer
Principal Investigator

Regional Hematology and Oncology PA

Thomas Lee Bauer
Ph: 302-733-6227

Thomas Lee Bauer
Principal Investigator

Rehoboth Beach

Beebe Health Campus

Thomas Lee Bauer
Ph: 302-733-6227

Thomas Lee Bauer
Principal Investigator

Seaford

Nanticoke Memorial Hospital

Thomas Lee Bauer
Ph: 302-733-6227

Thomas Lee Bauer
Principal Investigator

Wilmington

Christiana Care Health System-Wilmington Hospital

Thomas Lee Bauer
Ph: 302-733-6227

Thomas Lee Bauer
Principal Investigator

Florida
Hollywood

Memorial Regional Hospital/Joe DiMaggio Children's Hospital

Mark Ian Block
Ph: 954-265-2234

Mark Ian Block
Principal Investigator

Miami Beach

Mount Sinai Medical Center

Michael A. Schwartz
Ph: 305-674-2625
Email: info@msccop.com

Michael A. Schwartz
Principal Investigator

Idaho
Boise

Saint Alphonsus Cancer Care Center-Boise

Philip J. Stella
Ph: 734-712-4673

Philip J. Stella
Principal Investigator

Saint Luke's Mountain States Tumor Institute

Keith S. Lanier
Ph: 503-215-6412

Keith S. Lanier
Principal Investigator

Fruitland

Saint Luke's Mountain States Tumor Institute - Fruitland

Keith S. Lanier
Ph: 503-215-6412

Keith S. Lanier
Principal Investigator

Meridian

Saint Luke's Mountain States Tumor Institute - Meridian

Keith S. Lanier
Ph: 503-215-6412

Keith S. Lanier
Principal Investigator

Nampa

Saint Luke's Mountain States Tumor Institute - Nampa

Keith S. Lanier
Ph: 503-215-6412

Keith S. Lanier
Principal Investigator

Twin Falls

Saint Luke's Mountain States Tumor Institute-Twin Falls

Keith S. Lanier
Ph: 503-215-6412

Keith S. Lanier
Principal Investigator

Illinois
Evanston

NorthShore University HealthSystem-Evanston Hospital

John Anthony Howington
Ph: 847-570-2109

John Anthony Howington
Principal Investigator

Indiana
Indianapolis

Indiana University/Melvin and Bren Simon Cancer Center

Thomas John Birdas
Ph: 317-274-2552

Thomas John Birdas
Principal Investigator

Richard L. Roudebush Veterans Affairs Medical Center

Thomas John Birdas
Ph: 317-274-2552

Thomas John Birdas
Principal Investigator

Sidney and Lois Eskenazi Hospital

Thomas John Birdas
Ph: 317-274-2552

Thomas John Birdas
Principal Investigator

Mishawaka

Memorial Regional Cancer Center Day Road

Thomas Joseph Reid
Ph: 800-284-7370

Thomas Joseph Reid
Principal Investigator

South Bend

Memorial Hospital of South Bend

Thomas Joseph Reid
Ph: 800-284-7370

Thomas Joseph Reid
Principal Investigator

Iowa
Clive

Medical Oncology and Hematology Associates-West Des Moines

Joseph Daniel Verdirame
Ph: 402-398-6060

Joseph Daniel Verdirame
Principal Investigator

Mercy Cancer Center-West Lakes

Joseph Daniel Verdirame
Ph: 402-398-6060

Joseph Daniel Verdirame
Principal Investigator

Council Bluffs

Alegent Health Mercy Hospital

Joseph Daniel Verdirame
Ph: 402-398-6060

Joseph Daniel Verdirame
Principal Investigator

Des Moines

Medical Oncology and Hematology Associates-Laurel

Joseph Daniel Verdirame
Ph: 402-398-6060

Joseph Daniel Verdirame
Principal Investigator

Mercy Medical Center - Des Moines

Joseph Daniel Verdirame
Ph: 402-398-6060

Joseph Daniel Verdirame
Principal Investigator

West Des Moines

Mercy Medical Center-West Lakes

Joseph Daniel Verdirame
Ph: 402-398-6060

Joseph Daniel Verdirame
Principal Investigator

Kentucky
Bardstown

Flaget Memorial Hospital

Joseph Daniel Verdirame
Ph: 402-398-6060

Joseph Daniel Verdirame
Principal Investigator

Corbin

Commonwealth Cancer Center-Corbin

Joseph Daniel Verdirame
Ph: 402-398-6060

Joseph Daniel Verdirame
Principal Investigator

Lexington

Saint Joseph Hospital East

Joseph Daniel Verdirame
Ph: 402-398-6060

Joseph Daniel Verdirame
Principal Investigator

Saint Joseph Radiation Oncology Resource Center

Joseph Daniel Verdirame
Ph: 402-398-6060

Joseph Daniel Verdirame
Principal Investigator

Louisville

Jewish Hospital

Joseph Daniel Verdirame
Ph: 402-398-6060

Joseph Daniel Verdirame
Principal Investigator

Jewish Hospital Medical Center Northeast

Joseph Daniel Verdirame
Ph: 402-398-6060

Joseph Daniel Verdirame
Principal Investigator

Saints Mary and Elizabeth Hospital

Joseph Daniel Verdirame
Ph: 402-398-6060

Joseph Daniel Verdirame
Principal Investigator

Shepherdsville

Jewish Hospital Medical Center South

Joseph Daniel Verdirame
Ph: 402-398-6060

Joseph Daniel Verdirame
Principal Investigator

Louisiana
New Orleans

Ochsner Medical Center Jefferson

Brian Lamar Pettiford
Ph: 504-842-3708

Brian Lamar Pettiford
Principal Investigator

Maryland
Annapolis

Anne Arundel Medical Center

Stephen Michael Cattaneo
Ph: 443-481-1320
Email: kbodenhorn@aahs.org

Stephen Michael Cattaneo
Principal Investigator

Baltimore

Greater Baltimore Medical Center

Neri Meshulam Cohen
Ph: 443-849-3706

Neri Meshulam Cohen
Principal Investigator

Silver Spring

Holy Cross Hospital

Bryan M. Steinberg
Ph: 301-270-2844

Bryan M. Steinberg
Principal Investigator

Massachusetts
Boston

Boston Medical Center

Virginia R. Litle
Ph: 617-638-8265

Virginia R. Litle
Principal Investigator

Pittsfield

Berkshire Hematology Oncology PC

Harvey Zimbler
Ph: 413-496-8205
Email: ggero@bhs1.org

Harvey Zimbler
Principal Investigator

Springfield

Baystate Medical Center

Seth A. Kaufman
Ph: 413-794-9338

Seth A. Kaufman
Principal Investigator

Michigan
Ann Arbor

Saint Joseph Mercy Hospital

Philip J. Stella
Ph: 734-712-4673

Philip J. Stella
Principal Investigator

University of Michigan Comprehensive Cancer Center

Andrew Ching-Hung Chang
Ph: 800-865-1125

Andrew Ching-Hung Chang
Principal Investigator

Dearborn

Oakwood Hospital and Medical Center

Philip J. Stella
Ph: 734-712-4673

Philip J. Stella
Principal Investigator

Detroit

Saint John Hospital and Medical Center

Philip J. Stella
Ph: 734-712-4673

Philip J. Stella
Principal Investigator

Flint

Genesys Hurley Cancer Institute

Philip J. Stella
Ph: 734-712-4673

Philip J. Stella
Principal Investigator

Hurley Medical Center

Philip J. Stella
Ph: 734-712-4673

Philip J. Stella
Principal Investigator

Jackson

Allegiance Health

Philip J. Stella
Ph: 734-712-4673

Philip J. Stella
Principal Investigator

Lansing

Sparrow Hospital

Philip J. Stella
Ph: 734-712-4673

Philip J. Stella
Principal Investigator

Livonia

Saint Mary Mercy Hospital

Philip J. Stella
Ph: 734-712-4673

Philip J. Stella
Principal Investigator

Pontiac

Saint Joseph Mercy Oakland

Philip J. Stella
Ph: 734-712-4673

Philip J. Stella
Principal Investigator

Port Huron

Saint Joseph Mercy Port Huron

Philip J. Stella
Ph: 734-712-4673

Philip J. Stella
Principal Investigator

Saginaw

Saint Mary's of Michigan

Philip J. Stella
Ph: 734-712-4673

Philip J. Stella
Principal Investigator

Warren

Saint John Macomb-Oakland Hospital

Philip J. Stella
Ph: 734-712-4673

Philip J. Stella
Principal Investigator

Minnesota
Rochester

Mayo Clinic

Dennis A. Wigle
Ph: 507-538-7623

Dennis A. Wigle
Principal Investigator

Montana
Great Falls

Big Sky Oncology

Grant William Harrer
Ph: 406-731-8217

Grant William Harrer
Principal Investigator

Nebraska
Grand Island

CHI Health Saint Francis

Joseph Daniel Verdirame
Ph: 402-398-6060

Joseph Daniel Verdirame
Principal Investigator

Kearney

CHI Health Good Samaritan

Joseph Daniel Verdirame
Ph: 402-398-6060

Joseph Daniel Verdirame
Principal Investigator

Heartland Hematology and Oncology

Joseph Daniel Verdirame
Ph: 402-398-6060

Joseph Daniel Verdirame
Principal Investigator

Lincoln

Saint Elizabeth Regional Medical Center

Joseph Daniel Verdirame
Ph: 402-398-6060

Joseph Daniel Verdirame
Principal Investigator

Omaha

Alegent Health Bergan Mercy Medical Center

Joseph Daniel Verdirame
Ph: 402-398-6060

Joseph Daniel Verdirame
Principal Investigator

Alegent Health Immanuel Medical Center

Joseph Daniel Verdirame
Ph: 402-398-6060

Joseph Daniel Verdirame
Principal Investigator

Alegent Health Lakeside Hospital

Joseph Daniel Verdirame
Ph: 402-398-6060

Joseph Daniel Verdirame
Principal Investigator

Creighton University Medical Center

Joseph Daniel Verdirame
Ph: 402-398-6060

Joseph Daniel Verdirame
Principal Investigator

Hemotology and Oncology Consultants PC

Joseph Daniel Verdirame
Ph: 402-398-6060

Joseph Daniel Verdirame
Principal Investigator

Papillion

Midlands Community Hospital

Joseph Daniel Verdirame
Ph: 402-398-6060

Joseph Daniel Verdirame
Principal Investigator

New Jersey
Basking Ridge

Memorial Sloan Kettering Cancer Center at Basking Ridge

James Huang
Ph: 212-639-7202

James Huang
Principal Investigator

Brick

Ocean Medical Center

Thomas Lee Bauer
Ph: 732-776-4240

Thomas Lee Bauer
Principal Investigator

Manahawkin

Southern Ocean County Medical Center

Thomas Lee Bauer
Ph: 732-776-4240

Thomas Lee Bauer
Principal Investigator

Neptune

Jersey Shore Medical Center

Thomas Lee Bauer
Ph: 732-776-4240

Thomas Lee Bauer
Principal Investigator

Paramus

The Valley Hospital-Luckow Pavilion

Benjamin Enoch Lee
Ph: 201-634-5792

Benjamin Enoch Lee
Principal Investigator

Red Bank

Riverview Medical Center/Booker Cancer Center

Thomas Lee Bauer
Ph: 732-776-4240

Thomas Lee Bauer
Principal Investigator

Ridgewood

Valley Hospital

Benjamin Enoch Lee
Ph: 201-634-5792

Benjamin Enoch Lee
Principal Investigator

New York
Buffalo

Roswell Park Cancer Institute

Chukwumere E. Nwogu
Ph: 877-275-7724

Chukwumere E. Nwogu
Principal Investigator

Commack

Memorial Sloan Kettering Cancer Center Commack

James Huang
Ph: 212-639-7202

James Huang
Principal Investigator

New York

Memorial Sloan-Kettering Cancer Center

James Huang
Ph: 212-639-7202

James Huang
Principal Investigator

Rockville Centre

Memorial Sloan-Kettering Cancer Center Rockville Centre

James Huang
Ph: 212-639-7202

James Huang
Principal Investigator

Syracuse

State University of New York Upstate Medical University

Leslie J. Kohman
Ph: 315-464-5476

Leslie J. Kohman
Principal Investigator

West Harrison

Memorial Sloan-Kettering Cancer Center West Harrison

James Huang
Ph: 212-639-7202

James Huang
Principal Investigator

North Carolina
Asheville

Asheville VA Medical Center

John Charles Lucke
Ph: 828-299-5909

John Charles Lucke
Principal Investigator

Clinton

Southeastern Medical Oncology Center-Clinton

James N. Atkins
Ph: 919-580-0000

James N. Atkins
Principal Investigator

Durham

Duke University Medical Center

Jeffrey Crawford
Ph: 888-275-3853

Jeffrey Crawford
Principal Investigator

Goldsboro

Southeastern Medical Oncology Center-Goldsboro

James N. Atkins
Ph: 919-580-0000

James N. Atkins
Principal Investigator

Wayne Memorial Hospital

James N. Atkins
Ph: 919-580-0000

James N. Atkins
Principal Investigator

Ohio
Canton

Mercy Medical Center

Mitchell Haut
Ph: 888-293-4673

Mitchell Haut
Principal Investigator

Cincinnati

Bethesda North Hospital

Joseph Daniel Verdirame
Ph: 402-398-6060

Joseph Daniel Verdirame
Principal Investigator

Good Samaritan Hospital - Cincinnati

Joseph Daniel Verdirame
Ph: 402-398-6060

Joseph Daniel Verdirame
Principal Investigator

TriHealth Cancer Institute-Anderson

Joseph Daniel Verdirame
Ph: 402-398-6060

Joseph Daniel Verdirame
Principal Investigator

TriHealth Cancer Institute-Westside

Joseph Daniel Verdirame
Ph: 402-398-6060

Joseph Daniel Verdirame
Principal Investigator

Cleveland

Case Western Reserve University

Philip Aaron Linden
Ph: 800-641-2422

Philip Aaron Linden
Principal Investigator

Columbus

Ohio State University Comprehensive Cancer Center

Nasser K. Altorki
Ph: 212-746-5156
Email: nkaltork@med.cornell.edu

Nasser K. Altorki
Principal Investigator

Oklahoma
Oklahoma City

University of Oklahoma Health Sciences Center

Subrato J. Deb
Ph: 405-271-4272
Email: julie-traylor@ouhsc.edu

Subrato J. Deb
Principal Investigator

Oregon
Bend

Saint Charles Medical Center-Bend

Keith S. Lanier
Ph: 503-215-6412

Keith S. Lanier
Principal Investigator

Clackamas

Clackamas Radiation Oncology Center

Keith S. Lanier
Ph: 503-215-6412

Keith S. Lanier
Principal Investigator

Providence Oncology and Hematology Care Southeast

Keith S. Lanier
Ph: 503-215-6412

Keith S. Lanier
Principal Investigator

Coos Bay

Bay Area Hospital

Keith S. Lanier
Ph: 503-215-6412

Keith S. Lanier
Principal Investigator

Newberg

Providence Newberg Medical Center

Keith S. Lanier
Ph: 503-215-6412

Keith S. Lanier
Principal Investigator

Oregon City

Providence Willamette Falls Medical Center

Keith S. Lanier
Ph: 503-215-6412

Keith S. Lanier
Principal Investigator

Portland

Providence Portland Medical Center

Keith S. Lanier
Ph: 503-215-6412

Keith S. Lanier
Principal Investigator

Providence Saint Vincent Medical Center

Keith S. Lanier
Ph: 503-215-6412

Keith S. Lanier
Principal Investigator

Pennsylvania
Danville

Geisinger Medical Center

Matthew Alan Facktor
Ph: 570-271-5251

Matthew Alan Facktor
Principal Investigator

Monroeville

Forbes Hospital

Rodney Jerome Landreneau
Ph: 877-284-2000

Rodney Jerome Landreneau
Principal Investigator

Philadelphia

Fox Chase Cancer Center

Walter Joseph Scott
Ph: 215-728-4790

Walter Joseph Scott
Principal Investigator

Thomas Jefferson University Hospital

Nathaniel Rutherford Evans
Ph: 215-955-6084

Nathaniel Rutherford Evans
Principal Investigator

Pittsburgh

Allegheny General Hospital

Rodney Jerome Landreneau
Ph: 877-284-2000

Rodney Jerome Landreneau
Principal Investigator

University of Pittsburgh Cancer Institute (UPCI)

Matthew James Schuchert
Ph: 412-647-2811

Matthew James Schuchert
Principal Investigator

Reading

Penn State Health Saint Joseph Medical Center

Christian Lee Gilbert
Ph: 610-378-2336
Email: danielward2@catholichealth.net

Christian Lee Gilbert
Principal Investigator

Sayre

Guthrie Medical Group PC-Robert Packer Hospital

Bradley Walter Lash
Ph: 800-836-0388

Bradley Walter Lash
Principal Investigator

South Carolina
Charleston

Medical University of South Carolina

Chadrick Evan Denlinger
Ph: 843-792-9321

Chadrick Evan Denlinger
Principal Investigator

Tennessee
Chattanooga

Memorial Hospital

Joseph Daniel Verdirame
Ph: 402-398-6060

Joseph Daniel Verdirame
Principal Investigator

Hixson

Pulmonary Medicine Center of Chattanooga-Hixson

Joseph Daniel Verdirame
Ph: 402-398-6060

Joseph Daniel Verdirame
Principal Investigator

Knoxville

University of Tennessee - Knoxville

Thomas Edward Gaines
Ph: 865-305-9773

Thomas Edward Gaines
Principal Investigator

Nashville

Vanderbilt University/Ingram Cancer Center

Eric L. Grogan
Ph: 800-811-8480

Eric L. Grogan
Principal Investigator

Ooltewah

Memorial GYN Plus

Joseph Daniel Verdirame
Ph: 402-398-6060

Joseph Daniel Verdirame
Principal Investigator

Utah
American Fork

American Fork Hospital

David Reed Goff
Ph: 801-387-7426

David Reed Goff
Principal Investigator

Vermont
Burlington

University of Vermont College of Medicine

Bruce Jason Leavitt
Ph: 802-656-4101

Bruce Jason Leavitt
Principal Investigator

Virginia
Charlottesville

University of Virginia Cancer Center

Benjamin David Kozower
Ph: 434-243-6143

Benjamin David Kozower
Principal Investigator

Richmond

Virginia Commonwealth University/Massey Cancer Center

Anthony D. Cassano
Ph: 804-628-1939

Anthony D. Cassano
Principal Investigator

Washington
Aberdeen

Providence Regional Cancer System-Aberdeen

Keith S. Lanier
Ph: 503-215-6412

Keith S. Lanier
Principal Investigator

Anacortes

Cancer Care Center at Island Hospital

Keith S. Lanier
Ph: 503-215-6412

Keith S. Lanier
Principal Investigator

Bellevue

Swedish Cancer Institute-Eastside Oncology Hematology

Keith S. Lanier
Ph: 503-215-6412

Keith S. Lanier
Principal Investigator

Bellingham

PeaceHealth Saint Joseph Medical Center

Keith S. Lanier
Ph: 503-215-6412

Keith S. Lanier
Principal Investigator

Bremerton

Harrison HealthPartners Hematology and Oncology-Bremerton

Joseph Daniel Verdirame
Ph: 402-398-6060

Joseph Daniel Verdirame
Principal Investigator

Harrison Medical Center

Joseph Daniel Verdirame
Ph: 402-398-6060

Joseph Daniel Verdirame
Principal Investigator

Burien

Highline Medical Center-Main Campus

Joseph Daniel Verdirame
Ph: 402-398-6060

Joseph Daniel Verdirame
Principal Investigator

Centralia

Providence Regional Cancer System-Centralia

Yoshio Inoue
Ph: 888-823-5923
Email: ctsucontact@westat.com

Yoshio Inoue
Principal Investigator

Edmonds

Swedish Medical Center-Edmonds

Keith S. Lanier
Ph: 503-215-6412

Keith S. Lanier
Principal Investigator

Enumclaw

Saint Elizabeth Hospital

Joseph Daniel Verdirame
Ph: 402-398-6060

Joseph Daniel Verdirame
Principal Investigator

Everett

Providence Regional Cancer Partnership

Yoshio Inoue
Ph: 888-823-5923
Email: ctsucontact@westat.com

Yoshio Inoue
Principal Investigator

Federal Way

Saint Francis Hospital

Joseph Daniel Verdirame
Ph: 402-398-6060

Joseph Daniel Verdirame
Principal Investigator

Issaquah

Swedish Cancer Institute-Issaquah

Keith S. Lanier
Ph: 503-215-6412

Keith S. Lanier
Principal Investigator

Lacey

Providence Regional Cancer System-Lacey

Yoshio Inoue
Ph: 888-823-5923
Email: ctsucontact@westat.com

Yoshio Inoue
Principal Investigator

Lakewood

Saint Clare Hospital

Joseph Daniel Verdirame
Ph: 402-398-6060

Joseph Daniel Verdirame
Principal Investigator

Longview

Saint John Medical Center

Keith S. Lanier
Ph: 503-215-6412

Keith S. Lanier
Principal Investigator

Poulsbo

Harrison HealthPartners Hematology and Oncology-Poulsbo

Joseph Daniel Verdirame
Ph: 402-398-6060

Joseph Daniel Verdirame
Principal Investigator

Seattle

Group Health Cooperative-Seattle

Keith S. Lanier
Ph: 503-215-6412

Keith S. Lanier
Principal Investigator

Minor and James Medical PLLC

Keith S. Lanier
Ph: 503-215-6412

Keith S. Lanier
Principal Investigator

Pacific Gynecology Specialists

Keith S. Lanier
Ph: 503-215-6412

Keith S. Lanier
Principal Investigator

Swedish Medical Center-Ballard Campus

Keith S. Lanier
Ph: 503-215-6412

Keith S. Lanier
Principal Investigator

Swedish Medical Center-First Hill

Keith S. Lanier
Ph: 503-215-6412

Keith S. Lanier
Principal Investigator

Shelton

Providence Regional Cancer System-Shelton

Keith S. Lanier
Ph: 503-215-6412

Keith S. Lanier
Principal Investigator

Spokane

Evergreen Hematology and Oncology PS

Keith S. Lanier
Ph: 503-215-6412

Keith S. Lanier
Principal Investigator

Rockwood Cancer Treatment Center-DHEC-Downtown

Keith S. Lanier
Ph: 503-215-6412

Keith S. Lanier
Principal Investigator

Spokane Valley

Rockwood Clinic Cancer Treatment Center-Valley

Keith S. Lanier
Ph: 503-215-6412

Keith S. Lanier
Principal Investigator

Tacoma

Franciscan Research Center-Northwest Medical Plaza

Joseph Daniel Verdirame
Ph: 402-398-6060

Joseph Daniel Verdirame
Principal Investigator

Northwest Medical Specialties PLLC

Joseph Daniel Verdirame
Ph: 402-398-6060

Joseph Daniel Verdirame
Principal Investigator

Vancouver

PeaceHealth Southwest Medical Center

Keith S. Lanier
Ph: 503-215-6412

Keith S. Lanier
Principal Investigator

Walla Walla

Providence Saint Mary Regional Cancer Center

Keith S. Lanier
Ph: 503-215-6412

Keith S. Lanier
Principal Investigator

Yakima

North Star Lodge Cancer Center at Yakima Valley Memorial Hospital

Keith S. Lanier
Ph: 503-215-6412

Keith S. Lanier
Principal Investigator

Yelm

Providence Regional Cancer System-Yelm

Keith S. Lanier
Ph: 503-215-6412

Keith S. Lanier
Principal Investigator

Canada

British Columbia
Surrey

Surrey Memorial Hospital

Ahmad Shah Ashrafi
Ph: 888-823-5923
Email: ctsucontact@westat.com

Ahmad Shah Ashrafi
Principal Investigator

Ontario
Hamilton

Saint Joseph's Healthcare Charlton Campus

Yaron Shargall
Ph: 905-522-1155ext36115
Email: research@stjoes.ca

Yaron Shargall
Principal Investigator

London

London Regional Cancer Program

Richard Adam Malthaner
Ph: 519-685-8600

Richard Adam Malthaner
Principal Investigator

Ottawa

Ottawa Hospital and Cancer Center-General Campus

Andrew John Ervine Seely
Ph: 613-761-4395

Andrew John Ervine Seely
Principal Investigator

Toronto

University Health Network-Princess Margaret Hospital

Marc de Perrot
Ph: 416-946-4501
Email: clinical.trials@uhn.on.ca

Marc de Perrot
Principal Investigator

Quebec
Montreal

CHUM - Hopital Notre-Dame

Moishe Liberman
Ph: 514-890-8000ext23611
Email: sylvie.beaudoin.chum@ssss.gouv.qc.ca

Moishe Liberman
Principal Investigator

Quebec

University Institute of Cardiology and Pneumology of Quebec (Laval Hospital)

Paula A. Ugalde Figueroa
Ph: 418-656-8711

Paula A. Ugalde Figueroa
Principal Investigator

Sherbrooke

Centre Hospitalier Universitaire de Sherbrooke-Fleurimont

Marco Sirois
Ph: 819-820-6480
Email: crcinformation.chus@ssss.gouv.qc.ca

Marco Sirois
Principal Investigator

Link to the current ClinicalTrials.gov record.
NLM Identifer NCT00499330

Note: Information about participating sites on pharmaceutical industry trials may be incomplete. Please visit the ClinicalTrials.gov record via the link above for more information about participating sites.