Radiation Therapy with or without Androgen-Deprivation Therapy in Treating Patients with Prostate Cancer

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Basic Trial Information

PhaseTypeAgeTrial IDs
Phase IIITreatment18 and overRTOG 0815
NCI-2011-01948, CDR0000648194, NCT00936390

Trial Description

Summary

This randomized phase III trial studies radiation therapy to see how well it works compared with radiation therapy given together with androgen-deprivation therapy in treating patients with prostate cancer. Radiation therapy uses high-energy x-rays and other types of radiation to kill tumor cells and shrink tumors. Androgens can cause the growth of prostate cancer cells. Androgen-deprivation therapy may lessen the amount of androgens made by the body. It is not yet known whether radiation therapy is more effective with or without androgen-deprivation therapy in treating patients with prostate cancer.

Further Study Information

PRIMARY OBJECTIVES:

I. To demonstrate an overall survival (OS) advantage for the addition of short-term (6 months) androgen deprivation therapy (ADT) to dose-escalated radiation therapy (RT) for patients with intermediate-risk prostate cancer.

SECONDARY OBJECTIVES:

I. Determine whether the addition of ADT to dose-escalated RT improves clinical failures (local recurrence, regional recurrence, or distant metastasis), biochemical failure by the “nadir + 2” (Phoenix) definition, freedom from failure (the first occurrence of clinical failure or biochemical failure by the Phoenix definition), rate of salvage ADT, and prostate cancer-specific mortality without resulting in increased non-prostate cancer-specific mortality over dose-escalated RT alone.

II. Estimate the magnitude of benefit of ADT with respect to OS for patients treated with different RT modalities (i.e., extra beam radiation therapy [EBRT] alone vs. low dose rate [LDR] brachytherapy boost vs. high dose rate [HDR] brachytherapy boost).

III. Compare acute and late treatment adverse events for patients receiving vs. not receiving ADT and correlate this with the presence or absence of pre-existing comorbidity as documented by the Adult Comorbidity Evaluation 27 (ACE-27) assessment.

IV. Determine whether health-related quality of life (HRQOL) as measured by the Expanded Prostate Index Composite (EPIC) significantly worsens as a function of treatment assignment (i.e., ADT + RT compared to RT alone).

V. Demonstrate that the addition of ADT to dose-escalated RT is associated with higher fatigue severity than dose-escalated RT alone by the Patient-Reported Outcome Measurement Information System (PROMIS) fatigue domain.

VI. Demonstrate an incremental gain in OS with more aggressive therapy that outweighs the detriments in the primary generic domains of HRQOL (i.e., mobility, self-care, usual activities, pain/discomfort, and anxiety/depression), reported as quality-adjusted life-year (QALY).

VII. Determine whether the PROMIS score change is correlated with plasma cytokine change.

VIII. Collect paraffin-embedded tissue blocks, plasma, and whole blood for future translational research analyses.

OUTLINE: This is a dose-escalation study of radiation therapy. Patients are randomized to 1 of 2 treatment arms.

ARM I: Patients undergo EBRT* once daily (QD) on days 1-5 for up to 9 weeks (44 treatments). Some patients instead receive EBRT with high-dose rate or low-dose rate brachytherapy implant on days 1-5 for up to 5 weeks (25 treatments).

NOTE: *Type of RT is at discretion of treating physician and may include either 3 dimension (D)-conformal RT or intensity-modulated RT.

ARM II: Beginning 8 weeks before start of RT, patients receive androgen-deprivation therapy comprising luteinizing-hormone releasing-hormone (LHRH) agonist (leuprolide acetate subcutaneously [SC] or intramuscularly [IM], goserelin SC, buserelin, or triptorelin) every 1 to 3 months AND an anti-androgen therapy (flutamide orally [PO] trice daily [TID] or bicalutamide PO QD) for 6 months. Patients then undergo radiotherapy as in arm I.

After completion of study therapy, patients are followed up at 3, 6, 9, and 12 months, every 6 months for 4 years, and then yearly thereafter.

Eligibility Criteria

Inclusion Criteria:

No evidence of bone metastases (M0) on bone scan within the past 60 days prior to registration

Bone scan not required for patients enrolled with a single intermediate-risk factor only but this scan may be obtained at the discretion of the treating physician; patients with 2 or 3 risk factors will require a negative bone scan for eligibility

Equivocal bone scan findings are allowed if plain film x-rays are negative for metastasis

Patient must be able to provide study-specific informed consent prior to study entry

Hemoglobin >= 8.0 g/dL (Note: the use of transfusion or other intervention to achieve hemoglobin [Hgb] >= 8 g/dl is acceptable)

Absolute neutrophil count (ANC) >= 1,800 cells/mm^3

For patients undergoing brachytherapy only: complete blood count (CBC)/differential obtained within 60 days prior to registration, with adequate bone marrow function defined as follows:

Baseline serum PSA value performed with an Food and Drug Administration (FDA)-approved assay (e.g., Abbott, Hybritech) within 60 days prior to registration

Study entry PSA must not be obtained during the following time frames: (1) 10-day period following prostate biopsy; (2) following initiation of ADT; (3) within 30 days after discontinuation of finasteride; or (4) within 90 days after discontinuation of dutasteride

History/physical examination (to include, at a minimum, digital rectal examination of the prostate and examination of the skeletal system and abdomen, and formal comorbidity assessment via the ACE-27 instrument) within 60 days prior to registration; Note: the ACE-27 is posted on the 0815 protocol information page on the NRG Oncology/Radiation Therapy Oncology Group (RTOG) web site

Clinically negative lymph nodes as established by imaging (pelvic +/- abdominal computed tomography [CT] scan or magnetic resonance imaging [MRI]), nodal sampling, or dissection within 60 days prior to registration, except as noted immediately below:

Patients with a single intermediate risk factor only do not require abdominopelvic imaging, but these studies may be obtained at the discretion of the treating physician; patients with 2 or 3 risk factors are required to undergo pelvic +/- abdominal CT or MRI

Patients with lymph nodes equivocal or questionable by imaging are eligible without biopsy if the nodes are =< 1.5 cm; any node larger than this on imaging will require negative biopsy for eligibility

Platelet count >= 100,000 cells/mm^3

Pathologically (histologically) proven diagnosis of prostatic adenocarcinoma, at intermediate risk for recurrence, within 180 days prior to registration as determined by having one or more of the following intermediate-risk features:

Gleason score 7

Prostate specific antigen (PSA) > 10 but =< 20

Clinical stage T2b-T2c

Patients previously diagnosed with low risk (Gleason score =< 6, clinical stage < T2a, and PSA < 10) prostate cancer undergoing active surveillance who are re-biopsied and found to have intermediate risk disease according to the protocol criteria are eligible for enrollment within 180 days of the repeat biopsy procedure

Zubrod performance status 0-1

Exclusion Criteria:

Patients with Gleason score >= 8; PSA > 20; OR clinical stage >= T3 are ineligible for this trial

Should findings of extracapsular extension or seminal vesicle invasion be noted on prostate MRI, this study, if used, will not render patients ineligible for accrual to this protocol; primary tumor staging for eligibility purposes is to be based on palpable or core biopsy evidence only with respect to extracapsular extension or seminal vesicle involvement

Prior RT, including brachytherapy, to the region of the study cancer that would result in overlap of RT fields

Any patient undergoing brachytherapy must have transrectal ultrasound confirmation of prostate volume < 60 cc, American Urological Association (AUA) score =< 15 within 60 days of registration, and no history of prior transurethral resection of the prostate (TURP); prior TURP is permitted for patients who receive EBRT only

Patients with all three intermediate risk factors who also have >= 50% of the number of their biopsy cores positive for cancer are ineligible for this trial

Men who are sexually active with a woman of child-bearing potential and not willing/able to use medically acceptable forms of contraception (e.g., surgical, barrier, medicinal) during protocol treatment and during the first 3 months after cessation of protocol treatment

Severe, active co-morbidity, defined as follows:

Unstable angina and/or congestive heart failure requiring hospitalization within the last 6 months

Transmural myocardial infarction within the last 6 months

Acute bacterial or fungal infection requiring intravenous antibiotics at the time of registration

Chronic obstructive pulmonary disease exacerbation or other respiratory illness requiring hospitalization or precluding study therapy within 30 days before registration

Hepatic insufficiency resulting in clinical jaundice and/or coagulation defects; note, however, that laboratory tests for liver function and coagulation parameters are not required for entry into this protocol

Acquired immune deficiency syndrome (AIDS) based upon current Centers for Disease Control and Prevention (CDC) definition; note, however, that human immunodeficiency virus (HIV) testing is not required for entry into this protocol; patients who are HIV seropositive but do not meet criteria for diagnosis of AIDS are eligible for study participation

Use of finasteride within 30 days prior to registration

Prior invasive malignancy (except non-melanomatous skin cancer) or hematological (e.g., leukemia, lymphoma, myeloma) malignancy unless disease free for a minimum of 5 years (prior diagnoses of carcinoma in situ are permitted)

Prior or concurrent cytotoxic chemotherapy for prostate cancer; prior chemotherapy for a different cancer is permitted

Use of dutasteride within 90 days prior to registration

Prior hormonal therapy, such as LHRH agonists (e.g., goserelin, leuprolide), antiandrogens (e.g., flutamide, bicalutamide), estrogens (e.g., diethylstilbestrol [DES]), or bilateral orchiectomy

Prior radical surgery (prostatectomy), high-intensity focused ultrasound (HIFU) or cryosurgery for prostate cancer

Trial Contact Information

Trial Lead Organizations / Sponsors / Collaborators

NRG Oncology

  • National Cancer Institute
Alvaro Martinez, Principal Investigator

Trial Sites

U.S.A.

Alaska
Fairbanks

Fairbanks Memorial Hospital

Huong Thanh Pham
Ph: 206-342-6954
Email: vmmc.cancer_clinical_research@VirginiaMason.org

Huong Thanh Pham
Principal Investigator

Arizona
Phoenix

Saint Joseph's Hospital and Medical Center

David G. Brachman
Ph: 877-602-4111

David G. Brachman
Principal Investigator

Scottsdale

21st Century Oncology-Scottsdale

Karen A. Finkelstein
Ph: 505-843-7813

Karen A. Finkelstein
Principal Investigator

Arizona Oncology Services Foundation

David G. Brachman
Ph: 877-602-4111

David G. Brachman
Principal Investigator

Mayo Clinic in Arizona

Richard (Chunhee) Choo
Ph: 507-538-7623

Richard (Chunhee) Choo
Principal Investigator

Tucson

Arizona Oncology Associates-West Orange Grove

Vivek S. Kavadi
Ph: 281-277-5200

Vivek S. Kavadi
Principal Investigator

California
Berkeley

Alta Bates Summit Medical Center-Herrick Campus

Christopher Uwe Jones
Ph: 415-209-2686
Email: bernicl@sutterhealth.org

Christopher Uwe Jones
Principal Investigator

Burbank

Providence Saint Joseph Medical Center/Disney Family Cancer Center

Matthew C. Solhjem
Ph: 503-215-6412
Email: Julie.Cramer@providence.org

Matthew C. Solhjem
Principal Investigator

Chico

Enloe Medical Center

Grace E. Yuh
Ph: 530-332-3808

Grace E. Yuh
Principal Investigator

El Segundo

21st Century Oncology - El Segundo

David C. Khan
Ph: 888-326-9729

David C. Khan
Principal Investigator

Fresno

Fresno Cancer Center

Louis Fehrenbacher
Ph: 626-564-3455

Louis Fehrenbacher
Principal Investigator

Fullerton

Saint Jude Medical Center

William E. Lawler
Ph: 714-446-5642

William E. Lawler
Principal Investigator

Greenbrae

Marin General Hospital

Lloyd T. Miyawaki
Ph: 415-925-7325

Lloyd T. Miyawaki
Principal Investigator

Long Beach

Veterans Administration Long Beach Medical Center

Samar H. Azawi
Ph: 562-826-8000

Samar H. Azawi
Principal Investigator

Los Angeles

Los Angeles County-USC Medical Center

Leslie Ballas
Ph: 323-865-0451

Leslie Ballas
Principal Investigator

USC / Norris Comprehensive Cancer Center

Leslie Ballas
Ph: 323-865-0451

Leslie Ballas
Principal Investigator

Oakland

Kaiser Permanente Oakland-Broadway

Louis Fehrenbacher
Ph: 626-564-3455

Louis Fehrenbacher
Principal Investigator

Palm Springs

Desert Regional Medical Center

Amir Lavaf
Ph: 760-416-4730

Amir Lavaf
Principal Investigator

Paradise

Feather River Cancer Center

Sam Mazj
Ph: 530-876-7995
Email: haleew@ah.org

Sam Mazj
Principal Investigator

Pomona

Pomona Valley Hospital Medical Center

Yallapragada S. (Ram) Rao
Ph: 909-865-9555

Yallapragada S. (Ram) Rao
Principal Investigator

Rancho Cordova

Kaiser Permanente-Rancho Cordova Cancer Center

Louis Fehrenbacher
Ph: 626-564-3455

Louis Fehrenbacher
Principal Investigator

Rohnert Park

Rohnert Park Cancer Center

Louis Fehrenbacher
Ph: 626-564-3455

Louis Fehrenbacher
Principal Investigator

Roseville

The Permanente Medical Group-Roseville Radiation Oncology

Louis Fehrenbacher
Ph: 626-564-3455

Louis Fehrenbacher
Principal Investigator

Sacramento

South Sacramento Cancer Center

Louis Fehrenbacher
Ph: 626-564-3455

Louis Fehrenbacher
Principal Investigator

University of California Davis Comprehensive Cancer Center

Richard K. Valicenti
Ph: 916-734-3089

Richard K. Valicenti
Principal Investigator

San Diego

University of California San Diego

Loren K. Mell
Ph: 858-822-5354
Email: cancercto@ucsd.edu

Loren K. Mell
Principal Investigator

San Francisco

California Pacific Medical Center-Pacific Campus

Christopher Uwe Jones
Ph: 415-209-2686
Email: bernicl@sutterhealth.org

Christopher Uwe Jones
Principal Investigator

UCSF Medical Center-Mount Zion

I-Chow Joe Hsu
Ph: 877-827-3222

I-Chow Joe Hsu
Principal Investigator

Santa Clara

Kaiser Permanente Medical Center - Santa Clara

Louis Fehrenbacher
Ph: 626-564-3455

Louis Fehrenbacher
Principal Investigator

South San Francisco

Kaiser Permanente Cancer Treatment Center

Louis Fehrenbacher
Ph: 626-564-3455

Louis Fehrenbacher
Principal Investigator

Truckee

Tahoe Forest Cancer Center

Richard K. Valicenti
Ph: 916-734-3089

Richard K. Valicenti
Principal Investigator

Vallejo

Sutter Solano Medical Center/Cancer Center

Christopher Uwe Jones
Ph: 415-209-2686
Email: bernicl@sutterhealth.org

Christopher Uwe Jones
Principal Investigator

Colorado
Aurora

University of Colorado Cancer Center - Anschutz Cancer Pavilion

David Raben
Ph: 720-848-0650

David Raben
Principal Investigator

Fort Collins

Poudre Valley Hospital

Joshua Henry Petit
Ph: 970-482-3328

Joshua Henry Petit
Principal Investigator

Connecticut
Hartford

Hartford Hospital

Neal B. Goldberg
Ph: 860-224-5660

Neal B. Goldberg
Principal Investigator

Saint Francis Hospital and Medical Center

Samir Narayan
Ph: 734-712-4673

Samir Narayan
Principal Investigator

Hew Haven

Yale-New Haven Hospital Saint Raphael Campus

Joseph Guy Cardinale
Ph: 203-785-5702

Joseph Guy Cardinale
Principal Investigator

Meriden

Midstate Medical Center

Neal B. Goldberg
Ph: 860-224-5660

Neal B. Goldberg
Principal Investigator

New Britain

The Hospital of Central Connecticut

Neal B. Goldberg
Ph: 860-224-5660

Neal B. Goldberg
Principal Investigator

Delaware
Newark

Christiana Care Health System-Christiana Hospital

Adam Raben
Ph: 302-733-6227

Adam Raben
Principal Investigator

Helen F Graham Cancer Center

Adam Raben
Ph: 302-733-6227

Adam Raben
Principal Investigator

Rehoboth Beach

Beebe Health Campus

Adam Raben
Ph: 302-733-6227

Adam Raben
Principal Investigator

Florida
Fort Lauderdale

Broward Health Medical Center

Evan Matthew Landau
Ph: 954-355-5346

Evan Matthew Landau
Principal Investigator

Jacksonville

Mayo Clinic in Florida

Richard (Chunhee) Choo
Ph: 507-538-7623

Richard (Chunhee) Choo
Principal Investigator

Kissimmee

Florida Hospital Kissimmee

Lee M. Zehngebot
Ph: 407-303-5623

Lee M. Zehngebot
Principal Investigator

Orlando

Florida Hospital Orlando

Lee M. Zehngebot
Ph: 407-303-5623

Lee M. Zehngebot
Principal Investigator

Tampa

James A. Haley Veterans Affairs Hospital

Babu Zachariah
Ph: 800-456-7121
Email: canceranswers@moffitt.org

Babu Zachariah
Principal Investigator

Georgia
Atlanta

Emory University/Winship Cancer Institute

Scott Edelman
Ph: 404-321-6111ext7632

Scott Edelman
Principal Investigator

Grady Health System

Ashesh B. Jani
Ph: 404-778-1868

Ashesh B. Jani
Principal Investigator

Piedmont Hospital

Adam Wayne Nowlan
Ph: 404-425-7943
Email: ORS@piedmont.org

Adam Wayne Nowlan
Principal Investigator

Carrollton

Tanner Medical Center/Carrollton

James Richard Bland
Ph: 770-836-9824

James Richard Bland
Principal Investigator

Columbus

John B Amos Cancer Center

Douglas F. Ciuba
Ph: 706-660-6404

Douglas F. Ciuba
Principal Investigator

Decatur

Atlanta VA Medical Center

Scott Edelman
Ph: 404-321-6111ext7632

Scott Edelman
Principal Investigator

Gainesville

Northeast Georgia Medical Center

Frank Greer Lake
Ph: 770-219-8800
Email: cancerpatient.navigator@nghs.com

Frank Greer Lake
Principal Investigator

Savannah

Lewis Cancer and Research Pavilion at Saint Joseph's/Candler

Howard A. Zaren
Ph: 800-622-6877

Howard A. Zaren
Principal Investigator

Memorial University Medical Center

Aaron Watson Pederson
Ph: 912-350-8568

Aaron Watson Pederson
Principal Investigator

Hawaii
Honolulu

Queen's Medical Center

Paul Arthur DeMare
Ph: 808-545-8548

Paul Arthur DeMare
Principal Investigator

The Cancer Center of Hawaii-Liliha

Paul Arthur DeMare
Ph: 808-545-8548

Paul Arthur DeMare
Principal Investigator

University of Hawaii Cancer Center

Paul Arthur DeMare
Ph: 808-545-8548

Paul Arthur DeMare
Principal Investigator

Idaho
Boise

Saint Alphonsus Cancer Care Center-Boise

Samir Narayan
Ph: 734-712-4673

Samir Narayan
Principal Investigator

Post Falls

Kootenai Cancer Center

Benjamin T. Marchello
Ph: 800-648-6274

Benjamin T. Marchello
Principal Investigator

Illinois
Carbondale

Memorial Hospital of Carbondale

James Lloyd Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

James Lloyd Wade
Principal Investigator

Chicago

Advocate Illinois Masonic Medical Center

Santosh V. Yajnik
Ph: 773-296-5360

Santosh V. Yajnik
Principal Investigator

John H Stroger Jr Hospital of Cook County

Thomas E. Lad
Ph: 312-864-6000

Thomas E. Lad
Principal Investigator

University of Chicago Comprehensive Cancer Center

Stanley Lawrence Liauw
Ph: 773-834-7424

Stanley Lawrence Liauw
Principal Investigator

Decatur

Decatur Memorial Hospital

James Lloyd Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

James Lloyd Wade
Principal Investigator

Effingham

Crossroads Cancer Center

James Lloyd Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

James Lloyd Wade
Principal Investigator

Hines

Hines Veterans Administration Hospital

William Small
Ph: 708-226-4357

William Small
Principal Investigator

Maywood

Loyola University Medical Center

Matthew M. Harkenrider
Ph: 708-226-4357

Matthew M. Harkenrider
Principal Investigator

Pekin

Pekin Cancer Treatment Center

Nguyet Anh Le-Lindqwister
Ph: 800-793-2262

Nguyet Anh Le-Lindqwister
Principal Investigator

Peoria

OSF Saint Francis Medical Center

Nguyet Anh Le-Lindqwister
Ph: 800-793-2262

Nguyet Anh Le-Lindqwister
Principal Investigator

OSF Saint Francis Medical Center Radiation Oncology Service at the Central Illinois Comprehensive CC

Nguyet Anh Le-Lindqwister
Ph: 800-793-2262

Nguyet Anh Le-Lindqwister
Principal Investigator

Rockford

SwedishAmerican Regional Cancer Center/ACT

Harvey E. Einhorn
Ph: 779-696-9400
Email: cancercare@swedishamerican.org

Harvey E. Einhorn
Principal Investigator

Springfield

Memorial Medical Center

James Lloyd Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

James Lloyd Wade
Principal Investigator

Saint John's Hospital

Laurent Brard
Ph: 217-525-5666
Email: diana.weyhenmeyer@st-johns.org

Laurent Brard
Principal Investigator

Indiana
Anderson

Saint Vincent Anderson Regional Hospital/Cancer Center

Alexander M. Yeh
Ph: 765-646-8358

Alexander M. Yeh
Principal Investigator

Avon

IU Health West Hospital

Mark Peter Langer
Ph: 317-274-2552

Mark Peter Langer
Principal Investigator

Fort Wayne

Parkview Hospital Randallia

Brian K. Chang
Ph: 260-373-8888
Email: parkviewresearch@parkview.com

Brian K. Chang
Principal Investigator

Radiation Oncology Associates PC

Brian K. Chang
Ph: 260-373-8888
Email: parkviewresearch@parkview.com

Brian K. Chang
Principal Investigator

Indianapolis

Indiana University/Melvin and Bren Simon Cancer Center

Mark Peter Langer
Ph: 317-274-2552

Mark Peter Langer
Principal Investigator

IU Health Methodist Hospital

Mark Peter Langer
Ph: 317-274-2552

Mark Peter Langer
Principal Investigator

Iowa
Ames

McFarland Clinic PC-William R Bliss Cancer Center

Joseph James Merchant
Ph: 515-239-2621

Joseph James Merchant
Principal Investigator

Dubuque

Finley Hospital

Nagendra (Bobby) Sai Koneru
Ph: 800-397-2467

Nagendra (Bobby) Sai Koneru
Principal Investigator

Kansas
Lawrence

Lawrence Memorial Hospital

Shaker R. Dakhil
Ph: 316-262-4467

Shaker R. Dakhil
Principal Investigator

Kentucky
Owensboro

Owensboro Health Mitchell Memorial Cancer Center

Samuel Ryan Faught
Ph: 270-688-3691
Email: shawns@omhs.org

Samuel Ryan Faught
Principal Investigator

Louisiana
Baton Rouge

Mary Bird Perkins Cancer Center

Augusto C. Ochoa
Ph: 504-568-2428
Email: emede1@lsuhsc.edu

Augusto C. Ochoa
Principal Investigator

New Orleans

Ochsner Medical Center Jefferson

Troy Gene Scroggins
Ph: 888-562-4763

Troy Gene Scroggins
Principal Investigator

Tulane University Health Sciences Center

William Russell Robinson
Ph: 504-988-6121

William Russell Robinson
Principal Investigator

Maine
Scarborough

Maine Medical Center- Scarborough Campus

Ian Jared Bristol
Ph: 207-396-8090
Email: wrighd@mmc.org

Ian Jared Bristol
Principal Investigator

Maryland
Annapolis

Anne Arundel Medical Center

Angel E. Torano
Ph: 443-481-1320
Email: kbodenhorn@aahs.org

Angel E. Torano
Principal Investigator

Baltimore

Saint Agnes Hospital

Richard S. Hudes
Ph: 410-368-2910

Richard S. Hudes
Principal Investigator

University of Maryland/Greenebaum Cancer Center

Young Kwok
Ph: 800-888-8823

Young Kwok
Principal Investigator

Bel Air

Upper Chesapeake Medical Center

Young Kwok
Ph: 800-888-8823

Young Kwok
Principal Investigator

Bethesda

Walter Reed National Military Medical Center

Christopher Neil Premo
Ph: 301-319-2100

Christopher Neil Premo
Principal Investigator

Columbia

Central Maryland Radiation Oncology in Howard County

Young Kwok
Ph: 800-888-8823

Young Kwok
Principal Investigator

Glen Burnie

Tate Cancer Center

Young Kwok
Ph: 800-888-8823

Young Kwok
Principal Investigator

Silver Spring

Holy Cross Hospital

Daniel H. Clarke
Ph: 310-754-7552

Daniel H. Clarke
Principal Investigator

Massachusetts
Boston

Boston Medical Center

Ariel Elysse Hirsch
Ph: 617-638-8265

Ariel Elysse Hirsch
Principal Investigator

Massachusetts General Hospital Cancer Center

Jason Alexander Efstathiou
Ph: 877-726-5130

Jason Alexander Efstathiou
Principal Investigator

Danvers

Mass General/North Shore Cancer Center

Jason Alexander Efstathiou
Ph: 877-726-5130

Jason Alexander Efstathiou
Principal Investigator

Fall River

Saint Anne's Hospital

Michele Albert
Ph: 508-674-5600ext2515

Michele Albert
Principal Investigator

Hyannis

Cape Cod Hospital

Daniel Joseph Canaday
Ph: 508-862-5799

Daniel Joseph Canaday
Principal Investigator

Lowell

Lowell General Hospital

Jason Alexander Efstathiou
Ph: 877-726-5130

Jason Alexander Efstathiou
Principal Investigator

Pittsfield

Berkshire Hematology Oncology PC

Harvey Zimbler
Ph: 413-496-8205
Email: ggero@bhs1.org

Harvey Zimbler
Principal Investigator

Plymouth

Beth Israel Deaconess Hospital-Plymouth

James Matthew Koomey
Ph: 508-830-2390
Email: cancerinfo@jordanhospital.org

James Matthew Koomey
Principal Investigator

Springfield

Baystate Medical Center

Seth A. Kaufman
Ph: 413-794-9338

Seth A. Kaufman
Principal Investigator

Worcester

Saint Vincent Hospital/Reliant Medical Group

William B. Casey
Ph: 508-363-7018

William B. Casey
Principal Investigator

Michigan
Ann Arbor

Saint Joseph Mercy Hospital

Samir Narayan
Ph: 734-712-4673

Samir Narayan
Principal Investigator

University of Michigan Comprehensive Cancer Center

Alvaro Martinez
Email: alvaro.martinez@rtsx.com

Alvaro Martinez
Principal Investigator

Veteran's Administration Medical Center - Ann Arbor

Kyle C. Cuneo
Ph: 800-865-1125

Kyle C. Cuneo
Principal Investigator

Bay City

McLaren-Bay Region

Hesham El Gayar
Ph: 810-342-4071

Hesham El Gayar
Principal Investigator

Clinton Township

Henry Ford Macomb Hospital

Eleanor M. Walker
Ph: 313-916-1784

Eleanor M. Walker
Principal Investigator

Detroit

Henry Ford Hospital

Eleanor M. Walker
Ph: 313-916-1784

Eleanor M. Walker
Principal Investigator

Saint John Hospital and Medical Center

Samir Narayan
Ph: 734-712-4673

Samir Narayan
Principal Investigator

Farmington Hills

21st Century Oncology-Farmington Hills

Jeffrey David Forman
Ph: 248-858-6215

Jeffrey David Forman
Principal Investigator

Flint

Genesys Hurley Cancer Institute

Samir Narayan
Ph: 734-712-4673

Samir Narayan
Principal Investigator

McLaren-Flint

Hesham El Gayar
Ph: 810-342-4071

Hesham El Gayar
Principal Investigator

Kalamazoo

West Michigan Cancer Center

Sunil Nagpal
Ph: 269-373-7458

Sunil Nagpal
Principal Investigator

Lansing

Sparrow Hospital

Samir Narayan
Ph: 734-712-4673

Samir Narayan
Principal Investigator

Lapeer

McLaren Cancer Institute-Lapeer Campus

Hesham El Gayar
Ph: 810-342-4071

Hesham El Gayar
Principal Investigator

Mount Clemens

McLaren-Macomb

Hesham El Gayar
Ph: 810-342-4071

Hesham El Gayar
Principal Investigator

Mount Pleasant

McLaren-Central Michigan

Hesham El Gayar
Ph: 810-342-4071

Hesham El Gayar
Principal Investigator

Owosso

McLaren Cancer Institute-Owosso

Hesham El Gayar
Ph: 810-342-4071

Hesham El Gayar
Principal Investigator

Petoskey

McLaren-Northern Michigan

Hesham El Gayar
Ph: 810-342-4071

Hesham El Gayar
Principal Investigator

Pontiac

Saint Joseph Mercy Oakland

Samir Narayan
Ph: 734-712-4673

Samir Narayan
Principal Investigator

Port Huron

Saint Joseph Mercy Port Huron

Samir Narayan
Ph: 734-712-4673

Samir Narayan
Principal Investigator

Royal Oak

William Beaumont Hospital-Royal Oak

Daniel J. Krauss
Ph: 248-551-7695

Daniel J. Krauss
Principal Investigator

Saginaw

Saint Mary's of Michigan

Samir Narayan
Ph: 734-712-4673

Samir Narayan
Principal Investigator

Trenton

Downriver Center for Oncology

Eleanor M. Walker
Ph: 313-916-1784

Eleanor M. Walker
Principal Investigator

Troy

21st Century Oncology-Troy

Jeffrey David Forman
Ph: 248-858-6215

Jeffrey David Forman
Principal Investigator

William Beaumont Hospital - Troy

Daniel J. Krauss
Ph: 248-551-7695

Daniel J. Krauss
Principal Investigator

Warren

Saint John Macomb-Oakland Hospital

Samir Narayan
Ph: 734-712-4673

Samir Narayan
Principal Investigator

West Bloomfield

Henry Ford Medical Center - West Bloomfield

Eleanor M. Walker
Ph: 313-916-1784

Eleanor M. Walker
Principal Investigator

Minnesota
Bemidji

Sanford Clinic North-Bemidgi

Preston D. Steen
Ph: 701-234-6161

Preston D. Steen
Principal Investigator

Duluth

Miller-Dwan Hospital

Daniel A. Nikcevich
Ph: 888-203-7267

Daniel A. Nikcevich
Principal Investigator

Saint Luke's Hospital of Duluth

Steven R. Bonin
Ph: 888-823-5923
Email: ctsucontact@westat.com

Steven R. Bonin
Principal Investigator

Edina

Fairview-Southdale Hospital

Paul W. Sperduto
Ph: 952-993-1517
Email: MMCCOP@parknicollet.com

Paul W. Sperduto
Principal Investigator

Rochester

Mayo Clinic

Richard (Chunhee) Choo
Ph: 507-538-7623

Richard (Chunhee) Choo
Principal Investigator

Saint Paul

Regions Hospital

Paul W. Sperduto
Ph: 952-993-1517
Email: MMCCOP@parknicollet.com

Paul W. Sperduto
Principal Investigator

Missouri
Joplin

Mercy Hospital-Joplin

Jay W. Carlson
Ph: 800-821-7532

Jay W. Carlson
Principal Investigator

Rolla

Phelps County Regional Medical Center

Jay W. Carlson
Ph: 800-821-7532

Jay W. Carlson
Principal Investigator

Saint Louis

Barnes-Jewish West County Hospital

Jeff M. Michalski
Ph: 800-600-3606
Email: info@siteman.wustl.edu

Jeff M. Michalski
Principal Investigator

Mercy Hospital Saint Louis

Jay W. Carlson
Ph: 800-821-7532

Jay W. Carlson
Principal Investigator

Missouri Baptist Medical Center

James Lloyd Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

James Lloyd Wade
Principal Investigator

Washington University School of Medicine

Jeff M. Michalski
Ph: 800-600-3606
Email: info@siteman.wustl.edu

Jeff M. Michalski
Principal Investigator

Saint Peters

Siteman Cancer Center - Saint Peters

Jeff M. Michalski
Ph: 800-600-3606
Email: info@siteman.wustl.edu

Jeff M. Michalski
Principal Investigator

Springfield

CoxHealth South Hospital

Jay W. Carlson
Ph: 800-821-7532

Jay W. Carlson
Principal Investigator

Mercy Hospital Springfield

Jay W. Carlson
Ph: 800-821-7532

Jay W. Carlson
Principal Investigator

Montana
Billings

Billings Clinic Cancer Center

Benjamin T. Marchello
Ph: 800-648-6274

Benjamin T. Marchello
Principal Investigator

Nebraska
Omaha

Nebraska Methodist Hospital

Tien-Shew William Huang
Ph: 402-354-5144

Tien-Shew William Huang
Principal Investigator

University of Nebraska Medical Center

Andrew Owen Wahl
Ph: 402-559-6941
Email: unmcrsa@unmc.edu

Andrew Owen Wahl
Principal Investigator

New Hampshire
Concord

Concord Hospital

Su K. Metcalfe
Ph: 800-441-1138

Su K. Metcalfe
Principal Investigator

Exeter

Exeter Hospital

Gary Miller Proulx
Ph: 800-439-3837

Gary Miller Proulx
Principal Investigator

Keene

Cheshire Medical Center-Dartmouth-Hitchcock Keene

Alan Charles Hartford
Ph: 800-639-6918
Email: cancer.research.nurse@dartmouth.edu

Alan Charles Hartford
Principal Investigator

Lebanon

Dartmouth Hitchcock Medical Center

Alan Charles Hartford
Ph: 800-639-6918
Email: cancer.research.nurse@dartmouth.edu

Alan Charles Hartford
Principal Investigator

Manchester

Elliot Hospital

Brian Robert Knab
Ph: 603-663-1800

Brian Robert Knab
Principal Investigator

New Jersey
Brick

Ocean Medical Center

Douglas A. Miller
Ph: 732-206-8384

Douglas A. Miller
Principal Investigator

East Orange

Veterans Adminstration New Jersey Health Care System

Maria Denise Kelly
Ph: 800-475-2336
Email: patricia.goyer@med.va.gov

Maria Denise Kelly
Principal Investigator

Mount Holly

Fox Chase Cancer Center at Virtua Memorial Hospital of Burlington County

Lemuel S. Ariaratnam
Ph: 888-847-8823

Lemuel S. Ariaratnam
Principal Investigator

Neptune

Jersey Shore Medical Center

Douglas A. Miller
Ph: 732-206-8384

Douglas A. Miller
Principal Investigator

Red Bank

Riverview Medical Center/Booker Cancer Center

Douglas A. Miller
Ph: 732-206-8384

Douglas A. Miller
Principal Investigator

Sparta

Sparta Cancer Treatment Center

Maria Werner-Wasik
Ph: 215-955-6084

Maria Werner-Wasik
Principal Investigator

Toms River

Community Medical Center

David J. D'Ambrosio
Ph: 732-818-3882

David J. D'Ambrosio
Principal Investigator

New Mexico
Albuquerque

New Mexico Oncology Hematology Consultants

Benny J. Liem
Ph: 505-272-6972

Benny J. Liem
Principal Investigator

University of New Mexico

Alvaro Martinez
Email: alvaro.martinez@rtsx.com

Alvaro Martinez
Principal Investigator

University of New Mexico Cancer Center

Benny J. Liem
Ph: 505-272-6972

Benny J. Liem
Principal Investigator

Las Cruces

Memorial Medical Center - Las Cruces

Benny J. Liem
Ph: 505-272-6972

Benny J. Liem
Principal Investigator

New York
Bay Shore

Southside Hospital

Louis Potters
Ph: 516-562-3467

Louis Potters
Principal Investigator

Binghamton

Lourdes Hospital

Michael Fallon
Ph: 607-798-5230

Michael Fallon
Principal Investigator

Canandiaqua

Sands Cancer Center

Yuhchyau Chen
Ph: 585-275-5830

Yuhchyau Chen
Principal Investigator

Cooperstown

Mary Imogene Bassett Hospital

Naoyuki Gregory Saito
Ph: 607-547-3073
Email: diana.crean@bassett.org

Naoyuki Gregory Saito
Principal Investigator

Elmira

Arnot Ogden Medical Center/Falck Cancer Center

Chi K. Tsang
Ph: 607-271-7000

Chi K. Tsang
Principal Investigator

New Hyde Park

Long Island Jewish Medical Center

Louis Potters
Ph: 516-562-3467

Louis Potters
Principal Investigator

North Shore-LIJ Health System/Center for Advanced Medicine

Louis Potters
Ph: 516-562-3467

Louis Potters
Principal Investigator

New York

Columbia University Medical Center

Israel Deutsch
Ph: 212-305-8615

Israel Deutsch
Principal Investigator

Poughkeepsie

Hudson Valley Oncology Associates

Maria Werner-Wasik
Ph: 215-955-6084

Maria Werner-Wasik
Principal Investigator

Rochester

Highland Hospital

Yuhchyau Chen
Ph: 585-275-5830

Yuhchyau Chen
Principal Investigator

University of Rochester

Yuhchyau Chen
Ph: 585-275-5830

Yuhchyau Chen
Principal Investigator

University Radiation Oncology

Yuhchyau Chen
Ph: 585-275-5830

Yuhchyau Chen
Principal Investigator

North Carolina
Durham

Duke University Medical Center

William Robert Lee
Ph: 888-275-3853

William Robert Lee
Principal Investigator

Morehead City

The Coleman Radiation Center-Carteret General Hospital

Michael A. Papagikos
Ph: 910-251-1839

Michael A. Papagikos
Principal Investigator

New Bern

CarolinaEast Health System-Medical Center

Michael A. Papagikos
Ph: 910-251-1839

Michael A. Papagikos
Principal Investigator

Raleigh

Rex Cancer Center

Nathan Christopher Sheets
Ph: 919-784-7209

Nathan Christopher Sheets
Principal Investigator

Supply

South Atlantic Radiation Oncology

Michael A. Papagikos
Ph: 910-251-1839

Michael A. Papagikos
Principal Investigator

Wilmington

Coastal Carolina Radiation Oncology

Michael A. Papagikos
Ph: 910-251-1839

Michael A. Papagikos
Principal Investigator

New Hanover Regional Medical Center/Zimmer Cancer Center

Michael A. Papagikos
Ph: 910-251-1839

Michael A. Papagikos
Principal Investigator

North Dakota
Bismarck

Sanford Bismarck Medical Center

Preston D. Steen
Ph: 701-234-6161

Preston D. Steen
Principal Investigator

Fargo

Sanford Medical Center-Fargo

Preston D. Steen
Ph: 701-234-6161

Preston D. Steen
Principal Investigator

Minot

Trinity Cancer Care Center

Kevin B. Collins
Ph: 888-823-5923
Email: ctsucontact@westat.com

Kevin B. Collins
Principal Investigator

Ohio
Akron

Akron General Medical Center

Mitchel L. Fromm
Ph: 330-344-6348

Mitchel L. Fromm
Principal Investigator

Summa Akron City Hospital/Cooper Cancer Center

Desiree E. Doncals
Ph: 330-375-6101

Desiree E. Doncals
Principal Investigator

Barberton

Summa Barberton Hospital

Desiree E. Doncals
Ph: 330-375-6101

Desiree E. Doncals
Principal Investigator

Beachwood

UHHS-Chagrin Highlands Medical Center

Rodney J. Ellis
Ph: 800-641-2422

Rodney J. Ellis
Principal Investigator

Chardon

Geaugra Hospital

Rodney J. Ellis
Ph: 800-641-2422

Rodney J. Ellis
Principal Investigator

Chillicothe

Adena Regional Medical Center

John Philip Kuebler
Ph: 614-488-2745
Email: sheree@columbusccop.org

John Philip Kuebler
Principal Investigator

Cincinnati

University of Cincinnati

Kevin Patrick Redmond
Ph: 513-558-4553
Email: uchealthnews@uc.edu

Kevin Patrick Redmond
Principal Investigator

Cleveland

Case Western Reserve University

Rodney J. Ellis
Ph: 800-641-2422

Rodney J. Ellis
Principal Investigator

Columbus

Riverside Methodist Hospital

John Philip Kuebler
Ph: 614-488-2745
Email: sheree@columbusccop.org

John Philip Kuebler
Principal Investigator

The Mark H Zangmeister Center

John Philip Kuebler
Ph: 614-488-2745
Email: sheree@columbusccop.org

John Philip Kuebler
Principal Investigator

Elyria

Mercy Cancer Center-Elyria

Rodney J. Ellis
Ph: 800-641-2422

Rodney J. Ellis
Principal Investigator

Maumee

Toledo Clinic Cancer Centers-Maumee

Rex B. Mowat
Ph: 800-444-3561

Rex B. Mowat
Principal Investigator

Medina

Summa Health Center at Lake Medina

Desiree E. Doncals
Ph: 330-375-6101

Desiree E. Doncals
Principal Investigator

Mentor

Lake University Ireland Cancer Center

Rodney J. Ellis
Ph: 800-641-2422

Rodney J. Ellis
Principal Investigator

Middleburg Heights

Southwest General Health Center Ireland Cancer Center

Rodney J. Ellis
Ph: 800-641-2422

Rodney J. Ellis
Principal Investigator

Oregon

Saint Charles Hospital

Rex B. Mowat
Ph: 800-444-3561

Rex B. Mowat
Principal Investigator

Parma

University Hospitals Parma Medical Center

Rodney J. Ellis
Ph: 800-641-2422

Rodney J. Ellis
Principal Investigator

Portsmouth

Southern Ohio Medical Center

Alvaro Martinez
Email: alvaro.martinez@rtsx.com

Alvaro Martinez
Principal Investigator

Ravenna

Robinson Radiation Oncology

Mitchel L. Fromm
Ph: 330-344-6348

Mitchel L. Fromm
Principal Investigator

Sandusky

Ireland Cancer Center at Firelands Regional Medical Center

Rodney J. Ellis
Ph: 800-641-2422

Rodney J. Ellis
Principal Investigator

Sylvania

Flower Hospital

Jeffrey Henry Muler
Ph: 419-824-1842

Jeffrey Henry Muler
Principal Investigator

Toledo

Mercy Saint Anne Hospital

Rex B. Mowat
Ph: 800-444-3561

Rex B. Mowat
Principal Investigator

West Chester

University Pointe

Kevin Patrick Redmond
Ph: 513-558-4553
Email: uchealthnews@uc.edu

Kevin Patrick Redmond
Principal Investigator

Westlake

UHHS-Westlake Medical Center

Rodney J. Ellis
Ph: 800-641-2422

Rodney J. Ellis
Principal Investigator

Oklahoma
Oklahoma City

University of Oklahoma Health Sciences Center

Terence S. Herman
Ph: 405-271-4272
Email: julie-traylor@ouhsc.edu

Terence S. Herman
Principal Investigator

Oregon
Clackamas

Clackamas Radiation Oncology Center

Matthew C. Solhjem
Ph: 503-215-6412
Email: Julie.Cramer@providence.org

Matthew C. Solhjem
Principal Investigator

Eugene

Willamette Valley Cancer Center

Vivek S. Kavadi
Ph: 281-277-5200

Vivek S. Kavadi
Principal Investigator

Grants Pass

Three Rivers Community Hospital

Gordon L. Metz
Ph: 541-789-6176

Gordon L. Metz
Principal Investigator

Medford

Providence Medford Medical Center

Gordon L. Metz
Ph: 541-789-6176

Gordon L. Metz
Principal Investigator

Rogue Valley Medical Center

Gordon L. Metz
Ph: 541-789-6176

Gordon L. Metz
Principal Investigator

Portland

Providence Portland Medical Center

Matthew C. Solhjem
Ph: 503-215-6412
Email: Julie.Cramer@providence.org

Matthew C. Solhjem
Principal Investigator

Providence Saint Vincent Medical Center

Matthew C. Solhjem
Ph: 503-215-6412
Email: Julie.Cramer@providence.org

Matthew C. Solhjem
Principal Investigator

Pennsylvania
Abington

Abington Memorial Hospital

Wayne H. Pinover
Ph: 215-481-2402

Wayne H. Pinover
Principal Investigator

Bethlehem

Saint Luke's University Hospital-Bethlehem Campus

Nimisha Deb
Ph: 610-954-3582
Email: infolink@slhn.org

Nimisha Deb
Principal Investigator

Danville

Geisinger Medical Center

Thomas James Gergel
Ph: 570-271-5251

Thomas James Gergel
Principal Investigator

Darby

Mercy Fitzgerald Hospital

Maria Werner-Wasik
Ph: 215-955-6084

Maria Werner-Wasik
Principal Investigator

Drexel Hill

Delaware County Memorial Hospital

Rachelle M. Lanciano
Ph: 610-284-8237
Email: jolene.garney@crozer.org

Rachelle M. Lanciano
Principal Investigator

Dunmore

Northeast Radiation Oncology Center

Maria Werner-Wasik
Ph: 215-955-6084

Maria Werner-Wasik
Principal Investigator

Erie

The Regional Cancer Center

Andrew Thomas Figura
Ph: 814-838-0448
Email: mhaynes@trcc.org

Andrew Thomas Figura
Principal Investigator

Gettysburg

Adams Cancer Center

Amit B. Shah
Ph: 877-441-7957

Amit B. Shah
Principal Investigator

Hanover

Cherry Tree Cancer Center

Amit B. Shah
Ph: 877-441-7957

Amit B. Shah
Principal Investigator

Hershey

Penn State Milton S Hershey Medical Center

Henry Wagner
Ph: 717-531-3779
Email: CTO@hmc.psu.edu

Henry Wagner
Principal Investigator

Milford

Upper Delaware Valley Cancer Center

Maria Werner-Wasik
Ph: 215-955-6084

Maria Werner-Wasik
Principal Investigator

Philadelphia

Albert Einstein Medical Center

Kenneth Lee Zeitzer
Ph: 215-456-3880

Kenneth Lee Zeitzer
Principal Investigator

Fox Chase Cancer Center

Eric Mark Horwitz
Ph: 215-728-4790

Eric Mark Horwitz
Principal Investigator

Thomas Jefferson University Hospital

Maria Werner-Wasik
Ph: 215-955-6084

Maria Werner-Wasik
Principal Investigator

Pittsburgh

VA Pittsburgh Healthcare System

Kristina Gerszten
Ph: 412-688-6104

Kristina Gerszten
Principal Investigator

West Reading

Reading Hospital

Michael L. Haas
Ph: 610-988-9323

Michael L. Haas
Principal Investigator

York

WellSpan Health-York Hospital

Amit B. Shah
Ph: 877-441-7957

Amit B. Shah
Principal Investigator

South Carolina
Anderson

AnMed Health Hospital

Patricia C. Griffin
Ph: 800-486-5941

Patricia C. Griffin
Principal Investigator

Charleston

Medical University of South Carolina

David T. Marshall
Ph: 843-792-9321

David T. Marshall
Principal Investigator

Greenville

Greenville Health System Cancer Institute-Eastside

Jeffrey K. Giguere
Ph: 864-241-6251

Jeffrey K. Giguere
Principal Investigator

Greenville Health System Cancer Institute-Faris

Jeffrey K. Giguere
Ph: 864-241-6251

Jeffrey K. Giguere
Principal Investigator

Greenwood

Self Regional Healthcare

David T. Marshall
Ph: 843-792-9321

David T. Marshall
Principal Investigator

Greer

Gibbs Cancer Center-Pelham

Patricia C. Griffin
Ph: 800-486-5941

Patricia C. Griffin
Principal Investigator

Greenville Health System Cancer Institute-Greer

Jeffrey K. Giguere
Ph: 864-241-6251

Jeffrey K. Giguere
Principal Investigator

Myrtle Beach

Carolina Regional Cancer Center

Patrick Michael Francke
Ph: 877-460-2657

Patrick Michael Francke
Principal Investigator

Seneca

Greenville Health System Cancer Institute-Seneca

Jeffrey K. Giguere
Ph: 864-241-6251

Jeffrey K. Giguere
Principal Investigator

Spartanburg

Greenville Health System Cancer Institute-Spartanburg

Jeffrey K. Giguere
Ph: 864-241-6251

Jeffrey K. Giguere
Principal Investigator

Spartanburg Medical Center

Patricia C. Griffin
Ph: 800-486-5941

Patricia C. Griffin
Principal Investigator

South Dakota
Rapid City

Rapid City Regional Hospital

Michael J. Swartz
Ph: 605-716-3982
Email: research@rcrh.org

Michael J. Swartz
Principal Investigator

Tennessee
Knoxville

Thompson Cancer Survival Center

Daniel D. Scaperoth
Ph: 865-541-1812

Daniel D. Scaperoth
Principal Investigator

Maryville

Blount Memorial Hospital

Daniel D. Scaperoth
Ph: 865-541-1812

Daniel D. Scaperoth
Principal Investigator

Texas
Austin

Texas Oncology - Central Austin Cancer Center

Vivek S. Kavadi
Ph: 281-277-5200

Vivek S. Kavadi
Principal Investigator

Texas Oncology - South Austin Cancer Center

Vivek S. Kavadi
Ph: 281-277-5200

Vivek S. Kavadi
Principal Investigator

Texas Oncology-Austin Midtown

Vivek S. Kavadi
Ph: 281-277-5200

Vivek S. Kavadi
Principal Investigator

Bedford

Texas Oncology Bedford

Vivek S. Kavadi
Ph: 281-277-5200

Vivek S. Kavadi
Principal Investigator

Dallas

UT Southwestern/Simmons Cancer Center-Dallas

Raquibul Hannan
Ph: 214-648-7097

Raquibul Hannan
Principal Investigator

Denton

Texas Oncology-Denton South

Vivek S. Kavadi
Ph: 281-277-5200

Vivek S. Kavadi
Principal Investigator

Flower Mound

Texas Oncology-Flower Mound

Vivek S. Kavadi
Ph: 281-277-5200

Vivek S. Kavadi
Principal Investigator

Fort Sam Houston

Brooke Army Medical Center

Michael Day Dullea
Ph: 210-916-4837

Michael Day Dullea
Principal Investigator

Fort Worth

The Klabzuba Cancer Center

Vivek S. Kavadi
Ph: 281-277-5200

Vivek S. Kavadi
Principal Investigator

Galveston

University of Texas Medical Branch

Martin Colman
Ph: 409-772-1950
Email: clinical.research@utmb.edu

Martin Colman
Principal Investigator

Houston

M D Anderson Cancer Center

Thomas J. Pugh
Ph: 713-792-3245

Thomas J. Pugh
Principal Investigator

Memorial Hermann Memorial City Medical Center

Vivek S. Kavadi
Ph: 281-277-5200

Vivek S. Kavadi
Principal Investigator

League City

UTMB Cancer Center at Victory Lakes

Martin Colman
Ph: 409-772-1950
Email: clinical.research@utmb.edu

Martin Colman
Principal Investigator

Longview

Texas Oncology-Longview Cancer Center

Vivek S. Kavadi
Ph: 281-277-5200

Vivek S. Kavadi
Principal Investigator

Round Rock

Texas Oncology - Round Rock Cancer Center

Vivek S. Kavadi
Ph: 281-277-5200

Vivek S. Kavadi
Principal Investigator

Texas Oncology-Seton Williamson

Vivek S. Kavadi
Ph: 281-277-5200

Vivek S. Kavadi
Principal Investigator

Sherman

Texas Cancer Center-Sherman

Vivek S. Kavadi
Ph: 281-277-5200

Vivek S. Kavadi
Principal Investigator

Sugar Land

Texas Oncology Cancer Center Sugar Land

Vivek S. Kavadi
Ph: 281-277-5200

Vivek S. Kavadi
Principal Investigator

Utah
Murray

Intermountain Medical Center

R. Jeffrey Lee
Ph: 801-507-3950

R. Jeffrey Lee
Principal Investigator

Ogden

McKay-Dee Hospital Center

R. Jeffrey Lee
Ph: 801-507-3950

R. Jeffrey Lee
Principal Investigator

Saint George

Dixie Medical Center Regional Cancer Center

R. Jeffrey Lee
Ph: 801-507-3950

R. Jeffrey Lee
Principal Investigator

Salt Lake City

Huntsman Cancer Institute/University of Utah

Jonathan D. Tward
Ph: 801-581-4477
Email: clinical.trials@hci.utah.edu

Jonathan D. Tward
Principal Investigator

LDS Hospital

R. Jeffrey Lee
Ph: 801-507-3950

R. Jeffrey Lee
Principal Investigator

Utah Cancer Specialists-Salt Lake City

R. Jeffrey Lee
Ph: 801-507-3950

R. Jeffrey Lee
Principal Investigator

Vermont
Bennington

Southwestern Vermont Medical Center

Alan Charles Hartford
Ph: 800-639-6918
Email: cancer.research.nurse@dartmouth.edu

Alan Charles Hartford
Principal Investigator

Rutland

Rutland Regional Medical Center

Richard D. Lovett
Ph: 802-775-7111

Richard D. Lovett
Principal Investigator

Saint Johnsbury

Norris Cotton Cancer Center-North

Alan Charles Hartford
Ph: 800-639-6918
Email: cancer.research.nurse@dartmouth.edu

Alan Charles Hartford
Principal Investigator

Virginia
Alexandria

Inova Alexandria Hospital

Jane Grayson
Ph: 703-776-2580
Email: research@inova.org

Jane Grayson
Principal Investigator

Fishersville

Augusta Health Cancer Center

Robert M. Kyler
Ph: 540-689-7000

Robert M. Kyler
Principal Investigator

Hampton

Sentara Cancer Institute at Sentara CarePlex Hospital

Mark E. Shaves
Ph: 757-388-2406

Mark E. Shaves
Principal Investigator

Harrisonburg

Sentara Rockingham Memorial Hospital Hahn Cancer Center

Heather Anne White Morgan
Ph: 540-689-7000

Heather Anne White Morgan
Principal Investigator

Norfolk

Sentara Hospitals

Mark E. Shaves
Ph: 757-388-2406

Mark E. Shaves
Principal Investigator

Portsmouth

Naval Medical Center - Portsmouth

Edward F. Miles
Ph: 757-953-5939

Edward F. Miles
Principal Investigator

Roanoke

Oncology and Hematology Associates of Southwest Virginia

Vivek S. Kavadi
Ph: 281-277-5200

Vivek S. Kavadi
Principal Investigator

Virginia Beach

Sentara Virginia Beach General Hospital

Mark E. Shaves
Ph: 757-388-2406

Mark E. Shaves
Principal Investigator

Washington
Bellingham

PeaceHealth Saint Joseph Medical Center

Michael Andre Taylor
Ph: 360-788-8223
Email: cpatz@peacehealth.org

Michael Andre Taylor
Principal Investigator

Federal Way

Saint Francis Hospital

Huong Thanh Pham
Ph: 206-342-6954
Email: vmmc.cancer_clinical_research@VirginiaMason.org

Huong Thanh Pham
Principal Investigator

Seattle

Virginia Mason CCOP

Huong Thanh Pham
Ph: 206-342-6954
Email: vmmc.cancer_clinical_research@VirginiaMason.org

Huong Thanh Pham
Principal Investigator

Virginia Mason Medical Center

Huong Thanh Pham
Ph: 206-342-6954
Email: vmmc.cancer_clinical_research@VirginiaMason.org

Huong Thanh Pham
Principal Investigator

Vancouver

Compass Oncology Vancouver

Vivek S. Kavadi
Ph: 281-277-5200

Vivek S. Kavadi
Principal Investigator

PeaceHealth Southwest Medical Center

Matthew C. Solhjem
Ph: 503-215-6412
Email: Julie.Cramer@providence.org

Matthew C. Solhjem
Principal Investigator

Wisconsin
Appleton

Appleton Medical Center

Michael Edward Ray
Ph: 920-380-1500

Michael Edward Ray
Principal Investigator

Green Bay

Aurora BayCare Medical Center

Ellen L. Ziaja
Ph: 800-252-2990

Ellen L. Ziaja
Principal Investigator

Bellin Memorial Hospital

Charlie C. Pan
Ph: 920-435-8326

Charlie C. Pan
Principal Investigator

Saint Mary's Hospital

James L. Leenstra
Ph: 920-433-8889

James L. Leenstra
Principal Investigator

Saint Vincent Hospital

James L. Leenstra
Ph: 920-433-8889

James L. Leenstra
Principal Investigator

Johnson Creek

UW Cancer Center Johnson Creek

Gregory M. Cooley
Ph: 920-699-3500
Email: lynda.persico@uwmf.wisc.edu

Gregory M. Cooley
Principal Investigator

La Crosse

Gundersen Lutheran Medical Center

Collin D. Driscoll
Ph: 608-775-2385
Email: cancerctr@gundluth.org

Collin D. Driscoll
Principal Investigator

Mayo Clinic Health System-Franciscan Healthcare

David J. Schwartz
Ph: 608-392-9462

David J. Schwartz
Principal Investigator

Marinette

Bay Area Medical Center

James L. Leenstra
Ph: 920-433-8889

James L. Leenstra
Principal Investigator

Vince Lombardi Cancer Clinic-Marinette

Ellen L. Ziaja
Ph: 800-252-2990

Ellen L. Ziaja
Principal Investigator

Menomonee Falls

Community Memorial Hospital

Colleen A. F. Lawton
Ph: 414-805-4380

Colleen A. F. Lawton
Principal Investigator

Mequon

Columbia Saint Mary's Hospital - Ozaukee

Craig Allan Schulz
Ph: 414-326-2675
Email: clinicaltrials@columbia-stmarys.org

Craig Allan Schulz
Principal Investigator

Milwaukee

Aurora Saint Luke's Medical Center

Ellen L. Ziaja
Ph: 800-252-2990

Ellen L. Ziaja
Principal Investigator

Columbia Saint Mary's Water Tower Medical Commons

Craig Allan Schulz
Ph: 414-326-2675
Email: clinicaltrials@columbia-stmarys.org

Craig Allan Schulz
Principal Investigator

Froedtert and the Medical College of Wisconsin

Colleen A. F. Lawton
Ph: 414-805-4380

Colleen A. F. Lawton
Principal Investigator

Zablocki Veterans Administration Medical Center

Elizabeth M. Gore
Ph: 414-805-4380

Elizabeth M. Gore
Principal Investigator

Oshkosh

Vince Lombardi Cancer Clinic - Oshkosh

Ellen L. Ziaja
Ph: 800-252-2990

Ellen L. Ziaja
Principal Investigator

Racine

Wheaton Franciscan Cancer Care - All Saints

James H. Taylor
Ph: 414-874-4541
Email: Kelli.holton@wfhc.org

James H. Taylor
Principal Investigator

Sturgeon Bay

Door County Cancer Center

James L. Leenstra
Ph: 920-433-8889

James L. Leenstra
Principal Investigator

Summit

Aurora Medical Center in Summit

Ellen L. Ziaja
Ph: 800-252-2990

Ellen L. Ziaja
Principal Investigator

West Allis

Aurora West Allis Medical Center

Ellen L. Ziaja
Ph: 800-252-2990

Ellen L. Ziaja
Principal Investigator

West Bend

The Alyce and Elmore Kraemer Cancer Care Center

Colleen A. F. Lawton
Ph: 414-805-4380

Colleen A. F. Lawton
Principal Investigator

Wisconsin Rapids

Riverview Hospital

Gregory M. Cooley
Ph: 920-699-3500
Email: lynda.persico@uwmf.wisc.edu

Gregory M. Cooley
Principal Investigator

Canada

Alberta
Calgary

Tom Baker Cancer Centre

Steve J. Angyalfi
Ph: 403-521-3433

Steve J. Angyalfi
Principal Investigator

Edmonton

Cross Cancer Institute

Nawaid Usmani
Ph: 780-432-8500

Nawaid Usmani
Principal Investigator

New Brunswick
Saint John

Atlantic Health Sciences Corporation-Saint John Regional Hospital

Holly Anne Campbell
Ph: 506-648-6890

Holly Anne Campbell
Principal Investigator

Ontario
Hamilton

Juravinski Cancer Centre at Hamilton Health Sciences

Ian Stuart Dayes
Ph: 905-387-9495

Ian Stuart Dayes
Principal Investigator

London

London Regional Cancer Program

David Paul D'Souza
Ph: 519-685-8600

David Paul D'Souza
Principal Investigator

Ottawa

Ottawa Hospital and Cancer Center-General Campus

Gad Alexander Perry
Ph: 613-761-4395
Email: info@ohri.ca

Gad Alexander Perry
Principal Investigator

Thunder Bay

Thunder Bay Regional Health Science Centre

Sunil Premial Pushpakumar Gulavita
Ph: 877-696-7223
Email: cancercareinfo@tbh.net

Sunil Premial Pushpakumar Gulavita
Principal Investigator

Toronto

Odette Cancer Centre- Sunnybrook Health Sciences Centre

Gerard Christopher Morton
Ph: 416-480-5000

Gerard Christopher Morton
Principal Investigator

Quebec
Montreal

CHUM - Hopital Notre-Dame

Jean-Paul Bahary
Ph: 514-890-8000ext23611
Email: sylvie.beaudoin.chum@ssss.gouv.qc.ca

Jean-Paul Bahary
Principal Investigator

Hopital Maisonneuve-Rosemont

Peter Vavassis
Ph: 514-252-3400ext3329

Peter Vavassis
Principal Investigator

McGill University Department of Oncology

Fabio Luis Biagini Cury
Ph: 514-934-4400

Fabio Luis Biagini Cury
Principal Investigator

Quebec City

CHU de Quebec-L'Hotel-Dieu de Quebec (HDQ)

Eric Vigneault
Ph: 418-525-4444

Eric Vigneault
Principal Investigator

Sherbrooke

Centre Hospitalier Universitaire de Sherbrooke-Fleurimont

Abdenour Nabid
Ph: 819-820-6480
Email: crcinformation.chus@ssss.gouv.qc.ca

Abdenour Nabid
Principal Investigator

Saskatchewan
Regina

Allan Blair Cancer Centre

Tak Hing Patricia Tai
Ph: 306-766-2213

Tak Hing Patricia Tai
Principal Investigator

Link to the current ClinicalTrials.gov record.
NLM Identifer NCT00936390

Note: Information about participating sites on pharmaceutical industry trials may be incomplete. Please visit the ClinicalTrials.gov record via the link above for more information about participating sites.