Lisinopril or Coreg CR® in Reducing Side Effects in Women With Breast Cancer Receiving Trastuzumab

  • Resize font
  • Print
  • Email
  • Facebook
  • Twitter
  • Google+
  • Pinterest

Basic Trial Information

PhaseTypeStatusAgeSponsorProtocol IDs
Phase IISupportive careActive18 and overNCI, OtherSCUSF 0806
5U10CA081920-11, HLMCC-0806, NCT01009918

Trial Description

Summary

RATIONALE: Lisinopril or Coreg CR®, may help reduce side effects caused by trastuzumab. It is not yet known whether lisinopril or Coreg CR® are more effective than a placebo in reducing side effects caused by trastuzumab.

PURPOSE: This phase II trial is studying lisinopril and Coreg CR® to see how well they work compared with a placebo in reducing side effects in patients with HER2-positive breast cancer receiving trastuzumab.

Further Study Information

OBJECTIVES:

Primary

  • The primary objective of this study is to determine if administration of lisinopril or Coreg CR®, compared to placebo, will reduce the incidence of trastuzumab-induced cardiotoxicity, as measured by LVEF, in patients receiving adjuvant, or neoadjuvant,therapy for HER2 positive breast cancer.

Secondary

  • To determine whether subjects randomized to active agent have fewer interruptions in trastuzumab therapy due to cardiomyopathy.
  • To determine whether the treatment effect is consistent in anthracycline and nonanthracycline patient cohorts
  • To compare changes in HRQL among the treatment groups during the study intervention
  • To evaluate the long term effects on the prevention of cardiomyopathy and impact on HRQL for either or both study agents
  • To compare the predictive value of troponin I and BNP in the identification of trastuzumab-induced cardiotoxicity

OUTLINE: This is a multicenter study. Patients are stratified according to chemotherapy comprising an anthracycline (yes vs no). Patients are randomized to 1 of 3 treatment arms.

  • Arm I: Patients receive oral lisinopril once daily.
  • Arm II: Patients receive oral Coreg CR® once daily.
  • Arm III: Patients receive oral placebo once daily.

In all arms, study treatment begins with the first dose of trastuzumab and continues for up to 52 weeks or until the end of trastuzumab therapy.

Quality of life is assessed using the EORTC QLQ-C30 questionnaire at baseline, at 52 weeks (or at the end of trastuzumab therapy), and at 18 and 24 months (or 6 and 12 months after the completion of trastuzumab).

After completion of study treatment, patients are followed up at 3, 6, 9, and 12 months.

Eligibility Criteria

INCLUSION CRITERIA

  • Males and Females ≥ 18 years old diagnosed with HER2 positive breast cancer
  • Scheduled to receive neoadjuvant or adjuvant trastuzumab (Herceptin®) therapy (anthracycline-containing regimens are permitted). Patients receiving Herceptin® with their chemotherapy are permitted for eligibility work-up. Taxanes are permitted. Trastuzumab (Herceptin®) therapy may be given with or after primary chemotherapy. Pertuzumab may be used in conjunction with trastuzumab.
  • Left Ventricular Ejection Fraction (LVEF) ≥ 50% by MUGA scan or echocardiogram
  • Adequate renal function for administration of trastuzumab-containing chemotherapy regimen.
  • Sitting systolic blood pressure of > 90 mm Hg
  • Pulse ≥ 60 beats/minute
  • Not pregnant or breastfeeding
  • Female patients of childbearing potential, who are sexually active, must have a negative pregnancy test before starting the study
  • Both men and women must be willing to use effective contraception during the study. Teratogenicity is documented for both active study agents
  • Able to swallow capsules

EXCLUSION CRITERIA:

  • Patients with metastatic disease
  • Prior treatment with trastuzumab or anthracyclines prior to this chemotherapy regimen
  • Current treatment with angiotensin converting enzyme (ACE) inhibitors, angiotensin receptor blockers (ARBs), such as losartan, β-blockers or digoxin
  • Known cardiac history: heart failure, myocardial infarction, radiation-induced cardiac dysfunction
  • Known allergy to either ACE inhibitors or β-blockers
  • History of bronchial asthma or related bronchospastic conditions
  • Hereditary or idiopathic angioedema
  • History of severe hypersensitivity reactions to drugs or other causes, i.e. bee stings
  • This protocol does not exclude patients who are participating on other investigational studies. Refer to the local IRB guidelines.

Trial Contact Information

Trial Lead Organizations/Sponsors

H. Lee Moffitt Cancer Center and Research Institute at University of South Florida

  • National Cancer Institute
Maya Guglin, MD, PhD, Study Chair
Pamela N. Munster, Study Chair

Trial Sites

U.S.A.

Alabama
Anniston

Regional Medical Center

Charles P. Lattuada
Ph: 888-400-9357

California
Long Beach

Todd Cancer Institute at Long Beach Memorial Medical Center

Bichlien Nguyen
Ph: 562-933-0900

Martinez

Contra Costa Regional Medical Center

Maya Guglin
Ph: 813-259-0600
Email: mguglin@health.usf.edu

Rancho Mirage

Lucy Curci Cancer Center at Eisenhower Memorial Hospital and Medical Center

Luke P Dreisbach
Ph: 760-834-3798

Salinas

Salinas Valley Memorial Hospital

Laura V. Stampleman
Ph: 831-759-1838
Email: tnielsen2@svmh.com

Colorado
Aurora

Medical Center of Aurora - South Campus

Keren Sturtz
Ph: 888-785-6789

Boulder

Boulder Community Hospital

Keren Sturtz
Ph: 888-785-6789

Colorado Springs

Penrose Cancer Center at Penrose Hospital

Keren Sturtz
Ph: 888-785-6789

Denver

CCOP - Colorado Cancer Research Program

Keren Sturtz
Ph: 888-785-6789

Porter Adventist Hospital

Keren Sturtz
Ph: 888-785-6789

Presbyterian - St. Luke's Medical Center

Keren Sturtz
Ph: 888-785-6789

Rose Medical Center

Keren Sturtz
Ph: 888-785-6789

St. Joseph Hospital

Keren Sturtz
Ph: 888-785-6789

Englewood

Swedish Medical Center

Keren Sturtz
Ph: 888-785-6789

Fort Collins

Poudre Valley Hospital

Regina J Brown
Ph: 970-297-6150

Greeley

North Colorado Medical Center

Keren Sturtz
Ph: 888-785-6789

Lakewood

St. Anthony Central Hospital

Keren Sturtz
Ph: 888-785-6789

Littleton

Littleton Adventist Hospital

Keren Sturtz
Ph: 888-785-6789

Lone Tree

Sky Ridge Medical Center

Keren Sturtz
Ph: 888-785-6789

Longmont

Hope Cancer Care Center at Longmont United Hospital

Keren Sturtz
Ph: 888-785-6789

Loveland

McKee Medical Center

Keren Sturtz
Ph: 888-785-6789

Parker

Parker Adventist Hospital

Keren Sturtz
Ph: 888-785-6789

Pueblo

St. Mary - Corwin Regional Medical Center

Keren Sturtz
Ph: 888-785-6789

Wheat Ridge

Exempla Lutheran Medical Center

Keren Sturtz
Ph: 888-785-6789

Connecticut
Middletown

Middlesex Hospital Cancer Center

Susanna Hong
Ph: 860-358-2058

District of Columbia
Washington

George Washington University Cancer Institute

Lauren A Mauro
Ph: 202-741-2981

Lombardi Comprehensive Cancer Center at Georgetown University Medical Center

Claudine Isaacs
Ph: 202-444-0381

Washington Cancer Institute at Washington Hospital Center

Claudine Isaacs
Ph: 202-444-0381

Florida
Fort Lauderdale

Broward General Medical Center Cancer Center

Shazia Zafar
Ph: 954-355-5346

Lakeland

Lakeland Regional Cancer Center at Lakeland Regional Medical Center

Madhavi L. Venigalla
Ph: 863-904-1900

Georgia
Augusta

Medical College of Georgia Cancer Center

Randall F. Roberts
Ph: 706-721-1663
Email: cancer@georgiahealth.edu

Gainesville

Northeast Georgia Medical Center

Richard J. LoCicero
Ph: 770-219-8800
Email: cancerpatient.navigator@nghs.com

Savannah

Nancy N. and J. C. Lewis Cancer and Research Pavilion at St. Joseph's/Candler

Mark A. Taylor
Ph: 912-350-8568

Hawaii
Honolulu

OnCare Hawaii, Incorporated - Lusitana

Maya Guglin
Ph: 813-259-0600
Email: mguglin@health.usf.edu

Tripler Army Medical Center

Maya Guglin
Ph: 813-259-0600
Email: mguglin@health.usf.edu

Illinois
Bloomington

Illinois CancerCare - Bloomington

Nguyet A Le-Lindqwister
Ph: 800-793-2262

Canton

Illinois CancerCare - Canton

Nguyet A Le-Lindqwister
Ph: 800-793-2262

Carthage

Illinois CancerCare - Carthage

Nguyet A Le-Lindqwister
Ph: 800-793-2262

Chicago

John H. Stroger, Jr. Hospital of Cook County

Maya Guglin
Ph: 813-259-0600
Email: mguglin@health.usf.edu

Louis A. Weiss Memorial Hospital

Keith L. Shulman
Ph: 773-564-5044

Resurrection Medical Center

Christopher G. Rose
Ph: 773-792-5116

Decatur

Decatur Memorial Hospital Cancer Care Institute

James L. Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

Eureka

Illinois CancerCare - Eureka

Nguyet A Le-Lindqwister
Ph: 800-793-2262

Galesburg

Galesburg Clinic, PC

Nguyet A Le-Lindqwister
Ph: 800-793-2262

Kewanee

Illinois CancerCare - Kewanee Clinic

Nguyet A Le-Lindqwister
Ph: 800-793-2262

La Grange

La Grange Memorial Hospital

Renee H. Jacobs
Ph: 630-856-7526

Macomb

Illinois CancerCare - Macomb

Nguyet A Le-Lindqwister
Ph: 800-793-2262

Oak Lawn

Advocate Christ Medical Center

Amar Hamad
Ph: 800-323-8622

Ottawa

Illinois CancerCare - Ottawa

Nguyet A Le-Lindqwister
Ph: 800-793-2262

Pekin

Illinois CancerCare - Pekin

Nguyet A Le-Lindqwister
Ph: 800-793-2262

Peru

Illinois CancerCare - Princeton

Nguyet A Le-Lindqwister
Ph: 800-793-2262

Princeton

Illinois CancerCare - Princeton

Nguyet A Le-Lindqwister
Ph: 800-793-2262

River Forest

West Suburban Center for Cancer Care

Isoken Koko
Ph: 708-488-0882

Springfield

Regional Cancer Center at Memorial Medical Center

James L. Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

Indiana
Beech Grove

St. Francis Hospital and Health Centers - Beech Grove Campus

Howard M. Gross
Ph: 765-983-3000

Bloomington

Bloomington Hospital Regional Cancer Institute

David Y. Lee
Ph: 812-353-2831

Elkhart

Elkhart Clinic, LLC

Robin Zon
Ph: 574-234-5123

Michiana Hematology-Oncology, PC - Elkhart

Robin Zon
Ph: 574-234-5123

Mishawaka

Michiana Hematology-Oncology, PC - Mishawaka

Robin Zon
Ph: 574-234-5123

Saint Joseph's Medical Center

Robin Zon
Ph: 574-234-5123

Plymouth

Michiana Hematology Oncology PC - Plymouth

Robin Zon
Ph: 574-234-5123

South Bend

CCOP - Northern Indiana CR Consortium

Robin Zon
Ph: 574-234-5123

Memorial Hospital of South Bend

Robin Zon
Ph: 574-234-5123

Michiana Hematology-Oncology, PC - South Bend

Robin Zon
Ph: 574-234-5123

Westville

Michiana Hematology Oncology-PC Westville

Robin Zon
Ph: 574-234-5123

Iowa
Cedar Rapids

Cedar Rapids Oncology Associates

Deborah W Wilbur
Ph: 319-363-2690

Clive

Medical Oncology and Hematology Associates-West Des Moines

Robert J Behrens
Ph: 888-244-6061
Email: sherrijr@iora.org

Des Moines

CCOP - Iowa Oncology Research Association

Robert J Behrens
Ph: 888-244-6061
Email: sherrijr@iora.org

Medical Oncology and Hematology Associates at John Stoddard Cancer Center

Robert J Behrens
Ph: 888-244-6061
Email: sherrijr@iora.org

Medical Oncology and Hematology Associates at Mercy Cancer Center

Robert J Behrens
Ph: 888-244-6061
Email: sherrijr@iora.org

Mason City

Mercy Cancer Center at Mercy Medical Center - North Iowa

Arvind Y Vemula
Ph: 800-433-3883

Waterloo

Covenant Cancer Treatment Center

Mohammed T. Masri
Ph: 319-272-2070

Kentucky
Lexington

University of Kentucky Chandler Medical Center

Suleiman A Massarweh
Ph: 859-257-3379

Maine
Portland

Mercy Hospital

Roger C. Inhorn
Ph: 207-553-6866

Maryland
Baltimore

Alvin and Lois Lapidus Cancer Institute at Sinai Hospital

Mayer Gorbaty
Ph: 410-601-6120
Email: pridgely@lifebridgehealth.org

Mercy Medical Center

David A. Riseberg
Ph: 410-951-7950
Email: prc@mdmercy.com

Bethesda

Suburban Hospital

Carolyn Bennett Hendricks
Ph: 301-896-2719
Email: Bsquiller@suburbanhospital.org

Easton

Shore Regional Cancer Center at Memorial Hospital - Easton

Mary S. DeShields
Ph: 410-820-6800ext108
Email: srichter@shorehealth.org

Massachusetts
Plymouth

Jordan Hospital Club Cancer Center

James M Koomey
Ph: 508-830-2390
Email: cancerinfo@jordanhospital.org

Michigan
Battle Creek

Battle Creek Health System Cancer Care Center

Gilbert D Padula
Ph: 616-685-5225

Bay City

Bay Regional Medical Center

Justin F Klamerus
Ph: 800-248-6777

Clarkston

Great Lakes Cancer Institute

Justin F Klamerus
Ph: 800-248-6777

Detroit

Wayne State University

Lawrence E. Flaherty
Ph: 313-576-9363

Flint

Singh and Arora Hematology Oncology, PC

Justin F Klamerus
Ph: 800-248-6777

Grand Blanc

Genesys Regional Medical Center

Maya Guglin
Ph: 813-259-0600
Email: mguglin@health.usf.edu

Grand Rapids

Butterworth Hospital at Spectrum Health

Gilbert D Padula
Ph: 616-685-5225

Lacks Cancer Center at Saint Mary's Health Care

Gilbert D Padula
Ph: 616-685-5225

Kalamazoo

West Michigan Cancer Center

Raymond Sterling Lord
Ph: 269-373-7458

Lapeer

Great Lakes Cancer Institute - Lapeer Campus

Justin F Klamerus
Ph: 800-248-6777

Marquette

Upper Michigan Cancer Center at Marquette General Hospital

Amy Weise
Ph: 313-576-9363

Mount Clemens

Clemens Regional Medical Center

Justin F Klamerus
Ph: 800-248-6777

Mount Pleasant

Norval K. Morey Cancer Center at Central Michigan Community Hospital

Justin F Klamerus
Ph: 800-248-6777

Muskegon

Mercy General Health Partners

Gilbert D Padula
Ph: 616-685-5225

Niles

Michiana Hematology Oncology PC - Niles

Robin Zon
Ph: 574-234-5123

Petoskey

Northern Michigan Hospital

Justin F Klamerus
Ph: 800-248-6777

Royal Oak

William Beaumont Hospital - Royal Oak Campus

Maya Guglin
Ph: 813-259-0600
Email: mguglin@health.usf.edu

Saint Joseph

Lakeside Cancer Specialists, PLLC

Robin Zon
Ph: 574-234-5123

Southfield

Providence Hospital - Southfield

Anibal Drelichman
Ph: 248-849-5337
Email: jaswinder.grewal@stjohn.org

St. Joseph

Lakeland Regional Cancer Care Center - St. Joseph

Robin Zon
Ph: 574-234-5123

Traverse City

Munson Medical Center

Gilbert D Padula
Ph: 616-685-5225

Troy

William Beaumont Hospital - Troy Campus

Maya Guglin
Ph: 813-259-0600
Email: mguglin@health.usf.edu

Minnesota
Brainerd

St. Joseph's Medical Center

Daniel Nikcevich
Ph: 888-203-7267

Burnsville

Fairview Ridges Hospital

Joseph W Leach
Ph: 952-993-1517
Email: MMCCOP@parknicollet.com

Coon Rapids

Mercy and Unity Cancer Center at Mercy Hospital

Joseph W Leach
Ph: 952-993-1517
Email: MMCCOP@parknicollet.com

Duluth

CCOP - Duluth

Daniel Nikcevich
Ph: 888-203-7267

Edina

Fairview Southdale Hospital

Joseph W Leach
Ph: 952-993-1517
Email: MMCCOP@parknicollet.com

Fridley

Mercy and Unity Cancer Center at Unity Hospital

Joseph W Leach
Ph: 952-993-1517
Email: MMCCOP@parknicollet.com

Hutchinson

Hutchinson Area Health Care

Joseph W Leach
Ph: 952-993-1517
Email: MMCCOP@parknicollet.com

Maplewood

HealthEast Cancer Care at St. John's Hospital

Joseph W Leach
Ph: 952-993-1517
Email: MMCCOP@parknicollet.com

Minneapolis

Hennepin County Medical Center - Minneapolis

Joseph W Leach
Ph: 952-993-1517
Email: MMCCOP@parknicollet.com

Virginia Piper Cancer Institute at Abbott - Northwestern Hospital

Joseph W Leach
Ph: 952-993-1517
Email: MMCCOP@parknicollet.com

Robbinsdale

Humphrey Cancer Center at North Memorial Outpatient Center

Joseph W Leach
Ph: 952-993-1517
Email: MMCCOP@parknicollet.com

Saint Louis Park

CCOP - Metro-Minnesota

Joseph W Leach
Ph: 952-993-1517
Email: MMCCOP@parknicollet.com

Park Nicollet Cancer Center

Joseph W Leach
Ph: 952-993-1517
Email: MMCCOP@parknicollet.com

Saint Paul

Regions Hospital Cancer Care Center

Joseph W Leach
Ph: 952-993-1517
Email: MMCCOP@parknicollet.com

United Hospital

Joseph W Leach
Ph: 952-993-1517
Email: MMCCOP@parknicollet.com

Shakopee

St. Francis Cancer Center at St. Francis Medical Center

Joseph W Leach
Ph: 952-993-1517
Email: MMCCOP@parknicollet.com

Stillwater

Lakeview Hospital

Joseph W Leach
Ph: 952-993-1517
Email: MMCCOP@parknicollet.com

Waconia

Ridgeview Medical Center

Joseph W Leach
Ph: 952-993-1517
Email: MMCCOP@parknicollet.com

Woodbury

Minnesota Oncology - Woodbury

Joseph W Leach
Ph: 952-993-1517
Email: MMCCOP@parknicollet.com

Mississippi
Pascagoula

Regional Cancer Center at Singing River Hospital

James E. Clarkson
Ph: 228-809-5292

Missouri
Cape Girardeau

Southeast Cancer Center

Bryan A Faller
Ph: 800-392-0936

Jefferson City

Goldschmidt Cancer Center

Bryan A Faller
Ph: 800-392-0936

Rolla

Mercy Clinic Cancer and Hematology - Rolla

Maya Guglin
Ph: 813-259-0600
Email: mguglin@health.usf.edu

Saint Louis

Missouri Baptist Cancer Center

Bryan A Faller
Ph: 800-392-0936

Springfield

Hulston Cancer Center at Cox Medical Center South

Maya Guglin
Ph: 813-259-0600
Email: mguglin@health.usf.edu

St. John's Regional Health Center

Maya Guglin
Ph: 813-259-0600
Email: mguglin@health.usf.edu

Montana
Billings

Billings Clinic Cancer Center - 801 N 29th Street

Benjamin Thomas Marchello
Ph: 800-648-6274

CCOP - Montana Cancer Consortium

Benjamin Thomas Marchello
Ph: 800-648-6274

St. Vincent Healthcare Cancer Care Services

Benjamin Thomas Marchello
Ph: 800-648-6274

Bozeman

Bozeman Deaconess Cancer Center

Benjamin Thomas Marchello
Ph: 800-648-6274

Butte

St. James Healthcare Cancer Care

Benjamin Thomas Marchello
Ph: 800-648-6274

Great Falls

Benefis Sletten Cancer Institute

Grant William Harrer
Ph: 406-731-8217

Helena

St. Peter's Hospital

Benjamin Thomas Marchello
Ph: 800-648-6274

Kalispell

Kalispell Regional Medical Center

Benjamin Thomas Marchello
Ph: 800-648-6274

Missoula

Montana Cancer Center at St. Patrick Hospital and Health Sciences Center

Benjamin Thomas Marchello
Ph: 800-648-6274

Nebraska
Kearney

Good Samaritan Cancer Center at Good Samaritan Hospital

George K. Bascom
Ph: 308-865-7963

New Hampshire
Concord

New Hampshire Oncology - Hematology, PA at Payson Center for Cancer Care

Douglas Jay Weckstein
Ph: 603-224-2556

Hooksett

New Hampshire Oncology - Hematology, PA - Hooksett

Douglas Jay Weckstein
Ph: 603-224-2556

Laconia

Lakes Region General Hospital

Douglas Jay Weckstein
Ph: 603-224-2556

Lebanon

Norris Cotton Cancer Center at Dartmouth-Hitchcock Medical Center

Gary N Schwartz
Ph: 800-639-6918
Email: cancer.research.nurse@dartmouth.edu

Nashua

Oncology Center at St. Joseph Hospital

Mary Ann Voltz
Ph: 603-880-3408
Email: carcieri@sjh-nh.org

New Jersey
Englewood

Dizzy Gillespie Cancer Institute at Englewood Hospital and Medical Center

Jill S Morrison
Ph: 201-894-3456

Long Branch

Monmouth Medical Center

Seth D Cohen
Ph: 732-923-7689

Newark

UMDNJ University Hospital

Robert Wieder
Ph: 732-235-8675

Vineland

Frank and Edith Scarpa Regional Cancer Pavillion at South Jersey Healthcare

Shailja Roy
Ph: 856-641-7933

New Mexico
Albuquerque

Presbyterian Cancer Treatment Center at Presbyterian Kaseman Hospital

Zoneddy R Dayao
Ph: 505-272-6972

University of New Mexico Cancer Center

Zoneddy R Dayao
Ph: 505-272-6972

New York
Cooperstown

Bassett Healthcare Regional Cancer Program at Mary Imogene Bassett Hospital

Eric Bravin
Ph: 607-547-3073
Email: diana.crean@bassett.org

New Hyde Park

Long Island Jewish Medical Center

Kit L Cheng
Ph: 516-562-3467

Monter Cancer Center of the North Shore-LIJ Health System

Kit L Cheng
Ph: 516-562-3467

Staten Island

Nalitt Cancer Institute at Staten Island University Hospital

Qun Dai
Ph: 718-226-8888

North Carolina
Asheville

Mission Hospitals - Memorial Campus

Maya Guglin
Ph: 813-259-0600
Email: mguglin@health.usf.edu

Cary

Waverly Hematology Oncology

Maya Guglin
Ph: 813-259-0600
Email: mguglin@health.usf.edu

Charlotte

Presbyterian Cancer Center at Presbyterian Hospital

Maya Guglin
Ph: 813-259-0600
Email: mguglin@health.usf.edu

Goldsboro

Southeastern Medical Oncology Center - Goldsboro

Maya Guglin
Ph: 813-259-0600
Email: mguglin@health.usf.edu

Hendersonville

Park Ridge Hospital Breast Health Center

Maya Guglin
Ph: 813-259-0600
Email: mguglin@health.usf.edu

Winston-Salem

Forsyth Regional Cancer Center at Forsyth Medical Center

Maya Guglin
Ph: 813-259-0600
Email: mguglin@health.usf.edu

Ohio
Akron

McDowell Cancer Center at Akron General Medical Center

Esther H. Rehmus
Ph: 330-344-6348

Summa Center for Cancer Care at Akron City Hospital

Jennifer E Payne
Ph: 330-375-6101

Canton

Aultman Cancer Center at Aultman Hospital

Kisa E Weeman
Ph: 330-363-6891

Columbus

Doctors Hospital at Ohio Health

Maya Guglin
Ph: 813-259-0600
Email: mguglin@health.usf.edu

Grant Medical Center Cancer Care

Maya Guglin
Ph: 813-259-0600
Email: mguglin@health.usf.edu

Riverside Methodist Hospital Cancer Care

Maya Guglin
Ph: 813-259-0600
Email: mguglin@health.usf.edu

Lima

St. Rita's Medical Center

Henry Gerad
Ph: 419-226-9617

Newark

Licking Memorial Cancer Care Program at Licking Memorial Hospital

Maya Guglin
Ph: 813-259-0600
Email: mguglin@health.usf.edu

Springfield

Community Hospital of Springfield and Clark County

Maya Guglin
Ph: 813-259-0600
Email: mguglin@health.usf.edu

Wilmington

Clinton Memorial Hospital

Howard M. Gross
Ph: 317-783-8918

Oklahoma
Norman

Cancer Care Associates - Norman

Vikki Ann Canfield
Ph: 405-271-4272
Email: julie-traylor@ouhsc.edu

Oklahoma City

Cancer Care Associates - Mercy Campus

Vikki Ann Canfield
Ph: 405-271-4272
Email: julie-traylor@ouhsc.edu

Oregon
Salem

Salem Hospital Regional Cancer Care Services

John Strother
Ph: 503-561-2618

Pennsylvania
Danville

Geisinger Cancer Institute at Geisinger Health

Harsh Gandhi
Ph: 570-459-2901

Hazleton

Geisinger Hazleton Cancer Center

Harsh Gandhi
Ph: 570-459-2901

Phoenixville

Cancer Center at Phoenixville Hospital

Carl W. Sharer
Ph: 610-983-1908

Sayre

Guthrie Cancer Center at Guthrie Clinic Sayre

Cynthia A Lynch
Ph: 800-836-0388

State College

Geisinger Medical Group - Scenery Park

Harsh Gandhi
Ph: 570-459-2901

Wilkes-Barre

Frank M. and Dorothea Henry Cancer Center at Geisinger Wyoming Valley Medical Center

Harsh Gandhi
Ph: 570-459-2901

PR
San Juan

San Juan City Hospital

Maya Guglin
Ph: 813-259-0600
Email: mguglin@health.usf.edu

South Carolina
Anderson

AnMed Cancer Center

Maya Guglin
Ph: 813-259-0600
Email: mguglin@health.usf.edu

Beaufort

Keyserling Cancer Center at Beaufort Memorial Hospital

Majd Chahin
Ph: 843-522-7819

Greenville

CCOP - Greenville

Jeffrey Kent Giguere
Ph: 864-241-6251

Spartanburg

Gibbs Regional Cancer Center at Spartanburg Regional Medical Center

Maya Guglin
Ph: 813-259-0600
Email: mguglin@health.usf.edu

Texas
Austin

University Medical Center Brackenridge

Om N Pandey
Ph: 512-324-7991

Laredo

Doctor's Hospital of Laredo

Gary W. Unzeitig
Ph: 888-823-5923
Email: ctsucontact@westat.com

Temple

Scott and White Cancer Institute

Maya Guglin
Ph: 813-259-0600
Email: mguglin@health.usf.edu

Virginia
Charlottesville

Martha Jefferson Hospital Cancer Care Center

Robert S. Pritchard
Ph: 434-654-8400

Martinsville

Ravenel Oncology Center at Memorial Hospital of Martinsville and Henry County

Maya Guglin
Ph: 813-259-0600
Email: mguglin@health.usf.edu

Washington
Everett

Providence Regional Cancer Partnership

Maya Guglin
Ph: 813-259-0600
Email: mguglin@health.usf.edu

Tacoma

MultiCare Regional Cancer Center at Tacoma General Hospital

Maya Guglin
Ph: 813-259-0600
Email: mguglin@health.usf.edu

Wisconsin
Fond Du Lac

Central Wisconsin Cancer Program at Agnesian HealthCare

Michael W Jones
Ph: 800-494-2927

Janesville

Mercy Regional Cancer Center

Robert Delaune
Ph: 800-928-1103

La Crosse

Gundersen Lutheran Center for Cancer and Blood

Kurt Oettel
Ph: 608-775-2385
Email: cancerctr@gundluth.org

Madison

University of Wisconsin Paul P. Carbone Comprehensive Cancer Center

Mark E Burkard
Ph: 877-405-6866

Mukwonago

D.N. Greenwald Center

Timothy R Wassenaar
Ph: 262-928-7878

New Richmond

Cancer Center of Western Wisconsin

Joseph W Leach
Ph: 952-993-1517
Email: MMCCOP@parknicollet.com

Oconomowoc

Regional Cancer Center at Oconomowoc Memorial Hospital

Timothy R Wassenaar
Ph: 262-928-7878

Waukesha

Waukesha Memorial Hospital Regional Cancer Center

Timothy R Wassenaar
Ph: 262-928-7878

Wyoming
Sheridan

Welch Cancer Center at Sheridan Memorial Hospital

Benjamin Thomas Marchello
Ph: 800-648-6274

Link to the current ClinicalTrials.gov record.
NLM Identifier NCT01009918
ClinicalTrials.gov processed this data on February 27, 2015

Note: Information about this trial is from the ClinicalTrials.gov database. The versions designated for health professionals and patients contain the same text. Minor changes may be made to the ClinicalTrials.gov record to standardize the names of study sponsors, sites, and contacts. Cancer.gov only lists sites that are recruiting patients for active trials, whereas ClinicalTrials.gov lists all sites for all trials. Questions and comments regarding the presented information should be directed to ClinicalTrials.gov.