Lisinopril or Carvedilol Phosphate in Reducing Side Effects in Women with HER2-Positive Breast Cancer Receiving Trastuzumab

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Basic Trial Information

PhaseTypeAgeTrial IDs
Phase IISupportive care18 and overSCUSF 0806
NCI-2011-01438, CDR0000654123, HLMCC-0806, NCT01009918

Trial Description

Summary

This phase II trial is studying lisinopril and carvedilol phosphate to see how well they work compared with a placebo in reducing side effects in women with HER2-positive breast cancer receiving trastuzumab. Lisinopril or carvedilol phosphate may help reduce side effects caused by trastuzumab. It is not yet known whether lisinopril or carvedilol phosphate are more effective than a placebo in reducing side effects caused by trastuzumab.

Further Study Information

PRIMARY OBJECTIVES:

I. Determine if administration of lisinopril or carvedilol phosphate extended-release (compared to placebo) will reduce the incidence of trastuzumab-induced cardiotoxicity, as measured by LVEF, in women receiving adjuvant or neoadjuvant trastuzumab for HER2-positive breast cancer.

SECONDARY OBJECTIVES:

I. Determine whether patients randomized to receive lisinopril or carvedilol phosphate extended-release have fewer interruptions in trastuzumab therapy due to cardiomyopathy.

II. Determine changes in quality of life (QOL) in patients treated with these regimens.

III. Determine the long-term effects of lisinopril and/or carvedilol phosphate extended-release on the prevention of cardiomyopathy and their impact on QOL.

IV. Compare the predictive value of troponin I and BNP in the identification of trastuzumab-induced cardiotoxicity.

OUTLINE: This is a multicenter study. Patients are randomized to 1 of 3 treatment arms.

ARM I: Patients receive oral lisinopril once daily.

ARM II: Patients receive oral carvedilol phosphate extended-release once daily.

ARM III: Patients receive oral placebo once daily.

In all arms, study treatment begins with the first dose of trastuzumab and continues for up to 52 weeks or until the end of trastuzumab therapy.

Quality of life is assessed using the EORTC QLQ-C30 questionnaire at baseline, at 52 weeks (or at the end of trastuzumab therapy), and at 18 and 24 months (or 6 and 12 months after the completion of trastuzumab).

After completion of study treatment, patients are followed up at 3, 6, 9, and 12 months.

Eligibility Criteria

Inclusion Criteria:

Concurrent participation in other investigational studies allowed

No other concurrent angiotensin-converting enzyme (ACE) inhibitors, β-blockers, or digoxin

No prior trastuzumab or anthracyclines prior to this chemotherapy regimen

No history of severe hypersensitivity reactions to drugs or other causes (e.g., beestings)

No hereditary or idiopathic angioedema

No history of bronchial asthma or related bronchospastic conditions

No known allergy to either ACE inhibitors or β-blockers

No known cardiac history (i.e., heart failure, myocardial infarction, or radiation-induced cardiac dysfunction)

Able to swallow capsules

Fertile patients must use effective contraception

Negative pregnancy test

Not pregnant or nursing

Pulse ≥ 60 beats/minute

Sitting systolic BP > 90 mm Hg

Creatinine ≤ 1.2 mg/dL

LVEF ≥ 50% by MUGA or ECHO

Menopausal status not specified

Hormone receptor status not specified

Scheduled to receive adjuvant or neoadjuvant trastuzumab therapy

Anthracycline-containing regimens allowed

Patients receive trastuzumab with their chemotherapy allowed for eligibility work-up

Taxanes are allowed

Trastuzumab therapy may be given with or after primary chemotherapy

Diagnosis of HER2-positive breast cancer

Trial Contact Information

Trial Lead Organizations / Sponsors / Collaborators

SunCoast CCOP Research Base at the University of South Florida

  • National Cancer Institute
Maya Guglin, Principal Investigator

Trial Sites

U.S.A.

California
Martinez

Contra Costa Regional Medical Center

Maya Guglin
Ph: 813-259-0600
Email: mguglin@health.usf.edu

Maya Guglin
Principal Investigator

Rancho Mirage

Eisenhower Medical Center

Luke Philip Dreisbach
Ph: 760-834-3798

Luke Philip Dreisbach
Principal Investigator

Colorado
Aurora

The Medical Center of Aurora

Keren Sturtz
Ph: 888-785-6789

Keren Sturtz
Principal Investigator

Boulder

Boulder Community Hospital

Keren Sturtz
Ph: 888-785-6789

Keren Sturtz
Principal Investigator

Colorado Springs

Penrose-Saint Francis Healthcare

Keren Sturtz
Ph: 888-785-6789

Keren Sturtz
Principal Investigator

Denver

Colorado Cancer Research Program CCOP

Keren Sturtz
Ph: 888-785-6789

Keren Sturtz
Principal Investigator

Exempla Saint Joseph Hospital

Keren Sturtz
Ph: 888-785-6789

Keren Sturtz
Principal Investigator

Porter Adventist Hospital

Keren Sturtz
Ph: 888-785-6789

Keren Sturtz
Principal Investigator

Presbyterian - Saint Lukes Medical Center - Health One

Keren Sturtz
Ph: 888-785-6789

Keren Sturtz
Principal Investigator

Rose Medical Center

Keren Sturtz
Ph: 888-785-6789

Keren Sturtz
Principal Investigator

Englewood

Swedish Medical Center

Keren Sturtz
Ph: 888-785-6789

Keren Sturtz
Principal Investigator

Fort Collins

Poudre Valley Hospital

Regina Jeanise Brown
Ph: 970-297-6150

Regina Jeanise Brown
Principal Investigator

Greeley

North Colorado Medical Center

Keren Sturtz
Ph: 888-785-6789

Keren Sturtz
Principal Investigator

Lakewood

Saint Anthony Hospital

Keren Sturtz
Ph: 888-785-6789

Keren Sturtz
Principal Investigator

Littleton

Littleton Adventist Hospital

Keren Sturtz
Ph: 888-785-6789

Keren Sturtz
Principal Investigator

Lone Tree

Sky Ridge Medical Center

Keren Sturtz
Ph: 888-785-6789

Keren Sturtz
Principal Investigator

Longmont

Longmont United Hospital

Keren Sturtz
Ph: 888-785-6789

Keren Sturtz
Principal Investigator

Loveland

McKee Medical Center

Keren Sturtz
Ph: 888-785-6789

Keren Sturtz
Principal Investigator

Parker

Parker Adventist Hospital

Keren Sturtz
Ph: 888-785-6789

Keren Sturtz
Principal Investigator

Pueblo

Saint Mary Corwin Medical Center

Keren Sturtz
Ph: 888-785-6789

Keren Sturtz
Principal Investigator

Wheat Ridge

Exempla Lutheran Medical Center

Keren Sturtz
Ph: 888-785-6789

Keren Sturtz
Principal Investigator

Connecticut
Middletown

Middlesex Hospital

Susanna Hong
Ph: 860-358-2058

Susanna Hong
Principal Investigator

Florida
Fort Lauderdale

Broward Health Medical Center

Shazia Zafar
Ph: 954-355-5346

Shazia Zafar
Principal Investigator

Lakeland

Lakeland Regional Cancer Center

Madhavi L. Venigalla
Ph: 863-904-1900

Madhavi L. Venigalla
Principal Investigator

Georgia
Gainesville

Northeast Georgia Medical Center

Richard John LoCicero
Ph: 770-219-8800
Email: cancerpatient.navigator@nghs.com

Richard John LoCicero
Principal Investigator

Savannah

Lewis Cancer and Research Pavilion at Saint Joseph's/Candler

Mark Alexander Taylor
Ph: 912-350-8568

Mark Alexander Taylor
Principal Investigator

Hawaii
Honolulu

Oncare Hawaii Inc-POB II

Maya Guglin
Ph: 813-259-0600
Email: mguglin@health.usf.edu

Maya Guglin
Principal Investigator

Tripler Army Medical Center

Maya Guglin
Ph: 813-259-0600
Email: mguglin@health.usf.edu

Maya Guglin
Principal Investigator

Illinois
Bloomington

Illinois CancerCare-Bloomington

James Lloyd Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

James Lloyd Wade
Principal Investigator

Canton

Illinois CancerCare-Canton

James Lloyd Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

James Lloyd Wade
Principal Investigator

Carthage

Illinois CancerCare-Carthage

James Lloyd Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

James Lloyd Wade
Principal Investigator

Chicago

John H Stroger Jr Hospital of Cook County

Maya Guglin
Ph: 813-259-0600
Email: mguglin@health.usf.edu

Maya Guglin
Principal Investigator

Decatur

Decatur Memorial Hospital

James Lloyd Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

James Lloyd Wade
Principal Investigator

Eureka

Illinois CancerCare-Eureka

James Lloyd Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

James Lloyd Wade
Principal Investigator

Galesburg

Illinois CancerCare Galesburg

James Lloyd Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

James Lloyd Wade
Principal Investigator

Kewanee

Illinois CancerCare-Kewanee Clinic

James Lloyd Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

James Lloyd Wade
Principal Investigator

La Grange

Adventist La Grange Memorial Hospital

Renee Helene Jacobs
Ph: 630-856-7526

Renee Helene Jacobs
Principal Investigator

Macomb

Illinois CancerCare-Macomb

James Lloyd Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

James Lloyd Wade
Principal Investigator

Ottawa

Illinois CancerCare-Ottawa Clinic

James Lloyd Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

James Lloyd Wade
Principal Investigator

Pekin

Illinois CancerCare-Pekin

James Lloyd Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

James Lloyd Wade
Principal Investigator

Peoria

Illinois CancerCare-Peoria

James Lloyd Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

James Lloyd Wade
Principal Investigator

Peru

Illinois CancerCare-Peru

James Lloyd Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

James Lloyd Wade
Principal Investigator

Princeton

Illinois CancerCare-Princeton

James Lloyd Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

James Lloyd Wade
Principal Investigator

Springfield

Memorial Medical Center

James Lloyd Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

James Lloyd Wade
Principal Investigator

Indiana
South Bend

Memorial Hospital of South Bend

Thomas Joseph Reid
Ph: 800-284-7370

Thomas Joseph Reid
Principal Investigator

Iowa
Cedar Rapids

Oncology Associates at Mercy Medical Center

Deborah Weil Wilbur
Ph: 319-363-2690

Deborah Weil Wilbur
Principal Investigator

Des Moines

Iowa Oncology Research Association CCOP

Robert J. Behrens
Ph: 515-282-2921

Robert J. Behrens
Principal Investigator

Maine
Portland

Mercy Hospital

Roger Charles Inhorn
Ph: 207-553-6866

Roger Charles Inhorn
Principal Investigator

Maryland
Baltimore

Mercy Medical Center

David Andrew Riseberg
Ph: 410-951-7950
Email: prc@mdmercy.com

David Andrew Riseberg
Principal Investigator

Sinai Hospital of Baltimore

Mayer Gorbaty
Ph: 410-601-6120
Email: pridgely@lifebridgehealth.org

Mayer Gorbaty
Principal Investigator

Bethesda

Suburban Hospital

Carolyn B. Hendricks
Ph: 301-896-2719
Email: Bsquiller@suburbanhospital.org

Carolyn B. Hendricks
Principal Investigator

Easton

The Memorial Hospital at Easton

Mary S. De Shields
Ph: 410-820-6800ext108
Email: srichter@shorehealth.org

Mary S. De Shields
Principal Investigator

Massachusetts
Plymouth

Beth Israel Deaconess Hospital-Plymouth

James Matthew Koomey
Ph: 508-830-2390
Email: cancerinfo@jordanhospital.org

James Matthew Koomey
Principal Investigator

Michigan
Battle Creek

Bronson Battle Creek

Gilbert D.A. Padula
Ph: 616-685-5225
Email: connie.szczepanek@grcop.org

Gilbert D.A. Padula
Principal Investigator

Bay City

McLaren-Bay Region

Justin F. Klamerus
Ph: 810-342-4071

Justin F. Klamerus
Principal Investigator

Clarkston

Great Lakes Cancer Institute

Justin F. Klamerus
Ph: 810-342-4071

Justin F. Klamerus
Principal Investigator

Detroit

Wayne State University/Karmanos Cancer Institute

Lawrence E. Flaherty
Ph: 313-576-9363

Lawrence E. Flaherty
Principal Investigator

Flint

Singh and Arora Hematology Oncology PC

Justin F. Klamerus
Ph: 810-342-4071

Justin F. Klamerus
Principal Investigator

Grand Blanc

Genesys Regional Medical Center

Maya Guglin
Ph: 813-259-0600
Email: mguglin@health.usf.edu

Maya Guglin
Principal Investigator

Grand Rapids

Mercy Health Saint Mary's

Gilbert D.A. Padula
Ph: 616-685-5225
Email: connie.szczepanek@grcop.org

Gilbert D.A. Padula
Principal Investigator

Spectrum Health at Butterworth Campus

Gilbert D.A. Padula
Ph: 616-685-5225
Email: connie.szczepanek@grcop.org

Gilbert D.A. Padula
Principal Investigator

Kalamazoo

West Michigan Cancer Center

Sunil Nagpal
Ph: 269-373-7458

Sunil Nagpal
Principal Investigator

Lapeer

Great Lakes Cancer Institute-Lapeer Campus

Justin F. Klamerus
Ph: 810-342-4071

Justin F. Klamerus
Principal Investigator

Marquette

Marquette General Hospital

Amy M. Weise
Ph: 313-576-9363

Amy M. Weise
Principal Investigator

Mount Clemens

McLaren-Macomb

Justin F. Klamerus
Ph: 810-342-4071

Justin F. Klamerus
Principal Investigator

Mount Pleasant

McLaren-Central Michigan

Justin F. Klamerus
Ph: 810-342-4071

Justin F. Klamerus
Principal Investigator

Muskegon

Mercy Health Mercy Campus

Gilbert D.A. Padula
Ph: 616-685-5225
Email: connie.szczepanek@grcop.org

Gilbert D.A. Padula
Principal Investigator

Niles

Michiana Hematology Oncology PC-Niles

Robin T. Zon
Ph: 574-234-5123

Robin T. Zon
Principal Investigator

Petoskey

Northern Michigan Regional Hospital

Justin F. Klamerus
Ph: 810-342-4071

Justin F. Klamerus
Principal Investigator

Royal Oak

William Beaumont Hospital-Royal Oak

Maya Guglin
Ph: 813-259-0600
Email: mguglin@health.usf.edu

Maya Guglin
Principal Investigator

Southfield

Providence Hospital

Anibal Drelichman
Ph: 248-849-5337
Email: jaswinder.grewal@stjohn.org

Anibal Drelichman
Principal Investigator

Traverse City

Munson Medical Center

Gilbert D.A. Padula
Ph: 616-685-5225
Email: connie.szczepanek@grcop.org

Gilbert D.A. Padula
Principal Investigator

Troy

William Beaumont Hospital - Troy

Maya Guglin
Ph: 813-259-0600
Email: mguglin@health.usf.edu

Maya Guglin
Principal Investigator

Minnesota
Brainerd

Essentia Health Saint Joseph's Medical Center

Bret E.B. Friday
Ph: 888-203-7267

Bret E.B. Friday
Principal Investigator

Burnsville

Fairview Ridges Hospital

Joseph W. Leach
Ph: 952-993-1517
Email: MMCCOP@parknicollet.com

Joseph W. Leach
Principal Investigator

Coon Rapids

Mercy Hospital

Joseph W. Leach
Ph: 952-993-1517
Email: MMCCOP@parknicollet.com

Joseph W. Leach
Principal Investigator

Duluth

Essentia Health Cancer Center

Bret E.B. Friday
Ph: 888-203-7267

Bret E.B. Friday
Principal Investigator

Edina

Fairview-Southdale Hospital

Joseph W. Leach
Ph: 952-993-1517
Email: MMCCOP@parknicollet.com

Joseph W. Leach
Principal Investigator

Fridley

Unity Hospital

Joseph W. Leach
Ph: 952-993-1517
Email: MMCCOP@parknicollet.com

Joseph W. Leach
Principal Investigator

Hutchinson

Hutchinson Area Health Care

Joseph W. Leach
Ph: 952-993-1517
Email: MMCCOP@parknicollet.com

Joseph W. Leach
Principal Investigator

Maplewood

Saint John's Hospital - Healtheast

Joseph W. Leach
Ph: 952-993-1517
Email: MMCCOP@parknicollet.com

Joseph W. Leach
Principal Investigator

Minneapolis

Abbott-Northwestern Hospital

Joseph W. Leach
Ph: 952-993-1517
Email: MMCCOP@parknicollet.com

Joseph W. Leach
Principal Investigator

Hennepin County Medical Center

Joseph W. Leach
Ph: 952-993-1517
Email: MMCCOP@parknicollet.com

Joseph W. Leach
Principal Investigator

Robbinsdale

North Memorial Medical Health Center

Joseph W. Leach
Ph: 952-993-1517
Email: MMCCOP@parknicollet.com

Joseph W. Leach
Principal Investigator

Saint Louis Park

Park Nicollet Clinic - Saint Louis Park

Joseph W. Leach
Ph: 952-993-1517
Email: MMCCOP@parknicollet.com

Joseph W. Leach
Principal Investigator

Saint Paul

Regions Hospital

Joseph W. Leach
Ph: 952-993-1517
Email: MMCCOP@parknicollet.com

Joseph W. Leach
Principal Investigator

United Hospital

Joseph W. Leach
Ph: 952-993-1517
Email: MMCCOP@parknicollet.com

Joseph W. Leach
Principal Investigator

Shakopee

Saint Francis Regional Medical Center

Joseph W. Leach
Ph: 952-993-1517
Email: MMCCOP@parknicollet.com

Joseph W. Leach
Principal Investigator

Waconia

Ridgeview Medical Center

Joseph W. Leach
Ph: 952-993-1517
Email: MMCCOP@parknicollet.com

Joseph W. Leach
Principal Investigator

Willmar

Rice Memorial Hospital

Joseph W. Leach
Ph: 952-993-1517
Email: MMCCOP@parknicollet.com

Joseph W. Leach
Principal Investigator

Woodbury

Minnesota Oncology and Hematology PA-Woodbury

Joseph W. Leach
Ph: 952-993-1517
Email: MMCCOP@parknicollet.com

Joseph W. Leach
Principal Investigator

Mississippi
Pascagoula

Singing River Hospital

James E. Clarkson
Ph: 228-809-5292

James E. Clarkson
Principal Investigator

Missouri
Cape Girardeau

Southeast Cancer Center

James Lloyd Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

James Lloyd Wade
Principal Investigator

Jefferson City

Capital Region Medical Center-Goldschmidt Cancer Center

James Lloyd Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

James Lloyd Wade
Principal Investigator

Rolla

Saint John's Clinic-Rolla-Cancer and Hematology

Maya Guglin
Ph: 813-259-0600
Email: mguglin@health.usf.edu

Maya Guglin
Principal Investigator

Saint Louis

Missouri Baptist Medical Center

James Lloyd Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

James Lloyd Wade
Principal Investigator

Springfield

CoxHealth South Hospital

Maya Guglin
Ph: 813-259-0600
Email: mguglin@health.usf.edu

Maya Guglin
Principal Investigator

Mercy Hospital Springfield

Maya Guglin
Ph: 813-259-0600
Email: mguglin@health.usf.edu

Maya Guglin
Principal Investigator

Montana
Billings

Billings Clinic Cancer Center

Benjamin T. Marchello
Ph: 800-648-6274

Benjamin T. Marchello
Principal Investigator

Montana Cancer Consortium CCOP

Benjamin T. Marchello
Ph: 800-648-6274

Benjamin T. Marchello
Principal Investigator

Saint Vincent Healthcare

Benjamin T. Marchello
Ph: 800-648-6274

Benjamin T. Marchello
Principal Investigator

Bozeman

Bozeman Deaconess Hospital

Benjamin T. Marchello
Ph: 800-648-6274

Benjamin T. Marchello
Principal Investigator

Butte

Saint James Community Hospital and Cancer Treatment Center

Benjamin T. Marchello
Ph: 800-648-6274

Benjamin T. Marchello
Principal Investigator

Great Falls

Benefis Healthcare- Sletten Cancer Institute

Benjamin T. Marchello
Ph: 800-648-6274

Benjamin T. Marchello
Principal Investigator

Helena

Saint Peter's Community Hospital

Benjamin T. Marchello
Ph: 800-648-6274

Benjamin T. Marchello
Principal Investigator

Kalispell

Kalispell Regional Medical Center

Benjamin T. Marchello
Ph: 800-648-6274

Benjamin T. Marchello
Principal Investigator

Missoula

Saint Patrick Hospital - Community Hospital

Benjamin T. Marchello
Ph: 800-648-6274

Benjamin T. Marchello
Principal Investigator

Nebraska
Kearney

CHI Health Good Samaritan

George Kellogg Bascom
Ph: 888-823-5923
Email: ctsucontact@westat.com

George Kellogg Bascom
Principal Investigator

New Hampshire
Lebanon

Dartmouth Hitchcock Medical Center

Gary N. Schwartz
Ph: 800-639-6918
Email: cancer.research.nurse@dartmouth.edu

Gary N. Schwartz
Principal Investigator

New York
Cooperstown

Mary Imogene Bassett Hospital

Eric Bravin
Ph: 607-547-3073
Email: diana.crean@bassett.org

Eric Bravin
Principal Investigator

Staten Island

Staten Island University Hospital

Qun Dai
Ph: 718-226-8888

Qun Dai
Principal Investigator

North Carolina
Asheville

Mission Hospital-Memorial Campus

Maya Guglin
Ph: 813-259-0600
Email: mguglin@health.usf.edu

Maya Guglin
Principal Investigator

Cary

Waverly Hematology Oncology

Maya Guglin
Ph: 813-259-0600
Email: mguglin@health.usf.edu

Maya Guglin
Principal Investigator

Charlotte

Novant Health Presbyterian Medical Center

Maya Guglin
Ph: 813-259-0600
Email: mguglin@health.usf.edu

Maya Guglin
Principal Investigator

Goldsboro

Southeastern Medical Oncology Center-Goldsboro

Maya Guglin
Ph: 813-259-0600
Email: mguglin@health.usf.edu

Maya Guglin
Principal Investigator

Hendersonville

Park Ridge Hospital Breast Health Center

Maya Guglin
Ph: 813-259-0600
Email: mguglin@health.usf.edu

Maya Guglin
Principal Investigator

Winston-Salem

Novant Health Forsyth Medical Center

Maya Guglin
Ph: 813-259-0600
Email: mguglin@health.usf.edu

Maya Guglin
Principal Investigator

Ohio
Akron

Akron General Medical Center

Esther Hoogland Rehmus
Ph: 330-344-6348

Esther Hoogland Rehmus
Principal Investigator

Columbus

Doctors Hospital

Maya Guglin
Ph: 813-259-0600
Email: mguglin@health.usf.edu

Maya Guglin
Principal Investigator

Grant Medical Center

Maya Guglin
Ph: 813-259-0600
Email: mguglin@health.usf.edu

Maya Guglin
Principal Investigator

Riverside Methodist Hospital

Maya Guglin
Ph: 813-259-0600
Email: mguglin@health.usf.edu

Maya Guglin
Principal Investigator

Lima

Saint Rita's Medical Center

Henry Gerad
Ph: 419-226-9617

Henry Gerad
Principal Investigator

Newark

Licking Memorial Hospital

Maya Guglin
Ph: 813-259-0600
Email: mguglin@health.usf.edu

Maya Guglin
Principal Investigator

Springfield

Springfield Regional Medical Center

Maya Guglin
Ph: 813-259-0600
Email: mguglin@health.usf.edu

Maya Guglin
Principal Investigator

Oklahoma
Oklahoma City

Mercy Hospital Oklahoma City

Vikki A. Canfield
Ph: 405-751-4343

Vikki A. Canfield
Principal Investigator

Pennsylvania
Danville

Geisinger Medical Center

Victor G. Vogel
Ph: 570-271-5251

Victor G. Vogel
Principal Investigator

Hazleton

Geisinger Medical Center-Cancer Center Hazleton

Victor G. Vogel
Ph: 570-271-5251

Victor G. Vogel
Principal Investigator

Phoenixville

Phoenixville Hospital

Carl W. Sharer
Ph: 610-983-1908

Carl W. Sharer
Principal Investigator

Sayre

Guthrie Medical Group PC-Robert Packer Hospital

Cynthia Anne Lynch
Ph: 800-836-0388

Cynthia Anne Lynch
Principal Investigator

State College

Geisinger Medical Group

Victor G. Vogel
Ph: 570-271-5251

Victor G. Vogel
Principal Investigator

Wilkes-Barre

Geisinger Wyoming Valley/Henry Cancer Center

Victor G. Vogel
Ph: 570-271-5251

Victor G. Vogel
Principal Investigator

PR
San Juan

San Juan City Hospital

Maya Guglin
Ph: 813-259-0600
Email: mguglin@health.usf.edu

Maya Guglin
Principal Investigator

South Carolina
Anderson

AnMed Health Cancer Center

Maya Guglin
Ph: 813-259-0600
Email: mguglin@health.usf.edu

Maya Guglin
Principal Investigator

Beaufort

Beaufort Memorial Hospital

Majd Chahin
Ph: 843-522-7819

Majd Chahin
Principal Investigator

Greenville

Greenville Health System Cancer Institute-Eastside

Jeffrey K. Giguere
Ph: 864-241-6251

Jeffrey K. Giguere
Principal Investigator

Spartanburg

Spartanburg Medical Center

Maya Guglin
Ph: 813-259-0600
Email: mguglin@health.usf.edu

Maya Guglin
Principal Investigator

Texas
Austin

University Medical Center Brackenridge

Om Narayan Pandey
Ph: 512-324-7991

Om Narayan Pandey
Principal Investigator

Laredo

Doctor's Hospital of Laredo

Gary Walter Unzeitig
Ph: 888-823-5923
Email: ctsucontact@westat.com

Gary Walter Unzeitig
Principal Investigator

Temple

Scott and White Memorial Hospital

Maya Guglin
Ph: 813-259-0600
Email: mguglin@health.usf.edu

Maya Guglin
Principal Investigator

Virginia
Charlottesville

Martha Jefferson Hospital

Robert S. Pritchard
Ph: 434-654-8400

Robert S. Pritchard
Principal Investigator

Martinsville

Memorial Hospital Of Martinsville

Maya Guglin
Ph: 813-259-0600
Email: mguglin@health.usf.edu

Maya Guglin
Principal Investigator

Washington
Everett

Providence Regional Cancer Partnership

Maya Guglin
Ph: 813-259-0600
Email: mguglin@health.usf.edu

Maya Guglin
Principal Investigator

Tacoma

Multicare Health System

Maya Guglin
Ph: 813-259-0600
Email: mguglin@health.usf.edu

Maya Guglin
Principal Investigator

Wisconsin
Fond Du Lac

Saint Agnes Hospital/Agnesian Cancer Center

Michael W. Jones
Ph: 800-494-2927

Michael W. Jones
Principal Investigator

Janesville

Mercy Health System

Emily Gray Robinson
Ph: 800-928-1103

Emily Gray Robinson
Principal Investigator

La Crosse

Gundersen Lutheran Medical Center

Kurt Oettel
Ph: 608-775-2385
Email: cancerctr@gundluth.org

Kurt Oettel
Principal Investigator

Madison

University of Wisconsin Hospital and Clinics

Mark Edward Burkard
Ph: 877-405-6866

Mark Edward Burkard
Principal Investigator

Mukwonago

D N Greenwald Center

Timothy Robert Wassenaar
Ph: 262-928-7878

Timothy Robert Wassenaar
Principal Investigator

New Richmond

Cancer Center of Western Wisconsin

Joseph W. Leach
Ph: 952-993-1517
Email: MMCCOP@parknicollet.com

Joseph W. Leach
Principal Investigator

Oconomowoc

Oconomowoc Memorial Hospital-ProHealth Care Inc

Timothy Robert Wassenaar
Ph: 262-928-7878

Timothy Robert Wassenaar
Principal Investigator

Waukesha

Waukesha Memorial Hospital

Timothy Robert Wassenaar
Ph: 262-928-7878

Timothy Robert Wassenaar
Principal Investigator

Wyoming
Sheridan

Welch Cancer Center

Benjamin T. Marchello
Ph: 800-648-6274

Benjamin T. Marchello
Principal Investigator

Link to the current ClinicalTrials.gov record.
NLM Identifer NCT01009918

Note: Information about participating sites on pharmaceutical industry trials may be incomplete. Please visit the ClinicalTrials.gov record via the link above for more information about participating sites.