Sorafenib Tosylate With or Without Doxorubicin Hydrochloride in Treating Patients With Locally Advanced or Metastatic Liver Cancer

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Basic Trial Information

PhaseTypeStatusAgeSponsorProtocol IDs
Phase IIITreatmentActive18 and overNCINCI-2011-01989
CDR0000659348, CALGB 80802, U10CA180821, U10CA031946, NCT01015833

Trial Description

Summary

This randomized phase III trial studies sorafenib tosylate and doxorubicin hydrochloride to see how well they work compared with sorafenib tosylate alone in treating patients with liver cancer that has spread to nearby tissue or lymph nodes or has spread to other places in the body. Sorafenib tosylate may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth and by blocking blood flow to the tumor. Drugs used in chemotherapy, such as doxorubicin hydrochloride, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. It is not yet known whether giving sorafenib tosylate together with doxorubicin hydrochloride is more effective than sorafenib tosylate alone in treating liver cancer.

Further Study Information

PRIMARY OBJECTIVES:

I. Compare the overall survival (OS) of patients treated with sorafenib (sorafenib tosylate) and doxorubicin (doxorubicin hydrochloride) to that of those treated with sorafenib.

SECONDARY OBJECTIVES:

I. Compare time to progression (TTP) of patients treated with sorafenib and doxorubicin to that of those treated with sorafenib.

II. Compare progression-free-survival (PFS) of patients treated with sorafenib and doxorubicin to that of those treated with sorafenib.

III. Compare tumor response using Response Evaluation Criteria in Solid Tumors (RECIST) criteria of patients treated with sorafenib and doxorubicin to that of those treated with sorafenib.

OUTLINE: Patients are randomized to 1 of 2 treatment arms.

ARM I: Patients receive doxorubicin hydrochloride intravenously (IV) on day 1 and sorafenib tosylate orally (PO) once daily (QD) or twice daily (BID) on days 1-21. Treatment repeats every 21 days for 6 courses in the absence of disease progression or unacceptable toxicity. After 6 courses, patients may continue to receive sorafenib tosylate PO QD or BID in the absence of disease progression or unacceptable toxicity.

ARM II: Patients receive sorafenib tosylate PO QD or BID on days 1-21. Courses repeat every 21 days in the absence of disease progression or unacceptable toxicity.

After completion of study treatment, patients are followed up every 3 months for 1 year and then every 6 months for 2 years.

Eligibility Criteria

Inclusion Criteria:

  • Patients must have pathologically or cytologically proven hepatocellular carcinoma; known mixed histology (e.g. hepatocellular carcinoma plus cholangiocarcinoma) or fibrolamellar variant is not allowed
  • Patients must have locally advanced or metastatic disease; locally advanced disease is defined as disease deemed to be unresectable or non-eligible for transplant without distant metastases
  • Lesions must be accurately measurable in at least one dimension (longest diameter to be recorded) as >= 2 cm with conventional techniques or as >= 1 cm with spiral computed tomography (CT) scan
  • No prior adjuvant sorafenib or other v-RAF-1 murine leukemia viral oncogene homolog (Raf)/vascular endothelial growth factor (VEGF) inhibitors; other prior adjuvant therapy is allowed if completed > 6 months prior to registration with documented recurrence of hepatocellular carcinoma (HCC)
  • Patients may have been treated with loco regional therapies provided that they either have:
  • A target lesion that has not been subjected to local therapy or
  • The target lesion(s) within the field of the local therapy has shown an increase of >= 20% in the size since last treatment
  • Such therapy must be completed at least 4 weeks prior to registration; patients that have received palliative radiation therapy to the bone need not wait 4 weeks to begin protocol therapy
  • Prior therapies allowed include the following:
  • Bland embolization, radiation, radioactive microspheres, etc
  • Chemoembolization using any chemotherapy (except, see below)
  • Chemoembolization drug-eluting beads using doxorubicin
  • Prior therapy with chemoembolization using doxorubicin in the non drug eluting beads form is NOT allowed
  • No prior systemic therapy for metastatic disease
  • No prior exposure to systemic doxorubicin administered intravenously
  • Antiviral treatment is allowed, however interferon therapy must be stopped at least 4 weeks prior to registration
  • Allografts are not allowed: no prior history of any allograft, including but not limited to liver and bone marrow transplants
  • Patients must have completed any major surgery >= 4 weeks from registration
  • Concomitant treatment with Rifampin or St John's Wort is not allowed; patients should discontinue these drugs at least 4 weeks prior to registration
  • No known central nervous system (CNS) tumors including brain metastases
  • No clinically significant gastrointestinal bleeding events requiring intervention, transfusion, or admission to hospital within 30 days prior to registration
  • Patients with a history of hypertension should be well controlled (< 140/90 mmHg) on a regimen of anti-hypertensive therapy
  • Significant history of cardiac disease is not allowed:
  • Congestive heart failure > class II New York Heart Association (NYHA)
  • Myocardial infarction within 6 months prior to registration
  • Serious myocardial dysfunction, defined as scintigraphically (multigated acquisition scan [MUGA], myocardial scintigram) determined absolute left ventricular ejection fraction (LVEF) below 45% or an LVEF on echocardiogram (ECHO) below the normal limit at the individual institution
  • No history of bleeding diathesis
  • Patients receiving combination anti-retroviral therapy for human immunodeficiency virus (HIV) are excluded from the study
  • Eastern Cooperative Oncology Group (ECOG) performance status 0 or 1
  • Pregnancy/nursing status: women who are pregnant should not go on study; women should not breastfeed while participating in this study
  • Granulocytes >= 1,500/uL
  • Hemoglobin >= 8.5 g/dL; patients with recent or ongoing gastrointestinal bleed may not be transfused to reach the entry hemoglobin of 8.5 g/dL; physicians should ensure patients requiring transfusion prior to registration do not have an occult or clinically apparent gastrointestinal bleed
  • Platelets >= 75,000/uL
  • Creatinine =< 1.5 x upper limit of normal (ULN) (or creatinine clearance calculated >= 60 cc/minute)
  • Child-Pugh score A; patients must meet all laboratory value requirements
  • Bilirubin =< 3 mg/dL
  • Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) =< 5 x ULN
  • Prothrombin time (PT)-international normalized ratio (INR) =< 1.7 (not required for patients on anticoagulation agents; patients who are being therapeutically anticoagulated with an agent such as Coumadin or heparin will be allowed to participate provided that no prior evidence of underlying abnormality in these parameters exists)

Trial Contact Information

Trial Lead Organizations/Sponsors

National Cancer Institute

    Ghassan Abou-Alfa, Principal Investigator

    Trial Sites

    U.S.A.

    Alabama
    Birmingham

    UAB Comprehensive Cancer Center

    Carla I. Falkson
    Ph: 205-934-0309

    Mobile

    Southern Cancer Center PC-Providence

    Brian J Heller
    Ph: 888-625-6896

    Alaska
    Fairbanks

    Fairbanks Cancer Treatment Center at Fairbanks Memorial Hospital

    John A Keech
    Ph: 907-458-5380

    Arkansas
    Jonesboro

    NEA Medical Clinic - East Matthews

    Carroll Dean Scroggin
    Ph: 870-972-7235

    California
    Anaheim

    Kaiser Permanente Medical Center - Anaheim/Orange County

    Han A Koh
    Ph: 626-564-3455

    Antioch

    Kaiser Permanente - Deer Valley

    Louis Fehrenbacher
    Ph: 626-564-3455

    Baldwin Park

    Kaiser Permanente Medical Center - Baldwin Park

    Han A Koh
    Ph: 626-564-3455

    Bellflower

    Kaiser Permanente Medical Center - Bellflower

    Han A Koh
    Ph: 626-564-3455

    Fontana

    Kaiser Permanente Medical Center - Fontana

    Han A Koh
    Ph: 626-564-3455

    Fremont

    Kaiser Permanente - Fremont

    Louis Fehrenbacher
    Ph: 626-564-3455

    Fresno

    California Cancer Center - Woodward Park Office

    Uzair B. Chaudhary
    Ph: 559-447-4050

    Kaiser Permanente Fresno Medical Center

    Louis Fehrenbacher
    Ph: 626-564-3455

    University Oncology Associates

    Uzair B. Chaudhary
    Ph: 559-447-4050

    Greenbrae

    Marin Cancer Institute at Marin General Hospital

    Peter D. Eisenberg
    Ph: 415-925-5000
    Email: info@marinspecialtycare.com

    Peter D. Eisenberg
    Ph: 415-925-5000
    Email: info@marinspecialtycare.com

    Harbor City

    Kaiser Permanente Medical Center - Harbor City

    Han A Koh
    Ph: 626-564-3455

    Irvine

    Kaiser Permanente - Irvine

    Han A Koh
    Ph: 626-564-3455

    Los Angeles

    Kaiser Foundation Hospital - West Los Angeles

    Han A Koh
    Ph: 626-564-3455

    Kaiser Permanente Medical Center - Los Angeles

    Han A Koh
    Ph: 626-564-3455

    Modesto

    Kaiser Permanente-Modesto

    Louis Fehrenbacher
    Ph: 626-564-3455

    Oakland

    Kaiser Permanente-Oakland

    Louis Fehrenbacher
    Ph: 626-564-3455

    Orange

    St. Joseph Hospital Regional Cancer Center - Orange

    Timothy E Byun
    Ph: 714-734-6220

    Panorama City

    Kaiser Permanente Medical Group

    Han A Koh
    Ph: 626-564-3455

    Pleasant Hill

    East Bay Medical Oncology Hematology Associates - Pleasant Hill

    James H. Feusner
    Ph: 510-450-7600

    Redwood City

    Kaiser Permanente Medical Center - Redwood City

    Louis Fehrenbacher
    Ph: 626-564-3455

    Richmond

    Kaiser Permanente Medical Center - Richmond

    Louis Fehrenbacher
    Ph: 626-564-3455

    Riverside

    Kaiser Permanente Medical Center - Riverside

    Han A Koh
    Ph: 626-564-3455

    Roseville

    Kaiser Permanente Medical Center - Roseville

    Louis Fehrenbacher
    Ph: 626-564-3455

    Sacramento

    Kaiser Permanente Medical Center - Sacramento

    Louis Fehrenbacher
    Ph: 626-564-3455

    South Sacramento Kaiser-Permanente Medical Center

    Louis Fehrenbacher
    Ph: 626-564-3455

    San Diego

    Kaiser Permanente Medical Center - Kaiser Foundation Hospital - San Diego

    Han A Koh
    Ph: 626-564-3455

    Kaiser Permanente Medical Office -Vandever Medical Office

    Han A Koh
    Ph: 626-564-3455

    San Francisco

    Kaiser Permanente Medical Center - San Francisco Geary Campus

    Louis Fehrenbacher
    Ph: 626-564-3455

    San Jose

    Kaiser Permanente Medical Center - Santa Teresa

    Louis Fehrenbacher
    Ph: 626-564-3455

    San Leandro

    Kaiser Permanente Medical Center - Hayward

    Louis Fehrenbacher
    Ph: 626-564-3455

    San Marcos

    Kaiser Permanente Health Care

    Han A Koh
    Ph: 626-564-3455

    San Rafael

    Kaiser Foundation Hospital - San Rafael

    Louis Fehrenbacher
    Ph: 626-564-3455

    Santa Clara

    Kaiser Permanente Medical Center - Santa Clara Homestead Campus

    Louis Fehrenbacher
    Ph: 626-564-3455

    Santa Rosa

    Kaiser Permanente Medical Center - Santa Rosa

    Louis Fehrenbacher
    Ph: 626-564-3455

    South San Francisco

    Kaiser Permanente Medical Center - South San Francisco

    Louis Fehrenbacher
    Ph: 626-564-3455

    Stockton

    Kaiser Permanente Medical Facility - Stockton

    Louis Fehrenbacher
    Ph: 626-564-3455

    Vacaville

    Kaiser Permanente Medical Center - Vacaville

    Louis Fehrenbacher
    Ph: 626-564-3455

    Vallejo

    Kaiser Permanente Medical Center - Vallejo

    Louis Fehrenbacher
    Ph: 626-564-3455

    Walnut Creek

    Kaiser Permanente Medical Center - Walnut Creek

    Louis Fehrenbacher
    Ph: 626-564-3455

    Woodland Hills

    Kaiser Permanente Medical Cener - Woodland Hills

    Han A Koh
    Ph: 626-564-3455

    Colorado
    Aurora

    University of Colorado Cancer Center at UC Health Sciences Center

    Wells Messersmith
    Ph: 720-848-0650

    Denver

    Kaiser Permanente of Colorado

    Alexander Menter
    Ph: 303-614-1300

    Glenwood Springs

    Valley View Hospital Cancer Center

    Wells Messersmith
    Ph: 720-848-0650

    Grand Junction

    St. Mary's Regional Cancer Center at St. Mary's Hospital and Medical Center

    Wells Messersmith
    Ph: 720-848-0650

    Lafayette

    Kaiser Permanente - Lafayette

    Alexander Menter
    Ph: 303-614-1300

    Lone Tree

    Kaiser Permanente-Lone Tree

    Alexander Menter
    Ph: 303-614-1300

    Connecticut
    Hartford

    Saint Francis/Mount Sinai Regional Cancer Center at Saint Francis Hospital and Medical Center

    Philip J. Stella
    Ph: 734-712-4673

    Middletown

    Middlesex Hospital Cancer Center

    Susanna Hong
    Ph: 860-358-2058

    New Haven

    Yale Cancer Center

    Stacey M Stein
    Ph: 203-785-5702

    Delaware
    Lewes

    Tunnell Cancer Center at Beebe Medical Center

    Stephen Scott Grubbs
    Ph: 302-733-6227

    Newark

    Christiana Gynecologic Oncology, LLC

    Stephen Scott Grubbs
    Ph: 302-733-6227

    Delaware Clinical and Laboratory Physicians

    Stephen Scott Grubbs
    Ph: 302-733-6227

    Helen F. Graham Cancer Center at Christiana Hospital

    Stephen Scott Grubbs
    Ph: 302-733-6227

    Stephen Scott Grubbs
    Ph: 302-733-6227

    Medical Oncology Hematology Consultants, PA at Helen F. Graham Cancer Center

    Stephen Scott Grubbs
    Ph: 302-733-6227

    Regional Hematology/Oncology, PA - Newark

    Stephen Scott Grubbs
    Ph: 302-733-6227

    Rehoboth Beach

    Beebe Health Campus

    Stephen Scott Grubbs
    Ph: 302-733-6227

    Seaford

    Nanticoke Memorial Hospital

    Stephen Scott Grubbs
    Ph: 302-733-6227

    Wilmington

    Christiana Care Health System-Wilmington Hospital

    Stephen Scott Grubbs
    Ph: 302-733-6227

    District of Columbia
    Washington

    Veterans Affairs Medical Center - Washington, DC

    Steven H Krasnow
    Ph: 877-328-2621

    Florida
    Lakeland

    Lakeland Regional Cancer Center at Lakeland Regional Medical Center

    Manuel A Molina-Vega
    Ph: 863-904-1900

    Pensacola

    Sacred Heart Cancer Center at Sacred Heart Hospital

    Dee McLeod
    Ph: 850-416-4611

    Sacred Heart Medical Oncology Group

    Dee McLeod
    Ph: 850-416-4611

    Georgia
    Decatur

    Veterans Affairs Medical Center - Atlanta (Decatur)

    Samuel N Chan
    Ph: 404-321-6111ext7632

    Macon

    Medical Center of Central Georgia

    Frederick M. Schnell
    Ph: 404-501-3279

    Savannah

    Curtis and Elizabeth Anderson Cancer Institute at Memorial Health University Medical Center

    Harvey C. Lebos
    Ph: 912-350-8568

    Low Country Cancer Care Associates, PC

    Harvey C. Lebos
    Ph: 912-350-8568

    Nancy N. and J. C. Lewis Cancer and Research Pavilion at St. Joseph's/Candler

    Grant C Lewis
    Ph: 912-350-8568

    Summit Cancer Care-Memorial

    Harvey C. Lebos
    Ph: 912-350-8568

    Hawaii
    Aiea

    Kapiolani Medical Center at Pali Momi

    Jeffrey L. Berenberg
    Ph: 808-586-2979

    Honolulu

    Cancer Research Center of Hawaii

    Jeffrey L. Berenberg
    Ph: 808-586-2979

    Hawaii Medical Center - East

    Jeffrey L. Berenberg
    Ph: 808-586-2979

    Kaiser Permanente - Moanalua Medical Center and Clinic

    Louis Fehrenbacher
    Ph: 626-564-3455

    Kapiolani Medical Center for Women and Children

    Jeffrey L. Berenberg
    Ph: 808-586-2979

    OnCare Hawaii, Incorporated - Kuakini

    Jeffrey L. Berenberg
    Ph: 808-586-2979

    Jeffrey L. Berenberg
    Ph: 808-586-2979

    OnCare Hawaii, Incorporated - Lusitana

    Jeffrey L. Berenberg
    Ph: 808-586-2979

    Queen's Cancer Institute at Queen's Medical Center

    Jeffrey L. Berenberg
    Ph: 808-586-2979

    Straub Clinic and Hospital, Incorporated

    Jeffrey L. Berenberg
    Ph: 808-586-2979

    Idaho
    Boise

    Saint Alphonsus Cancer Care Center at Saint Alphonsus Regional Medical Center

    Philip J. Stella
    Ph: 734-712-4673

    Lewiston

    St. Joseph Regional Medical Center

    Yoshio Inoue
    Ph: 253-403-2394

    Illinois
    Aurora

    Rush-Copley Cancer Care Center

    Kendrith M. Rowland
    Ph: 800-446-5532

    Bloomington

    Illinois CancerCare - Bloomington

    James L. Wade
    Ph: 217-876-4740
    Email: kcheek@dmhhs.org

    St. Joseph Medical Center

    James L. Wade
    Ph: 217-876-4740
    Email: kcheek@dmhhs.org

    Canton

    Illinois CancerCare - Canton

    James L. Wade
    Ph: 217-876-4740
    Email: kcheek@dmhhs.org

    Carbondale

    Memorial Hospital of Carbondale

    James L. Wade
    Ph: 217-876-4740
    Email: kcheek@dmhhs.org

    Carthage

    Illinois CancerCare - Carthage

    James L. Wade
    Ph: 217-876-4740
    Email: kcheek@dmhhs.org

    Centralia

    Centralia Oncology Clinic

    James L. Wade
    Ph: 217-876-4740
    Email: kcheek@dmhhs.org

    Chicago

    Robert H. Lurie Comprehensive Cancer Center at Northwestern University

    Mary Mulcahy
    Ph: 312-695-1301
    Email: cancer@northwestern.edu

    Saint Joseph Hospital

    Ira Oliff
    Ph: 773-665-3109

    University of Chicago Cancer Research Center

    Daniel V Catenacci
    Ph: 773-834-7424

    University of Illinois Cancer Center

    Howard Ozer
    Ph: 312-355-3046

    Danville

    Carle on Vermilion

    Kendrith M. Rowland
    Ph: 800-446-5532

    Decatur

    Cancer Care Center of Decatur

    James L. Wade
    Ph: 217-876-4740
    Email: kcheek@dmhhs.org

    Decatur Memorial Hospital Cancer Care Institute

    James L. Wade
    Ph: 217-876-4740
    Email: kcheek@dmhhs.org

    Effingham

    Carle Physician Group-Effingham

    Kendrith M. Rowland
    Ph: 800-446-5532

    Crossroads Cancer Center

    James L. Wade
    Ph: 217-876-4740
    Email: kcheek@dmhhs.org

    Eureka

    Illinois CancerCare - Eureka

    James L. Wade
    Ph: 217-876-4740
    Email: kcheek@dmhhs.org

    Galesburg

    Galesburg Clinic, PC

    James L. Wade
    Ph: 217-876-4740
    Email: kcheek@dmhhs.org

    InterCommunity Cancer Center of Western Illinois

    James L. Wade
    Ph: 217-876-4740
    Email: kcheek@dmhhs.org

    Highland Park

    Hematology Oncology Associates of Illinois-Highland Park

    Mary Mulcahy
    Ph: 312-695-1301
    Email: cancer@northwestern.edu

    Joliet

    Joliet Oncology-Hematology Associates, Limited - West

    Kulumani M Sivarajan
    Ph: 815-730-3098
    Email: maureenc@jolietoncology.com

    Kankakee

    Provena St. Mary's Regional Cancer Center - Kankakee

    Mary Mulcahy
    Ph: 312-695-1301
    Email: cancer@northwestern.edu

    Kewanee

    Illinois CancerCare - Kewanee Clinic

    James L. Wade
    Ph: 217-876-4740
    Email: kcheek@dmhhs.org

    Libertyville

    North Shore Oncology and Hematology Associates, Limited - Libertyville

    Mary Mulcahy
    Ph: 312-695-1301
    Email: cancer@northwestern.edu

    Macomb

    Illinois CancerCare - Macomb

    James L. Wade
    Ph: 217-876-4740
    Email: kcheek@dmhhs.org

    Mattoon

    Carle Physician Group-Mattoon/Charleston

    Kendrith M. Rowland
    Ph: 800-446-5532

    Mount Vernon

    Good Samaritan Regional Health Center

    Jay W Carlson
    Ph: 800-821-7532

    Niles

    Cancer Care and Hematology Specialists of Chicagoland - Niles

    Mary Mulcahy
    Ph: 312-695-1301
    Email: cancer@northwestern.edu

    Ottawa

    Illinois CancerCare - Ottawa

    James L. Wade
    Ph: 217-876-4740
    Email: kcheek@dmhhs.org

    Radiation Oncology of Northern Illinois

    James L. Wade
    Ph: 217-876-4740
    Email: kcheek@dmhhs.org

    Pekin

    Cancer Treatment Center at Pekin Hospital

    James L. Wade
    Ph: 217-876-4740
    Email: kcheek@dmhhs.org

    Illinois CancerCare - Pekin

    James L. Wade
    Ph: 217-876-4740
    Email: kcheek@dmhhs.org

    Peoria

    Illinois CancerCare - Peoria

    James L. Wade
    Ph: 217-876-4740
    Email: kcheek@dmhhs.org

    Methodist Medical Center of Illinois

    James L. Wade
    Ph: 217-876-4740
    Email: kcheek@dmhhs.org

    OSF Saint Francis Medical Center Radiation Oncology Service at the Central Illinois Comprehensive CC

    James L. Wade
    Ph: 217-876-4740
    Email: kcheek@dmhhs.org

    OSF St. Francis Medical Center

    James L. Wade
    Ph: 217-876-4740
    Email: kcheek@dmhhs.org

    Peru

    Illinois CancerCare - Princeton

    James L. Wade
    Ph: 217-876-4740
    Email: kcheek@dmhhs.org

    Valley Cancer Center

    James L. Wade
    Ph: 217-876-4740
    Email: kcheek@dmhhs.org

    Princeton

    Illinois CancerCare - Princeton

    James L. Wade
    Ph: 217-876-4740
    Email: kcheek@dmhhs.org

    Rockford

    Advanced Care and Treatment Medical Group, PC

    Harvey Eric Einhorn
    Ph: 779-696-9400
    Email: cancercare@swedishamerican.org

    Skokie

    Hematology Oncology Associates - Skokie

    Mary Mulcahy
    Ph: 312-695-1301
    Email: cancer@northwestern.edu

    Springfield

    Central Illinois Hematology Oncology Center

    James L. Wade
    Ph: 217-876-4740
    Email: kcheek@dmhhs.org

    Regional Cancer Center at Memorial Medical Center

    James L. Wade
    Ph: 217-876-4740
    Email: kcheek@dmhhs.org

    Simmons Cooper Cancer Institute

    James L. Wade
    Ph: 217-876-4740
    Email: kcheek@dmhhs.org

    Springfield Clinic - Main Campus

    James L. Wade
    Ph: 217-876-4740
    Email: kcheek@dmhhs.org

    Swansea

    Cancer Care Specialists of Illinois-Swansea

    James L. Wade
    Ph: 217-876-4740
    Email: kcheek@dmhhs.org

    Urbana

    Carle Cancer Center at Carle Foundation Hospital

    Kendrith M. Rowland
    Ph: 800-446-5532

    Kendrith M. Rowland
    Ph: 800-446-5532

    Yorkville

    Rush-Copley Healthcare Center

    Kendrith M. Rowland
    Ph: 800-446-5532

    Indiana
    Elkhart

    Michiana Hematology-Oncology, PC - Elkhart

    Rafat H. Ansari
    Ph: 574-234-5123

    Michigan City

    Saint Anthony Memorial Health Centers

    Kendrith M. Rowland
    Ph: 800-446-5532

    Woodland Cancer Care Center

    Kendrith M. Rowland
    Ph: 800-446-5532

    Mishawaka

    Memorial Regional Cancer Center Day Road

    Thomas Joseph Reid
    Ph: 800-284-7370

    Michiana Hematology-Oncology, PC - Mishawaka

    Rafat H. Ansari
    Ph: 574-234-5123

    Saint Joseph's Medical Center

    Rafat H. Ansari
    Ph: 574-234-5123

    South Bend

    CCOP - Northern Indiana CR Consortium

    Rafat H. Ansari
    Ph: 574-234-5123

    Memorial Hospital of South Bend

    Thomas Joseph Reid
    Ph: 800-284-7370

    Michiana Hematology-Oncology, PC - South Bend

    Rafat H. Ansari
    Ph: 574-234-5123

    Westville

    Michiana Hematology Oncology-PC Westville

    Rafat H. Ansari
    Ph: 574-234-5123

    Iowa
    Ames

    McFarland Clinic, PC

    Joseph James Merchant
    Ph: 515-239-2621

    William R. Bliss Cancer Center at Mary Greeley Medical Center

    Joseph James Merchant
    Ph: 515-239-2621

    Bettendorf

    Hematology Oncology Associates of the Quad Cities

    Shobha R. Chitneni
    Ph: 563-355-7733
    Email: kedaprile@rccqc.com

    Boone

    McFarland Clinic PC-Boone

    Joseph James Merchant
    Ph: 515-239-2621

    Clive

    Medical Oncology and Hematology Associates-West Des Moines

    Mehmet S. Copur
    Ph: 800-998-2119

    Mercy Cancer Center - West Lakes

    Mehmet S. Copur
    Ph: 800-998-2119

    Council Bluffs

    Alegent Health Mercy Hospital

    Mehmet S. Copur
    Ph: 800-998-2119

    Des Moines

    Medical Oncology and Hematology Associates at Mercy Cancer Center

    Mehmet S. Copur
    Ph: 800-998-2119

    Mercy Cancer Center at Mercy Medical Center - Des Moines

    Mehmet S. Copur
    Ph: 800-998-2119

    Fort Dodge

    Trinity Regional Medical Center

    Joseph James Merchant
    Ph: 515-239-2621

    Iowa City

    Veterans Affairs Medical Center - Iowa City

    Daniel A Vaena
    Ph: 800-237-1225

    Jefferson

    McFarland Clinic PC-Jefferson

    Joseph James Merchant
    Ph: 515-239-2621

    Marshalltown

    McFarland Clinic PC-Marshalltown

    Joseph James Merchant
    Ph: 515-239-2621

    Sioux City

    Siouxland Hematology-Oncology Associates, LLP

    Donald Bruce Wender
    Ph: 712-252-0088

    West Des Moines

    Methodist West Hospital

    Mehmet S. Copur
    Ph: 800-998-2119

    Kansas
    Chanute

    Cancer Center of Kansas, PA - Chanute

    Shaker R. Dakhil
    Ph: 316-262-4467

    Dodge City

    Cancer Center of Kansas, PA - Dodge City

    Shaker R. Dakhil
    Ph: 316-262-4467

    El Dorado

    Cancer Center of Kansas, PA - El Dorado

    Shaker R. Dakhil
    Ph: 316-262-4467

    Fort Scott

    Cancer Center of Kansas - Fort Scott

    Shaker R. Dakhil
    Ph: 316-262-4467

    Independence

    Cancer Center of Kansas-Independence

    Shaker R. Dakhil
    Ph: 316-262-4467

    Kingman

    Cancer Center of Kansas, PA - Kingman

    Shaker R. Dakhil
    Ph: 316-262-4467

    Lawrence

    Lawrence Memorial Hospital

    Shaker R. Dakhil
    Ph: 316-262-4467

    Liberal

    Cancer Center of Kansas, PA - Liberal

    Shaker R. Dakhil
    Ph: 316-262-4467

    Newton

    Cancer Center of Kansas, PA - Newton

    Shaker R. Dakhil
    Ph: 316-262-4467

    Overland Park

    Menorah Medical Center

    Rakesh Gaur
    Ph: 913-948-5588
    Email: aroland@kccop.org

    Saint Luke's Hospital - South

    Rakesh Gaur
    Ph: 913-948-5588
    Email: aroland@kccop.org

    Parsons

    Cancer Center of Kansas, PA - Parsons

    Shaker R. Dakhil
    Ph: 316-262-4467

    Pratt

    Cancer Center of Kansas, PA - Pratt

    Shaker R. Dakhil
    Ph: 316-262-4467

    Salina

    Cancer Center of Kansas, PA - Salina

    Shaker R. Dakhil
    Ph: 316-262-4467

    Topeka

    Cotton-O'Neil Cancer Center

    Karissa W Boyd
    Ph: 785-270-4963

    Wellington

    Cancer Center of Kansas, PA - Wellington

    Shaker R. Dakhil
    Ph: 316-262-4467

    Wichita

    Associates in Women's Health, PA - North Hillside

    Shaker R. Dakhil
    Ph: 316-262-4467

    Cancer Center of Kansas, PA - Medical Arts Tower

    Shaker R. Dakhil
    Ph: 316-262-4467

    Cancer Center of Kansas, PA - Wichita

    Shaker R. Dakhil
    Ph: 316-262-4467

    Via Christi Cancer Center at Via Christi Regional Medical Center

    Shaker R. Dakhil
    Ph: 316-262-4467

    Winfield

    Cancer Center of Kansas, PA - Winfield

    Shaker R. Dakhil
    Ph: 316-262-4467

    Kentucky
    Bardstown

    Flaget Memorial Hospital

    Mehmet S. Copur
    Ph: 800-998-2119

    Corbin

    Commonwealth Cancer Center-Corbin

    Mehmet S. Copur
    Ph: 800-998-2119

    Lexington

    Saint Joseph East

    Mehmet S. Copur
    Ph: 800-998-2119

    United Radiation Oncology - Bob-O-Link Drive Office

    Mehmet S. Copur
    Ph: 800-998-2119

    Louisville

    Jewish Hospital

    Mehmet S. Copur
    Ph: 800-998-2119

    Jewish Hospital Medical Center Northeast

    Mehmet S. Copur
    Ph: 800-998-2119

    Saints Mary and Elizabeth Hospital

    Mehmet S. Copur
    Ph: 800-998-2119

    Shepherdsville

    Jewish Hospital Medical Center South

    Mehmet S. Copur
    Ph: 800-998-2119

    Louisiana
    Baton Rouge

    Earl K. Long Medical Center

    Augusto C Ochoa
    Ph: 504-568-2428
    Email: emede1@lsuhsc.edu

    Hematology-Oncology Clinic

    Hana F Safah
    Ph: 504-988-6121

    Louisiana Hematology Oncology Associates at Mary Bird Cancer Center

    Augusto C Ochoa
    Ph: 504-568-2428
    Email: emede1@lsuhsc.edu

    Mary Bird Perkins Cancer Center - Baton Rouge

    Augusto C Ochoa
    Ph: 504-568-2428
    Email: emede1@lsuhsc.edu

    Medical Oncology, LLC

    Augusto C Ochoa
    Ph: 504-568-2428
    Email: emede1@lsuhsc.edu

    Ochsner Health Center - Bluebonnet

    Jyotsna Fuloria
    Ph: 888-562-4763

    Pennington Cancer Center at Baton Rouge General

    Hana F Safah
    Ph: 504-988-6121

    Covington

    Ochsner Health Center - Covington

    Jyotsna Fuloria
    Ph: 888-562-4763

    Houma

    Terrebonne General Medical Center

    Augusto C Ochoa
    Ph: 504-568-2428
    Email: emede1@lsuhsc.edu

    Marrero

    West Jefferson Medical Center

    Hana F Safah
    Ph: 504-988-6121

    Metairie

    Robert Veith MD LLC

    Augusto C Ochoa
    Ph: 504-568-2428
    Email: emede1@lsuhsc.edu

    New Orleans

    Medical Center of Louisiana - New Orleans

    Augusto C Ochoa
    Ph: 504-568-2428
    Email: emede1@lsuhsc.edu

    Ochsner Cancer Institute at Ochsner Clinic Foundation

    Jyotsna Fuloria
    Ph: 888-562-4763

    Stanley S. Scott Cancer Center at Louisiana State University Medical Center - New Orleans

    Augusto C Ochoa
    Ph: 504-568-2428
    Email: emede1@lsuhsc.edu

    Tulane Cancer Center at Tulane University Hospital and Clinic

    Hana F Safah
    Ph: 504-988-6121

    Shreveport

    Feist-Weiller Cancer Center at Louisiana State University Health Sciences

    Ghassan Abou-Alfa
    Ph: 212-639-7202
    Email: abou-alg@mskcc.org

    Maine
    York

    York Hospital's Oncology Treatment Center

    Marilyn A McLaughlin
    Ph: 207-351-3777

    Maryland
    Baltimore

    Alvin and Lois Lapidus Cancer Institute at Sinai Hospital

    Mayer Gorbaty
    Ph: 410-601-6120
    Email: pridgely@lifebridgehealth.org

    Greater Baltimore Medical Center Cancer Center

    Paul Celano
    Ph: 443-849-3706

    St. Agnes Hospital Cancer Center

    Carole Miller
    Ph: 410-368-2910

    Randallstown

    Northwest Hospital Center

    Mayer Gorbaty
    Ph: 410-601-6120
    Email: pridgely@lifebridgehealth.org

    Massachusetts
    Boston

    Boston University Cancer Research Center

    Kevan Leighton Hartshorn
    Ph: 617-638-8265

    Michigan
    Ann Arbor

    Saint Joseph Mercy Cancer Center

    Philip J. Stella
    Ph: 734-712-4673

    Dearborn

    Oakwood Cancer Center at Oakwood Hospital and Medical Center

    Philip J. Stella
    Ph: 734-712-4673

    Detroit

    Van Elslander Cancer Center at St. John Hospital and Medical Center

    Philip J. Stella
    Ph: 734-712-4673

    Escanaba

    Green Bay Oncology, Limited - Escanaba

    Anthony J. Jaslowski
    Ph: 800-432-6049

    Flint

    Genesys Hurley Cancer Institute

    Philip J. Stella
    Ph: 734-712-4673

    Hurley Medical Center

    Philip J. Stella
    Ph: 734-712-4673

    Iron Mountain

    Green Bay Oncology - Iron Mountain

    Anthony J. Jaslowski
    Ph: 800-432-6049

    Jackson

    Gayle M. Jacob Cancer Center at Allegiance Health

    Philip J. Stella
    Ph: 734-712-4673

    Kalamazoo

    West Michigan Cancer Center

    Sunil Nagpal
    Ph: 269-373-7458

    Lansing

    Sparrow Regional Cancer Center

    Philip J. Stella
    Ph: 734-712-4673

    Livonia

    St. Mary Mercy Hospital

    Philip J. Stella
    Ph: 734-712-4673

    Niles

    Lakeland Hospital - Niles

    Rafat H. Ansari
    Ph: 574-234-5123

    Pontiac

    St. Joseph Mercy Oakland

    Philip J. Stella
    Ph: 734-712-4673

    Port Huron

    Mercy Regional Cancer Center at Mercy Hospital

    Philip J. Stella
    Ph: 734-712-4673

    Saginaw

    Seton Cancer Institute at Saint Mary's - Saginaw

    Philip J. Stella
    Ph: 734-712-4673

    St. Joseph

    Lakeland Regional Cancer Care Center - St. Joseph

    Rafat H. Ansari
    Ph: 574-234-5123

    Warren

    St. John Macomb Hospital

    Philip J. Stella
    Ph: 734-712-4673

    Minnesota
    Burnsville

    Fairview Ridges Hospital

    Patrick J. Flynn
    Ph: 952-993-1517
    Email: MMCCOP@parknicollet.com

    Coon Rapids

    Mercy and Unity Cancer Center at Mercy Hospital

    Patrick J. Flynn
    Ph: 952-993-1517
    Email: MMCCOP@parknicollet.com

    Duluth

    CCOP - Duluth

    Bret E Friday
    Ph: 888-203-7267

    Essentia Health - Duluth Clinic

    Bret E Friday
    Ph: 888-203-7267

    Miller - Dwan Medical Center

    Bret E Friday
    Ph: 888-203-7267

    Edina

    Fairview Southdale Hospital

    Patrick J. Flynn
    Ph: 952-993-1517
    Email: MMCCOP@parknicollet.com

    Fridley

    Mercy and Unity Cancer Center at Unity Hospital

    Patrick J. Flynn
    Ph: 952-993-1517
    Email: MMCCOP@parknicollet.com

    Hutchinson

    Hutchinson Area Health Care

    Patrick J. Flynn
    Ph: 952-993-1517
    Email: MMCCOP@parknicollet.com

    Maplewood

    HealthEast Cancer Care at St. John's Hospital

    Patrick J. Flynn
    Ph: 952-993-1517
    Email: MMCCOP@parknicollet.com

    Minnesota Oncology - Maplewood

    Patrick J. Flynn
    Ph: 952-993-1517
    Email: MMCCOP@parknicollet.com

    Minneapolis

    Health Partners Inc

    Patrick J. Flynn
    Ph: 952-993-1517
    Email: MMCCOP@parknicollet.com

    Hennepin County Medical Center - Minneapolis

    Patrick J. Flynn
    Ph: 952-993-1517
    Email: MMCCOP@parknicollet.com

    Veterans Affairs Medical Center - Minneapolis

    Sharon D Luikart
    Ph: 612-467-2800

    Virginia Piper Cancer Institute at Abbott - Northwestern Hospital

    Patrick J. Flynn
    Ph: 952-993-1517
    Email: MMCCOP@parknicollet.com

    New Ulm

    New Ulm Medical Center

    Patrick J. Flynn
    Ph: 952-993-1517
    Email: MMCCOP@parknicollet.com

    Robbinsdale

    Humphrey Cancer Center at North Memorial Outpatient Center

    Patrick J. Flynn
    Ph: 952-993-1517
    Email: MMCCOP@parknicollet.com

    Saint Louis Park

    Park Nicollet Cancer Center

    Patrick J. Flynn
    Ph: 952-993-1517
    Email: MMCCOP@parknicollet.com

    Saint Paul

    Regions Hospital Cancer Care Center

    Patrick J. Flynn
    Ph: 952-993-1517
    Email: MMCCOP@parknicollet.com

    United Hospital

    Patrick J. Flynn
    Ph: 952-993-1517
    Email: MMCCOP@parknicollet.com

    Shakopee

    St. Francis Cancer Center at St. Francis Medical Center

    Patrick J. Flynn
    Ph: 952-993-1517
    Email: MMCCOP@parknicollet.com

    Stillwater

    Lakeview Hospital

    Patrick J. Flynn
    Ph: 952-993-1517
    Email: MMCCOP@parknicollet.com

    Waconia

    Ridgeview Medical Center

    Patrick J. Flynn
    Ph: 952-993-1517
    Email: MMCCOP@parknicollet.com

    Willmar

    Willmar Cancer Center at Rice Memorial Hospital

    Patrick J. Flynn
    Ph: 952-993-1517
    Email: MMCCOP@parknicollet.com

    Woodbury

    Minnesota Oncology - Woodbury

    Patrick J. Flynn
    Ph: 952-993-1517
    Email: MMCCOP@parknicollet.com

    Mississippi
    Hattiesburg

    Forrest General Cancer Center at Forrest General Hospital

    Augusto C Ochoa
    Ph: 504-568-2428
    Email: emede1@lsuhsc.edu

    Hattiesburg Clinic, PA at Forrest General

    Augusto C Ochoa
    Ph: 504-568-2428
    Email: emede1@lsuhsc.edu

    Missouri
    Bolivar

    Central Care Cancer Center at Carrie J. Babb Cancer Center

    Jay W Carlson
    Ph: 800-821-7532

    Bonne Terre

    Parkland Health Center-Bonne Terre

    Alan Philip Lyss
    Ph: 800-392-0936

    Branson

    Skaggs Cancer Center at Skaggs Regional Medical Center

    Jay W Carlson
    Ph: 800-821-7532

    Cape Girardeau

    Saint Francis Medical Center

    James L. Wade
    Ph: 217-876-4740
    Email: kcheek@dmhhs.org

    Southeast Cancer Center

    Alan Philip Lyss
    Ph: 800-392-0936

    Columbia

    Ellis Fischel Cancer Center at University of Missouri - Columbia

    Donald C Doll
    Ph: 573-882-7440

    Independence

    Independence Regional Health Center

    Rakesh Gaur
    Ph: 913-948-5588
    Email: aroland@kccop.org

    Jefferson City

    Goldschmidt Cancer Center

    James L. Wade
    Ph: 217-876-4740
    Email: kcheek@dmhhs.org

    Kansas City

    Heartland Hematology Oncology Associates, Incorporated

    Rakesh Gaur
    Ph: 913-948-5588
    Email: aroland@kccop.org

    Research Medical Center

    Rakesh Gaur
    Ph: 913-948-5588
    Email: aroland@kccop.org

    Saint Luke's Hospital

    Rakesh Gaur
    Ph: 913-948-5588
    Email: aroland@kccop.org

    Lee's Summit

    Saint Luke's East - Lee's Summit

    Rakesh Gaur
    Ph: 913-948-5588
    Email: aroland@kccop.org

    Liberty

    Parvin Radiation Oncology

    Rakesh Gaur
    Ph: 913-948-5588
    Email: aroland@kccop.org

    Rolla

    Mercy Clinic Cancer and Hematology - Rolla

    Jay W Carlson
    Ph: 800-821-7532

    Phelps County Regional Medical Center

    Jay W Carlson
    Ph: 800-821-7532

    Saint Joseph

    Heartland Regional Medical Center

    Rakesh Gaur
    Ph: 913-948-5588
    Email: aroland@kccop.org

    Saint Louis

    David C. Pratt Cancer Center at St. John's Mercy

    Jay W Carlson
    Ph: 800-821-7532

    Mercy Clinic St. Louis Cancer and Breast Institute

    Jay W Carlson
    Ph: 800-821-7532

    Missouri Baptist Cancer Center

    James L. Wade
    Ph: 217-876-4740
    Email: kcheek@dmhhs.org

    Siteman Cancer Center at Barnes-Jewish Hospital - Saint Louis

    Benjamin R Tan
    Ph: 800-600-3606
    Email: info@siteman.wustl.edu

    Sainte Genevieve

    Sainte Genevieve County Memorial Hospital

    Alan Philip Lyss
    Ph: 800-392-0936

    Springfield

    Hulston Cancer Center at Cox Medical Center South

    Jay W Carlson
    Ph: 800-821-7532

    St. John's Regional Health Center

    Jay W Carlson
    Ph: 800-821-7532

    Sullivan

    Missouri Baptist Sullivan Hospital

    Alan Philip Lyss
    Ph: 800-392-0936

    Sunset Hills

    Missouri Baptist Outpatient Center-Sunset Hills

    Alan Philip Lyss
    Ph: 800-392-0936

    Nebraska
    Grand Island

    Saint Francis Cancer Treatment Center at Saint Francis Memorial Health Center

    Mehmet S. Copur
    Ph: 800-998-2119

    Kearney

    Good Samaritan Cancer Center at Good Samaritan Hospital

    Mehmet S. Copur
    Ph: 800-998-2119

    Heartland Hematology and Oncology

    Mehmet S. Copur
    Ph: 800-998-2119

    Lincoln

    Saint Elizabeth Cancer Institute at Saint Elizabeth Regional Medical Center

    Mehmet S. Copur
    Ph: 800-998-2119

    Omaha

    Alegant Health Cancer Center at Bergan Mercy Medical Center

    Mehmet S. Copur
    Ph: 800-998-2119

    Creighton University Medical Center

    Mehmet S. Copur
    Ph: 800-998-2119

    Hematology/Oncology Consultants

    Mehmet S. Copur
    Ph: 800-998-2119

    Immanuel Medical Center

    Mehmet S. Copur
    Ph: 800-998-2119

    Lakeside Hospital

    Mehmet S. Copur
    Ph: 800-998-2119

    Methodist Estabrook Cancer Center

    Robert M. Langdon
    Ph: 402-354-5144

    Papillion

    Midlands Cancer Center at Midlands Community Hospital

    Mehmet S. Copur
    Ph: 800-998-2119

    Nevada
    Henderson

    21st Century Oncology - Henderson

    John Allan Ellerton
    Ph: 702-384-0013

    Cancer and Blood Specialists-Henderson

    John Allan Ellerton
    Ph: 702-384-0013

    Comprehensive Cancer Centers of Nevada - Henderson

    John Allan Ellerton
    Ph: 702-384-0013

    Comprehensive Cancer Centers of Nevada-Southeast Henderson

    John Allan Ellerton
    Ph: 702-384-0013

    Las Vegas Cancer Center - Henderson

    John Allan Ellerton
    Ph: 702-384-0013

    Las Vegas

    21st Century Oncology - Fort Apache

    John Allan Ellerton
    Ph: 702-384-0013

    21st Century Oncology - Vegas Sunrise

    John Allan Ellerton
    Ph: 702-384-0013

    21st Century Oncology - Vegas Tenaya

    John Allan Ellerton
    Ph: 702-384-0013

    Cancer and Blood Specialists-Fort Apache

    John Allan Ellerton
    Ph: 702-384-0013

    Cancer and Blood Specialists-Shadow

    John Allan Ellerton
    Ph: 702-384-0013

    Cancer and Blood Specialists-Tenaya

    John Allan Ellerton
    Ph: 702-384-0013

    Cancer Institute of Nevada at Summerlin Hospital Medical Center

    John Allan Ellerton
    Ph: 702-384-0013

    Cancer Therapy and Integrative Medicine

    John Allan Ellerton
    Ph: 702-384-0013

    CCOP - Nevada Cancer Research Foundation

    John Allan Ellerton
    Ph: 702-384-0013

    Comprehensive Cancer Centers of Nevada - Central Valley

    John Allan Ellerton
    Ph: 702-384-0013

    Comprehensive Cancer Centers of Nevada - Northwest

    John Allan Ellerton
    Ph: 702-384-0013

    Comprehensive Cancer Centers of Nevada - Southwest

    John Allan Ellerton
    Ph: 702-384-0013

    HealthCare Partners Medical Group Oncology/Hematology-Centennial Hills

    John Allan Ellerton
    Ph: 702-384-0013

    HealthCare Partners Medical Group Oncology/Hematology-Maryland Parkway

    John Allan Ellerton
    Ph: 702-384-0013

    HealthCare Partners Medical Group Oncology/Hematology-San Martin

    John Allan Ellerton
    Ph: 702-384-0013

    HealthCare Partners Medical Group Oncology/Hematology-Tenaya

    John Allan Ellerton
    Ph: 702-384-0013

    Las Vegas Cancer Center-Medical Center

    John Allan Ellerton
    Ph: 702-384-0013

    Radiation Oncology Centers of Las Vegas - Downtown Location

    John Allan Ellerton
    Ph: 702-384-0013

    Radiation Oncology Centers of Las Vegas - Eastern Location

    John Allan Ellerton
    Ph: 702-384-0013

    University Medical Center of Southern Nevada

    John Allan Ellerton
    Ph: 702-384-0013

    Reno

    Abrass and Conrath Hematology - Oncology

    Vodur S Reddy
    Ph: 775-770-3854

    Alpine Hematology-Oncology

    Vodur S Reddy
    Ph: 775-770-3854

    Radiation Oncology Associates - Reno

    Vodur S Reddy
    Ph: 775-770-3854

    Renown Institute for Cancer at Renown Regional Medical Center

    Don J Park
    Ph: 269-373-7458

    Saint Mary's Regional Medical Center

    Vodur S Reddy
    Ph: 775-770-3854

    New Jersey
    East Orange

    Veterans Affairs Medical Center - East Orange

    Victor T Chang
    Ph: 800-475-2336
    Email: patricia.goyer@med.va.gov

    Vineland

    Frank and Edith Scarpa Regional Cancer Pavillion at South Jersey Healthcare

    Tami L Bach
    Ph: 856-641-7933

    Woodbury

    Underwood Memorial Hospital

    Tami L Bach
    Ph: 856-641-7933

    New Mexico
    Albuquerque

    University of New Mexico Cancer Center

    Fa-Chyi Lee
    Ph: 505-272-6972

    Las Cruces

    Memorial Medical Center

    Fa-Chyi Lee
    Ph: 505-272-6972

    New York
    Bronx

    Jack D. Weiler Hospital at Montefiore Medical Center - East Campus

    Andreas Kaubisch
    Ph: 718-904-2730
    Email: aecc@aecom.yu.edu

    Montefiore Medical Center

    Andreas Kaubisch
    Ph: 718-904-2730
    Email: aecc@aecom.yu.edu

    Veterans Affairs Medical Center - Bronx

    Yeun-Hee A Park
    Ph: 212-305-8615

    Buffalo

    Veterans Affairs Medical Center - Buffalo

    Lynn Marie Steinbrenner
    Ph: 716-862-3191

    Glens Falls

    Charles R. Wood Cancer Center at Glens Falls Hospital

    Aqeel A Gillani
    Ph: 518-926-6700

    Manhasset

    Don Monti Comprehensive Cancer Center at North Shore University Hospital

    Vincent P. Vinciguerra
    Ph: 516-562-3467

    New Hyde Park

    Long Island Jewish Medical Center

    Vincent P. Vinciguerra
    Ph: 516-562-3467

    Monter Cancer Center of the North Shore-LIJ Health System

    Vincent P. Vinciguerra
    Ph: 516-562-3467

    New York

    Beth Israel Medical Center - Petrie Division

    Peter Kozuch
    Ph: 212-844-6286

    Herbert Irving Comprehensive Cancer Center at Columbia University Medical Center

    Abby Siegel
    Ph: 212-305-8615

    Memorial Sloan-Kettering Cancer Center

    Ghassan Abou-Alfa
    Ph: 212-639-7202

    St. Luke's - Roosevelt Hospital Center - St.Luke's Division

    Peter Kozuch
    Ph: 212-844-6286

    Stony Brook

    Stony Brook University Cancer Center

    Minsig Choi
    Ph: 800-862-2215

    Syracuse

    SUNY Upstate Medical University Hospital

    Rahul Seth
    Ph: 315-464-5476

    North Carolina
    Asheville

    Cancer Care of Western North Carolina

    Christopher H Chay
    Ph: 828-213-4150

    Mission Hospitals - Memorial Campus

    Christopher H Chay
    Ph: 828-213-4150

    Clinton

    Sampson Radiation Oncology

    James N. Atkins
    Ph: 919-580-0000

    Southeastern Medical Oncology Center-Clinton

    James N. Atkins
    Ph: 919-580-0000

    Goldsboro

    Southeastern Medical Oncology Center - Goldsboro

    James N. Atkins
    Ph: 919-580-0000

    Wayne Memorial Hospital, Incorporated

    James N. Atkins
    Ph: 919-580-0000

    Wayne Radiation Oncology

    James N. Atkins
    Ph: 919-580-0000

    Jacksonville

    Onslow Memorial Hospital

    James N. Atkins
    Ph: 919-580-0000

    Southeastern Medical Oncology Center-Jacksonville

    James N. Atkins
    Ph: 919-580-0000

    Kinston

    Kinston Medical Specialists

    Peter R. Watson
    Ph: 252-559-2200

    Statesville

    Iredell Memorial Hospital

    Ruby A. Grimm
    Ph: 704-873-5661

    Wilson

    Southeastern Medical Oncology Center - Wilson

    James N. Atkins
    Ph: 919-580-0000

    Winston-Salem

    Wake Forest University Comprehensive Cancer Center

    Angela T Alistar
    Ph: 336-713-6771

    North Dakota
    Bismarck

    Bismarck Cancer Center

    Edward J. Wos
    Ph: 701-323-5760
    Email: tfischer@mohs.org

    Minot

    Trinity CancerCare Center

    Patanit Watanaboonyakhet
    Ph: 800-862-0005

    Ohio
    Belpre

    Strecker Cancer Center-Belpre

    J. Philip Kuebler
    Ph: 614-488-2745
    Email: sheree@columbusccop.org

    Canton

    Aultman Cancer Center at Aultman Hospital

    Kisa E Weeman
    Ph: 330-363-6891

    Chillicothe

    Adena Regional Medical Center

    J. Philip Kuebler
    Ph: 614-488-2745
    Email: sheree@columbusccop.org

    Cincinnati

    Bethesda North Hospital

    Mehmet S. Copur
    Ph: 800-998-2119

    Good Samaritan Hospital Cancer Treatment Center

    Mehmet S. Copur
    Ph: 800-998-2119

    TriHealth Cancer Institute-Anderson

    Mehmet S. Copur
    Ph: 800-998-2119

    TriHealth Cancer Institute-Westside

    Mehmet S. Copur
    Ph: 800-998-2119

    Cleveland

    MetroHealth Cancer Care Center at MetroHealth Medical Center

    Bruce J. Averbook
    Ph: 216-778-8526
    Email: kbauchens@metrohealth.org

    Columbus

    Arthur G. James Cancer Hospital and Richard J. Solove Research Institute at Ohio State University Comprehensive Cancer Center

    Ghassan Abou-Alfa
    Ph: 212-639-7202
    Email: abou-alg@mskcc.org

    Columbus Oncology Associates, Incorporated

    J. Philip Kuebler
    Ph: 614-488-2745
    Email: sheree@columbusccop.org

    Doctors Hospital at Ohio Health

    J. Philip Kuebler
    Ph: 614-488-2745
    Email: sheree@columbusccop.org

    Grant Medical Center Cancer Care

    J. Philip Kuebler
    Ph: 614-488-2745
    Email: sheree@columbusccop.org

    Mount Carmel Health - West Hospital

    J. Philip Kuebler
    Ph: 614-488-2745
    Email: sheree@columbusccop.org

    Riverside Methodist Hospital Cancer Care

    J. Philip Kuebler
    Ph: 614-488-2745
    Email: sheree@columbusccop.org

    Zangmeister Center

    J. Philip Kuebler
    Ph: 614-488-2745
    Email: sheree@columbusccop.org

    Delaware

    Delaware Health Center

    J. Philip Kuebler
    Ph: 614-488-2745
    Email: sheree@columbusccop.org

    Delaware Radiation Oncology

    J. Philip Kuebler
    Ph: 614-488-2745
    Email: sheree@columbusccop.org

    Grady Memorial Hospital

    J. Philip Kuebler
    Ph: 614-488-2745
    Email: sheree@columbusccop.org

    Lancaster

    Fairfield Medical Center

    J. Philip Kuebler
    Ph: 614-488-2745
    Email: sheree@columbusccop.org

    Lima

    St. Rita's Medical Center

    Henry Gerad
    Ph: 419-226-9617

    Marietta

    Strecker Cancer Center at Marietta Memorial Hospital

    J. Philip Kuebler
    Ph: 614-488-2745
    Email: sheree@columbusccop.org

    Mount Vernon

    Knox Community Hospital

    J. Philip Kuebler
    Ph: 614-488-2745
    Email: sheree@columbusccop.org

    Newark

    Licking Memorial Cancer Care Program at Licking Memorial Hospital

    J. Philip Kuebler
    Ph: 614-488-2745
    Email: sheree@columbusccop.org

    Newark Radiation Oncology

    J. Philip Kuebler
    Ph: 614-488-2745
    Email: sheree@columbusccop.org

    Portsmouth

    Southern Ohio Medical Center Cancer Center

    J. Philip Kuebler
    Ph: 614-488-2745
    Email: sheree@columbusccop.org

    Springfield

    Community Hospital of Springfield and Clark County

    J. Philip Kuebler
    Ph: 614-488-2745
    Email: sheree@columbusccop.org

    Westerville

    Mount Carmel St. Ann's Cancer Center

    J. Philip Kuebler
    Ph: 614-488-2745
    Email: sheree@columbusccop.org

    Zanesville

    Genesis - Good Samaritan Hospital

    J. Philip Kuebler
    Ph: 614-488-2745
    Email: sheree@columbusccop.org

    Oklahoma
    Oklahoma City

    Stephenson Cancer Center at the University of Oklahoma

    Shubham Pant
    Ph: 405-271-4272
    Email: julie-traylor@ouhsc.edu

    Tulsa

    Cancer Care Associates-Yale

    Shubham Pant
    Ph: 405-271-4272
    Email: julie-traylor@ouhsc.edu

    Pennsylvania
    Abington

    Rosenfeld Cancer Center at Abington Memorial Hospital

    Willard G. Andrews
    Ph: 215-481-2402

    Allentown

    Morgan Cancer Center at Lehigh Valley Hospital - Cedar Crest

    Eliot Lawrence Friedman
    Ph: 610-402-2273

    Pittsburgh

    Veterans Affairs Medical Center - Pittsburgh

    Jocelyn L Tan-Shalaby
    Ph: 412-688-6104

    Sayre

    Guthrie Cancer Center at Guthrie Clinic Sayre

    Bradley W Lash
    Ph: 800-836-0388

    West Reading

    McGlinn Family Regional Cancer Center at Reading Hospital and Medical Center

    Terrence P. Cescon
    Ph: 610-988-9323

    PR
    San Juan

    Fundacion de Investagacion De Diego

    Deana Hallman Navarro
    Ph: 787-765-2363

    Rhode Island
    Providence

    Roger Williams Medical Center

    Ponnandai S Somasundar
    Ph: 401-456-2268
    Email: rdavies@rwmc.org

    South Carolina
    Anderson

    AnMed Cancer Center

    Charles E Bowers
    Ph: 800-486-5941

    Charles E Bowers
    Ph: 800-486-5941

    Greenville

    Bon Secours St. Francis Health System

    Charles E Bowers
    Ph: 800-486-5941

    Cancer Centers of the Carolinas - Faris Road

    Jeffrey Kent Giguere
    Ph: 864-241-6251

    Cancer Centers of the Carolinas - Grove Commons

    Jeffrey Kent Giguere
    Ph: 864-241-6251

    CCOP - Greenville

    Jeffrey Kent Giguere
    Ph: 864-241-6251

    Greenville Memorial Hospital

    Jeffrey Kent Giguere
    Ph: 864-241-6251

    Saint Francis Cancer Center

    Robert D. Siegel
    Ph: 864-255-1713

    Greer

    Cancer Centers of the Carolinas - Greer Radiation Oncology

    Jeffrey Kent Giguere
    Ph: 864-241-6251

    Gibbs Cancer Center-Pelham

    Charles E Bowers
    Ph: 800-486-5941

    Seneca

    Cancer Centers of the Carolinas - Seneca

    Jeffrey Kent Giguere
    Ph: 864-241-6251

    Spartanburg

    Cancer Centers of the Carolinas - Spartanburg

    Jeffrey Kent Giguere
    Ph: 864-241-6251

    Gibbs Regional Cancer Center at Spartanburg Regional Medical Center

    Charles E Bowers
    Ph: 800-486-5941

    South Dakota
    Rapid City

    Rapid City Regional Hospital

    Joshua C Lukenbill
    Ph: 605-716-3982
    Email: research@rcrh.org

    Sioux Falls

    Avera Cancer Institute

    Addison R Tolentino
    Ph: 800-657-4377
    Email: Jan.Healy@avera.org

    Tennessee
    Bristol

    Blue Ridge Medical Specialists, PC

    Asheesh Shipstone
    Ph: 423-578-8538

    Wellmont-Bristol Regional Medical Center

    Asheesh Shipstone
    Ph: 423-578-8538

    Chattanooga

    H. Clay Evans Johnson Cancer Center at Memorial Hospital

    Mehmet S. Copur
    Ph: 800-998-2119

    Hixson

    Pulmonary Medicine Center of Chattanooga-Hixson

    Mehmet S. Copur
    Ph: 800-998-2119

    Kingsport

    Christine LaGuardia Phillips Cancer Center at Wellmont Holston Valley Medical Center

    Asheesh Shipstone
    Ph: 423-578-8538

    Kingsport Hematology-Oncology Associates

    Asheesh Shipstone
    Ph: 423-578-8538

    Knoxville

    U.T. Medical Center Cancer Institute

    Wahid T. Hanna
    Ph: 865-544-9773

    Ooltewah

    Memorial GYN Plus

    Mehmet S. Copur
    Ph: 800-998-2119

    Texas
    Amarillo

    Harrington Cancer Center

    Stewart Allen Sharp
    Ph: 806-359-4673
    Email: ryokubaitis@harringtoncc.org

    El Paso

    Texas Tech University Health Sciences Center School of Medicine - El Paso

    Sumit Gaur
    Ph: 888-823-5923
    Email: ctsucontact@westat.com

    Houston

    Ben Taub General Hospital

    Martha P Mims
    Ph: 713-798-1354
    Email: burton@bcm.edu

    Dan L. Duncan Cancer Center at Baylor College of Medicine

    Martha P Mims
    Ph: 713-798-1354
    Email: burton@bcm.edu

    Methodist Hospital

    Alexandra Phan
    Ph: 713-790-2700

    St. Luke's Texas Cancer Institute at St. Luke's Episcopal Hospital

    Martha P Mims
    Ph: 713-798-1354
    Email: burton@bcm.edu

    Veterans Affairs Medical Center - Houston

    Martha P Mims
    Ph: 713-798-1354
    Email: burton@bcm.edu

    Vermont
    White River Junction

    Veterans Affairs Medical Center - White River Junction

    Nancy B Kuemmerle
    Email: calgbco@calgb.org

    Virginia
    Danville

    Danville Hematology and Oncology, Incorporated

    Qiwei W Gai
    Ph: 434-793-0044

    Danville Regional Medical Center

    Qiwei W Gai
    Ph: 434-793-0044

    Martinsville

    Ravenel Oncology Center at Memorial Hospital of Martinsville and Henry County

    Sreedhar Katragadda
    Ph: 276-666-7827

    Norton

    Southwest Virginia Regional Cancer Center at Wellmonth Health

    Asheesh Shipstone
    Ph: 423-578-8538

    Washington
    Auburn

    Auburn Regional Center for Cancer Care

    John A Keech
    Ph: 907-458-5380

    Bainbridge Island

    Virginia Mason Bainbridge Island Medical Center

    John A Keech
    Ph: 907-458-5380

    Bellevue

    Overlake Cancer Center at Overlake Hospital Medical Center

    John A Keech
    Ph: 907-458-5380

    Bremerton

    Harrison Medical Center

    Mehmet S. Copur
    Ph: 800-998-2119

    Olympic Hematology and Oncology

    Mehmet S. Copur
    Ph: 800-998-2119

    Burien

    Highline Medical Center Cancer Center

    Mehmet S. Copur
    Ph: 800-998-2119

    Centralia

    Providence Centralia Hospital

    Yoshio Inoue
    Ph: 253-403-2394

    Enumclaw

    Saint Elizabeth Hospital

    Mehmet S. Copur
    Ph: 800-998-2119

    Everett

    Providence Regional Cancer Partnership

    Yoshio Inoue
    Ph: 253-403-2394

    Federal Way

    St. Francis Hospital

    Mehmet S. Copur
    Ph: 800-998-2119

    Virginia Mason Federal Way Medical Center

    John A Keech
    Ph: 907-458-5380

    Gig Harbor

    MultiCare Gig Harbor Medical Park

    John A Keech
    Ph: 907-458-5380

    Tacoma/Valley Radiation Oncology Centers-Gig Harbor

    John A Keech
    Ph: 907-458-5380

    Kennewick

    Northwest Cancer Clinic

    John A Keech
    Ph: 907-458-5380

    Lacey

    Western Washington Oncology, Incorporated, PS at Western Washington Cancer Center

    Yoshio Inoue
    Ph: 253-403-2394

    Lakewood

    St. Clare Hospital

    Mehmet S. Copur
    Ph: 800-998-2119

    Lynnwood

    Virginia Mason Lynnwood Medical Center

    John A Keech
    Ph: 907-458-5380

    Poulsbo

    Harrison Poulsbo Hematology and Onocology

    Mehmet S. Copur
    Ph: 800-998-2119

    Peninsula Cancer Center

    John A Keech
    Ph: 907-458-5380

    Puyallup

    Good Samaritan Cancer Center

    John A Keech
    Ph: 907-458-5380

    Takoma/Valley Radiation Oncology Center at Good Samaritan

    John A Keech
    Ph: 907-458-5380

    Seattle

    Virginia Mason Medical Center

    John A Keech
    Ph: 907-458-5380

    Tacoma

    Franciscan Research Center-Northwest Medical Plaza

    Mehmet S. Copur
    Ph: 800-998-2119

    MultiCare Regional Cancer Center at Tacoma General Hospital

    John A Keech
    Ph: 907-458-5380

    Northwest Medical Specialties, PLLC - Tacoma

    Mehmet S. Copur
    Ph: 800-998-2119

    Tacoma/Valley Radiation Oncology Center - St. Joseph

    John A Keech
    Ph: 907-458-5380

    Tacoma/Valley Radiation Oncology Centers-Jackson Hall

    John A Keech
    Ph: 907-458-5380

    Wisconsin
    Antigo

    Langlade Memorial Hospital

    Christopher G Peterson
    Ph: 877-405-6866

    Green Bay

    Green Bay Oncology, Limited at St. Mary's Hospital

    Anthony J. Jaslowski
    Ph: 800-432-6049

    Green Bay Oncology, Limited at St. Vincent Hospital Regional Cancer Center

    Anthony J. Jaslowski
    Ph: 800-432-6049

    St. Mary's Hospital Medical Center - Green Bay

    Anthony J. Jaslowski
    Ph: 800-432-6049

    St. Vincent Hospital Regional Cancer Center

    Anthony J. Jaslowski
    Ph: 800-432-6049

    La Crosse

    Gundersen Lutheran Center for Cancer and Blood

    Kurt Oettel
    Ph: 608-775-2385
    Email: cancerctr@gundluth.org

    Manitowoc

    Holy Family Memorial Medical Center Cancer Care Center

    Anthony J. Jaslowski
    Ph: 800-432-6049

    Marinette

    Bay Area Cancer Care Center at Bay Area Medical Center

    Anthony J. Jaslowski
    Ph: 800-432-6049

    Mukwonago

    D.N. Greenwald Center

    Timothy R Wassenaar
    Ph: 262-928-7878

    New Richmond

    Cancer Center of Western Wisconsin

    Patrick J. Flynn
    Ph: 952-993-1517
    Email: MMCCOP@parknicollet.com

    Oconomowoc

    Regional Cancer Center at Oconomowoc Memorial Hospital

    Timothy R Wassenaar
    Ph: 262-928-7878

    Oconto Falls

    Green Bay Oncology, Limited - Oconto Falls

    Anthony J. Jaslowski
    Ph: 800-432-6049

    Sheboygan

    Saint Nicholas Hospital

    Anthony J. Jaslowski
    Ph: 800-432-6049

    Sturgeon Bay

    Green Bay Oncology, Limited - Sturgeon Bay

    Anthony J. Jaslowski
    Ph: 800-432-6049

    Waukesha

    Waukesha Memorial Hospital Regional Cancer Center

    Timothy R Wassenaar
    Ph: 262-928-7878

    Wausau

    University of Wisconcin Cancer Center at Aspirus Wausau Hospital

    Christopher G Peterson
    Ph: 877-405-6866

    Canada

    Alberta
    Calgary

    Tom Baker Cancer Centre - Calgary

    Vincent C Tam
    Ph: 403-521-3433

    British Columbia
    Vancouver

    British Columbia Cancer Agency - Vancouver Cancer Centre

    Howard J Lim
    Ph: 888-939-3333

    Manitoba
    Winnipeg

    CancerCare Manitoba

    Ralph P. W. Wong
    Ph: 866-561-1026
    Email: CIO_Web@cancercare.mb.ca

    Ontario
    Kitchener

    Grand River Regional Cancer Centre at Grand River Hospital

    Gregory J Knight
    Ph: 519-749-4300ext2307

    London

    London Regional Cancer Program at London Health Sciences Centre

    Walter I Kocha
    Ph: 519-685-8600

    Ottawa

    Ottawa Hospital Regional Cancer Centre - General Campus

    Rakesh Goel
    Ph: 613-761-4395
    Email: info@ohri.ca

    Toronto

    Princess Margaret Hospital

    Jennifer J Knox
    Ph: 416-946-4501
    Email: clinical.trials@uhn.on.ca

    Quebec
    Montreal

    CHUM - Hopital Saint-Luc

    Mustapha Tehfe
    Ph: 514-890-8000ext23611
    Email: sylvie.beaudoin.chum@ssss.gouv.qc.ca

    McGill Cancer Centre at McGill University

    Petr Kavan
    Ph: 514-398-1444
    Email: penny.chipman@mcgill.ca

    Saskatchewan
    Saskatoon

    Saskatoon Cancer Centre at the University of Saskatchewan

    Shahid Ahmed
    Ph: 306-655-2914

    Link to the current ClinicalTrials.gov record.
    NLM Identifier NCT01015833
    ClinicalTrials.gov processed this data on May 20, 2015

    Note: Information about this trial is from the ClinicalTrials.gov database. The versions designated for health professionals and patients contain the same text. Minor changes may be made to the ClinicalTrials.gov record to standardize the names of study sponsors, sites, and contacts. Cancer.gov only lists sites that are recruiting patients for active trials, whereas ClinicalTrials.gov lists all sites for all trials. Questions and comments regarding the presented information should be directed to ClinicalTrials.gov.