Irinotecan Hydrochloride and Cetuximab With or Without Ramucirumab in Treating Patients With Advanced Colorectal Cancer With Progressive Disease After Treatment With Bevacizumab-Containing Chemotherapy

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Basic Trial Information

PhaseTypeStatusAgeSponsorProtocol IDs
Phase IITreatmentActive18 and overNCICDR0000666736
ECOG-E7208, E7208, NCT01079780

Trial Description

Summary

RATIONALE: Drugs used in chemotherapy, such as irinotecan hydrochloride, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Monoclonal antibodies, such as cetuximab and ramucirumab, can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread. Others find tumor cells and help kill them or carry tumor-killing substances to them. Cetuximab and ramucirumab may also stop the growth of colorectal cancer by blocking blood flow to the tumor. It is not yet know whether giving cetuximab and irinotecan hydrochloride together is more effective with or without ramucirumab in treating colorectal cancer.

PURPOSE: This randomized phase II trial is studying the side effects and how well giving cetuximab and irinotecan hydrochloride with or without ramucirumab work in treating patients with advanced colorectal cancer with progressive disease after treatment with bevacizumab-containing chemotherapy.

Further Study Information

OBJECTIVES:

  • To evaluate the progression-free survival of patients with advanced K-ras wild-type colorectal cancer, following progression on bevacizumab-contained chemotherapy, treated with irinotecan hydrochloride and cetuximab with versus without ramucirumab as second-line therapy.
  • To evaluate the response rate in patients treated with these regimens.
  • To evaluate the grade 3-4 toxicity rates of these regimens in these patients.
  • To evaluate the overall suvival of patients treated with these regimens.

OUTLINE: This is a multicenter, randomized study. Patients are stratified according to performance status (0 vs 1), discontinuation of oxaliplatin before disease progression (yes vs no), and time to disease progression since last treatment (≤ 6 months vs > 6 months). Patients are randomized to 1 of 2 treatment arms.

  • Arm I: Patients receive cetuximab IV over 60-120 minutes and irinotecan hydrochloride over 60-90 minutes on day 1.
  • Arm II: Patients receive ramucirumab IV over 60 minutes on day 1 and cetuximab and irinotecan hydrochloride as in arm I.

In both arms, courses repeat every 14 days in the absence of disease progression or unacceptable toxicity.

After completion of study therapy, patients are followed up periodically for 5 years.

Eligibility Criteria

DISEASE CHARACTERISTICS:

  • Histologically confirmed adenocarcinoma of the colon or rectum, including:
  • Advanced disease
  • Histologic variants of adenocarcinoma allowed
  • K-ras wild type based on either primary or metastatic tumor
  • No mutated type
  • Measurable disease
  • Must have received prior first-line therapy comprising oxaliplatin-based fluoropyrimidine-containing chemotherapy and bevacizumab for metastatic colorectal cancer
  • No more than 42 days since confirmed disease progression
  • No brain or CNS metastases

PATIENT CHARACTERISTICS:

  • Performance status 0-1
  • ANC ≥ 1,500/μL
  • Platelet count ≥ 75,000/μL
  • Hemoglobin ≥ 9 g/dL
  • Serum creatinine ≤ 1.5 times upper limit of normal (ULN) OR creatinine clearance ≥ 40 mL/min
  • Urine protein ≤ 1+ on dipstick or routine urinalysis (if ≥ 2+, a 24-hour urine collection must demonstrate < 1,000 mg of protein)
  • Total bilirubin ≤ 2.0 mg/dL
  • AST and ALT ≤ 3.0 times ULN (5.0 times ULN for patients with liver metastases)
  • INR ≤ 1.6 (≤ 3.0 for patients on warfarin and no active bleeding [i.e., no bleeding within the past 14 days])
  • Not pregnant or nursing
  • Negative pregnancy test
  • Fertile patients must use effective contraception during and for 3 months after completion of study therapy
  • No clinically significant (equivalent to NCI CTCAE grade 3-4) bleeding episodes within the past 3 months
  • None of the following:
  • Active infection
  • Symptomatic congestive heart failure
  • Unstable angina pectoris
  • Symptomatic or poorly controlled cardiac arrhythmia
  • Uncontrolled thrombotic or hemorrhagic disorder
  • No uncontrolled or poorly controlled hypertension despite standard medical management (e.g., consistently systolic BP > 160 mm Hg and diastolic BP > 90 mm Hg)
  • No acute arterial thrombotic events within the past 6 months, including cerebrovascular accident, transient ischemic attack, myocardial infarction, or unstable angina
  • No other cancer requiring therapy within the past 3 years except in situ carcinoma or nonmelanoma skin cancer
  • No acute or subacute intestinal obstruction
  • No history of inflammatory bowel disease requiring pharmacological and/or surgical intervention within the past 12 months
  • No known allergy to any of the treatment components

PRIOR CONCURRENT THERAPY:

  • See Disease Characteristics
  • At least 28 days and no more than 90 days since prior bevacizumab
  • No prior therapy with drugs other than oxaliplatin and a fluoropyrimidine plus bevacizumab for colorectal cancer
  • No major surgery within the past 28 days
  • No subcutaneous venous access device placement within the past 7 days
  • Concurrent stable dose of oral anticoagulant or low-molecular weight heparin allowed

Trial Contact Information

Trial Lead Organizations/Sponsors

Pam Cogliano

  • National Cancer Institute
Howard S. Hochster, Principal Investigator

Trial Sites

U.S.A.

Alabama
Birmingham

UAB Comprehensive Cancer Center

Carla I. Falkson
Ph: 205-934-0309

Arizona
Tucson

Arizona Cancer Center at UMC Orange Grove

Emad Elquza
Ph: 520-626-9008

Arizona Cancer Center at University Medical Center North

Emad Elquza
Ph: 520-626-9008

Arizona Cancer Center at University of Arizona Health Sciences Center

Emad Elquza
Ph: 520-626-9008

California
Dublin

Epic Care-Dublin

Jon M Greif
Ph: 510-835-9900

Emeryville

Bay Area Breast Surgeons, Incorporated

Jon M Greif
Ph: 510-835-9900

Epic Care - Oakland

Jon M Greif
Ph: 510-835-9900

Los Angeles

USC/Norris Comprehensive Cancer Center and Hospital

Heinz-Josef Lenz
Ph: 323-865-0451

Martinez

Contra Costa Regional Medical Center

Jon M Greif
Ph: 510-835-9900

Oakland

Alta Bates Summit Medical Center - Summit Campus

Jon M Greif
Ph: 510-835-9900

CCOP - Bay Area Tumor Institute

Jon M Greif
Ph: 510-835-9900

Larry G Strieff MD Medical Corporation

Jon M Greif
Ph: 510-835-9900

Orange

Chao Family Comprehensive Cancer Center at University of California Irvine Medical Center

Jason A Zell
Ph: 877-827-8839
Email: ucstudy@uci.edu

Connecticut
Hartford

Saint Francis/Mount Sinai Regional Cancer Center at Saint Francis Hospital and Medical Center

Philip J. Stella
Ph: 734-712-4673

New Haven

Yale Cancer Center

Howard S. Hochster
Ph: 203-785-5702

North Haven

Yale-New Haven Hospital North Haven Medical Center

Howard S. Hochster
Ph: 203-785-5702

Waterbury

Harold Leever Regional Cancer Center

Howard S. Hochster
Ph: 203-785-5702

District of Columbia
Washington

Lombardi Comprehensive Cancer Center at Georgetown University Medical Center

Mohamed E Salem
Ph: 202-444-0381

Washington Cancer Institute at Washington Hospital Center

Mohamed E Salem
Ph: 202-444-0381

Florida
Gainesville

UF Health Cancer Center

Thomas J George
Ph: 352-273-8675
Email: trials@cancer.ufl.edu

Georgia
Savannah

Nancy N. and J. C. Lewis Cancer and Research Pavilion at St. Joseph's/Candler

Mark A. Taylor
Ph: 912-350-8568

Idaho
Boise

Saint Alphonsus Cancer Care Center at Saint Alphonsus Regional Medical Center

Philip J. Stella
Ph: 734-712-4673

Illinois
Aurora

Rush-Copley Cancer Care Center

Ronnie F Luyun
Ph: 800-446-5532

Bloomington

Illinois CancerCare - Bloomington

Nguyet A Le-Lindqwister
Ph: 800-793-2262

St. Joseph Medical Center

James L. Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

Canton

Illinois CancerCare - Canton

James L. Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

Carbondale

Memorial Hospital of Carbondale

James L. Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

Carthage

Illinois CancerCare - Carthage

James L. Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

Centralia

Centralia Oncology Clinic

James L. Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

Chicago

John H. Stroger, Jr. Hospital of Cook County

Michael Russell Mullane
Ph: 312-864-6000

Robert H. Lurie Comprehensive Cancer Center at Northwestern University

Al Bowen Benson
Ph: 312-695-1301
Email: cancer@northwestern.edu

Danville

Carle on Vermilion

Ronnie F Luyun
Ph: 800-446-5532

Decatur

Cancer Care Center of Decatur

James L. Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

Decatur Memorial Hospital Cancer Care Institute

James L. Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

Effingham

Carle Physician Group-Effingham

Ronnie F Luyun
Ph: 800-446-5532

Crossroads Cancer Center

James L. Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

Eureka

Illinois CancerCare - Eureka

James L. Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

Galesburg

Galesburg Clinic, PC

James L. Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

InterCommunity Cancer Center of Western Illinois

James L. Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

Highland Park

Hematology Oncology Associates of Illinois-Highland Park

Al Bowen Benson
Ph: 312-695-1301
Email: cancer@northwestern.edu

Hinsdale

Hinsdale Hematology Oncology Associates

Elyse Cheryl Schneiderman
Ph: 630-654-1790
Email: info@hhoaltd.com

Kankakee

Provena St. Mary's Regional Cancer Center - Kankakee

Al Bowen Benson
Ph: 312-695-1301
Email: cancer@northwestern.edu

Kewanee

Illinois CancerCare - Kewanee Clinic

James L. Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

Libertyville

North Shore Oncology and Hematology Associates, Limited - Libertyville

Al Bowen Benson
Ph: 312-695-1301
Email: cancer@northwestern.edu

Macomb

Illinois CancerCare - Macomb

James L. Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

Mattoon

Carle Physician Group-Mattoon/Charleston

Ronnie F Luyun
Ph: 800-446-5532

Moline

Garneau, Stewart C MD (UIA Investigator)

David M Spector
Ph: 309-779-4200

Spector, David MD (UIA Investigator)

David M Spector
Ph: 309-779-4200

Trinity Cancer Center at Trinity Medical Center - 7th Street Campus

David M Spector
Ph: 309-779-4200

Mount Vernon

Good Samaritan Regional Health Center

Jay W Carlson
Ph: 800-821-7532

Niles

Cancer Care and Hematology Specialists of Chicagoland - Niles

Al Bowen Benson
Ph: 312-695-1301
Email: cancer@northwestern.edu

Ottawa

Illinois CancerCare - Ottawa

James L. Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

Radiation Oncology of Northern Illinois

James L. Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

Pekin

Cancer Treatment Center at Pekin Hospital

James L. Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

Illinois CancerCare - Pekin

James L. Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

Peoria

Illinois CancerCare - Peoria

James L. Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

Methodist Medical Center of Illinois

James L. Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

OSF Saint Francis Medical Center Radiation Oncology Service at the Central Illinois Comprehensive CC

James L. Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

OSF St. Francis Medical Center

James L. Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

Peru

Illinois CancerCare - Princeton

James L. Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

Valley Cancer Center

James L. Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

Princeton

Illinois CancerCare - Princeton

James L. Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

Rockford

Advanced Care and Treatment Medical Group, PC

Harvey Eric Einhorn
Ph: 779-696-9400
Email: cancercare@swedishamerican.org

Skokie

Hematology Oncology Associates - Skokie

Al Bowen Benson
Ph: 312-695-1301
Email: cancer@northwestern.edu

Springfield

Regional Cancer Center at Memorial Medical Center

James L. Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

Urbana

Carle Cancer Center at Carle Foundation Hospital

Ronnie F Luyun
Ph: 800-446-5532

Ronnie F Luyun
Ph: 800-446-5532

Yorkville

Rush-Copley Healthcare Center

Ronnie F Luyun
Ph: 800-446-5532

Indiana
Indianapolis

Indiana University Melvin and Bren Simon Cancer Center

Paul R Helft
Ph: 317-274-2552

Methodist Cancer Center at Methodist Hospital

Paul R Helft
Ph: 317-274-2552

Spring Mill Medical Center

Paul R Helft
Ph: 317-274-2552

William N. Wishard Memorial Hospital

Paul R Helft
Ph: 317-274-2552

Lafayette

Clarian Arnett Cancer Care

Paul R Helft
Ph: 317-274-2552

Merrillville

Premier Oncology Hematology Associates

Bharat H. Barai
Ph: 219-736-2800

Michigan City

Saint Anthony Memorial Health Centers

Ronnie F Luyun
Ph: 800-446-5532

Woodland Cancer Care Center

Ronnie F Luyun
Ph: 800-446-5532

Richmond

Reid Hospital & Health Care Services

Howard M. Gross
Ph: 937-775-1350

Iowa
Ames

McFarland Clinic, PC

Joseph James Merchant
Ph: 515-239-2621

William R. Bliss Cancer Center at Mary Greeley Medical Center

Joseph James Merchant
Ph: 515-239-2621

Bettendorf

Constantinou, Costas L MD (UIA Investigator)

David M Spector
Ph: 309-779-4200

Hematology Oncology Associates of the Quad Cities

Shobha R. Chitneni
Ph: 563-355-7733
Email: kedaprile@rccqc.com

Boone

McFarland Clinic PC-Boone

Joseph James Merchant
Ph: 515-239-2621

Cedar Rapids

Cedar Rapids Oncology Associates

Deborah W Wilbur
Ph: 319-363-2690

Mercy Regional Cancer Center at Mercy Medical Center

Deborah W Wilbur
Ph: 319-363-2690

Davenport

Genesis Regional Cancer Center at Genesis Medical Center

George Kovach
Ph: 800-446-6088
Email: werners@genesishealth.com

Des Moines

CCOP - Iowa Oncology Research Association

Robert J Behrens
Ph: 515-282-2921

John Stoddard Cancer Center at Iowa Lutheran Hospital

Robert J Behrens
Ph: 515-282-2921

John Stoddard Cancer Center at Iowa Methodist Medical Center

Robert J Behrens
Ph: 515-282-2921

Medical Oncology and Hematology Associates at John Stoddard Cancer Center

Robert J Behrens
Ph: 515-282-2921

Fort Dodge

Trinity Regional Medical Center

Joseph James Merchant
Ph: 515-239-2621

Jefferson

McFarland Clinic PC-Jefferson

Joseph James Merchant
Ph: 515-239-2621

Marshalltown

McFarland Clinic PC-Marshalltown

Joseph James Merchant
Ph: 515-239-2621

Mason City

Mercy Cancer Center at Mercy Medical Center - North Iowa

Arvind Y Vemula
Ph: 800-433-3883

Sioux City

Siouxland Hematology-Oncology Associates, LLP

Donald Bruce Wender
Ph: 712-252-0088

West Des Moines

Methodist West Hospital

Robert J Behrens
Ph: 515-282-2921

Kansas
Chanute

Cancer Center of Kansas, PA - Chanute

Shaker R. Dakhil
Ph: 316-262-4467

Dodge City

Cancer Center of Kansas, PA - Dodge City

Shaker R. Dakhil
Ph: 316-262-4467

El Dorado

Cancer Center of Kansas, PA - El Dorado

Shaker R. Dakhil
Ph: 316-262-4467

Fort Scott

Cancer Center of Kansas - Fort Scott

Shaker R. Dakhil
Ph: 316-262-4467

Independence

Cancer Center of Kansas-Independence

Shaker R. Dakhil
Ph: 316-262-4467

Kingman

Cancer Center of Kansas, PA - Kingman

Shaker R. Dakhil
Ph: 316-262-4467

Lawrence

Lawrence Memorial Hospital

Shaker R. Dakhil
Ph: 316-262-4467

Liberal

Cancer Center of Kansas, PA - Liberal

Shaker R. Dakhil
Ph: 316-262-4467

Newton

Cancer Center of Kansas, PA - Newton

Shaker R. Dakhil
Ph: 316-262-4467

Parsons

Cancer Center of Kansas, PA - Parsons

Shaker R. Dakhil
Ph: 316-262-4467

Pratt

Cancer Center of Kansas, PA - Pratt

Shaker R. Dakhil
Ph: 316-262-4467

Salina

Cancer Center of Kansas, PA - Salina

Shaker R. Dakhil
Ph: 316-262-4467

Wellington

Cancer Center of Kansas, PA - Wellington

Shaker R. Dakhil
Ph: 316-262-4467

Wichita

Associates in Women's Health, PA - North Hillside

Shaker R. Dakhil
Ph: 316-262-4467

Cancer Center of Kansas, PA - Medical Arts Tower

Shaker R. Dakhil
Ph: 316-262-4467

Cancer Center of Kansas, PA - Wichita

Shaker R. Dakhil
Ph: 316-262-4467

Via Christi Cancer Center at Via Christi Regional Medical Center

Shaker R. Dakhil
Ph: 316-262-4467

Winfield

Cancer Center of Kansas, PA - Winfield

Shaker R. Dakhil
Ph: 316-262-4467

Kentucky
Crestview Hills

Oncology Hematology Care, Incorporated - Crestview Hills

Howard M. Gross
Ph: 937-775-1350

Louisiana
Baton Rouge

Mary Bird Perkins Cancer Center - Baton Rouge

Augusto C Ochoa
Ph: 504-568-2428
Email: emede1@lsuhsc.edu

Ochsner Health Center - Bluebonnet

Jyotsna Fuloria
Ph: 888-562-4763

Covington

Ochsner Health Center - Covington

Jyotsna Fuloria
Ph: 888-562-4763

New Orleans

Medical Center of Louisiana - New Orleans

Augusto C Ochoa
Ph: 504-568-2428
Email: emede1@lsuhsc.edu

Ochsner Cancer Institute at Ochsner Clinic Foundation

Jyotsna Fuloria
Ph: 888-562-4763

Stanley S. Scott Cancer Center at Louisiana State University Medical Center - New Orleans

Augusto C Ochoa
Ph: 504-568-2428
Email: emede1@lsuhsc.edu

Maryland
Baltimore

Greater Baltimore Medical Center Cancer Center

Gary I. Cohen
Ph: 443-849-3706

Harry and Jeanette Weinberg Cancer Institute at Franklin Square Hospital Center

Mohamed E Salem
Ph: 202-444-0381

Massachusetts
Springfield

Baystate Medical Center

Armen Asik
Ph: 413-794-3565
Email: tamara.wrenn@baystatehealth.org

Michigan
Ann Arbor

Saint Joseph Mercy Cancer Center

Philip J. Stella
Ph: 734-712-4673

University of Michigan Comprehensive Cancer Center

John C Krauss
Ph: 800-865-1125

Battle Creek

Battle Creek Health System Cancer Care Center

Gilbert D Padula
Ph: 616-685-5225
Email: connie.szczepanek@grcop.org

Dearborn

Oakwood Cancer Center at Oakwood Hospital and Medical Center

Philip J. Stella
Ph: 734-712-4673

Detroit

Van Elslander Cancer Center at St. John Hospital and Medical Center

Philip J. Stella
Ph: 734-712-4673

Escanaba

Green Bay Oncology, Limited - Escanaba

Brian L Burnette
Ph: 800-432-6049

Flint

Genesys Hurley Cancer Institute

Philip J. Stella
Ph: 734-712-4673

Hurley Medical Center

Philip J. Stella
Ph: 734-712-4673

Grand Rapids

Butterworth Hospital at Spectrum Health

Gilbert D Padula
Ph: 616-685-5225
Email: connie.szczepanek@grcop.org

Lacks Cancer Center at Saint Mary's Health Care

Gilbert D Padula
Ph: 616-685-5225
Email: connie.szczepanek@grcop.org

Iron Mountain

Green Bay Oncology - Iron Mountain

Brian L Burnette
Ph: 800-432-6049

Jackson

Gayle M. Jacob Cancer Center at Allegiance Health

Philip J. Stella
Ph: 734-712-4673

Kalamazoo

Borgess Medical Center

Raymond Sterling Lord
Ph: 269-373-7458

Bronson Methodist Hospital

Raymond Sterling Lord
Ph: 269-373-7458

West Michigan Cancer Center

Raymond Sterling Lord
Ph: 269-373-7458

Lansing

Sparrow Regional Cancer Center

Philip J. Stella
Ph: 734-712-4673

Livonia

St. Mary Mercy Hospital

Philip J. Stella
Ph: 734-712-4673

Muskegon

Mercy General Health Partners

Gilbert D Padula
Ph: 616-685-5225
Email: connie.szczepanek@grcop.org

Niles

Lakeland Hospital - Niles

Gilbert D Padula
Ph: 616-685-5225
Email: connie.szczepanek@grcop.org

Pontiac

St. Joseph Mercy Oakland

Philip J. Stella
Ph: 734-712-4673

Port Huron

Mercy Regional Cancer Center at Mercy Hospital

Philip J. Stella
Ph: 734-712-4673

Reed City

Spectrum Health Reed City Hospital

Gilbert D Padula
Ph: 616-685-5225
Email: connie.szczepanek@grcop.org

Saginaw

Seton Cancer Institute at Saint Mary's - Saginaw

Philip J. Stella
Ph: 734-712-4673

Saint Joseph

Lakeside Cancer Specialists, PLLC

Gilbert D Padula
Ph: 616-685-5225
Email: connie.szczepanek@grcop.org

St. Joseph

Lakeland Regional Cancer Care Center - St. Joseph

Gilbert D Padula
Ph: 616-685-5225
Email: connie.szczepanek@grcop.org

Traverse City

Munson Medical Center

Gilbert D Padula
Ph: 616-685-5225
Email: connie.szczepanek@grcop.org

Warren

St. John Macomb Hospital

Philip J. Stella
Ph: 734-712-4673

Minnesota
Bemidji

MeritCare Bemidji

Preston D. Steen
Ph: 701-234-6161

Burnsville

Fairview Ridges Hospital

Patrick J. Flynn
Ph: 952-993-1517
Email: MMCCOP@parknicollet.com

Coon Rapids

Mercy and Unity Cancer Center at Mercy Hospital

Patrick J. Flynn
Ph: 952-993-1517
Email: MMCCOP@parknicollet.com

Duluth

CCOP - Duluth

Bret E Friday
Ph: 888-203-7267

Essentia Health - Duluth Clinic

Daniel Nikcevich
Ph: 888-203-7267

Miller - Dwan Medical Center

Daniel Nikcevich
Ph: 888-203-7267

Edina

Fairview Southdale Hospital

Patrick J. Flynn
Ph: 952-993-1517
Email: MMCCOP@parknicollet.com

Fridley

Mercy and Unity Cancer Center at Unity Hospital

Patrick J. Flynn
Ph: 952-993-1517
Email: MMCCOP@parknicollet.com

Hutchinson

Hutchinson Area Health Care

Patrick J. Flynn
Ph: 952-993-1517
Email: MMCCOP@parknicollet.com

Maplewood

HealthEast Cancer Care at St. John's Hospital

Patrick J. Flynn
Ph: 952-993-1517
Email: MMCCOP@parknicollet.com

Minnesota Oncology - Maplewood

Patrick J. Flynn
Ph: 952-993-1517
Email: MMCCOP@parknicollet.com

Minneapolis

Health Partners Inc

Patrick J. Flynn
Ph: 952-993-1517
Email: MMCCOP@parknicollet.com

Hennepin County Medical Center - Minneapolis

Patrick J. Flynn
Ph: 952-993-1517
Email: MMCCOP@parknicollet.com

Virginia Piper Cancer Institute at Abbott - Northwestern Hospital

Patrick J. Flynn
Ph: 952-993-1517
Email: MMCCOP@parknicollet.com

Robbinsdale

Humphrey Cancer Center at North Memorial Outpatient Center

Patrick J. Flynn
Ph: 952-993-1517
Email: MMCCOP@parknicollet.com

Saint Louis Park

Park Nicollet Cancer Center

Patrick J. Flynn
Ph: 952-993-1517
Email: MMCCOP@parknicollet.com

Saint Paul

Regions Hospital Cancer Care Center

Patrick J. Flynn
Ph: 952-993-1517
Email: MMCCOP@parknicollet.com

United Hospital

Patrick J. Flynn
Ph: 952-993-1517
Email: MMCCOP@parknicollet.com

Shakopee

St. Francis Cancer Center at St. Francis Medical Center

Patrick J. Flynn
Ph: 952-993-1517
Email: MMCCOP@parknicollet.com

Waconia

Ridgeview Medical Center

Patrick J. Flynn
Ph: 952-993-1517
Email: MMCCOP@parknicollet.com

Willmar

Willmar Cancer Center at Rice Memorial Hospital

Patrick J. Flynn
Ph: 952-993-1517
Email: MMCCOP@parknicollet.com

Woodbury

Minnesota Oncology - Woodbury

Patrick J. Flynn
Ph: 952-993-1517
Email: MMCCOP@parknicollet.com

Missouri
Bolivar

Central Care Cancer Center at Carrie J. Babb Cancer Center

Jay W Carlson
Ph: 800-821-7532

Bonne Terre

Parkland Health Center-Bonne Terre

James L. Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

Branson

Skaggs Cancer Center at Skaggs Regional Medical Center

Jay W Carlson
Ph: 800-821-7532

Cape Girardeau

Saint Francis Medical Center

James L. Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

Southeast Cancer Center

James L. Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

Jefferson City

Goldschmidt Cancer Center

James L. Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

Rolla

Mercy Clinic Cancer and Hematology - Rolla

Jay W Carlson
Ph: 800-821-7532

Phelps County Regional Medical Center

Jay W Carlson
Ph: 800-821-7532

Saint Louis

David C. Pratt Cancer Center at St. John's Mercy

Jay W Carlson
Ph: 800-821-7532

Mercy Clinic St. Louis Cancer and Breast Institute

Jay W Carlson
Ph: 800-821-7532

Missouri Baptist Cancer Center

James L. Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

Siteman Cancer Center at Barnes-Jewish Hospital - Saint Louis

Benjamin R Tan
Ph: 800-600-3606
Email: info@siteman.wustl.edu

Springfield

Hulston Cancer Center at Cox Medical Center South

Jay W Carlson
Ph: 800-821-7532

St. John's Regional Health Center

Jay W Carlson
Ph: 800-821-7532

Sullivan

Missouri Baptist Sullivan Hospital

James L. Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

Sunset Hills

Missouri Baptist Outpatient Center-Sunset Hills

James L. Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

Nebraska
Lincoln

Cancer Resource Center - Lincoln

Gamini S. Soori
Ph: 402-991-8070ext202
Email: mwilwerding@mvcc.cc

Nebraska Hematology and Oncology

Gamini S. Soori
Ph: 402-991-8070ext202
Email: mwilwerding@mvcc.cc

Southeast Nebraska Hematology Oncology Consultants at Southeast Nebraska Cancer Center

Gamini S. Soori
Ph: 402-991-8070
Email: mwilwerding@mvcc.cc

Norfolk

Carson Cancer Center at Faith Regional Hospital

Gamini S. Soori
Ph: 402-991-8070ext202
Email: mwilwerding@mvcc.cc

North Platte

Callahan Cancer Center at Great Plains Regional Medical Center

Gamini S. Soori
Ph: 402-991-8070ext202
Email: mwilwerding@mvcc.cc

Omaha

CCOP - Missouri Valley Cancer Consortium

Gamini S. Soori
Ph: 402-991-8070ext202
Email: mwilwerding@mvcc.cc

Oncology Hematology West PC

Gamini S. Soori
Ph: 402-991-8070ext202
Email: mwilwerding@mvcc.cc

Oncology Hematology West, PC - Omaha Bergan

Gamini S. Soori
Ph: 402-991-8070ext202
Email: mwilwerding@mvcc.cc

Scottsbluff

Cancer Treatment Center at Regional West Medical Center

Gamini S. Soori
Ph: 402-991-8070ext202
Email: mwilwerding@mvcc.cc

New Jersey
East Orange

Veterans Affairs Medical Center - East Orange

Victor T Chang
Ph: 800-475-2336
Email: patricia.goyer@med.va.gov

Somerville

Somerset Medical Center

Jonathan Z Rosenbluth
Ph: 908-685-2481

Vineland

Frank and Edith Scarpa Regional Cancer Pavillion at South Jersey Healthcare

Carl J. Minniti
Ph: 856-641-7933

Woodbury

Underwood Memorial Hospital

Carl J. Minniti
Ph: 856-641-7933

New Mexico
Albuquerque

University of New Mexico Cancer Center

Howard S. Hochster

North Carolina
Clinton

Southeastern Medical Oncology Center-Clinton

James N. Atkins
Ph: 919-580-0000

Goldsboro

Southeastern Medical Oncology Center - Goldsboro

James N. Atkins
Ph: 919-580-0000

Wayne Memorial Hospital, Incorporated

James N. Atkins
Ph: 919-580-0000

Hendersonville

Comprehensive Cancer Center at Pardee Hospital

James E. Radford
Ph: 828-696-4716

Hendersonville Hematology and Oncology

James E. Radford
Ph: 828-696-4716

Jacksonville

Southeastern Medical Oncology Center-Jacksonville

James N. Atkins
Ph: 919-580-0000

Kinston

Kinston Medical Specialists

Peter R. Watson
Ph: 252-559-2200

Statesville

Iredell Memorial Hospital

Ruby A. Grimm
Ph: 704-873-5661

Wilson

Southeastern Medical Oncology Center - Wilson

James N. Atkins
Ph: 919-580-0000

North Dakota
Bismarck

Medcenter One Hospital Cancer Care Center

Preston D. Steen
Ph: 701-234-6161

Fargo

Roger Maris Cancer Center at MeritCare Hospital

Preston D. Steen
Ph: 701-234-6161

Preston D. Steen
Ph: 701-234-6161

Sanford Clinic North-Fargo

Preston D. Steen
Ph: 701-234-6161

Grand Forks

Altru Cancer Center at Altru Hospital

Grant R Seeger
Ph: 701-780-6520

Ohio
Belpre

Strecker Cancer Center-Belpre

J. Philip Kuebler
Ph: 614-566-3275

Chillicothe

Adena Regional Medical Center

J. Philip Kuebler
Ph: 614-566-3275

Cincinnati

Bethesda North Hospital

David J Draper
Ph: 513-862-2230

Good Samaritan Hospital Cancer Treatment Center

David J Draper
Ph: 513-862-2230

Oncology Hematology Care Inc - Western Hills

Howard M. Gross
Ph: 937-775-1350

Oncology Hematology Care, Incorporated - Anderson

Howard M. Gross
Ph: 937-775-1350

Oncology Hematology Care, Incorporated - Blue Ash

Howard M. Gross
Ph: 937-775-1350

Oncology Hematology Care, Incorporated - Kenwood

Howard M. Gross
Ph: 937-775-1350

Oncology Hematology Care, Incorporated - Mt. Auburn/Taft Road

Howard M. Gross
Ph: 937-775-1350

TriHealth Cancer Institute-Anderson

David J Draper
Ph: 513-862-2230

TriHealth Cancer Institute-Westside

David J Draper
Ph: 513-862-2230

University of Cincinnati

Olugbenga Olowokure (Gbenga)
Ph: 513-558-4553
Email: uchealthnews@uc.edu

Cleveland

MetroHealth Cancer Care Center at MetroHealth Medical Center

Bruce J. Averbook
Ph: 216-778-8526
Email: kbauchens@metrohealth.org

Columbus

Columbus Oncology Associates, Incorporated

J. Philip Kuebler
Ph: 614-566-3275

Doctors Hospital at Ohio Health

J. Philip Kuebler
Ph: 614-566-3275

Grant Medical Center Cancer Care

J. Philip Kuebler
Ph: 614-566-3275

Mount Carmel Health - West Hospital

J. Philip Kuebler
Ph: 614-566-3275

Riverside Methodist Hospital Cancer Care

J. Philip Kuebler
Ph: 614-566-3275

Zangmeister Center

J. Philip Kuebler
Ph: 614-566-3275

Dayton

David L. Rike Cancer Center at Miami Valley Hospital

Howard M. Gross
Ph: 937-775-1350

Good Samaritan Hospital

Howard M. Gross
Ph: 937-775-1350

Samaritan North Cancer Care Center

Howard M. Gross
Ph: 937-775-1350

Delaware

Delaware Health Center

J. Philip Kuebler
Ph: 614-566-3275

Delaware Radiation Oncology

J. Philip Kuebler
Ph: 614-566-3275

Grady Memorial Hospital

J. Philip Kuebler
Ph: 614-488-2745
Email: sheree@columbusccop.org

Fairfield

Oncology Hematology Care, Incorporated - Fairfield Healthplex

Howard M. Gross
Ph: 937-775-1350

Findlay

Blanchard Valley Regional Cancer Center

Howard M. Gross
Ph: 937-775-1350

Franklin

Atrium Medical Center

Howard M. Gross
Ph: 937-775-1350

Greenville

Wayne Hospital

Howard M. Gross
Ph: 937-775-1350

Kettering

Charles F. Kettering Memorial Hospital

Howard M. Gross
Ph: 937-775-1350

Lancaster

Fairfield Medical Center

J. Philip Kuebler
Ph: 614-566-3275

Lima

St. Rita's Medical Center

Henry Gerad
Ph: 419-226-9617

Marietta

Strecker Cancer Center at Marietta Memorial Hospital

J. Philip Kuebler
Ph: 614-566-3275

Mount Vernon

Knox Community Hospital

J. Philip Kuebler
Ph: 614-566-3275

Newark

Licking Memorial Cancer Care Program at Licking Memorial Hospital

J. Philip Kuebler
Ph: 614-566-3275

Newark Radiation Oncology

J. Philip Kuebler
Ph: 614-566-3275

Portsmouth

Southern Ohio Medical Center Cancer Center

J. Philip Kuebler
Ph: 614-566-3275

Springfield

Community Hospital of Springfield and Clark County

J. Philip Kuebler
Ph: 614-488-2745
Email: sheree@columbusccop.org

Troy

UVMC Cancer Care Center at Upper Valley Medical Center

Howard M. Gross
Ph: 937-775-1350

West Chester

University Pointe

Olugbenga Olowokure (Gbenga)
Ph: 513-558-4553
Email: uchealthnews@uc.edu

Westerville

Mount Carmel St. Ann's Cancer Center

J. Philip Kuebler
Ph: 614-566-3275

Wright-Patterson Afb

United States Air Force Medical Center - Wright-Patterson

Brandon J Cutler
Ph: 937-257-1398

Zanesville

Genesis - Good Samaritan Hospital

J. Philip Kuebler
Ph: 614-488-2745
Email: sheree@columbusccop.org

Oklahoma
Oklahoma City

Stephenson Cancer Center at the University of Oklahoma

Shubham Pant
Ph: 405-271-4272
Email: julie-traylor@ouhsc.edu

Tulsa

Cancer Care Associates-Yale

Shubham Pant
Ph: 405-271-4272
Email: julie-traylor@ouhsc.edu

Pennsylvania
Bethlehem

St. Luke's Cancer Network at St. Luke's Hospital

Sanjiv S. Agarwala
Ph: 610-954-3582
Email: infolink@slhn.org

Bryn Mawr

Bryn Mawr Hospital

Albert S DeNittis
Ph: 866-225-5654

Danville

Geisinger Cancer Institute at Geisinger Health

Ying M Zeng
Ph: 570-271-5251

Drexel Hill

Delaware County Regional Cancer Center at Delaware County Memorial Hospital

Stephen A. Shore
Ph: 610-284-8237
Email: jolene.garney@crozer.org

Harrisburg

PinnacleHealth Regional Cancer Center at Polyclinic Hospital

Robert Alan Gordon
Ph: 717-724-6765
Email: klitchfield@PINNACLEHEALTH.org

Hazleton

Geisinger Hazleton Cancer Center

Ying M Zeng
Ph: 570-271-5251

Lewistown

Lewistown Hospital

Ying M Zeng
Ph: 570-271-5251

Media

Riddle Memorial Hospital Cancer Center

Albert S DeNittis
Ph: 866-225-5654

Paoli

Cancer Center of Paoli Memorial Hospital

Albert S DeNittis
Ph: 866-225-5654

Philadelphia

Abramson Cancer Center of the University of Pennsylvania

Bruce J Giantonio
Ph: 800-474-9892

Fox Chase Cancer Center - Philadelphia

Steven J. Cohen
Ph: 215-728-4790

Joan Karnell Cancer Center at Pennsylvania Hospital

Lee Hartner
Ph: 800-474-9892

Kimmel Cancer Center at Thomas Jefferson University - Philadelphia

Edith P. Mitchell
Ph: 215-955-6084

Pottstown

Pottstown Memorial Regional Cancer Center

Wei Song
Ph: 610-327-7544

Scranton

Hematology and Oncology Associates of North East Pennsylvania

Edith P. Mitchell
Ph: 215-955-6084

Scranton Hematology Oncology

Martin B. Hyzinski
Ph: 570-558-3020

State College

Geisinger Medical Group - Scenery Park

Ying M Zeng
Ph: 570-271-5251

West Chester

Cancer Center of Chester County

William E. Luginbuhl
Ph: 610-431-5297

West Reading

McGlinn Family Regional Cancer Center at Reading Hospital and Medical Center

Terrence P. Cescon
Ph: 610-988-9323

Wilkes-Barre

Frank M. and Dorothea Henry Cancer Center at Geisinger Wyoming Valley Medical Center

Ying M Zeng
Ph: 570-271-5251

Wynnewood

Lankenau Cancer Center at Lankenau Hospital

Albert S DeNittis
Ph: 866-225-5654

South Carolina
Easley

Cancer Centers of the Carolinas - Easley

Jeffrey Kent Giguere
Ph: 864-241-6251

Florence

McLeod Regional Medical Center

Rajesh Bajaj
Ph: 843-679-7256

Greenville

Cancer Centers of the Carolinas - Andrews

Jeffrey Kent Giguere
Ph: 864-241-6251

Cancer Centers of the Carolinas - Faris Road

Jeffrey Kent Giguere
Ph: 864-241-6251

Cancer Centers of the Carolinas - Grove Commons

Jeffrey Kent Giguere
Ph: 864-241-6251

CCOP - Greenville

Jeffrey Kent Giguere
Ph: 864-241-6251

Greenville Memorial Hospital

Jeffrey Kent Giguere
Ph: 864-241-6251

Greer

Cancer Centers of the Carolinas - Greer Radiation Oncology

Jeffrey Kent Giguere
Ph: 864-241-6251

Seneca

Cancer Centers of the Carolinas - Seneca

Jeffrey Kent Giguere
Ph: 864-241-6251

Spartanburg

Cancer Centers of the Carolinas - Spartanburg

Jeffrey Kent Giguere
Ph: 864-241-6251

South Dakota
Sioux Falls

Sanford Cancer Center at Sanford USD Medical Center

Preston D. Steen
Ph: 701-234-6161

Preston D. Steen
Ph: 701-234-6161

Tennessee
Bristol

Wellmont-Bristol Regional Medical Center

Asheesh Shipstone
Ph: 423-578-8538

Johnson City

Wellmont Medical Associates Oncology and Hematology-Johnson City

Asheesh Shipstone
Ph: 423-578-8538

Kingsport

Christine LaGuardia Phillips Cancer Center at Wellmont Holston Valley Medical Center

Asheesh Shipstone
Ph: 423-578-8538

Kingsport Hematology-Oncology Associates

Asheesh Shipstone
Ph: 423-578-8538

Texas
Austin

University Medical Center Brackenridge

Om N Pandey
Ph: 512-324-7991

Dallas

Parkland Memorial Hospital

Udit Verma
Ph: 214-648-7097

Simmons Comprehensive Cancer Center at University of Texas Southwestern Medical Center - Dallas

Udit Verma
Ph: 214-648-7097

Lubbock

Covenant Medical Center

Ibrahim A Shalaby
Ph: 806-725-8000
Email: jaccresearch@covhs.org

Virginia
Martinsville

Ravenel Oncology Center at Memorial Hospital of Martinsville and Henry County

Sreedhar Katragadda
Ph: 276-666-7827

Norton

Southwest Virginia Regional Cancer Center at Wellmonth Health

Asheesh Shipstone
Ph: 423-578-8538

West Virginia
Charleston

West Virginia University Medical School - Charleston

Steven J. Jubelirer
Ph: 304-344-3457

Wisconsin
Antigo

Langlade Memorial Hospital

Hamied R. Rezazadeh
Ph: 877-405-6866

Green Bay

Green Bay Oncology, Limited at St. Mary's Hospital

Brian L Burnette
Ph: 800-432-6049

Green Bay Oncology, Limited at St. Vincent Hospital Regional Cancer Center

Brian L Burnette
Ph: 800-432-6049

St. Mary's Hospital Medical Center - Green Bay

Brian L Burnette
Ph: 800-432-6049

St. Vincent Hospital Regional Cancer Center

Brian L Burnette
Ph: 800-432-6049

La Crosse

Gundersen Lutheran Center for Cancer and Blood

Kurt Oettel
Ph: 608-775-2385
Email: cancerctr@gundluth.org

Manitowoc

Holy Family Memorial Medical Center Cancer Care Center

Brian L Burnette
Ph: 800-432-6049

Marinette

Bay Area Cancer Care Center at Bay Area Medical Center

Brian L Burnette
Ph: 800-432-6049

Mukwonago

D.N. Greenwald Center

Timothy R Wassenaar
Ph: 262-928-7878

New Richmond

Cancer Center of Western Wisconsin

Patrick J. Flynn
Ph: 952-993-1517
Email: MMCCOP@parknicollet.com

Oconomowoc

Regional Cancer Center at Oconomowoc Memorial Hospital

Timothy R Wassenaar
Ph: 262-928-7878

Oconto Falls

Green Bay Oncology, Limited - Oconto Falls

Brian L Burnette
Ph: 800-432-6049

Sheboygan

Saint Nicholas Hospital

Brian L Burnette
Ph: 800-432-6049

Sturgeon Bay

Green Bay Oncology, Limited - Sturgeon Bay

Brian L Burnette
Ph: 800-432-6049

Waukesha

Waukesha Memorial Hospital Regional Cancer Center

Timothy R Wassenaar
Ph: 262-928-7878

Wausau

University of Wisconcin Cancer Center at Aspirus Wausau Hospital

Hamied R. Rezazadeh
Ph: 877-405-6866

Wisconsin Rapids

Riverview UW Cancer Center at Riverview Hospital

Ron James Kirschling
Ph: 877-405-6866

Link to the current ClinicalTrials.gov record.
NLM Identifier NCT01079780
ClinicalTrials.gov processed this data on February 27, 2015

Note: Information about this trial is from the ClinicalTrials.gov database. The versions designated for health professionals and patients contain the same text. Minor changes may be made to the ClinicalTrials.gov record to standardize the names of study sponsors, sites, and contacts. Cancer.gov only lists sites that are recruiting patients for active trials, whereas ClinicalTrials.gov lists all sites for all trials. Questions and comments regarding the presented information should be directed to ClinicalTrials.gov.