Pemetrexed Disodium or Observation in Treating Patients With Malignant Pleural Mesothelioma Without Progressive Disease After First-Line Chemotherapy

  • Resize font
  • Print
  • Email
  • Facebook
  • Twitter
  • Google+
  • Pinterest

Basic Trial Information

PhaseTypeStatusAgeSponsorProtocol IDs
Phase IITreatmentActive18 and overNCI, OtherCDR0000667496
CALGB-30901, NCT01085630

Trial Description

Summary

RATIONALE: Pemetrexed disodium may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.

PURPOSE: This randomized phase II trial is studying how well pemetrexed disodium or observation works in treating patients with malignant pleural mesothelioma without progressive disease after first-line chemotherapy.

Further Study Information

OBJECTIVES:

Primary

  • To determine if maintenance therapy with pemetrexed disodium versus observation improves progression-free survival of patients with malignant pleural mesothelioma who have at least stable disease after completion of first-line therapy comprising pemetrexed disodium with cisplatin or carboplatin.

Secondary

  • To determine the overall survival of patients treated with this regimen versus observation.
  • To evaluate the frequency of responses in patients treated with this regimen.
  • To assess the toxicity of this regimen in these patients.

OUTLINE: This is a multicenter study. Patients are stratified according to first-line chemotherapy regimen (cisplatin/pemetrexed disodium vs carboplatin/pemetrexed disodium), histologic subtype (epithelioid vs other) and number of courses received (< 6 vs 6).

  • Arm I: Patients receive pemetrexed disodium IV over 10 minutes on day 1. Treatment repeats every 21 days in the absence of disease progression or unacceptable toxicity.
  • Arm II: Patients undergo observation until disease progression. After completion of study therapy, patients are followed up every 6 months for 3 years.

Eligibility Criteria

DISEASE CHARACTERISTICS:

  • Histologically confirmed malignant pleural mesothelioma meeting 1 of the following cell types:
  • Epithelial
  • Sarcomatoid
  • Mixed type
  • Disease not amenable to surgery
  • Must be enrolled on imaging protocol CALGB-580903
  • Complete response, partial response, or stable disease after completion of 4 courses of first-line chemotherapy comprising pemetrexed disodium AND cisplatin or carboplatin
  • Study therapy will begin within 9 weeks following day 1 of cycle 4 of first-line treatment
  • No clinically significant pleural or peritoneal effusions that cannot be adequately managed by drainage before or during pemetrexed disodium

PATIENT CHARACTERISTICS:

  • ECOG performance status of 0-1
  • Life expectancy ≥ 12 weeks
  • Granulocytes ≥ 1,500/μL
  • Platelet count ≥ 100,000/μL
  • Total bilirubin ≤ 1.5 times upper limit of normal (ULN)
  • AST ≤ 2 times ULN
  • Creatinine clearance ≥ 45 mL/min
  • Not pregnant or nursing
  • Negative pregnancy test
  • Fertile patients must use effective contraception
  • No psychiatric illness that would prevent the patient from giving informed consent
  • No second malignancy except non-melanoma skin cancer or carcinoma in situ of the cervix unless curatively treated with no evidence of active disease for ≥ 5 years
  • No medical conditions that, in the opinion of the treating physician, would make study treatment unreasonably hazardous for the patient including, but not limited to, the following:
  • Ongoing or active infection such as HIV positivity
  • Inability to take oral medications
  • Psychiatric illness/social situations that would limit compliance with study requirements

PRIOR CONCURRENT THERAPY:

  • See Disease Characteristics
  • Prior intracavitary cytotoxic or sclerosing therapy (including bleomycin) allowed
  • Prior intrapleural cytotoxic chemotherapy not considered systemic chemotherapy
  • Prior surgery allowed
  • Prior radiotherapy allowed
  • No concurrent palliative radiotherapy
  • No concurrent hormones or other chemotherapeutic agents except for the following:
  • Steroids for adrenal failure
  • Hormones for nondisease-related conditions (e.g., insulin for diabetes)
  • Intermittent use of dexamethasone as an antiemetic or premedication for pemetrexed disodium

Trial Contact Information

Trial Lead Organizations/Sponsors

Cancer and Leukemia Group B

  • National Cancer Institute
Arkadiusz Dudek, Principal Investigator

Trial Sites

U.S.A.

Alaska
Anchorage

Alaska Women's Cancer Care

Alison K Conlin
Ph: 503-215-6412

Providence Cancer Center

Alison K Conlin
Ph: 503-215-6412

California
Loma Linda

Loma Linda University Cancer Institute at Loma Linda University Medical Center

Hamid R Mirshahidi
Ph: 909-558-3375

Palo Alto

Stanford Cancer Center

Joel W Neal
Ph: 650-498-7061
Email: ccto-office@stanford.edu

Veterans Affairs Medical Center - Palo Alto

Joel W Neal
Ph: 650-498-7061
Email: ccto-office@stanford.edu

Colorado
Aurora

Rocky Mountain Cancer Centers - Aurora

Keren Sturtz
Ph: 888-785-6789

Boulder

Rocky Mountain Cancer Centers-Boulder

Keren Sturtz
Ph: 888-785-6789

Colorado Springs

Penrose Cancer Center at Penrose Hospital

Keren Sturtz
Ph: 888-785-6789

Denver

CCOP - Colorado Cancer Research Program

Keren Sturtz
Ph: 888-785-6789

Porter Adventist Hospital

Keren Sturtz
Ph: 888-785-6789

Presbyterian - St. Luke's Medical Center

Keren Sturtz
Ph: 888-785-6789

Rose Medical Center

Keren Sturtz
Ph: 888-785-6789

St. Joseph Hospital

Keren Sturtz
Ph: 888-785-6789

Durango

Mercy Medical Center

Keren Sturtz
Ph: 888-785-6789

Englewood

Swedish Medical Center

Keren Sturtz
Ph: 888-785-6789

Greeley

North Colorado Medical Center

Keren Sturtz
Ph: 888-785-6789

Lakewood

Rocky Mountain Cancer Centers-Lakewood

Keren Sturtz
Ph: 888-785-6789

Littleton

Rocky Mountain Cancer Centers - Littleton

Keren Sturtz
Ph: 888-785-6789

Lone Tree

Rocky Mountain Cancer Centers - Lone Tree

Keren Sturtz
Ph: 888-785-6789

Longmont

Hope Cancer Care Center at Longmont United Hospital

Keren Sturtz
Ph: 888-785-6789

Loveland

McKee Medical Center

Keren Sturtz
Ph: 888-785-6789

Parker

Parker Adventist Hospital

Keren Sturtz
Ph: 888-785-6789

Pueblo

St. Mary - Corwin Regional Medical Center

Keren Sturtz
Ph: 888-785-6789

Thornton

Rocky Mountain Cancer Centers - Thornton

Keren Sturtz
Ph: 888-785-6789

Wheat Ridge

Exempla Lutheran Medical Center

Keren Sturtz
Ph: 888-785-6789

Connecticut
Hartford

Saint Francis/Mount Sinai Regional Cancer Center at Saint Francis Hospital and Medical Center

Philip J. Stella
Ph: 734-712-4673

New Britain

George Bray Cancer Center at the Hospital of Central Connecticut - New Britain Campus

Brian J Byrne
Ph: 860-224-5660

Delaware
Lewes

Tunnell Cancer Center at Beebe Medical Center

Stephen Scott Grubbs
Ph: 302-733-6227

Newark

Christiana Gynecologic Oncology, LLC

Stephen Scott Grubbs
Ph: 302-733-6227

Delaware Clinical and Laboratory Physicians

Stephen Scott Grubbs
Ph: 302-733-6227

Helen F. Graham Cancer Center at Christiana Hospital

Stephen Scott Grubbs
Ph: 302-733-6227

Stephen Scott Grubbs
Ph: 302-733-6227

Medical Oncology Hematology Consultants, PA at Helen F. Graham Cancer Center

Stephen Scott Grubbs
Ph: 302-733-6227

Regional Hematology/Oncology, PA - Newark

Stephen Scott Grubbs
Ph: 302-733-6227

Rehoboth Beach

Beebe Health Campus

Stephen Scott Grubbs
Ph: 302-733-6227

Seaford

Nanticoke Memorial Hospital

Stephen Scott Grubbs
Ph: 302-733-6227

Wilmington

Christiana Care Health System-Wilmington Hospital

Stephen Scott Grubbs
Ph: 302-733-6227

Idaho
Boise

Saint Alphonsus Cancer Care Center at Saint Alphonsus Regional Medical Center

Philip J. Stella
Ph: 734-712-4673

Illinois
Bloomington

Illinois CancerCare - Bloomington

James L. Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

St. Joseph Medical Center

Nguyet A Le-Lindqwister
Ph: 800-793-2262

Canton

Illinois CancerCare - Canton

James L. Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

Carbondale

Memorial Hospital of Carbondale

James L. Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

Carthage

Illinois CancerCare - Carthage

James L. Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

Centralia

Centralia Oncology Clinic

James L. Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

Chicago

University of Chicago Cancer Research Center

Hedy L. Kindler
Ph: 773-834-7424

University of Illinois Cancer Center

Arkadiusz Z Dudek
Ph: 312-355-3046

Decatur

Cancer Care Center of Decatur

James L. Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

Decatur Memorial Hospital Cancer Care Institute

James L. Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

Effingham

Crossroads Cancer Center

James L. Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

Eureka

Illinois CancerCare - Eureka

James L. Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

Galesburg

Galesburg Clinic, PC

James L. Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

InterCommunity Cancer Center of Western Illinois

James L. Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

Medical and Surgical Specialists, LLC

Nguyet A Le-Lindqwister
Ph: 800-793-2262

Kewanee

Illinois CancerCare - Kewanee Clinic

James L. Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

Macomb

Illinois CancerCare - Macomb

James L. Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

Ottawa

Illinois CancerCare - Ottawa

James L. Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

Radiation Oncology of Northern Illinois

James L. Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

Pekin

Cancer Treatment Center at Pekin Hospital

James L. Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

Illinois CancerCare - Pekin

Nguyet A Le-Lindqwister
Ph: 800-793-2262

Peoria

Illinois CancerCare - Peoria

James L. Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

Methodist Medical Center of Illinois

James L. Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

OSF St. Francis Medical Center

James L. Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

Peru

Illinois CancerCare - Princeton

James L. Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

Valley Cancer Center

James L. Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

Princeton

Illinois CancerCare - Princeton

James L. Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

Springfield

Central Illinois Hematology Oncology Center

James L. Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

Regional Cancer Center at Memorial Medical Center

James L. Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

Simmons Cooper Cancer Institute

James L. Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

Springfield Clinic - Main Campus

James L. Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

Swansea

Cancer Care Specialists of Illinois-Swansea

James L. Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

Indiana
Elkhart

Michiana Hematology-Oncology, PC - Elkhart

Rafat H. Ansari
Ph: 574-234-5123

Mishawaka

Memorial Regional Cancer Center Day Road

Thomas Joseph Reid
Ph: 800-284-7370

Michiana Hematology-Oncology, PC - Mishawaka

Rafat H. Ansari
Ph: 574-234-5123

Saint Joseph's Medical Center

Rafat H. Ansari
Ph: 574-234-5123

Plymouth

Michiana Hematology Oncology PC - Plymouth

Rafat H. Ansari
Ph: 574-234-5123

South Bend

CCOP - Northern Indiana CR Consortium

Rafat H. Ansari
Ph: 574-234-5123

Memorial Hospital of South Bend

Thomas Joseph Reid
Ph: 800-284-7370

Michiana Hematology-Oncology, PC - South Bend

Rafat H. Ansari
Ph: 574-234-5123

Westville

Michiana Hematology Oncology-PC Westville

Rafat H. Ansari
Ph: 574-234-5123

Iowa
Sioux City

Siouxland Hematology-Oncology Associates, LLP

Donald Bruce Wender
Ph: 712-252-0088

Kansas
Chanute

Cancer Center of Kansas, PA - Chanute

Shaker R. Dakhil
Ph: 316-262-4467

Dodge City

Cancer Center of Kansas, PA - Dodge City

Shaker R. Dakhil
Ph: 316-262-4467

El Dorado

Cancer Center of Kansas, PA - El Dorado

Shaker R. Dakhil
Ph: 316-262-4467

Fort Scott

Cancer Center of Kansas - Fort Scott

Shaker R. Dakhil
Ph: 316-262-4467

Independence

Cancer Center of Kansas-Independence

Shaker R. Dakhil
Ph: 316-262-4467

Kingman

Cancer Center of Kansas, PA - Kingman

Shaker R. Dakhil
Ph: 316-262-4467

Lawrence

Lawrence Memorial Hospital

Shaker R. Dakhil
Ph: 316-262-4467

Liberal

Cancer Center of Kansas, PA - Liberal

Shaker R. Dakhil
Ph: 316-262-4467

Newton

Cancer Center of Kansas, PA - Newton

Shaker R. Dakhil
Ph: 316-262-4467

Parsons

Cancer Center of Kansas, PA - Parsons

Shaker R. Dakhil
Ph: 316-262-4467

Pratt

Cancer Center of Kansas, PA - Pratt

Shaker R. Dakhil
Ph: 316-262-4467

Salina

Cancer Center of Kansas, PA - Salina

Shaker R. Dakhil
Ph: 316-262-4467

Wellington

Cancer Center of Kansas, PA - Wellington

Shaker R. Dakhil
Ph: 316-262-4467

Wichita

Associates in Women's Health, PA - North Hillside

Shaker R. Dakhil
Ph: 316-262-4467

Cancer Center of Kansas, PA - Medical Arts Tower

Shaker R. Dakhil
Ph: 316-262-4467

Cancer Center of Kansas, PA - Wichita

Shaker R. Dakhil
Ph: 316-262-4467

Via Christi Cancer Center at Via Christi Regional Medical Center

Shaker R. Dakhil
Ph: 316-262-4467

Winfield

Cancer Center of Kansas, PA - Winfield

Shaker R. Dakhil
Ph: 316-262-4467

Louisiana
Baton Rouge

Ochsner Health Center - Bluebonnet

Suma P Satti
Ph: 888-562-4763

Covington

Ochsner Health Center - Covington

Suma P Satti
Ph: 888-562-4763

New Orleans

New Orleans Cancer Institute at Memorial Medical Center

Suma P Satti
Ph: 888-562-4763

Ochsner Cancer Institute at Ochsner Clinic Foundation

Suma P Satti
Ph: 888-562-4763

Michigan
Ann Arbor

Saint Joseph Mercy Cancer Center

Philip J. Stella
Ph: 734-712-4673

Dearborn

Oakwood Cancer Center at Oakwood Hospital and Medical Center

Philip J. Stella
Ph: 734-712-4673

Detroit

Josephine Ford Cancer Center at Henry Ford Hospital

Robert Anthony Chapman
Ph: 313-916-1784

Van Elslander Cancer Center at St. John Hospital and Medical Center

Philip J. Stella
Ph: 734-712-4673

Flint

Genesys Hurley Cancer Institute

Philip J. Stella
Ph: 734-712-4673

Hurley Medical Center

Philip J. Stella
Ph: 734-712-4673

Jackson

Gayle M. Jacob Cancer Center at Allegiance Health

Philip J. Stella
Ph: 734-712-4673

Kalamazoo

Borgess Medical Center

Raymond Sterling Lord
Ph: 269-373-7458

Bronson Methodist Hospital

Raymond Sterling Lord
Ph: 269-373-7458

West Michigan Cancer Center

Raymond Sterling Lord
Ph: 269-373-7458

Lansing

Sparrow Regional Cancer Center

Philip J. Stella
Ph: 734-712-4673

Livonia

St. Mary Mercy Hospital

Philip J. Stella
Ph: 734-712-4673

Niles

Lakeland Hospital - Niles

Rafat H. Ansari
Ph: 574-234-5123

Pontiac

St. Joseph Mercy Oakland

Philip J. Stella
Ph: 734-712-4673

Port Huron

Mercy Regional Cancer Center at Mercy Hospital

Philip J. Stella
Ph: 734-712-4673

Saginaw

Seton Cancer Institute at Saint Mary's - Saginaw

Philip J. Stella
Ph: 734-712-4673

St. Joseph

Lakeland Regional Cancer Care Center - St. Joseph

Rafat H. Ansari
Ph: 574-234-5123

Warren

St. John Macomb Hospital

Philip J. Stella
Ph: 734-712-4673

Minnesota
Brainerd

St. Joseph's Medical Center

Daniel Nikcevich
Ph: 888-203-7267

Duluth

CCOP - Duluth

Bret E Friday
Ph: 888-203-7267

Essentia Health - Duluth Clinic

Daniel Nikcevich
Ph: 888-203-7267

Miller - Dwan Medical Center

Daniel Nikcevich
Ph: 888-203-7267

Minneapolis

Masonic Cancer Center at University of Minnesota

Bruce A. Peterson
Ph: 612-624-2620

Missouri
Bonne Terre

Parkland Health Center-Bonne Terre

James L. Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

Cape Girardeau

Saint Francis Medical Center

James L. Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

Southeast Cancer Center

James L. Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

Jefferson City

Goldschmidt Cancer Center

James L. Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

Saint Louis

Missouri Baptist Cancer Center

James L. Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

Sainte Genevieve

Sainte Genevieve County Memorial Hospital

James L. Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

Sullivan

Missouri Baptist Sullivan Hospital

James L. Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

Sunset Hills

Missouri Baptist Outpatient Center-Sunset Hills

James L. Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

Nevada
Henderson

21st Century Oncology - Henderson

John Allan Ellerton
Ph: 702-384-0013

Cancer and Blood Specialists-Henderson

John Allan Ellerton
Ph: 702-384-0013

Comprehensive Cancer Centers of Nevada - Henderson

John Allan Ellerton
Ph: 702-384-0013

Comprehensive Cancer Centers of Nevada-Southeast Henderson

John Allan Ellerton
Ph: 702-384-0013

Las Vegas Cancer Center - Henderson

John Allan Ellerton
Ph: 702-384-0013

Las Vegas

21st Century Oncology - Fort Apache

John Allan Ellerton
Ph: 702-384-0013

21st Century Oncology - Vegas Sunrise

John Allan Ellerton
Ph: 702-384-0013

21st Century Oncology - Vegas Tenaya

John Allan Ellerton
Ph: 702-384-0013

Cancer and Blood Specialists-Fort Apache

John Allan Ellerton
Ph: 702-384-0013

Cancer and Blood Specialists-Shadow

John Allan Ellerton
Ph: 702-384-0013

Cancer and Blood Specialists-Tenaya

John Allan Ellerton
Ph: 702-384-0013

Cancer Institute of Nevada at Summerlin Hospital Medical Center

John Allan Ellerton
Ph: 702-384-0013

Cancer Therapy and Integrative Medicine

John Allan Ellerton
Ph: 702-384-0013

CCOP - Nevada Cancer Research Foundation

John Allan Ellerton
Ph: 702-384-0013

Comprehensive Cancer Centers of Nevada - Central Valley

John Allan Ellerton
Ph: 702-384-0013

Comprehensive Cancer Centers of Nevada - Northwest

John Allan Ellerton
Ph: 702-384-0013

Comprehensive Cancer Centers of Nevada - Southwest

John Allan Ellerton
Ph: 702-384-0013

HealthCare Partners Medical Group Oncology/Hematology-Centennial Hills

John Allan Ellerton
Ph: 702-384-0013

HealthCare Partners Medical Group Oncology/Hematology-Maryland Parkway

John Allan Ellerton
Ph: 702-384-0013

HealthCare Partners Medical Group Oncology/Hematology-San Martin

John Allan Ellerton
Ph: 702-384-0013

HealthCare Partners Medical Group Oncology/Hematology-Tenaya

John Allan Ellerton
Ph: 702-384-0013

Las Vegas Cancer Center-Medical Center

John Allan Ellerton
Ph: 702-384-0013

Radiation Oncology Centers of Las Vegas - Downtown Location

John Allan Ellerton
Ph: 702-384-0013

Radiation Oncology Centers of Las Vegas - Eastern Location

John Allan Ellerton
Ph: 702-384-0013

University Medical Center of Southern Nevada

John Allan Ellerton
Ph: 702-384-0013

New Jersey
Vineland

Frank and Edith Scarpa Regional Cancer Pavillion at South Jersey Healthcare

Shailja Roy
Ph: 856-641-7933

Woodbury

Underwood Memorial Hospital

Carl J. Minniti
Ph: 856-641-7933

New York
Middletown

Tucker Center for Cancer Care at Orange Regional Medical Center

Jeffrey M. Stewart
Ph: 845-342-7609

Syracuse

SUNY Upstate Medical University Hospital

Stephen L. Graziano
Ph: 315-464-5476

North Carolina
Clinton

Southeastern Medical Oncology Center-Clinton

James N. Atkins
Ph: 919-580-0000

Goldsboro

Southeastern Medical Oncology Center - Goldsboro

James N. Atkins
Ph: 919-580-0000

Wayne Memorial Hospital, Incorporated

James N. Atkins
Ph: 919-580-0000

Jacksonville

Southeastern Medical Oncology Center-Jacksonville

James N. Atkins
Ph: 919-580-0000

Kinston

Kinston Medical Specialists

Peter R. Watson
Ph: 252-559-2200

Statesville

Iredell Memorial Hospital

Ruby A. Grimm
Ph: 704-873-5661

Wilson

Southeastern Medical Oncology Center - Wilson

James N. Atkins
Ph: 919-580-0000

North Dakota
Bismarck

Bismarck Cancer Center

Edward J. Wos
Ph: 701-323-5760
Email: tfischer@mohs.org

Medcenter One Hospital Cancer Care Center

Preston D. Steen
Ph: 701-234-6161

Ohio
Beachwood

Cleveland Clinic Taussig Cancer Center

Anjali S Advani
Ph: 866-223-8100

Cleveland

Cleveland Clinic Cancer Center at Fairview Hospital

Anjali S Advani
Ph: 866-223-8100

Cleveland Clinic Taussig Cancer Center

Anjali S Advani
Ph: 866-223-8100

Independence

Cleveland Clinic Taussig Cancer Center

Anjali S Advani
Ph: 866-223-8100

Mansfield

Cleveland Clinic Cancer Center Mansfield

Anjali S Advani
Ph: 866-223-8100

Mayfield Heights

Hillcrest Cancer Center at Hillcrest Hospital

Anjali S Advani
Ph: 866-223-8100

Sandusky

North Coast Cancer Care, Incorporated

Anjali S Advani
Ph: 866-223-8100

Strongsville

Cleveland Clinic Foundation - Strongsville

Anjali S Advani
Ph: 866-223-8100

Warrensville Heights

South Pointe Hospital Cancer Care Center

Anjali S Advani
Ph: 866-223-8100

Wooster

Cleveland Clinic - Wooster

Anjali S Advani
Ph: 866-223-8100

Oregon
Clackamas

Clackamas Radiation Oncology Center

Alison K Conlin
Ph: 503-215-6412

Newberg

Providence Newberg Medical Center

Alison K Conlin
Ph: 503-215-6412

Oregon City

Willamette Falls Hospital

Alison K Conlin
Ph: 503-215-6412

Portland

Providence Cancer Center at Providence Portland Medical Center

Alison K Conlin
Ph: 503-215-6412

Providence St. Vincent Medical Center

Alison K Conlin
Ph: 503-215-6412

Pennsylvania
Abington

Rosenfeld Cancer Center at Abington Memorial Hospital

Willard G. Andrews
Ph: 215-481-2402

Danville

Geisinger Cancer Institute at Geisinger Health

Rajiv Panikkar
Ph: 570-271-5251

Hazleton

Geisinger Hazleton Cancer Center

Rajiv Panikkar
Ph: 570-271-5251

Lewisburg

Geisinger Medical Oncology at Evangelical Community Hospital

Rajiv Panikkar
Ph: 570-271-5251

Lewistown

Lewistown Hospital

Rajiv Panikkar
Ph: 570-271-5251

Philadelphia

Fox Chase Cancer Center - Philadelphia

Hossein Borghaei
Ph: 215-728-4790

Pittsburgh

UPMC Cancer Centers

Mark A. Socinski
Ph: 412-647-8073

Pottsville

Geisinger Medical Oncology-Pottsville

Rajiv Panikkar
Ph: 570-271-5251

State College

Geisinger Medical Group - Scenery Park

Rajiv Panikkar
Ph: 570-271-5251

Wilkes-Barre

Frank M. and Dorothea Henry Cancer Center at Geisinger Wyoming Valley Medical Center

Rajiv Panikkar
Ph: 570-271-5251

South Carolina
Charleston

Charleston Hematology Oncology Associates PA-St. Francis

James Michael Orcutt
Ph: 843-720-8386
Email: elizabeth.strojny@roperstfrancis.com

Charleston Hematology Oncology Associates, PA

James Michael Orcutt
Ph: 843-720-8386
Email: elizabeth.strojny@roperstfrancis.com

Lowcountry Hematology Oncology PA-Charleston

James Michael Orcutt
Ph: 843-720-8386
Email: elizabeth.strojny@roperstfrancis.com

Lowcountry Hematology Oncology PA-West Ashley

James Michael Orcutt
Ph: 843-720-8386
Email: elizabeth.strojny@roperstfrancis.com

Roper St. Francis Cancer Center at Roper Hospital

James Michael Orcutt
Ph: 843-720-8386
Email: elizabeth.strojny@roperstfrancis.com

Mount Pleasant

Lowcountry Hematology and Oncology, PA

James Michael Orcutt
Ph: 843-720-8386
Email: elizabeth.strojny@roperstfrancis.com

Virginia
Danville

Danville Hematology and Oncology, Incorporated

Qiwei W Gai
Ph: 434-793-0044

Danville Regional Medical Center

Timothy W. Brotherton
Ph: 434-793-0044

Martinsville

Ravenel Oncology Center at Memorial Hospital of Martinsville and Henry County

Sreedhar Katragadda
Ph: 276-666-7827

Washington
Longview

Lower Columbia Regional Cancer Center at PeaceHealth-St. John Medical Center

Alison K Conlin
Ph: 503-215-6412

Vancouver

Southwest Washington Medical Center Cancer Center

Alison K Conlin
Ph: 503-215-6412

West Virginia
Huntington

Edwards Comprehensive Cancer Center at Cabell Huntington Hospital

Maria-Rosalia B. Tria Tirona
Ph: 304-399-6617

Wisconsin
La Crosse

Gundersen Lutheran Center for Cancer and Blood

Kurt Oettel
Ph: 608-775-2385
Email: cancerctr@gundluth.org

Wyoming
Cheyenne

Cheyenne Regional Medical Center

Keren Sturtz
Ph: 888-785-6789

Link to the current ClinicalTrials.gov record.
NLM Identifier NCT01085630
ClinicalTrials.gov processed this data on March 30, 2015

Note: Information about this trial is from the ClinicalTrials.gov database. The versions designated for health professionals and patients contain the same text. Minor changes may be made to the ClinicalTrials.gov record to standardize the names of study sponsors, sites, and contacts. Cancer.gov only lists sites that are recruiting patients for active trials, whereas ClinicalTrials.gov lists all sites for all trials. Questions and comments regarding the presented information should be directed to ClinicalTrials.gov.