Cisplatin and Etoposide With or Without Veliparib in Treating Patients With Extensive Stage Small Cell Lung Cancer or Metastatic Large Cell Neuroendocrine Non-small Cell Lung Cancer

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Basic Trial Information

PhaseTypeStatusAgeSponsorProtocol IDs
Phase II, Phase IBiomarker/Laboratory analysis, TreatmentActive18 and overNCINCI-2012-01985
U10CA021115, ECOG-E2511, CDR0000736704, E2511, U10CA180820, NCT01642251

Trial Description

Summary

This randomized phase I/II trial studies the side effects and best dose of veliparib when given together with or without cisplatin and etoposide and to see how well they work in treating patients with extensive stage small cell lung cancer or large cell neuroendocrine non-small cell lung cancer that has spread to other parts of the body. Drugs used in chemotherapy, such as cisplatin and etoposide, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Veliparib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Giving cisplatin and etoposide with or without veliparib may work better in treating patients with extensive stage small cell lung cancer or metastatic large cell neuroendocrine non-small cell lung cancer.

Further Study Information

PRIMARY OBJECTIVES:

I. To determine the recommended phase II dose (RP2D) of veliparib to use in combination with cisplatin and etoposide (CE). (Phase I) II. To determine whether the addition of ABT-888 (veliparib) to cisplatin etoposide (CE) results in improved progression free survival (PFS) over CE with placebo in the frontline therapy of newly diagnosed extensive stage small cell lung cancer. (Phase II)

SECONDARY OBJECTIVES:

I. To determine the overall survival (OS) associated with the combination of CE plus ABT-888. (Phase II) II. To assess the overall response rate (ORR) as well as complete response rate (CRR) associated with the combination of CE plus ABT-888. (Phase II) III. To determine the toxicity profile of the combination of ABT-888 and CE chemotherapy in this patient population. (Phase II) IV. To conduct exploritory correlative analysis of the impact of the select biomarkers. (Phase II) V. To compare the overall toxicity profile and specifically the incidence and severity of chemotherapy-induced peripheral neuropathy with the addition of ABT-888 to CE. (Phase II)

OUTLINE: This is a phase I, dose-escalation study of veliparib followed by a phase II study.

Phase I: Patients receive veliparib orally (PO) twice daily (BID) on days 1-7, etoposide intravenously (IV) over 60-120 minutes on days 1-3, and cisplatin IV over 60-120 minutes on day 1. Treatment repeats every 21 days for 4 courses in the absence of disease progression or unacceptable toxicity.

Phase II: Patients are randomized to 1 of 2 treatment arms.

ARM A: Patients receive veliparib PO BID on days 1-7, etoposide IV over 60-120 minutes on days 1-3, and cisplatin IV over 60-120 minutes on day 1. Treatment repeats every 21 days for 4 courses in the absence of disease progression or unacceptable toxicity.

ARM B: Patients receive placebo PO BID on days 1-7, etoposide IV over 60-120 minutes on days 1-3, and cisplatin IV over 60-120 minutes on day 1. Treatment repeats every 21 days for 4 courses in the absence of disease progression or unacceptable toxicity.

After completion of study treatment, patients are followed up every 3 months for 2 years and then every 6 months for 1 year.

Eligibility Criteria

Inclusion Criteria:

  • Women must not be pregnant or breastfeeding; breastfeeding must be discontinued or the subject is not eligible for the study
  • All females of childbearing potential must have a blood test within 2 weeks prior to randomization to rule out pregnancy; a female of childbearing potential is any woman, regardless of sexual orientation or whether they have undergone tubal ligation, who meets the following criteria: 1) has not undergone a hysterectomy or bilateral oophorectomy; or 2) has not been naturally postmenopausal for at least 24 consecutive months (i.e., has had menses at any time in the preceding 24 consecutive months)
  • Women of childbearing potential and sexually active males must be strongly advised to use an accepted and effective method of contraception
  • Patients must have histologically or cytologically confirmed:
  • Extensive stage small cell lung cancer (SCLC) or
  • Stage IV (M1a or M1b according to American Joint Committee on Cancer [AJCC] Staging Manual, 7th edition) large cell neuroendocrine non-small cell lung cancer (NSCLC) or
  • Small cell carcinoma of unknown primary or extrapulmonary origin and must be a candidate for systemic therapy
  • NOTE: The extensive disease SCLC classification for this protocol includes all patients with disease sites not defined as limited stage; limited stage disease category includes patients with disease restricted to one hemithorax with regional lymph node metastases, including hilar, ipsilateral and contralateral mediastinal, and/or ipsilateral supraclavicular nodes; extensive disease patients are defined as those patients with extrathoracic metastatic disease, malignant pleural effusion, bilateral or contralateral supraclavicular adenopathy
  • Patients must have measurable or non-measurable disease based on Response Evaluation Criteria in Solid Tumors (RECIST) 1.1; baseline measurements and evaluations of all sites of disease must be obtained =< 4 weeks prior to registration (Phase I)
  • Eastern Cooperative Oncology Group (ECOG) performance status 0 or 1
  • Absolute neutrophil count >= 1,500/mm^3
  • Platelets >= 100,000/mm^3
  • Leukocytes >= 3,000/mm^3
  • Hemoglobin >= 9 g/dL
  • Total bilirubin =< 1.5 times institutional upper limit of normal (ULN)
  • Aspartate aminotransferase (AST) (serum glutamic oxaloacetic transaminase [SGOT]) and alanine aminotransferase (ALT) (serum glutamate pyruvate transaminase[SGPT]) =< 3 times institutional ULN (=< 5 times if liver function test [LFT] elevations due to known liver metastases)
  • Creatinine =< 1.5 X ULN OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels > 1.5 x ULN
  • Patients with central nervous system (CNS) metastases or a history of CNS metastases are ineligible
  • Patients cannot have had prior chemotherapy or biologic therapy for SCLC or large cell neuroendocrine NSCLC, or small cell carcinoma of unknown primary or extrapulmonary origin; patients receiving prior radiation cannot register within 7 days after completion of radiation, and must have resolved adverse events attributed to radiation to =< grade 1; no previous irradiation to the only site of measurable or evaluable disease, unless that site had subsequent evidence of progression
  • Patients receiving prior radiation cannot register within 7 days after completion of radiation, and must have resolved adverse events attributed to radiation to =< grade 1; no previous irradiation to the only site of measurable or evaluable disease, unless that site had subsequent evidence of progression
  • Patients must NOT have active seizure(s) or history of seizure(s)
  • Patients must NOT have history of allergic reactions attributed to compounds of similar chemical or biologic composition to veliparib or other agents used in the study
  • Patients must NOT have uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, uncontrolled cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements
  • Human immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligible
  • Patient must be able to swallow pills
  • PHASE II: Women must not be pregnant or breastfeeding; breastfeeding must be discontinued or the subject is not eligible for the study
  • PHASE II: All females of childbearing potential must have a blood test within 2 weeks prior to randomization to rule out pregnancy; a female of childbearing potential is any woman, regardless of sexual orientation or whether they have undergone tubal ligation, who meets the following criteria: 1) has not undergone a hysterectomy or bilateral oophorectomy; or 2) has not been naturally postmenopausal for at least 24 consecutive months (i.e., has had menses at any time in the preceding 24 consecutive months) with the current month counted as month 1
  • PHASE II: Women of childbearing potential and sexually active males must be strongly advised to use an accepted and effective method of contraception
  • PHASE II: Patients must have extensive stage, histologically or cytologically confirmed small cell lung cancer; NOTE: the extensive disease classification for this protocol includes all patients with disease sites not defined as limited stage; limited stage disease category includes patients with disease restricted to one hemithorax with regional lymph node metastases, including hilar, ipsilateral and contralateral mediastinal, and/or ipsilateral supraclavicular nodes; extensive disease patients are defined as those patients with extrathoracic metastatic disease, malignant pleural effusion, bilateral or contralateral supraclavicular adenopathy
  • PHASE II: Patients must have measurable disease based on RECIST 1.1; baseline measurements and evaluations of all sites of disease must be obtained =< 4 weeks prior to registration
  • PHASE II: ECOG performance status 0 or 1
  • PHASE II: Absolute neutrophil count >= 1,500/mm^3
  • PHASE II: Platelets >= 100,000/mm^3
  • PHASE II: Leukocytes >= 3,000/mm^3
  • PHASE II: Hemoglobin >= 9 g/dL
  • PHASE II: Total bilirubin =< 1.5 times institutional upper limit of normal (ULN)
  • PHASE II: AST (SGOT) and ALT (SGPT) =< 3 times institutional ULN (=< 5 times if LFT elevations due to known liver metastases)
  • PHASE II: Creatinine =< 1.5 X ULN OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels > 1.5 x ULN
  • PHASE II: Patients with CNS metastases or a history of CNS metastases are ineligible
  • PHASE II: Patients cannot have had prior chemotherapy or biologic therapy for small cell lung cancer; patients receiving prior radiation cannot register within 7 days after completion of radiation, and must have resolved adverse events attributed to radiation to =< grade 1; no previous irradiation to the only site of measurable or evaluable disease, unless that site had subsequent evidence of progression
  • PHASE II: Patient must be able to swallow pills
  • PHASE II: Patients may not be receiving any other investigational agents while on study
  • PHASE II: Patients must NOT have history of allergic reactions attributed to compounds of similar chemical or biologic composition to veliparib or other agents used in the study
  • PHASE II: Patients must NOT have active seizure(s) or history of seizure(s)
  • PHASE II: Patients must NOT have uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, uncontrolled cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements
  • PHASE II: HIV-positive patients on combination antiretroviral therapy are ineligible because of the potential for pharmacokinetic interactions with veliparib; in addition, these patients are at increased risk of lethal infections when treated with marrow-suppressive therapy; appropriate studies will be undertaken in patients receiving combination antiretroviral therapy when indicated

Trial Contact Information

Trial Lead Organizations/Sponsors

National Cancer Institute

    Taofeek Owonikoko, Principal Investigator

    Trial Sites

    U.S.A.

    California
    Loma Linda

    Loma Linda University Cancer Institute at Loma Linda University Medical Center

    Hamid R Mirshahidi
    Ph: 909-558-3375

    Palo Alto

    Stanford Cancer Center

    Heather A Wakelee
    Ph: 650-498-7061
    Email: ccto-office@stanford.edu

    Colorado
    Aurora

    Medical Center of Aurora - South Campus

    Keren Sturtz
    Ph: 888-785-6789

    Rocky Mountain Cancer Centers - Aurora

    Keren Sturtz
    Ph: 888-785-6789

    Boulder

    Boulder Community Hospital

    Keren Sturtz
    Ph: 888-785-6789

    Rocky Mountain Cancer Centers-Boulder

    Keren Sturtz
    Ph: 888-785-6789

    Colorado Springs

    Penrose Cancer Center at Penrose Hospital

    Keren Sturtz
    Ph: 888-785-6789

    Rocky Mountain Cancer Centers at the Pavilion

    Keren Sturtz
    Ph: 888-785-6789

    Denver

    CCOP - Colorado Cancer Research Program

    Keren Sturtz
    Ph: 888-785-6789

    Colorado Blood Cancer Institute

    Keren Sturtz
    Ph: 888-785-6789

    Porter Adventist Hospital

    Keren Sturtz
    Ph: 888-785-6789

    Presbyterian - St. Luke's Medical Center

    Keren Sturtz
    Ph: 888-785-6789

    Rocky Mountain Cancer Centers - Denver Midtown

    Keren Sturtz
    Ph: 888-785-6789

    Rocky Mountain Cancer Centers-Rose

    Keren Sturtz
    Ph: 888-785-6789

    Rose Medical Center

    Keren Sturtz
    Ph: 888-785-6789

    St. Joseph Hospital

    Keren Sturtz
    Ph: 888-785-6789

    Durango

    Mercy Medical Center

    Keren Sturtz
    Ph: 888-785-6789

    Southwest Oncology, PC

    Keren Sturtz
    Ph: 888-785-6789

    Englewood

    Comprehensive Cancer Care and Research Institute of Colorado LLC

    Keren Sturtz
    Ph: 888-785-6789

    Swedish Medical Center

    Keren Sturtz
    Ph: 888-785-6789

    Golden

    Mountain Blue Cancer Care Center

    Keren Sturtz
    Ph: 888-785-6789

    Greeley

    North Colorado Medical Center

    Keren Sturtz
    Ph: 888-785-6789

    Greenwood Village

    Breast Cancer Care Consultants

    Keren Sturtz
    Ph: 888-785-6789

    Lakewood

    Rocky Mountain Cancer Centers-Lakewood

    Keren Sturtz
    Ph: 888-785-6789

    St. Anthony Central Hospital

    Keren Sturtz
    Ph: 888-785-6789

    Littleton

    Littleton Adventist Hospital

    Keren Sturtz
    Ph: 888-785-6789

    Rocky Mountain Cancer Centers - Littleton

    Keren Sturtz
    Ph: 888-785-6789

    Lone Tree

    Rocky Mountain Cancer Centers - Lone Tree

    Keren Sturtz
    Ph: 888-785-6789

    Sky Ridge Medical Center

    Keren Sturtz
    Ph: 888-785-6789

    Longmont

    Hope Cancer Care Center at Longmont United Hospital

    Keren Sturtz
    Ph: 888-785-6789

    Rocky Mountain Cancer Centers - Longmont

    Keren Sturtz
    Ph: 888-785-6789

    Loveland

    McKee Medical Center

    Keren Sturtz
    Ph: 888-785-6789

    Parker

    Parker Adventist Hospital

    Keren Sturtz
    Ph: 888-785-6789

    Rocky Mountain Cancer Centers - Parker

    Keren Sturtz
    Ph: 888-785-6789

    Pueblo

    Rocky Mountain Cancer Centers - Pueblo

    Keren Sturtz
    Ph: 888-785-6789

    St. Mary - Corwin Regional Medical Center

    Keren Sturtz
    Ph: 888-785-6789

    Thornton

    Rocky Mountain Cancer Centers - Thornton

    Keren Sturtz
    Ph: 888-785-6789

    Wheat Ridge

    Exempla Lutheran Medical Center

    Keren Sturtz
    Ph: 888-785-6789

    Connecticut
    Hartford

    Saint Francis/Mount Sinai Regional Cancer Center at Saint Francis Hospital and Medical Center

    Tareq Al Baghdadi
    Ph: 734-712-4673

    Georgia
    Decatur

    Charles B. Eberhart Cancer Center at DeKalb Medical Center

    Jayanthi Srinivasiah
    Ph: 404-501-3279

    Savannah

    Nancy N. and J. C. Lewis Cancer and Research Pavilion at St. Joseph's/Candler

    Mark A. Taylor
    Ph: 912-350-8568

    Hawaii
    Aiea

    Kapiolani Medical Center at Pali Momi

    Jeffrey L. Berenberg
    Ph: 808-586-2979

    Jeffrey L. Berenberg
    Ph: 808-586-2979

    Ewa Beach

    Leeward Radiation Oncology

    Jeffrey L. Berenberg
    Ph: 808-586-2979

    Honolulu

    Cancer Research Center of Hawaii

    Jeffrey L. Berenberg
    Ph: 808-586-2979

    Hawaii Medical Center - East

    Jeffrey L. Berenberg
    Ph: 808-586-2979

    Kapiolani Medical Center for Women and Children

    Jeffrey L. Berenberg
    Ph: 808-586-2979

    OnCare Hawaii, Incorporated - Kuakini

    Jeffrey L. Berenberg
    Ph: 808-586-2979

    Jeffrey L. Berenberg
    Ph: 808-586-2979

    OnCare Hawaii, Incorporated - Lusitana

    Jeffrey L. Berenberg
    Ph: 808-586-2979

    Queen's Cancer Institute at Queen's Medical Center

    Jeffrey L. Berenberg
    Ph: 808-586-2979

    Straub Clinic and Hospital, Incorporated

    Jeffrey L. Berenberg
    Ph: 808-586-2979

    Lihue

    Kauai Medical Clinic

    Jeffrey L. Berenberg
    Ph: 808-586-2979

    Idaho
    Boise

    Saint Alphonsus Cancer Care Center at Saint Alphonsus Regional Medical Center

    Tareq Al Baghdadi
    Ph: 734-712-4673

    Post Falls

    Kootenai Cancer Center - Post Falls

    Benjamin Thomas Marchello
    Ph: 800-648-6274

    Illinois
    Aurora

    Rush-Copley Cancer Care Center

    James R Egner
    Ph: 800-446-5532

    Bloomington

    Illinois CancerCare - Bloomington

    Nguyet A Le-Lindqwister
    Ph: 800-793-2262

    St. Joseph Medical Center

    Nguyet A Le-Lindqwister
    Ph: 800-793-2262

    Canton

    Illinois CancerCare - Canton

    Nguyet A Le-Lindqwister
    Ph: 800-793-2262

    Carbondale

    Memorial Hospital of Carbondale

    James L. Wade
    Ph: 217-876-4740
    Email: kcheek@dmhhs.org

    Carthage

    Illinois CancerCare - Carthage

    Nguyet A Le-Lindqwister
    Ph: 800-793-2262

    Centralia

    Centralia Oncology Clinic

    James L. Wade
    Ph: 217-876-4740
    Email: kcheek@dmhhs.org

    Chicago

    John H. Stroger, Jr. Hospital of Cook County

    Thomas E. Lad
    Ph: 312-864-6000

    Robert H. Lurie Comprehensive Cancer Center at Northwestern University

    Melissa L Johnson
    Ph: 312-695-1301
    Email: cancer@northwestern.edu

    University of Chicago Cancer Research Center

    Victoria M Villaflor
    Ph: 773-834-7424

    Danville

    Carle on Vermilion

    James R Egner
    Ph: 800-446-5532

    Decatur

    Cancer Care Center of Decatur

    James L. Wade
    Ph: 217-876-4740
    Email: kcheek@dmhhs.org

    Decatur Memorial Hospital Cancer Care Institute

    James L. Wade
    Ph: 217-876-4740
    Email: kcheek@dmhhs.org

    Effingham

    Carle Physician Group-Effingham

    James R Egner
    Ph: 800-446-5532

    Crossroads Cancer Center

    James L. Wade
    Ph: 217-876-4740
    Email: kcheek@dmhhs.org

    Eureka

    Illinois CancerCare - Eureka

    Nguyet A Le-Lindqwister
    Ph: 800-793-2262

    Evanston

    CCOP - Evanston

    Thomas Hensing
    Ph: 847-570-2109

    Galesburg

    Galesburg Clinic, PC

    Nguyet A Le-Lindqwister
    Ph: 800-793-2262

    Medical and Surgical Specialists, LLC

    Nguyet A Le-Lindqwister
    Ph: 800-793-2262

    Glenview

    Glenbrook Hospital

    Thomas Hensing
    Ph: 847-570-2109

    Harvey

    Ingalls Cancer Care Center at Ingalls Memorial Hospital

    Mark F. Kozloff
    Ph: 708-915-4673
    Email: clinicaltrials@ingalls.org

    Highland Park

    Hematology Oncology Associates of Illinois-Highland Park

    Melissa L Johnson
    Ph: 312-695-1301
    Email: cancer@northwestern.edu

    Highland Park Hospital

    Thomas Hensing
    Ph: 847-570-2109

    Joliet

    Joliet Oncology-Hematology Associates, Limited - West

    Kulumani M Sivarajan
    Ph: 815-730-3098
    Email: maureenc@jolietoncology.com

    Kankakee

    Provena St. Mary's Regional Cancer Center - Kankakee

    Melissa L Johnson
    Ph: 312-695-1301
    Email: cancer@northwestern.edu

    Kewanee

    Illinois CancerCare - Kewanee Clinic

    Nguyet A Le-Lindqwister
    Ph: 800-793-2262

    Libertyville

    North Shore Oncology and Hematology Associates, Limited - Libertyville

    Melissa L Johnson
    Ph: 312-695-1301
    Email: cancer@northwestern.edu

    Macomb

    Illinois CancerCare - Macomb

    Nguyet A Le-Lindqwister
    Ph: 800-793-2262

    Mattoon

    Carle Physician Group-Mattoon/Charleston

    James R Egner
    Ph: 800-446-5532

    Moline

    Garneau, Stewart C MD (UIA Investigator)

    David M Spector
    Ph: 309-779-4200

    Spector, David MD (UIA Investigator)

    David M Spector
    Ph: 309-779-4200

    Trinity Cancer Center at Trinity Medical Center - 7th Street Campus

    David M Spector
    Ph: 309-779-4200

    Mount Vernon

    Good Samaritan Regional Health Center

    Jay W Carlson
    Ph: 800-821-7532

    New Lennox

    Silver Cross Hospital

    Victoria M Villaflor
    Ph: 773-834-7424

    Niles

    Cancer Care and Hematology Specialists of Chicagoland - Niles

    Melissa L Johnson
    Ph: 312-695-1301
    Email: cancer@northwestern.edu

    Ottawa

    Illinois CancerCare - Ottawa

    Nguyet A Le-Lindqwister
    Ph: 800-793-2262

    Pekin

    Cancer Treatment Center at Pekin Hospital

    Nguyet A Le-Lindqwister
    Ph: 800-793-2262

    Illinois CancerCare - Pekin

    Nguyet A Le-Lindqwister
    Ph: 800-793-2262

    Peoria

    Illinois CancerCare - Peoria

    Nguyet A Le-Lindqwister
    Ph: 800-793-2262

    Methodist Medical Center of Illinois

    Nguyet A Le-Lindqwister
    Ph: 800-793-2262

    OSF St. Francis Medical Center

    Nguyet A Le-Lindqwister
    Ph: 800-793-2262

    Peru

    Illinois CancerCare - Princeton

    Nguyet A Le-Lindqwister
    Ph: 800-793-2262

    Princeton

    Illinois CancerCare - Princeton

    Nguyet A Le-Lindqwister
    Ph: 800-793-2262

    Rockford

    Advanced Care and Treatment Medical Group, PC

    Harvey Eric Einhorn
    Ph: 779-696-9400
    Email: cancercare@swedishamerican.org

    Skokie

    Hematology Oncology Associates - Skokie

    Melissa L Johnson
    Ph: 312-695-1301
    Email: cancer@northwestern.edu

    Springfield

    Regional Cancer Center at Memorial Medical Center

    James L. Wade
    Ph: 217-876-4740
    Email: kcheek@dmhhs.org

    Urbana

    Carle Cancer Center at Carle Foundation Hospital

    James R Egner
    Ph: 800-446-5532

    James R Egner
    Ph: 800-446-5532

    Yorkville

    Rush-Copley Healthcare Center

    James R Egner
    Ph: 800-446-5532

    Indiana
    Elkhart

    Michiana Hematology-Oncology, PC - Elkhart

    Jose A. Bufill
    Ph: 574-237-1328

    Indianapolis

    Indiana University Melvin and Bren Simon Cancer Center

    Shadia I Jalal
    Ph: 317-274-2552

    Michigan City

    Saint Anthony Memorial Health Centers

    James R Egner
    Ph: 800-446-5532

    Woodland Cancer Care Center

    James R Egner
    Ph: 800-446-5532

    Mishawaka

    Memorial Regional Cancer Center Day Road

    Thomas Joseph Reid
    Ph: 800-284-7370

    Michiana Hematology-Oncology, PC - Mishawaka

    Jose A. Bufill
    Ph: 574-237-1328

    Saint Joseph's Medical Center

    Jose A. Bufill
    Ph: 574-237-1328

    Plymouth

    Michiana Hematology Oncology PC - Plymouth

    Jose A. Bufill
    Ph: 574-237-1328

    Richmond

    Reid Hospital & Health Care Services

    Howard M. Gross
    Ph: 937-775-1350

    South Bend

    CCOP - Northern Indiana CR Consortium

    Jose A. Bufill
    Ph: 574-237-1328

    Memorial Hospital of South Bend

    Thomas Joseph Reid
    Ph: 800-284-7370

    Michiana Hematology-Oncology, PC - South Bend

    Jose A. Bufill
    Ph: 574-237-1328

    Westville

    Michiana Hematology Oncology-PC Westville

    Jose A. Bufill
    Ph: 574-237-1328

    Iowa
    Bettendorf

    Constantinou, Costas L MD (UIA Investigator)

    David M Spector
    Ph: 309-779-4200

    Hematology Oncology Associates of the Quad Cities

    Shobha R. Chitneni
    Ph: 563-355-7733
    Email: kedaprile@rccqc.com

    Cedar Rapids

    Cedar Rapids Oncology Associates

    Deborah W Wilbur
    Ph: 319-363-2690

    Mercy Regional Cancer Center at Mercy Medical Center

    Deborah W Wilbur
    Ph: 319-363-2690

    Davenport

    Genesis Regional Cancer Center at Genesis Medical Center

    George Kovach
    Ph: 800-446-6088
    Email: werners@genesishealth.com

    Des Moines

    CCOP - Iowa Oncology Research Association

    Robert J Behrens
    Ph: 515-282-2921

    John Stoddard Cancer Center at Iowa Lutheran Hospital

    Robert J Behrens
    Ph: 515-282-2921

    John Stoddard Cancer Center at Iowa Methodist Medical Center

    Robert J Behrens
    Ph: 515-282-2921

    Medical Oncology and Hematology Associates at John Stoddard Cancer Center

    Robert J Behrens
    Ph: 515-282-2921

    Sioux City

    Siouxland Hematology-Oncology Associates, LLP

    Donald Bruce Wender
    Ph: 712-252-0088

    West Des Moines

    Methodist West Hospital

    Robert J Behrens
    Ph: 515-282-2921

    Kansas
    Chanute

    Cancer Center of Kansas, PA - Chanute

    Shaker R. Dakhil
    Ph: 316-262-4467

    Dodge City

    Cancer Center of Kansas, PA - Dodge City

    Shaker R. Dakhil
    Ph: 316-262-4467

    El Dorado

    Cancer Center of Kansas, PA - El Dorado

    Shaker R. Dakhil
    Ph: 316-262-4467

    Fort Scott

    Cancer Center of Kansas - Fort Scott

    Shaker R. Dakhil
    Ph: 316-262-4467

    Independence

    Cancer Center of Kansas-Independence

    Shaker R. Dakhil
    Ph: 316-262-4467

    Kingman

    Cancer Center of Kansas, PA - Kingman

    Shaker R. Dakhil
    Ph: 316-262-4467

    Lawrence

    Lawrence Memorial Hospital

    Shaker R. Dakhil
    Ph: 316-262-4467

    Liberal

    Cancer Center of Kansas, PA - Liberal

    Shaker R. Dakhil
    Ph: 316-262-4467

    Newton

    Cancer Center of Kansas, PA - Newton

    Shaker R. Dakhil
    Ph: 316-262-4467

    Parsons

    Cancer Center of Kansas, PA - Parsons

    Shaker R. Dakhil
    Ph: 316-262-4467

    Pratt

    Cancer Center of Kansas, PA - Pratt

    Shaker R. Dakhil
    Ph: 316-262-4467

    Salina

    Cancer Center of Kansas, PA - Salina

    Shaker R. Dakhil
    Ph: 316-262-4467

    Wellington

    Cancer Center of Kansas, PA - Wellington

    Shaker R. Dakhil
    Ph: 316-262-4467

    Wichita

    Associates in Women's Health, PA - North Hillside

    Shaker R. Dakhil
    Ph: 316-262-4467

    Cancer Center of Kansas, PA - Medical Arts Tower

    Shaker R. Dakhil
    Ph: 316-262-4467

    Cancer Center of Kansas, PA - Wichita

    Shaker R. Dakhil
    Ph: 316-262-4467

    Via Christi Cancer Center at Via Christi Regional Medical Center

    Shaker R. Dakhil
    Ph: 316-262-4467

    Winfield

    Cancer Center of Kansas, PA - Winfield

    Shaker R. Dakhil
    Ph: 316-262-4467

    Kentucky
    Crestview Hills

    Oncology Hematology Care, Incorporated - Crestview Hills

    Howard M. Gross
    Ph: 937-775-1350

    Maine
    Augusta

    Harold Alfond Center for Cancer Care

    Thomas Henry Openshaw
    Ph: 207-973-4274

    Bangor

    CancerCare of Maine at Eastern Maine Medical Center

    Thomas Henry Openshaw
    Ph: 207-973-4274

    Brewer

    Lafayette Family Cancer Center-EMMC

    Thomas Henry Openshaw
    Ph: 207-973-4274

    Rockport

    Penobscot Bay Medical Center Cancer Care Center

    Thomas Henry Openshaw
    Ph: 207-973-4274

    Maryland
    Baltimore

    Alvin and Lois Lapidus Cancer Institute at Sinai Hospital

    Roberto F Martinez
    Ph: 410-601-6120
    Email: pridgely@lifebridgehealth.org

    Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

    Christine L Hann
    Ph: 410-955-8804
    Email: jhcccro@jhmi.edu

    Massachusetts
    Boston

    Boston University Cancer Research Center

    Timothy P Cooley
    Ph: 617-638-8265

    Springfield

    Baystate Medical Center

    John McCann
    Ph: 413-794-3565
    Email: tamara.wrenn@baystatehealth.org

    Worcester

    UMASS Memorial Cancer Center - University Campus

    Vijay K Kasturi
    Ph: 508-856-3216
    Email: cancer.research@umassmed.edu

    Michigan
    Ann Arbor

    Saint Joseph Mercy Cancer Center

    Tareq Al Baghdadi
    Ph: 734-712-4673

    Dearborn

    Oakwood Cancer Center at Oakwood Hospital and Medical Center

    Tareq Al Baghdadi
    Ph: 734-712-4673

    Detroit

    Josephine Ford Cancer Center at Henry Ford Hospital

    Robert Anthony Chapman
    Ph: 313-916-1784

    Van Elslander Cancer Center at St. John Hospital and Medical Center

    Tareq Al Baghdadi
    Ph: 734-712-4673

    Escanaba

    Green Bay Oncology, Limited - Escanaba

    Brian L Burnette
    Ph: 800-432-6049

    Flint

    Genesys Hurley Cancer Institute

    Tareq Al Baghdadi
    Ph: 734-712-4673

    Hurley Medical Center

    Tareq Al Baghdadi
    Ph: 734-712-4673

    Iron Mountain

    Green Bay Oncology - Iron Mountain

    Brian L Burnette
    Ph: 800-432-6049

    Jackson

    Gayle M. Jacob Cancer Center at Allegiance Health

    Tareq Al Baghdadi
    Ph: 734-712-4673

    Kalamazoo

    Borgess Medical Center

    Raymond Sterling Lord
    Ph: 269-373-7458

    Bronson Methodist Hospital

    Raymond Sterling Lord
    Ph: 269-373-7458

    West Michigan Cancer Center

    Raymond Sterling Lord
    Ph: 269-373-7458

    Lansing

    Sparrow Regional Cancer Center

    Tareq Al Baghdadi
    Ph: 734-712-4673

    Livonia

    St. Mary Mercy Hospital

    Tareq Al Baghdadi
    Ph: 734-712-4673

    Pontiac

    St. Joseph Mercy Oakland

    Tareq Al Baghdadi
    Ph: 734-712-4673

    Port Huron

    Mercy Regional Cancer Center at Mercy Hospital

    Tareq Al Baghdadi
    Ph: 734-712-4673

    Saginaw

    Seton Cancer Institute at Saint Mary's - Saginaw

    Tareq Al Baghdadi
    Ph: 734-712-4673

    Warren

    St. John Macomb Hospital

    Tareq Al Baghdadi
    Ph: 734-712-4673

    Minnesota
    Bemidji

    MeritCare Bemidji

    Preston D. Steen
    Ph: 701-234-6161

    Brainerd

    St. Joseph's Medical Center

    Bret E Friday
    Ph: 888-203-7267

    Burnsville

    Fairview Ridges Hospital

    Joseph W Leach
    Ph: 952-993-1517
    Email: MMCCOP@parknicollet.com

    Coon Rapids

    Mercy and Unity Cancer Center at Mercy Hospital

    Joseph W Leach
    Ph: 952-993-1517
    Email: MMCCOP@parknicollet.com

    Duluth

    CCOP - Duluth

    Bret E Friday
    Ph: 888-203-7267

    Essentia Health - Duluth Clinic

    Bret E Friday
    Ph: 888-203-7267

    Miller - Dwan Medical Center

    Bret E Friday
    Ph: 888-203-7267

    St. Luke's Hospital Cancer Care Center

    Basem S Goueli
    Ph: 888-823-5923
    Email: ctsucontact@westat.com

    Edina

    Fairview Southdale Hospital

    Joseph W Leach
    Ph: 952-993-1517
    Email: MMCCOP@parknicollet.com

    Fergus Falls

    Lake Region Healthcare Corporation-Cancer Care

    Bret E Friday
    Ph: 888-203-7267

    Fridley

    Mercy and Unity Cancer Center at Unity Hospital

    Joseph W Leach
    Ph: 952-993-1517
    Email: MMCCOP@parknicollet.com

    Hutchinson

    Hutchinson Area Health Care

    Joseph W Leach
    Ph: 952-993-1517
    Email: MMCCOP@parknicollet.com

    Maplewood

    HealthEast Cancer Care at St. John's Hospital

    Joseph W Leach
    Ph: 952-993-1517
    Email: MMCCOP@parknicollet.com

    Minnesota Oncology - Maplewood

    Joseph W Leach
    Ph: 952-993-1517
    Email: MMCCOP@parknicollet.com

    Minneapolis

    Health Partners Inc

    Joseph W Leach
    Ph: 952-993-1517
    Email: MMCCOP@parknicollet.com

    Hennepin County Medical Center - Minneapolis

    Joseph W Leach
    Ph: 952-993-1517
    Email: MMCCOP@parknicollet.com

    Virginia Piper Cancer Institute at Abbott - Northwestern Hospital

    Joseph W Leach
    Ph: 952-993-1517
    Email: MMCCOP@parknicollet.com

    New Ulm

    New Ulm Medical Center

    Joseph W Leach
    Ph: 952-993-1517
    Email: MMCCOP@parknicollet.com

    Robbinsdale

    Humphrey Cancer Center at North Memorial Outpatient Center

    Joseph W Leach
    Ph: 952-993-1517
    Email: MMCCOP@parknicollet.com

    Saint Louis Park

    Park Nicollet Cancer Center

    Joseph W Leach
    Ph: 952-993-1517
    Email: MMCCOP@parknicollet.com

    Saint Paul

    Regions Hospital Cancer Care Center

    Joseph W Leach
    Ph: 952-993-1517
    Email: MMCCOP@parknicollet.com

    United Hospital

    Joseph W Leach
    Ph: 952-993-1517
    Email: MMCCOP@parknicollet.com

    Shakopee

    St. Francis Cancer Center at St. Francis Medical Center

    Joseph W Leach
    Ph: 952-993-1517
    Email: MMCCOP@parknicollet.com

    Stillwater

    Lakeview Hospital

    Joseph W Leach
    Ph: 952-993-1517
    Email: MMCCOP@parknicollet.com

    Waconia

    Ridgeview Medical Center

    Joseph W Leach
    Ph: 952-993-1517
    Email: MMCCOP@parknicollet.com

    Willmar

    Willmar Cancer Center at Rice Memorial Hospital

    Joseph W Leach
    Ph: 952-993-1517
    Email: MMCCOP@parknicollet.com

    Woodbury

    Minnesota Oncology - Woodbury

    Joseph W Leach
    Ph: 952-993-1517
    Email: MMCCOP@parknicollet.com

    Missouri
    Bolivar

    Central Care Cancer Center at Carrie J. Babb Cancer Center

    Jay W Carlson
    Ph: 800-821-7532

    Bonne Terre

    Parkland Health Center-Bonne Terre

    James L. Wade
    Ph: 217-876-4740
    Email: kcheek@dmhhs.org

    Cape Girardeau

    Saint Francis Medical Center

    James L. Wade
    Ph: 217-876-4740
    Email: kcheek@dmhhs.org

    Southeast Cancer Center

    James L. Wade
    Ph: 217-876-4740
    Email: kcheek@dmhhs.org

    Jefferson City

    Goldschmidt Cancer Center

    James L. Wade
    Ph: 217-876-4740
    Email: kcheek@dmhhs.org

    Rolla

    Phelps County Regional Medical Center

    Jay W Carlson
    Ph: 800-821-7532

    Saint Louis

    David C. Pratt Cancer Center at St. John's Mercy

    Jay W Carlson
    Ph: 800-821-7532

    Mercy Clinic St. Louis Cancer and Breast Institute

    Jay W Carlson
    Ph: 800-821-7532

    Missouri Baptist Cancer Center

    James L. Wade
    Ph: 217-876-4740
    Email: kcheek@dmhhs.org

    Springfield

    Hulston Cancer Center at Cox Medical Center South

    Jay W Carlson
    Ph: 800-821-7532

    St. John's Regional Health Center

    Jay W Carlson
    Ph: 800-821-7532

    Sullivan

    Missouri Baptist Sullivan Hospital

    James L. Wade
    Ph: 217-876-4740
    Email: kcheek@dmhhs.org

    Sunset Hills

    Missouri Baptist Outpatient Center-Sunset Hills

    James L. Wade
    Ph: 217-876-4740
    Email: kcheek@dmhhs.org

    Montana
    Billings

    Billings Clinic Cancer Center - 801 N 29th Street

    Benjamin Thomas Marchello
    Ph: 800-648-6274

    CCOP - Montana Cancer Consortium

    Benjamin Thomas Marchello
    Ph: 800-648-6274

    St. Vincent Healthcare Cancer Care Services

    Benjamin Thomas Marchello
    Ph: 800-648-6274

    Bozeman

    Bozeman Deaconess Cancer Center

    Benjamin Thomas Marchello
    Ph: 800-648-6274

    Butte

    St. James Healthcare Cancer Care

    Benjamin Thomas Marchello
    Ph: 800-648-6274

    Great Falls

    Benefis Sletten Cancer Institute

    Benjamin Thomas Marchello
    Ph: 800-648-6274

    Helena

    St. Peter's Hospital

    Benjamin Thomas Marchello
    Ph: 800-648-6274

    Kalispell

    Kalispell Regional Medical Center

    Benjamin Thomas Marchello
    Ph: 800-648-6274

    Missoula

    Montana Cancer Center at St. Patrick Hospital and Health Sciences Center

    Benjamin Thomas Marchello
    Ph: 800-648-6274

    Nebraska
    Lincoln

    Cancer Resource Center - Lincoln

    Gamini S. Soori
    Ph: 402-280-4100

    Nebraska Hematology and Oncology

    Gamini S. Soori
    Ph: 402-991-8070ext202
    Email: mwilwerding@mvcc.cc

    Southeast Nebraska Hematology Oncology Consultants at Southeast Nebraska Cancer Center

    Gamini S. Soori
    Ph: 402-991-8070
    Email: mwilwerding@mvcc.cc

    Norfolk

    Carson Cancer Center at Faith Regional Hospital

    Gamini S. Soori
    Ph: 402-991-8070ext202
    Email: mwilwerding@mvcc.cc

    North Platte

    Callahan Cancer Center at Great Plains Regional Medical Center

    Gamini S. Soori
    Ph: 402-991-8070ext202
    Email: mwilwerding@mvcc.cc

    Omaha

    CCOP - Missouri Valley Cancer Consortium

    Gamini S. Soori
    Ph: 402-398-6060

    Methodist Estabrook Cancer Center

    Robert M. Langdon
    Ph: 402-354-5144

    Oncology Hematology West PC

    Gamini S. Soori
    Ph: 402-991-8070
    Email: mwilwerding@mvcc.cc

    Oncology Hematology West, PC - Omaha Bergan

    Gamini S. Soori
    Ph: 402-991-8070ext202
    Email: mwilwerding@mvcc.cc

    Scottsbluff

    Cancer Treatment Center at Regional West Medical Center

    Gamini S. Soori
    Ph: 402-991-8070ext202
    Email: mwilwerding@mvcc.cc

    New Jersey
    East Orange

    Veterans Affairs Medical Center - East Orange

    Victor T Chang
    Ph: 800-475-2336
    Email: patricia.goyer@med.va.gov

    Mount Holly

    Virtua Fox Chase Health Cancer Program at Virtua Memorial Hospital Burlington County

    Michael S. Entmacher
    Ph: 888-847-8823

    New Brunswick

    Cancer Institute of New Jersey at UMDNJ - Robert Wood Johnson Medical School

    Joseph Aisner
    Ph: 732-235-8675

    Voorhees

    Fox Chase Virtua Health Cancer Program at Virtua West Jersey

    Michael S. Entmacher
    Ph: 888-847-8823

    New York
    Bronx

    Albert Einstein Cancer Center at Albert Einstein College of Medicine

    Haiying Cheng
    Ph: 718-904-2730
    Email: aecc@aecom.yu.edu

    Jack D. Weiler Hospital at Montefiore Medical Center - East Campus

    Haiying Cheng
    Ph: 718-904-2730
    Email: aecc@aecom.yu.edu

    Montefiore Medical Center

    Haiying Cheng
    Ph: 718-904-2730
    Email: aecc@aecom.yu.edu

    White Plains

    Dickstein Cancer Treatment Center at White Plains Hospital Center

    Dan Costin
    Ph: 914-681-2290

    North Carolina
    Asheboro

    Randolph Hospital

    Mohamed K Mohamed
    Ph: 336-832-0821

    Burlington

    Alamance Cancer Center at Alamance Regional Medical Center

    Mohamed K Mohamed
    Ph: 336-832-0821

    Clinton

    Southeastern Medical Oncology Center-Clinton

    James N. Atkins
    Ph: 919-580-0000

    Goldsboro

    Southeastern Medical Oncology Center - Goldsboro

    James N. Atkins
    Ph: 919-580-0000

    Wayne Memorial Hospital, Incorporated

    James N. Atkins
    Ph: 919-580-0000

    Greensboro

    Moses Cone Regional Cancer Center at Wesley Long Community Hospital

    Mohamed K Mohamed
    Ph: 336-832-0821

    Hendersonville

    Comprehensive Cancer Center at Pardee Hospital

    James E. Radford
    Ph: 828-696-4716

    Hendersonville Hematology and Oncology

    James E. Radford
    Ph: 828-696-4716

    Jacksonville

    Southeastern Medical Oncology Center-Jacksonville

    James N. Atkins
    Ph: 919-580-0000

    Kinston

    Kinston Medical Specialists

    Peter R. Watson
    Ph: 252-559-2200

    Mebane

    Cone Heath Cancer Center at Mebane

    Mohamed K Mohamed
    Ph: 336-832-0821

    Pinehurst

    FirstHealth Moore Regional Community Hospital Comprehensive Cancer Center

    Charles S Kuzma
    Ph: 910-715-2200

    Reidsville

    Annie Penn Cancer Center

    Mohamed K Mohamed
    Ph: 336-832-0821

    Statesville

    Iredell Memorial Hospital

    Ruby A. Grimm
    Ph: 704-873-5661

    Wilson

    Southeastern Medical Oncology Center - Wilson

    James N. Atkins
    Ph: 919-580-0000

    North Dakota
    Bismarck

    Medcenter One Hospital Cancer Care Center

    Preston D. Steen
    Ph: 701-234-6161

    Fargo

    Roger Maris Cancer Center at MeritCare Hospital

    Preston D. Steen
    Ph: 701-234-6161

    Preston D. Steen
    Ph: 701-234-6161

    Sanford Clinic North-Fargo

    Preston D. Steen
    Ph: 701-234-6161

    Grand Forks

    Altru Cancer Center at Altru Hospital

    Grant R Seeger
    Ph: 701-780-6520

    Ohio
    Akron

    Summa Center for Cancer Care at Akron City Hospital

    Jennifer E Payne
    Ph: 330-375-6101

    Belpre

    Strecker Cancer Center-Belpre

    J. Philip Kuebler
    Ph: 614-566-3275

    Canton

    Mercy Cancer Center at Mercy Medical Center

    Mitchell Haut
    Ph: 888-293-4673

    Chillicothe

    Adena Regional Medical Center

    J. Philip Kuebler
    Ph: 614-566-3275

    Cincinnati

    Oncology Hematology Care Inc - Western Hills

    Howard M. Gross
    Ph: 937-775-1350

    Oncology Hematology Care, Incorporated - Anderson

    Howard M. Gross
    Ph: 937-775-1350

    Oncology Hematology Care, Incorporated - Blue Ash

    Howard M. Gross
    Ph: 937-775-1350

    Oncology Hematology Care, Incorporated - Kenwood

    Howard M. Gross
    Ph: 937-775-1350

    Oncology Hematology Care, Incorporated - Mt. Auburn/Taft Road

    Howard M. Gross
    Ph: 937-775-1350

    Columbus

    Columbus Oncology Associates, Incorporated

    J. Philip Kuebler
    Ph: 614-566-3275

    Doctors Hospital at Ohio Health

    J. Philip Kuebler
    Ph: 614-566-3275

    Grant Medical Center Cancer Care

    J. Philip Kuebler
    Ph: 614-566-3275

    Mount Carmel Health - West Hospital

    J. Philip Kuebler
    Ph: 614-566-3275

    Riverside Methodist Hospital Cancer Care

    J. Philip Kuebler
    Ph: 614-566-3275

    Zangmeister Center

    J. Philip Kuebler
    Ph: 614-566-3275

    Dayton

    David L. Rike Cancer Center at Miami Valley Hospital

    Howard M. Gross
    Ph: 937-775-1350

    Good Samaritan Hospital

    Howard M. Gross
    Ph: 937-775-1350

    Samaritan North Cancer Care Center

    Howard M. Gross
    Ph: 937-775-1350

    Delaware

    Delaware Health Center

    J. Philip Kuebler
    Ph: 614-566-3275

    Delaware Radiation Oncology

    J. Philip Kuebler
    Ph: 614-566-3275

    Grady Memorial Hospital

    J. Philip Kuebler
    Ph: 614-566-3275

    Fairfield

    Oncology Hematology Care, Incorporated - Fairfield Healthplex

    Howard M. Gross
    Ph: 937-775-1350

    Findlay

    Blanchard Valley Regional Cancer Center

    Howard M. Gross
    Ph: 937-775-1350

    Franklin

    Atrium Medical Center

    Howard M. Gross
    Ph: 937-775-1350

    Greenville

    Wayne Hospital

    Howard M. Gross
    Ph: 937-775-1350

    Kettering

    Charles F. Kettering Memorial Hospital

    Howard M. Gross
    Ph: 937-775-1350

    Lancaster

    Fairfield Medical Center

    J. Philip Kuebler
    Ph: 614-566-3275

    Marietta

    Strecker Cancer Center at Marietta Memorial Hospital

    J. Philip Kuebler
    Ph: 614-566-3275

    Mount Vernon

    Knox Community Hospital

    J. Philip Kuebler
    Ph: 614-566-3275

    Newark

    Licking Memorial Cancer Care Program at Licking Memorial Hospital

    J. Philip Kuebler
    Ph: 614-566-3275

    Newark Radiation Oncology

    J. Philip Kuebler
    Ph: 614-566-3275

    Portsmouth

    Southern Ohio Medical Center Cancer Center

    J. Philip Kuebler
    Ph: 614-566-3275

    Springfield

    Community Hospital of Springfield and Clark County

    J. Philip Kuebler
    Ph: 614-566-3275

    Troy

    UVMC Cancer Care Center at Upper Valley Medical Center

    Howard M. Gross
    Ph: 937-775-1350

    Westerville

    Mount Carmel St. Ann's Cancer Center

    J. Philip Kuebler
    Ph: 614-566-3275

    Zanesville

    Genesis - Good Samaritan Hospital

    J. Philip Kuebler
    Ph: 614-488-2745
    Email: sheree@columbusccop.org

    Oklahoma
    Oklahoma City

    Mercy Health Center

    Vikki Ann Canfield
    Ph: 405-751-4343

    Stephenson Cancer Center at the University of Oklahoma

    Mohammad A Razaq
    Ph: 405-271-4272
    Email: julie-traylor@ouhsc.edu

    Tulsa

    Cancer Care Associates-Yale

    Mohammad A Razaq
    Ph: 405-271-4272
    Email: julie-traylor@ouhsc.edu

    Pennsylvania
    Bryn Mawr

    Bryn Mawr Hospital

    Albert S DeNittis
    Ph: 866-225-5654

    Danville

    Geisinger Cancer Institute at Geisinger Health

    Rajiv Panikkar
    Ph: 570-271-5251

    Ephrata

    Ephrata Cancer Center at Ephrata Community Hospital

    Amir Tabatabai
    Ph: 877-441-7957

    Gettysburg

    Adams Cancer Center

    Amir Tabatabai
    Ph: 877-441-7957

    Hazleton

    Geisinger Hazleton Cancer Center

    Rajiv Panikkar
    Ph: 570-271-5251

    Hershey

    Penn State Hershey Cancer Institute at Milton S. Hershey Medical Center

    Chandra Prakash Belani
    Ph: 717-531-3779
    Email: CTO@hmc.psu.edu

    Lewisburg

    Geisinger Medical Oncology at Evangelical Community Hospital

    Rajiv Panikkar
    Ph: 570-271-5251

    Lewistown

    Lewistown Hospital

    Rajiv Panikkar
    Ph: 570-271-5251

    Paoli

    Cancer Center of Paoli Memorial Hospital

    Albert S DeNittis
    Ph: 866-225-5654

    Philadelphia

    Abramson Cancer Center of the University of Pennsylvania

    Charu Aggarwal
    Ph: 800-474-9892

    Albert Einstein Cancer Center

    William J. Tester
    Ph: 215-456-3880

    Fox Chase Cancer Center - Philadelphia

    Ranee Mehra
    Ph: 215-728-4790

    Kimmel Cancer Center at Thomas Jefferson University - Philadelphia

    Barbara Campling
    Ph: 215-955-6084

    Pottsville

    Geisinger Medical Oncology-Pottsville

    Rajiv Panikkar
    Ph: 570-271-5251

    Reading

    St. Joseph Medical Center

    Marc Rovito
    Ph: 610-378-2336
    Email: danielward2@catholichealth.net

    Sayre

    Guthrie Cancer Center at Guthrie Clinic Sayre

    Bradley W Lash
    Ph: 800-836-0388

    Scranton

    Hematology and Oncology Associates of North East Pennsylvania

    Barbara Campling
    Ph: 215-955-6084

    State College

    Geisinger Medical Group - Scenery Park

    Rajiv Panikkar
    Ph: 570-271-5251

    West Reading

    McGlinn Family Regional Cancer Center at Reading Hospital and Medical Center

    Terrence P. Cescon
    Ph: 610-988-9323

    Wilkes-Barre

    Frank M. and Dorothea Henry Cancer Center at Geisinger Wyoming Valley Medical Center

    Rajiv Panikkar
    Ph: 570-271-5251

    Wynnewood

    Lankenau Cancer Center at Lankenau Hospital

    Albert S DeNittis
    Ph: 866-225-5654

    York

    WellSpan Health

    Amir Tabatabai
    Ph: 877-441-7957

    South Carolina
    Easley

    Cancer Centers of the Carolinas - Easley

    Jeffrey Kent Giguere
    Ph: 864-241-6251

    Florence

    McLeod Regional Medical Center

    Rajesh Bajaj
    Ph: 843-679-7256

    Gaffney

    Gibbs Cancer Center-Gaffney

    Charles E Bowers
    Ph: 800-486-5941

    Greenville

    Cancer Centers of the Carolinas - Andrews

    Jeffrey Kent Giguere
    Ph: 864-241-6251

    Cancer Centers of the Carolinas - Faris Road

    Jeffrey Kent Giguere
    Ph: 864-241-6251

    Cancer Centers of the Carolinas - Grove Commons

    Jeffrey Kent Giguere
    Ph: 864-241-6251

    CCOP - Greenville

    Jeffrey Kent Giguere
    Ph: 864-241-6251

    Greenville Memorial Hospital

    Jeffrey Kent Giguere
    Ph: 864-241-6251

    Greer

    Cancer Centers of the Carolinas - Greer Radiation Oncology

    Jeffrey Kent Giguere
    Ph: 864-241-6251

    Gibbs Cancer Center-Pelham

    Charles E Bowers
    Ph: 800-486-5941

    Seneca

    Cancer Centers of the Carolinas - Seneca

    Jeffrey Kent Giguere
    Ph: 864-241-6251

    Spartanburg

    Cancer Centers of the Carolinas - Spartanburg

    Jeffrey Kent Giguere
    Ph: 864-241-6251

    Gibbs Regional Cancer Center at Spartanburg Regional Medical Center

    Charles E Bowers
    Ph: 800-486-5941

    South Dakota
    Sioux Falls

    Sanford Cancer Center at Sanford USD Medical Center

    Preston D. Steen
    Ph: 701-234-6161

    Preston D. Steen
    Ph: 701-234-6161

    Tennessee
    Bristol

    Wellmont-Bristol Regional Medical Center

    Asheesh Shipstone
    Ph: 423-578-8538

    Johnson City

    Wellmont Medical Associates Oncology and Hematology-Johnson City

    Asheesh Shipstone
    Ph: 423-578-8538

    Kingsport

    Christine LaGuardia Phillips Cancer Center at Wellmont Holston Valley Medical Center

    Asheesh Shipstone
    Ph: 423-578-8538

    Kingsport Hematology-Oncology Associates

    Asheesh Shipstone
    Ph: 423-578-8538

    Nashville

    MBCCOP - Meharry Medical College - Nashville

    Philip E Lammers
    Ph: 615-327-5724
    Email: jmurray@mmc.edu

    Texas
    Dallas

    Parkland Memorial Hospital

    David E Gerber
    Ph: 214-648-7097

    Simmons Comprehensive Cancer Center at University of Texas Southwestern Medical Center - Dallas

    David E Gerber
    Ph: 214-648-7097

    Vermont
    Berlin

    Mountainview Medical

    Claire F. Verschraegen
    Ph: 802-656-4101

    Burlington

    University of Vermont Cancer Center

    Claire F. Verschraegen
    Ph: 802-656-4101

    Virginia
    Charlottesville

    University of Virginia Cancer Center

    Thao P Dang
    Ph: 434-243-6143

    Martinsville

    Ravenel Oncology Center at Memorial Hospital of Martinsville and Henry County

    Sreedhar Katragadda
    Ph: 276-666-7827

    Norton

    Southwest Virginia Regional Cancer Center at Wellmonth Health

    Asheesh Shipstone
    Ph: 423-578-8538

    West Virginia
    Morgantown

    Mary Babb Randolph Cancer Center at West Virginia University Hospitals

    Manish Monga
    Ph: 304-293-2745
    Email: sfilburn@hsc.wvu.edu

    Wisconsin
    Antigo

    Langlade Memorial Hospital

    Hamied R. Rezazadeh
    Ph: 877-405-6866

    Green Bay

    Green Bay Oncology, Limited at St. Mary's Hospital

    Brian L Burnette
    Ph: 800-432-6049

    Green Bay Oncology, Limited at St. Vincent Hospital Regional Cancer Center

    Brian L Burnette
    Ph: 800-432-6049

    St. Mary's Hospital Medical Center - Green Bay

    Brian L Burnette
    Ph: 800-432-6049

    St. Vincent Hospital Regional Cancer Center

    Brian L Burnette
    Ph: 800-432-6049

    Johnson Creek

    UW Cancer Center Johnson Creek

    Anne M. Traynor
    Ph: 877-405-6866

    La Crosse

    Gundersen Lutheran Center for Cancer and Blood

    Kurt Oettel
    Ph: 608-775-2385
    Email: cancerctr@gundluth.org

    Madison

    University of Wisconsin Paul P. Carbone Comprehensive Cancer Center

    Anne M. Traynor
    Ph: 877-405-6866

    Manitowoc

    Holy Family Memorial Medical Center Cancer Care Center

    Brian L Burnette
    Ph: 800-432-6049

    Marinette

    Bay Area Cancer Care Center at Bay Area Medical Center

    Brian L Burnette
    Ph: 800-432-6049

    Mukwonago

    D.N. Greenwald Center

    Timothy R Wassenaar
    Ph: 262-928-7878

    New Richmond

    Cancer Center of Western Wisconsin

    Joseph W Leach
    Ph: 952-993-1517
    Email: MMCCOP@parknicollet.com

    Oconomowoc

    Regional Cancer Center at Oconomowoc Memorial Hospital

    Timothy R Wassenaar
    Ph: 262-928-7878

    Oconto Falls

    Green Bay Oncology, Limited - Oconto Falls

    Brian L Burnette
    Ph: 800-432-6049

    Sheboygan

    Saint Nicholas Hospital

    Brian L Burnette
    Ph: 800-432-6049

    Sturgeon Bay

    Green Bay Oncology, Limited - Sturgeon Bay

    Brian L Burnette
    Ph: 800-432-6049

    Waukesha

    Waukesha Memorial Hospital Regional Cancer Center

    Timothy R Wassenaar
    Ph: 262-928-7878

    Wausau

    University of Wisconcin Cancer Center at Aspirus Wausau Hospital

    Hamied R. Rezazadeh
    Ph: 877-405-6866

    Wisconsin Rapids

    Riverview UW Cancer Center at Riverview Hospital

    Ron James Kirschling
    Ph: 877-405-6866

    Wyoming
    Cheyenne

    Cheyenne Regional Medical Center

    Keren Sturtz
    Ph: 888-785-6789

    Sheridan

    Welch Cancer Center at Sheridan Memorial Hospital

    Benjamin Thomas Marchello
    Ph: 800-648-6274

    Link to the current ClinicalTrials.gov record.
    NLM Identifier NCT01642251
    ClinicalTrials.gov processed this data on May 21, 2015

    Note: Information about this trial is from the ClinicalTrials.gov database. The versions designated for health professionals and patients contain the same text. Minor changes may be made to the ClinicalTrials.gov record to standardize the names of study sponsors, sites, and contacts. Cancer.gov only lists sites that are recruiting patients for active trials, whereas ClinicalTrials.gov lists all sites for all trials. Questions and comments regarding the presented information should be directed to ClinicalTrials.gov.