Temozolomide with or without Capecitabine in Treating Patients with Advanced Pancreatic Neuroendocrine Tumors

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Basic Trial Information

PhaseTypeAgeTrial IDs
Phase IIBiomarker/Laboratory analysis, Treatment18 and overE2211
NCI-2012-02007, NCT01824875

Trial Description

Summary

This randomized phase II trial studies how well giving temozolomide with or without capecitabine works in treating patients with pancreatic neuroendocrine tumors that have spread to other places in the body and usually cannot be cured or controlled with treatment (advanced). Drugs used in chemotherapy, such as temozolomide and capecitabine, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. It is not yet known whether temozolomide is more effective with or without capecitabine in treating patients with advanced pancreatic neuroendocrine tumors.

Further Study Information

PRIMARY OBJECTIVES:

I. To evaluate progression-free survival (PFS) associated with temozolomide alone or temozolomide and capecitabine in patients with advanced pancreatic neuroendocrine tumors.

SECONDARY OBJECTIVES:

I. To evaluate response rates (RR) associated with temozolomide alone or temozolomide and capecitabine treatment in patients with advanced pancreatic neuroendocrine tumors.

II. To evaluate overall survival (OS) associated with temozolomide alone or temozolomide and capecitabine in patients with advanced pancreatic neuroendocrine tumors.

III. To evaluate the toxicity associated with temozolomide alone or temozolomide and capecitabine treatment in patients with advanced pancreatic neuroendocrine tumors.

IV. To evaluate the usefulness of methyl guanine methyltransferase (MGMT) status (by immunohistochemistry [IHC] and promoter methylation) for predicting response in pancreatic neuroendocrine tumor patients treated with either temozolomide or temozolomide and capecitabine.

V. To bank radiology images for evaluation of quality, reproducibility, and compliance with computed tomography (CT) methodology.

OUTLINE: Patients are randomized to 1 of 2 treatment arms.

ARM A: Patients receive temozolomide orally (PO) once daily (QD) on days 1-5. Treatment repeats every 28 days for up to 13 courses in the absence of disease progression or unacceptable toxicity.

ARM B: Patients receive capecitabine PO twice daily (BID) on days 1-14 and temozolomide PO QD on days 10-14. Treatment repeats every 28 days for up to 13 courses in the absence of disease progression or unacceptable toxicity.

After completion of study treatment, patients are followed up every 3 months for 3 years, and then every 6 months for 3-5 years from randomization.

Eligibility Criteria

Inclusion Criteria:

Women of childbearing potential and sexually active males must be strongly advised to use an accepted and effective method of contraception or to abstain from sexual intercourse for the duration of their participation in the study; should a woman become pregnant while participating in this study, she should inform her treating physician immediately; if a man impregnates a woman while participating in this study, he should inform his treating physician immediately

Women must not be pregnant or breast-feeding; all females of childbearing potential must have a blood test or urine study within =< 2 weeks prior to randomization to rule out pregnancy; a female of childbearing potential is any woman, regardless of sexual orientation or whether they have undergone tubal ligation, who meets the following criteria:

Has not undergone a hysterectomy or bilateral oophorectomy; or

Has not been naturally postmenopausal for at least 24 consecutive months (i.e., has had menses at any time in the preceding 24 consecutive months)

Patients must NOT have previous or concurrent malignancy; exceptions are made for patients who meet any of the following conditions:

Non-melanoma skin cancer, in situ cervical cancer, or breast cancer in situ OR

Prior malignancy completely excised or removed and patient has been continuously disease free for > 5 years OR

Prior malignancy cured by non-surgical modalities and patient has been continuously disease free for > 5 years

Patients with symptomatic peripheral vascular disease are not eligible

Patient must NOT have absorption issues that would limit the ability to absorb study agents

Patients must NOT have history of allergic reactions attributed to compounds of similar chemical or biologic composition to temozolomide or capecitabine

Patients must NOT have active or uncontrolled infection or serious medical or psychiatric illness

Patient must have life expectancy >= 12 weeks

Patient must have Eastern Cooperative Oncology Group (ECOG) performance status 0-1

Serum creatinine =< 1.5 X institutional ULN

Aspartate aminotransferase (AST) (serum glutamic oxaloacetic transaminase [SGOT])/alanine aminotransferase (ALT) (serum glutamate pyruvate transaminase [SGPT]) =< 3 X institutional ULN or (=< 5 X institutional ULN if the patient has liver metastases)

Total bilirubin =< institutional upper limit of normal (ULN) or =< 1.5 X institutional ULN (if the patient has liver metastases)

Platelets >= 100,000/mm^3

Absolute neutrophil count >= 1,500/mm^3

Leukocytes >= 3,000/mm^3

Patients may not be receiving Coumadin while on treatment; other anticoagulants are allowed

Patients may not be receiving any other investigational agents while on study treatment

Chemoembolization is allowed if >= 4 weeks from study entry; there are 3 possible scenarios:

If patient has hepatic disease only: they need to have progressed in the liver since chemoembolization and have measureable disease by RECIST 1.1 in order to be eligible

If patient has hepatic and extrahepatic disease: they will need to have progressed inside OR outside the liver and have measureable disease by RECIST 1.1 in order to be eligible

Prior everolimus and/or sunitinib therapy is allowed, so long as it was discontinued >= 4 weeks prior to randomization

Patient must not have received prior temozolomide, dacarbazine (DTIC), or capecitabine, or 5-FU (fluorouracil) therapy

Patient must have documented disease progression, and date of last documented disease progression must be within 12 months from date of randomization

Patient must have measurable disease by Response Evaluation Criteria in Solid Tumors (RECIST) 1.1 criteria; baseline measurements and evaluations of all sites of disease must be obtained =< 4 weeks prior to randomization and must be acquired by multiphasic CT or contrast magnetic resonance imaging (MRI)

Patient must have histologically or pathologically confirmed locally unresectable or metastatic low or intermediate grade pancreatic neuroendocrine tumor, excluding small cell carcinoma

Patients with a history of the following within =< 12 months of study entry are not eligible:

Arterial thromboembolic events

Unstable angina

Myocardial Infarction

Patients with either clinically apparent central nervous system metastases or carcinomatous meningitis are ineligible

Hemoglobin >= 9 g/dL

Patient must be able to tolerate CT or magnetic resonance (MR) imaging including contrast agents as required for their treatment and the protocol

Patient must be able to swallow pills

Concurrent somatostatin analogues are allowed provided that the patient

Has been on a stable dose (+/- 10mg) for 8 weeks and

Has documented disease progression on that dose

Trial Contact Information

Trial Lead Organizations / Sponsors / Collaborators

ECOG-ACRIN Cancer Research Group

  • National Cancer Institute
Pamela L. Kunz, Principal Investigator

Trial Sites

U.S.A.

Arizona
Tucson

The University of Arizona Cancer Center-North Campus

Emad Elquza
Ph: 520-626-9008

Emad Elquza
Principal Investigator

The University of Arizona Cancer Center-Orange Grove Campus

Emad Elquza
Ph: 520-626-9008

Emad Elquza
Principal Investigator

The University of Arizona Medical Center-University Campus

Emad Elquza
Ph: 520-626-9008

Emad Elquza
Principal Investigator

California
Anaheim

Kaiser Permanente-Anaheim

Han A. Koh
Ph: 626-564-3455

Han A. Koh
Principal Investigator

Antioch

Kaiser Permanente-Deer Valley Medical Center

Tatjana Kolevska
Ph: 626-564-3455

Tatjana Kolevska
Principal Investigator

Auburn

Sutter Auburn Faith Hospital

David Alan Shiba
Ph: 415-209-2686
Email: bernicl@sutterhealth.org

David Alan Shiba
Principal Investigator

Sutter Cancer Centers Radiation Oncology Services-Auburn

David Alan Shiba
Ph: 415-209-2686
Email: bernicl@sutterhealth.org

David Alan Shiba
Principal Investigator

Baldwin Park

Kaiser Permanente-Baldwin Park

Han A. Koh
Ph: 626-564-3455

Han A. Koh
Principal Investigator

Bellflower

Kaiser Permanente-Bellflower

Han A. Koh
Ph: 626-564-3455

Han A. Koh
Principal Investigator

Berkeley

Alta Bates Summit Medical Center-Herrick Campus

David Alan Shiba
Ph: 415-209-2686
Email: bernicl@sutterhealth.org

David Alan Shiba
Principal Investigator

Burlingame

Mills - Peninsula Hospitals

David Alan Shiba
Ph: 415-209-2686
Email: bernicl@sutterhealth.org

David Alan Shiba
Principal Investigator

Cameron Park

Sutter Cancer Centers Radiation Oncology Services-Cameron Park

David Alan Shiba
Ph: 415-209-2686
Email: bernicl@sutterhealth.org

David Alan Shiba
Principal Investigator

Davis

Sutter Davis Hospital

David Alan Shiba
Ph: 415-209-2686
Email: bernicl@sutterhealth.org

David Alan Shiba
Principal Investigator

Fontana

Kaiser Permanente Hospital

Han A. Koh
Ph: 626-564-3455

Han A. Koh
Principal Investigator

Fremont

Kaiser Permanente-Fremont

Tatjana Kolevska
Ph: 626-564-3455

Tatjana Kolevska
Principal Investigator

Fresno

Kaiser Permanente

Tatjana Kolevska
Ph: 626-564-3455

Tatjana Kolevska
Principal Investigator

Harbor City

Kaiser Permanente - Harbor City

Han A. Koh
Ph: 626-564-3455

Han A. Koh
Principal Investigator

Irvine

Kaiser Permanente-Irvine

Han A. Koh
Ph: 626-564-3455

Han A. Koh
Principal Investigator

Los Angeles

Cedars-Sinai Medical Center

Andrew E. Hendifar
Ph: 310-423-8965

Andrew E. Hendifar
Principal Investigator

Kaiser Permanente Los Angeles Medical Center

Han A. Koh
Ph: 626-564-3455

Han A. Koh
Principal Investigator

Kaiser Permanente-Cadillac

Han A. Koh
Ph: 626-564-3455

Han A. Koh
Principal Investigator

Los Angeles County-USC Medical Center

Syma Iqbal
Ph: 323-865-0451

Syma Iqbal
Principal Investigator

USC / Norris Comprehensive Cancer Center

Syma Iqbal
Ph: 323-865-0451

Syma Iqbal
Principal Investigator

Modesto

Kaiser Permanente-Modesto

Tatjana Kolevska
Ph: 626-564-3455

Tatjana Kolevska
Principal Investigator

Memorial Medical Center

David Alan Shiba
Ph: 415-209-2686
Email: bernicl@sutterhealth.org

David Alan Shiba
Principal Investigator

Monterey

Community Hospital of Monterey Peninsula

John Hausdorff
Ph: 831-625-4753

John Hausdorff
Principal Investigator

Mountain View

Palo Alto Medical Foundation-Camino Division

David Alan Shiba
Ph: 415-209-2686
Email: bernicl@sutterhealth.org

David Alan Shiba
Principal Investigator

Palo Alto Medical Foundation-Gynecologic Oncology

David Alan Shiba
Ph: 415-209-2686
Email: bernicl@sutterhealth.org

David Alan Shiba
Principal Investigator

Novato

Sutter Cancer Research Consortium

David Alan Shiba
Ph: 415-209-2686
Email: bernicl@sutterhealth.org

David Alan Shiba
Principal Investigator

Oakland

Kaiser Permanente-Oakland

Tatjana Kolevska
Ph: 626-564-3455

Tatjana Kolevska
Principal Investigator

Orange

UC Irvine Health/Chao Family Comprehensive Cancer Center

Tara Elisabeth Seery
Ph: 877-827-8839
Email: ucstudy@uci.edu

Tara Elisabeth Seery
Principal Investigator

Palo Alto

Palo Alto Medical Foundation Health Care

David Alan Shiba
Ph: 415-209-2686
Email: bernicl@sutterhealth.org

David Alan Shiba
Principal Investigator

Panorama City

Kaiser Permanente - Panorama City

Han A. Koh
Ph: 626-564-3455

Han A. Koh
Principal Investigator

Redwood City

Kaiser Permanente-Redwood City

Tatjana Kolevska
Ph: 626-564-3455

Tatjana Kolevska
Principal Investigator

Richmond

Kaiser Permanente-Richmond

Tatjana Kolevska
Ph: 626-564-3455

Tatjana Kolevska
Principal Investigator

Riverside

Kaiser Permanente-Riverside

Han A. Koh
Ph: 626-564-3455

Han A. Koh
Principal Investigator

Roseville

Kaiser Permanente-Roseville

Tatjana Kolevska
Ph: 626-564-3455

Tatjana Kolevska
Principal Investigator

Sutter Cancer Centers Radiation Oncology Services-Roseville

David Alan Shiba
Ph: 415-209-2686
Email: bernicl@sutterhealth.org

David Alan Shiba
Principal Investigator

Sutter Roseville Medical Center

David Alan Shiba
Ph: 415-209-2686
Email: bernicl@sutterhealth.org

David Alan Shiba
Principal Investigator

Sacramento

Kaiser Permanente - Sacramento

Tatjana Kolevska
Ph: 626-564-3455

Tatjana Kolevska
Principal Investigator

Kaiser Permanente-South Sacramento

Tatjana Kolevska
Ph: 626-564-3455

Tatjana Kolevska
Principal Investigator

Sutter General Hospital

David Alan Shiba
Ph: 415-209-2686
Email: bernicl@sutterhealth.org

David Alan Shiba
Principal Investigator

San Diego

Kaiser Permanente-San Diego Mission

Han A. Koh
Ph: 626-564-3455

Han A. Koh
Principal Investigator

Kaiser Permanente-San Diego Zion

Han A. Koh
Ph: 626-564-3455

Han A. Koh
Principal Investigator

San Francisco

California Pacific Medical Center-Pacific Campus

David Alan Shiba
Ph: 415-209-2686
Email: bernicl@sutterhealth.org

David Alan Shiba
Principal Investigator

Kaiser Permanente-San Francisco

Tatjana Kolevska
Ph: 626-564-3455

Tatjana Kolevska
Principal Investigator

UCSF Medical Center-Mission Bay

Emily K. Bergsland
Ph: 877-827-3222

Emily K. Bergsland
Principal Investigator

UCSF Medical Center-Mount Zion

Emily K. Bergsland
Ph: 877-827-3222

Emily K. Bergsland
Principal Investigator

San Jose

Kaiser Permanente-Santa Teresa-San Jose

Tatjana Kolevska
Ph: 626-564-3455

Tatjana Kolevska
Principal Investigator

San Leandro

Kaiser Permanente San Leandro

Tatjana Kolevska
Ph: 626-564-3455

Tatjana Kolevska
Principal Investigator

San Marcos

Kaiser Permanente-San Marcos

Han A. Koh
Ph: 626-564-3455

Han A. Koh
Principal Investigator

San Rafael

Kaiser Permanente-San Rafael

Tatjana Kolevska
Ph: 626-564-3455

Tatjana Kolevska
Principal Investigator

Santa Clara

Kaiser Permanente Medical Center - Santa Clara

Tatjana Kolevska
Ph: 626-564-3455

Tatjana Kolevska
Principal Investigator

Santa Cruz

Palo Alto Medical Foundation-Santa Cruz

David Alan Shiba
Ph: 415-209-2686
Email: bernicl@sutterhealth.org

David Alan Shiba
Principal Investigator

Santa Rosa

Kaiser Permanente-Santa Rosa

Tatjana Kolevska
Ph: 626-564-3455

Tatjana Kolevska
Principal Investigator

Sutter Pacific Medical Foundation

David Alan Shiba
Ph: 415-209-2686
Email: bernicl@sutterhealth.org

David Alan Shiba
Principal Investigator

South San Francisco

Kaiser Permanente-South San Francisco

Tatjana Kolevska
Ph: 626-564-3455

Tatjana Kolevska
Principal Investigator

Stockton

Kaiser Permanente-Stockton

Tatjana Kolevska
Ph: 626-564-3455

Tatjana Kolevska
Principal Investigator

Sunnyvale

Palo Atlo Medical Foundation-Sunnyvale

David Alan Shiba
Ph: 415-209-2686
Email: bernicl@sutterhealth.org

David Alan Shiba
Principal Investigator

Vacaville

Kaiser Permanente Medical Center-Vacaville

Tatjana Kolevska
Ph: 626-564-3455

Tatjana Kolevska
Principal Investigator

Sutter Cancer Centers Radiation Oncology Services-Vacaville

David Alan Shiba
Ph: 415-209-2686
Email: bernicl@sutterhealth.org

David Alan Shiba
Principal Investigator

Vallejo

Kaiser Permanente-Vallejo

Tatjana Kolevska
Ph: 626-564-3455

Tatjana Kolevska
Principal Investigator

Sutter Solano Medical Center/Cancer Center

David Alan Shiba
Ph: 415-209-2686
Email: bernicl@sutterhealth.org

David Alan Shiba
Principal Investigator

Walnut Creek

Kaiser Permanente-Walnut Creek

Tatjana Kolevska
Ph: 626-564-3455

Tatjana Kolevska
Principal Investigator

Woodland Hills

Kaiser Permanente

Han A. Koh
Ph: 626-564-3455

Han A. Koh
Principal Investigator

Colorado
Aurora

Rocky Mountain Cancer Centers-Aurora

Keren Sturtz
Ph: 888-785-6789

Keren Sturtz
Principal Investigator

The Medical Center of Aurora

Keren Sturtz
Ph: 888-785-6789

Keren Sturtz
Principal Investigator

Boulder

Boulder Community Hospital

Keren Sturtz
Ph: 888-785-6789

Keren Sturtz
Principal Investigator

Rocky Mountain Cancer Centers-Boulder

Keren Sturtz
Ph: 888-785-6789

Keren Sturtz
Principal Investigator

Colorado Springs

Penrose-Saint Francis Healthcare

Keren Sturtz
Ph: 888-785-6789

Keren Sturtz
Principal Investigator

Rocky Mountain Cancer Centers-Penrose

Keren Sturtz
Ph: 888-785-6789

Keren Sturtz
Principal Investigator

Denver

Colorado Blood Cancer Institute

Keren Sturtz
Ph: 888-785-6789

Keren Sturtz
Principal Investigator

Exempla Saint Joseph Hospital

Keren Sturtz
Ph: 888-785-6789

Keren Sturtz
Principal Investigator

Porter Adventist Hospital

Keren Sturtz
Ph: 888-785-6789

Keren Sturtz
Principal Investigator

Presbyterian - Saint Lukes Medical Center - Health One

Keren Sturtz
Ph: 888-785-6789

Keren Sturtz
Principal Investigator

Rocky Mountain Cancer Centers-Midtown

Keren Sturtz
Ph: 888-785-6789

Keren Sturtz
Principal Investigator

Rocky Mountain Cancer Centers-Rose

Keren Sturtz
Ph: 888-785-6789

Keren Sturtz
Principal Investigator

Rose Medical Center

Keren Sturtz
Ph: 888-785-6789

Keren Sturtz
Principal Investigator

Durango

Mercy Medical Center

Keren Sturtz
Ph: 888-785-6789

Keren Sturtz
Principal Investigator

Southwest Oncology PC

Keren Sturtz
Ph: 888-785-6789

Keren Sturtz
Principal Investigator

Englewood

Comprehensive Cancer Care and Research Institute of Colorado LLC

Keren Sturtz
Ph: 888-785-6789

Keren Sturtz
Principal Investigator

Swedish Medical Center

Keren Sturtz
Ph: 888-785-6789

Keren Sturtz
Principal Investigator

Golden

Mountain Blue Cancer Care Center

Keren Sturtz
Ph: 888-785-6789

Keren Sturtz
Principal Investigator

Greeley

North Colorado Medical Center

Keren Sturtz
Ph: 888-785-6789

Keren Sturtz
Principal Investigator

Greenwood Village

Rocky Mountain Cancer Centers-Greenwood Village

Keren Sturtz
Ph: 888-785-6789

Keren Sturtz
Principal Investigator

Lakewood

Rocky Mountain Cancer Centers-Lakewood

Keren Sturtz
Ph: 888-785-6789

Keren Sturtz
Principal Investigator

Saint Anthony Hospital

Keren Sturtz
Ph: 888-785-6789

Keren Sturtz
Principal Investigator

Littleton

Littleton Adventist Hospital

Keren Sturtz
Ph: 888-785-6789

Keren Sturtz
Principal Investigator

Rocky Mountain Cancer Centers-Littleton

Keren Sturtz
Ph: 888-785-6789

Keren Sturtz
Principal Investigator

Lone Tree

Rocky Mountain Cancer Centers-Sky Ridge

Keren Sturtz
Ph: 888-785-6789

Keren Sturtz
Principal Investigator

Sky Ridge Medical Center

Keren Sturtz
Ph: 888-785-6789

Keren Sturtz
Principal Investigator

Longmont

Longmont United Hospital

Keren Sturtz
Ph: 888-785-6789

Keren Sturtz
Principal Investigator

Rocky Mountain Cancer Centers-Longmont

Keren Sturtz
Ph: 888-785-6789

Keren Sturtz
Principal Investigator

Loveland

McKee Medical Center

Keren Sturtz
Ph: 888-785-6789

Keren Sturtz
Principal Investigator

Parker

Parker Adventist Hospital

Keren Sturtz
Ph: 888-785-6789

Keren Sturtz
Principal Investigator

Rocky Mountain Cancer Centers-Parker

Keren Sturtz
Ph: 888-785-6789

Keren Sturtz
Principal Investigator

Pueblo

Rocky Mountain Cancer Centers - Pueblo

Keren Sturtz
Ph: 888-785-6789

Keren Sturtz
Principal Investigator

Saint Mary Corwin Medical Center

Keren Sturtz
Ph: 888-785-6789

Keren Sturtz
Principal Investigator

Thornton

Rocky Mountain Cancer Centers-Thornton

Keren Sturtz
Ph: 888-785-6789

Keren Sturtz
Principal Investigator

Wheat Ridge

Exempla Lutheran Medical Center

Keren Sturtz
Ph: 888-785-6789

Keren Sturtz
Principal Investigator

Connecticut
Hartford

Saint Francis Hospital and Medical Center

Tareq Al Baghdadi
Ph: 734-712-4673

Tareq Al Baghdadi
Principal Investigator

Middletown

Middlesex Hospital

Susanna Hong
Ph: 860-358-2058

Susanna Hong
Principal Investigator

Stamford

Stamford Hospital/Bennett Cancer Center

Anthony P. Gulati
Ph: 203-323-8944

Anthony P. Gulati
Principal Investigator

Georgia
Atlanta

Emory University/Winship Cancer Institute

Walid L. Shaib
Ph: 404-778-1868

Walid L. Shaib
Principal Investigator

Hawaii
Aiea

Oncare Hawaii Inc-Pali Momi

Jeffrey L. Berenberg
Ph: 808-586-2979

Jeffrey L. Berenberg
Principal Investigator

Pali Momi Medical Center

Jeffrey L. Berenberg
Ph: 808-586-2979

Jeffrey L. Berenberg
Principal Investigator

Honolulu

Kaiser Permanente Moanalua Medical Center

Tatjana Kolevska
Ph: 626-564-3455

Tatjana Kolevska
Principal Investigator

Oncare Hawaii Inc-Kuakini

Jeffrey L. Berenberg
Ph: 808-586-2979

Jeffrey L. Berenberg
Principal Investigator

Oncare Hawaii Inc-POB II

Jeffrey L. Berenberg
Ph: 808-586-2979

Jeffrey L. Berenberg
Principal Investigator

OnCare Hawaii-Liliha

Jeffrey L. Berenberg
Ph: 808-586-2979

Jeffrey L. Berenberg
Principal Investigator

Queen's Medical Center

Jeffrey L. Berenberg
Ph: 808-586-2979

Jeffrey L. Berenberg
Principal Investigator

Straub Clinic and Hospital

Jeffrey L. Berenberg
Ph: 808-586-2979

Jeffrey L. Berenberg
Principal Investigator

University of Hawaii Cancer Center

Jeffrey L. Berenberg
Ph: 808-586-2979

Jeffrey L. Berenberg
Principal Investigator

Lihue

Wilcox Memorial Hospital and Kauai Medical Clinic

Jeffrey L. Berenberg
Ph: 808-586-2979

Jeffrey L. Berenberg
Principal Investigator

Idaho
Boise

Saint Alphonsus Cancer Care Center-Boise

Tareq Al Baghdadi
Ph: 734-712-4673

Tareq Al Baghdadi
Principal Investigator

Lewiston

Saint Joseph Regional Medical Center

John A. Keech
Ph: 907-458-5380

John A. Keech
Principal Investigator

Illinois
Bloomington

Illinois CancerCare-Bloomington

Nguyet Anh Le-Lindqwister
Ph: 800-793-2262

Nguyet Anh Le-Lindqwister
Principal Investigator

Saint Joseph Medical Center

Nguyet Anh Le-Lindqwister
Ph: 800-793-2262

Nguyet Anh Le-Lindqwister
Principal Investigator

Canton

Illinois CancerCare-Canton

Nguyet Anh Le-Lindqwister
Ph: 800-793-2262

Nguyet Anh Le-Lindqwister
Principal Investigator

Carbondale

Memorial Hospital of Carbondale

James Lloyd Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

James Lloyd Wade
Principal Investigator

Carthage

Illinois CancerCare-Carthage

Nguyet Anh Le-Lindqwister
Ph: 800-793-2262

Nguyet Anh Le-Lindqwister
Principal Investigator

Centralia

Centralia Oncology Clinic

James Lloyd Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

James Lloyd Wade
Principal Investigator

Chicago

Northwestern University

Halla S. Nimeiri
Ph: 312-695-1301
Email: cancer@northwestern.edu

Halla S. Nimeiri
Principal Investigator

University of Illinois

Neeta Kiran Venepalli
Ph: 312-355-3046

Neeta Kiran Venepalli
Principal Investigator

Decatur

Cancer Care Center of Decatur

James Lloyd Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

James Lloyd Wade
Principal Investigator

Decatur Memorial Hospital

James Lloyd Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

James Lloyd Wade
Principal Investigator

Effingham

Crossroads Cancer Center

James Lloyd Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

James Lloyd Wade
Principal Investigator

Eureka

Illinois CancerCare-Eureka

Nguyet Anh Le-Lindqwister
Ph: 800-793-2262

Nguyet Anh Le-Lindqwister
Principal Investigator

Galesburg

Illinois CancerCare Galesburg

Nguyet Anh Le-Lindqwister
Ph: 800-793-2262

Nguyet Anh Le-Lindqwister
Principal Investigator

Illinois CancerCare-Galesburg Cottage Plaza Office

Nguyet Anh Le-Lindqwister
Ph: 800-793-2262

Nguyet Anh Le-Lindqwister
Principal Investigator

Western Illinois Cancer Treatment Center

James Lloyd Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

James Lloyd Wade
Principal Investigator

Highland Park

Hematology Oncology Associates of Illinois-Highland Park

Halla S. Nimeiri
Ph: 312-695-1301
Email: cancer@northwestern.edu

Halla S. Nimeiri
Principal Investigator

Hinsdale

Hinsdale Hematology Oncology Associates Incorporated

Elyse Cheryl Schneiderman
Ph: 630-654-1790
Email: info@hhoaltd.com

Elyse Cheryl Schneiderman
Principal Investigator

Kankakee

Presence Saint Mary's Hospital

Halla S. Nimeiri
Ph: 312-695-1301
Email: cancer@northwestern.edu

Halla S. Nimeiri
Principal Investigator

Kewanee

Illinois CancerCare-Kewanee Clinic

Nguyet Anh Le-Lindqwister
Ph: 800-793-2262

Nguyet Anh Le-Lindqwister
Principal Investigator

Libertyville

North Shore Hematology Oncology

Halla S. Nimeiri
Ph: 312-695-1301
Email: cancer@northwestern.edu

Halla S. Nimeiri
Principal Investigator

Macomb

Illinois CancerCare-Macomb

Nguyet Anh Le-Lindqwister
Ph: 800-793-2262

Nguyet Anh Le-Lindqwister
Principal Investigator

Moline

Garneau, Stewart C MD (UIA Investigator)

David Martens Spector
Ph: 309-779-4200

David Martens Spector
Principal Investigator

Spector, David MD (UIA Investigator)

David Martens Spector
Ph: 309-779-4200

David Martens Spector
Principal Investigator

Trinity Medical Center

David Martens Spector
Ph: 309-779-4200

David Martens Spector
Principal Investigator

Mount Vernon

Good Samaritan Regional Health Center

Jay W. Carlson
Ph: 800-821-7532

Jay W. Carlson
Principal Investigator

Niles

Illinois Cancer Specialists-Niles

Halla S. Nimeiri
Ph: 312-695-1301
Email: cancer@northwestern.edu

Halla S. Nimeiri
Principal Investigator

Ottawa

Illinois CancerCare-Ottawa Clinic

Nguyet Anh Le-Lindqwister
Ph: 800-793-2262

Nguyet Anh Le-Lindqwister
Principal Investigator

Radiation Oncology of Northern Illinois

James Lloyd Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

James Lloyd Wade
Principal Investigator

Pekin

Illinois CancerCare-Pekin

Nguyet Anh Le-Lindqwister
Ph: 800-793-2262

Nguyet Anh Le-Lindqwister
Principal Investigator

Pekin Cancer Treatment Center

Nguyet Anh Le-Lindqwister
Ph: 800-793-2262

Nguyet Anh Le-Lindqwister
Principal Investigator

Peoria

Illinois CancerCare-Peoria

Nguyet Anh Le-Lindqwister
Ph: 800-793-2262

Nguyet Anh Le-Lindqwister
Principal Investigator

Methodist Medical Center of Illinois

Nguyet Anh Le-Lindqwister
Ph: 800-793-2262

Nguyet Anh Le-Lindqwister
Principal Investigator

OSF Saint Francis Medical Center

Nguyet Anh Le-Lindqwister
Ph: 800-793-2262

Nguyet Anh Le-Lindqwister
Principal Investigator

OSF Saint Francis Medical Center Radiation Oncology Service at the Central Illinois Comprehensive CC

James Lloyd Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

James Lloyd Wade
Principal Investigator

Peru

Illinois CancerCare-Peru

Nguyet Anh Le-Lindqwister
Ph: 800-793-2262

Nguyet Anh Le-Lindqwister
Principal Investigator

Valley Radiation Oncology

James Lloyd Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

James Lloyd Wade
Principal Investigator

Princeton

Illinois CancerCare-Princeton

Nguyet Anh Le-Lindqwister
Ph: 800-793-2262

Nguyet Anh Le-Lindqwister
Principal Investigator

Rockford

SwedishAmerican Regional Cancer Center/ACT

Harvey E. Einhorn
Ph: 779-696-9400
Email: cancercare@swedishamerican.org

Harvey E. Einhorn
Principal Investigator

Skokie

Hematology Oncology Associates of Illinois - Skokie

Halla S. Nimeiri
Ph: 312-695-1301
Email: cancer@northwestern.edu

Halla S. Nimeiri
Principal Investigator

Springfield

Central Illinois Hematology Oncology Center

James Lloyd Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

James Lloyd Wade
Principal Investigator

Memorial Medical Center

James Lloyd Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

James Lloyd Wade
Principal Investigator

Southern Illinois University School of Medicine

James Lloyd Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

James Lloyd Wade
Principal Investigator

Springfield Clinic

James Lloyd Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

James Lloyd Wade
Principal Investigator

Indiana
Richmond

Reid Hospital and Health Care Services

Howard M. Gross
Ph: 937-775-1350

Howard M. Gross
Principal Investigator

Iowa
Ames

Mary Greeley Medical Center

Joseph James Merchant
Ph: 515-239-2621

Joseph James Merchant
Principal Investigator

McFarland Clinic PC-William R Bliss Cancer Center

Joseph James Merchant
Ph: 515-239-2621

Joseph James Merchant
Principal Investigator

Bettendorf

Constantinou, Costas L MD (UIA Investigator)

David Martens Spector
Ph: 309-779-4200

David Martens Spector
Principal Investigator

Boone

McFarland Clinic PC-Boone

Joseph James Merchant
Ph: 515-239-2621

Joseph James Merchant
Principal Investigator

Clive

Medical Oncology and Hematology Associates-West Des Moines

Robert J. Behrens
Ph: 515-282-2921

Robert J. Behrens
Principal Investigator

Mercy Cancer Center-West Lakes

Robert J. Behrens
Ph: 515-282-2921

Robert J. Behrens
Principal Investigator

Des Moines

Iowa Lutheran Hospital

Robert J. Behrens
Ph: 515-282-2921

Robert J. Behrens
Principal Investigator

Iowa Methodist Medical Center

Robert J. Behrens
Ph: 515-282-2921

Robert J. Behrens
Principal Investigator

Iowa Oncology Research Association CCOP

Robert J. Behrens
Ph: 515-282-2921

Robert J. Behrens
Principal Investigator

Medical Oncology and Hematology Associates-Des Moines

Robert J. Behrens
Ph: 515-282-2921

Robert J. Behrens
Principal Investigator

Medical Oncology and Hematology Associates-Laurel

Robert J. Behrens
Ph: 515-282-2921

Robert J. Behrens
Principal Investigator

Mercy Medical Center - Des Moines

Robert J. Behrens
Ph: 515-282-2921

Robert J. Behrens
Principal Investigator

Fort Dodge

McFarland Clinic PC-Trinity Cancer Center

Joseph James Merchant
Ph: 515-239-2621

Joseph James Merchant
Principal Investigator

Iowa City

University of Iowa/Holden Comprehensive Cancer Center

Daniel Alberto Vaena
Ph: 800-237-1225

Daniel Alberto Vaena
Principal Investigator

Jefferson

McFarland Clinic PC-Jefferson

Joseph James Merchant
Ph: 515-239-2621

Joseph James Merchant
Principal Investigator

Marshalltown

McFarland Clinic PC-Marshalltown

Joseph James Merchant
Ph: 515-239-2621

Joseph James Merchant
Principal Investigator

Sioux City

Siouxland Regional Cancer Center

Donald B. Wender
Ph: 712-252-0088

Donald B. Wender
Principal Investigator

West Des Moines

Mercy Medical Center-West Lakes

Robert J. Behrens
Ph: 515-282-2921

Robert J. Behrens
Principal Investigator

Methodist West Hospital

Robert J. Behrens
Ph: 515-282-2921

Robert J. Behrens
Principal Investigator

Kansas
Chanute

Cancer Center of Kansas - Chanute

Shaker R. Dakhil
Ph: 316-262-4467

Shaker R. Dakhil
Principal Investigator

Dodge City

Cancer Center of Kansas - Dodge City

Shaker R. Dakhil
Ph: 316-262-4467

Shaker R. Dakhil
Principal Investigator

El Dorado

Cancer Center of Kansas - El Dorado

Shaker R. Dakhil
Ph: 316-262-4467

Shaker R. Dakhil
Principal Investigator

Emporia

Newman Regional Health

Joaquina Celebre Baranda
Ph: 913-588-4709

Joaquina Celebre Baranda
Principal Investigator

Fort Scott

Cancer Center of Kansas - Fort Scott

Shaker R. Dakhil
Ph: 316-262-4467

Shaker R. Dakhil
Principal Investigator

Garden City

Saint Catherine Hospital

Joaquina Celebre Baranda
Ph: 913-588-4709

Joaquina Celebre Baranda
Principal Investigator

Great Bend

Saint Rose Ambulatory and Surgery Center

Joaquina Celebre Baranda
Ph: 913-588-4709

Joaquina Celebre Baranda
Principal Investigator

Hays

Hays Medical Center

Joaquina Celebre Baranda
Ph: 913-588-4709

Joaquina Celebre Baranda
Principal Investigator

Independence

Cancer Center of Kansas-Independence

Shaker R. Dakhil
Ph: 316-262-4467

Shaker R. Dakhil
Principal Investigator

Kansas City

Kansas City Cancer Center-West

Joaquina Celebre Baranda
Ph: 913-588-4709

Joaquina Celebre Baranda
Principal Investigator

University of Kansas Cancer Center

Joaquina Celebre Baranda
Ph: 913-588-4709

Joaquina Celebre Baranda
Principal Investigator

Kingman

Cancer Center of Kansas-Kingman

Shaker R. Dakhil
Ph: 316-262-4467

Shaker R. Dakhil
Principal Investigator

Lawrence

Lawrence Memorial Hospital

Shaker R. Dakhil
Ph: 316-262-4467

Shaker R. Dakhil
Principal Investigator

Liberal

Cancer Center of Kansas-Liberal

Shaker R. Dakhil
Ph: 316-262-4467

Shaker R. Dakhil
Principal Investigator

Newton

Cancer Center of Kansas - Newton

Shaker R. Dakhil
Ph: 316-262-4467

Shaker R. Dakhil
Principal Investigator

Olathe

Olathe Medical Center

Joaquina Celebre Baranda
Ph: 913-588-4709

Joaquina Celebre Baranda
Principal Investigator

Overland Park

Kansas City Cancer Centers-Southwest

Joaquina Celebre Baranda
Ph: 913-588-4709

Joaquina Celebre Baranda
Principal Investigator

Parsons

Cancer Center of Kansas - Parsons

Shaker R. Dakhil
Ph: 316-262-4467

Shaker R. Dakhil
Principal Investigator

Pittsburg

Via Christi Hospital-Pittsburg

Joaquina Celebre Baranda
Ph: 913-588-4709

Joaquina Celebre Baranda
Principal Investigator

Pratt

Cancer Center of Kansas - Pratt

Shaker R. Dakhil
Ph: 316-262-4467

Shaker R. Dakhil
Principal Investigator

Salina

Cancer Center of Kansas - Salina

Shaker R. Dakhil
Ph: 316-262-4467

Shaker R. Dakhil
Principal Investigator

Salina Regional Health Center

Joaquina Celebre Baranda
Ph: 913-588-4709

Joaquina Celebre Baranda
Principal Investigator

Topeka

Saint Francis Hospital and Medical Center - Topeka

Joaquina Celebre Baranda
Ph: 913-588-4709

Joaquina Celebre Baranda
Principal Investigator

Wellington

Cancer Center of Kansas - Wellington

Shaker R. Dakhil
Ph: 316-262-4467

Shaker R. Dakhil
Principal Investigator

Wichita

Associates In Womens Health

Shaker R. Dakhil
Ph: 316-262-4467

Shaker R. Dakhil
Principal Investigator

Cancer Center of Kansas - Main Office

Shaker R. Dakhil
Ph: 316-262-4467

Shaker R. Dakhil
Principal Investigator

Cancer Center of Kansas-Wichita Medical Arts Tower

Shaker R. Dakhil
Ph: 316-262-4467

Shaker R. Dakhil
Principal Investigator

Via Christi Regional Medical Center

Shaker R. Dakhil
Ph: 316-262-4467

Shaker R. Dakhil
Principal Investigator

Winfield

Cancer Center of Kansas - Winfield

Shaker R. Dakhil
Ph: 316-262-4467

Shaker R. Dakhil
Principal Investigator

Kentucky
Crestview Hills

Oncology Hematology Care Inc-Crestview

Howard M. Gross
Ph: 937-775-1350

Howard M. Gross
Principal Investigator

Lexington

University of Kentucky/Markey Cancer Center

Lowell Brian Anthony
Ph: 859-257-3379

Lowell Brian Anthony
Principal Investigator

Louisiana
Baton Rouge

Ochsner Health Center-Summa

Jyotsna Fuloria
Ph: 888-562-4763

Jyotsna Fuloria
Principal Investigator

Kenner

Ochsner Medical Center Kenner

Jyotsna Fuloria
Ph: 888-562-4763

Jyotsna Fuloria
Principal Investigator

New Orleans

Ochsner Medical Center Jefferson

Jyotsna Fuloria
Ph: 888-562-4763

Jyotsna Fuloria
Principal Investigator

Massachusetts
Boston

Boston Medical Center

Kevan Leighton Hartshorn
Ph: 617-638-8265

Kevan Leighton Hartshorn
Principal Investigator

Burlington

Lahey Hospital and Medical Center

Keith Ellis Stuart
Ph: 781-744-8027

Keith Ellis Stuart
Principal Investigator

Michigan
Ann Arbor

Saint Joseph Mercy Hospital

Tareq Al Baghdadi
Ph: 734-712-4673

Tareq Al Baghdadi
Principal Investigator

University of Michigan Comprehensive Cancer Center

Mark M. Zalupski
Ph: 800-865-1125

Mark M. Zalupski
Principal Investigator

Dearborn

Oakwood Hospital and Medical Center

Tareq Al Baghdadi
Ph: 734-712-4673

Tareq Al Baghdadi
Principal Investigator

Detroit

Saint John Hospital and Medical Center

Tareq Al Baghdadi
Ph: 734-712-4673

Tareq Al Baghdadi
Principal Investigator

Wayne State University/Karmanos Cancer Institute

Philip Agop Philip
Ph: 313-576-9363

Philip Agop Philip
Principal Investigator

Flint

Genesys Hurley Cancer Institute

Tareq Al Baghdadi
Ph: 734-712-4673

Tareq Al Baghdadi
Principal Investigator

Hurley Medical Center

Tareq Al Baghdadi
Ph: 734-712-4673

Tareq Al Baghdadi
Principal Investigator

Jackson

Allegiance Health

Tareq Al Baghdadi
Ph: 734-712-4673

Tareq Al Baghdadi
Principal Investigator

Kalamazoo

Borgess Medical Center

Raymond Sterling Lord
Ph: 269-373-7458

Raymond Sterling Lord
Principal Investigator

Bronson Methodist Hospital

Raymond Sterling Lord
Ph: 269-373-7458

Raymond Sterling Lord
Principal Investigator

West Michigan Cancer Center

Raymond Sterling Lord
Ph: 269-373-7458

Raymond Sterling Lord
Principal Investigator

Lansing

Sparrow Hospital

Tareq Al Baghdadi
Ph: 734-712-4673

Tareq Al Baghdadi
Principal Investigator

Livonia

Saint Mary Mercy Hospital

Tareq Al Baghdadi
Ph: 734-712-4673

Tareq Al Baghdadi
Principal Investigator

Pontiac

Saint Joseph Mercy Oakland

Tareq Al Baghdadi
Ph: 734-712-4673

Tareq Al Baghdadi
Principal Investigator

Port Huron

Saint Joseph Mercy Port Huron

Tareq Al Baghdadi
Ph: 734-712-4673

Tareq Al Baghdadi
Principal Investigator

Royal Oak

William Beaumont Hospital-Royal Oak

Joseph Mark Anderson
Ph: 937-775-1350
Email: som_dcop@wright.edu

Joseph Mark Anderson
Principal Investigator

Saginaw

Saint Mary's of Michigan

Tareq Al Baghdadi
Ph: 734-712-4673

Tareq Al Baghdadi
Principal Investigator

Troy

William Beaumont Hospital - Troy

Joseph Mark Anderson
Ph: 937-775-1350
Email: som_dcop@wright.edu

Joseph Mark Anderson
Principal Investigator

Warren

Saint John Macomb-Oakland Hospital

Tareq Al Baghdadi
Ph: 734-712-4673

Tareq Al Baghdadi
Principal Investigator

Minnesota
Burnsville

Fairview Ridges Hospital

Joseph W. Leach
Ph: 952-993-1517
Email: MMCCOP@parknicollet.com

Joseph W. Leach
Principal Investigator

Coon Rapids

Mercy Hospital

Joseph W. Leach
Ph: 952-993-1517
Email: MMCCOP@parknicollet.com

Joseph W. Leach
Principal Investigator

Edina

Fairview-Southdale Hospital

Joseph W. Leach
Ph: 952-993-1517
Email: MMCCOP@parknicollet.com

Joseph W. Leach
Principal Investigator

Fridley

Unity Hospital

Joseph W. Leach
Ph: 952-993-1517
Email: MMCCOP@parknicollet.com

Joseph W. Leach
Principal Investigator

Hutchinson

Hutchinson Area Health Care

Joseph W. Leach
Ph: 952-993-1517
Email: MMCCOP@parknicollet.com

Joseph W. Leach
Principal Investigator

Maplewood

Minnesota Oncology Hematology PA-Maplewood

Joseph W. Leach
Ph: 952-993-1517
Email: MMCCOP@parknicollet.com

Joseph W. Leach
Principal Investigator

Saint John's Hospital - Healtheast

Joseph W. Leach
Ph: 952-993-1517
Email: MMCCOP@parknicollet.com

Joseph W. Leach
Principal Investigator

Minneapolis

Abbott-Northwestern Hospital

Joseph W. Leach
Ph: 952-993-1517
Email: MMCCOP@parknicollet.com

Joseph W. Leach
Principal Investigator

Health Partners Inc

Joseph W. Leach
Ph: 952-993-1517
Email: MMCCOP@parknicollet.com

Joseph W. Leach
Principal Investigator

Hennepin County Medical Center

Joseph W. Leach
Ph: 952-993-1517
Email: MMCCOP@parknicollet.com

Joseph W. Leach
Principal Investigator

Robbinsdale

North Memorial Medical Health Center

Joseph W. Leach
Ph: 952-993-1517
Email: MMCCOP@parknicollet.com

Joseph W. Leach
Principal Investigator

Saint Louis Park

Park Nicollet Clinic - Saint Louis Park

Joseph W. Leach
Ph: 952-993-1517
Email: MMCCOP@parknicollet.com

Joseph W. Leach
Principal Investigator

Saint Paul

Regions Hospital

Joseph W. Leach
Ph: 952-993-1517
Email: MMCCOP@parknicollet.com

Joseph W. Leach
Principal Investigator

United Hospital

Joseph W. Leach
Ph: 952-993-1517
Email: MMCCOP@parknicollet.com

Joseph W. Leach
Principal Investigator

Shakopee

Saint Francis Regional Medical Center

Joseph W. Leach
Ph: 952-993-1517
Email: MMCCOP@parknicollet.com

Joseph W. Leach
Principal Investigator

Waconia

Ridgeview Medical Center

Joseph W. Leach
Ph: 952-993-1517
Email: MMCCOP@parknicollet.com

Joseph W. Leach
Principal Investigator

Willmar

Rice Memorial Hospital

Joseph W. Leach
Ph: 952-993-1517
Email: MMCCOP@parknicollet.com

Joseph W. Leach
Principal Investigator

Woodbury

Minnesota Oncology and Hematology PA-Woodbury

Joseph W. Leach
Ph: 952-993-1517
Email: MMCCOP@parknicollet.com

Joseph W. Leach
Principal Investigator

Missouri
Bolivar

Central Care Cancer Center-Carrie J Babb Cancer Center

Jay W. Carlson
Ph: 800-821-7532

Jay W. Carlson
Principal Investigator

Bonne Terre

Parkland Health Center-Bonne Terre

James Lloyd Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

James Lloyd Wade
Principal Investigator

Branson

CoxHealth Cancer Center

Jay W. Carlson
Ph: 800-821-7532

Jay W. Carlson
Principal Investigator

Cape Girardeau

Saint Francis Medical Center

James Lloyd Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

James Lloyd Wade
Principal Investigator

Southeast Cancer Center

Alan P. Lyss
Ph: 800-392-0936

Alan P. Lyss
Principal Investigator

Jefferson City

Capital Region Medical Center-Goldschmidt Cancer Center

Alan P. Lyss
Ph: 800-392-0936

Alan P. Lyss
Principal Investigator

Kansas City

Kansas City Cancer Center - South

Joaquina Celebre Baranda
Ph: 913-588-4709

Joaquina Celebre Baranda
Principal Investigator

Kansas City Cancer Centers - North

Joaquina Celebre Baranda
Ph: 913-588-4709

Joaquina Celebre Baranda
Principal Investigator

Truman Medical Center

Joaquina Celebre Baranda
Ph: 913-588-4709

Joaquina Celebre Baranda
Principal Investigator

Lee's Summit

Kansas City Cancer Center-Lee's Summit

Joaquina Celebre Baranda
Ph: 913-588-4709

Joaquina Celebre Baranda
Principal Investigator

Rolla

Phelps County Regional Medical Center

Jay W. Carlson
Ph: 800-821-7532

Jay W. Carlson
Principal Investigator

Saint John's Clinic-Rolla-Cancer and Hematology

Jay W. Carlson
Ph: 800-821-7532

Jay W. Carlson
Principal Investigator

Saint Louis

Mercy Hospital Saint Louis

Jay W. Carlson
Ph: 800-821-7532

Jay W. Carlson
Principal Investigator

Missouri Baptist Medical Center

Alan P. Lyss
Ph: 800-392-0936

Alan P. Lyss
Principal Investigator

Saint Louis Cancer and Breast Institute-South City

Jay W. Carlson
Ph: 800-821-7532

Jay W. Carlson
Principal Investigator

Sainte Genevieve

Sainte Genevieve County Memorial Hospital

James Lloyd Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

James Lloyd Wade
Principal Investigator

Springfield

CoxHealth South Hospital

Jay W. Carlson
Ph: 800-821-7532

Jay W. Carlson
Principal Investigator

Mercy Hospital Springfield

Jay W. Carlson
Ph: 800-821-7532

Jay W. Carlson
Principal Investigator

Sullivan

Missouri Baptist Sullivan Hospital

James Lloyd Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

James Lloyd Wade
Principal Investigator

Sunset Hills

Missouri Baptist Outpatient Center-Sunset Hills

James Lloyd Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

James Lloyd Wade
Principal Investigator

Nebraska
Omaha

Nebraska Methodist Hospital

Robert M. Langdon
Ph: 402-354-5144

Robert M. Langdon
Principal Investigator

Nevada
Henderson

21st Century Oncology - Henderson

John Allan Ellerton
Ph: 702-384-0013

John Allan Ellerton
Principal Investigator

Cancer and Blood Specialists-Henderson

John Allan Ellerton
Ph: 702-384-0013

John Allan Ellerton
Principal Investigator

Comprehensive Cancer Centers of Nevada - Henderson

John Allan Ellerton
Ph: 702-384-0013

John Allan Ellerton
Principal Investigator

Comprehensive Cancer Centers of Nevada-Southeast Henderson

John Allan Ellerton
Ph: 702-384-0013

John Allan Ellerton
Principal Investigator

Las Vegas Cancer Center-Henderson

John Allan Ellerton
Ph: 702-384-0013

John Allan Ellerton
Principal Investigator

Las Vegas

21st Century Oncology

John Allan Ellerton
Ph: 702-384-0013

John Allan Ellerton
Principal Investigator

21st Century Oncology - Fort Apache

John Allan Ellerton
Ph: 702-384-0013

John Allan Ellerton
Principal Investigator

21st Century Oncology - Vegas Tenaya

John Allan Ellerton
Ph: 702-384-0013

John Allan Ellerton
Principal Investigator

Cancer and Blood Specialists-Fort Apache

John Allan Ellerton
Ph: 702-384-0013

John Allan Ellerton
Principal Investigator

Cancer and Blood Specialists-Shadow

John Allan Ellerton
Ph: 702-384-0013

John Allan Ellerton
Principal Investigator

Cancer and Blood Specialists-Tenaya

John Allan Ellerton
Ph: 702-384-0013

John Allan Ellerton
Principal Investigator

Cancer Therapy and Integrative Medicine

John Allan Ellerton
Ph: 702-384-0013

John Allan Ellerton
Principal Investigator

Comprehensive Cancer Centers of Nevada

John Allan Ellerton
Ph: 702-384-0013

John Allan Ellerton
Principal Investigator

Comprehensive Cancer Centers of Nevada - Central Valley

John Allan Ellerton
Ph: 702-384-0013

John Allan Ellerton
Principal Investigator

Comprehensive Cancer Centers of Nevada - Northwest

John Allan Ellerton
Ph: 702-384-0013

John Allan Ellerton
Principal Investigator

Comprehensive Cancer Centers of Nevada-Summerlin

John Allan Ellerton
Ph: 702-384-0013

John Allan Ellerton
Principal Investigator

HealthCare Partners Medical Group Oncology/Hematology-Centennial Hills

John Allan Ellerton
Ph: 702-384-0013

John Allan Ellerton
Principal Investigator

HealthCare Partners Medical Group Oncology/Hematology-Maryland Parkway

John Allan Ellerton
Ph: 702-384-0013

John Allan Ellerton
Principal Investigator

HealthCare Partners Medical Group Oncology/Hematology-San Martin

John Allan Ellerton
Ph: 702-384-0013

John Allan Ellerton
Principal Investigator

HealthCare Partners Medical Group Oncology/Hematology-Tenaya

John Allan Ellerton
Ph: 702-384-0013

John Allan Ellerton
Principal Investigator

Las Vegas Cancer Center-Medical Center

John Allan Ellerton
Ph: 702-384-0013

John Allan Ellerton
Principal Investigator

Nevada Cancer Research Foundation CCOP

John Allan Ellerton
Ph: 702-384-0013

John Allan Ellerton
Principal Investigator

Radiation Oncology Centers of Nevada Central

John Allan Ellerton
Ph: 702-384-0013

John Allan Ellerton
Principal Investigator

Radiation Oncology Centers of Nevada Southeast

John Allan Ellerton
Ph: 702-384-0013

John Allan Ellerton
Principal Investigator

University Medical Center of Southern Nevada

John Allan Ellerton
Ph: 702-384-0013

John Allan Ellerton
Principal Investigator

New Jersey
Mount Holly

Fox Chase Cancer Center at Virtua Memorial Hospital of Burlington County

Michael S. Entmacher
Ph: 888-847-8823

Michael S. Entmacher
Principal Investigator

Voorhees

Virtua West Jersey Hospital Voorhees

Michael S. Entmacher
Ph: 888-847-8823

Michael S. Entmacher
Principal Investigator

New York
Albany

New York Oncology Hematology PC -Albany Medical Center

Charles H. Weissman
Ph: 518-489-3612
Email: gerryann.currier@usoncology.com

Charles H. Weissman
Principal Investigator

Bronx

Montefiore Medical Center - Moses Campus

Steven Kenneth Libutti
Ph: 718-904-2730
Email: aecc@aecom.yu.edu

Steven Kenneth Libutti
Principal Investigator

Montefiore Medical Center-Einstein Campus

Steven Kenneth Libutti
Ph: 718-904-2730
Email: aecc@aecom.yu.edu

Steven Kenneth Libutti
Principal Investigator

New York

Columbia University Medical Center

Paul Eliezer Oberstein
Ph: 212-305-8615

Paul Eliezer Oberstein
Principal Investigator

Memorial Sloan-Kettering Cancer Center

Diane Lauren Reidy-Lagunes
Ph: 212-639-7202

Diane Lauren Reidy-Lagunes
Principal Investigator

Rochester

University of Rochester

Jonathan Willmann Friedberg
Ph: 585-275-5830

Jonathan Willmann Friedberg
Principal Investigator

North Carolina
Kinston

Kinston Medical Specialists PA

Peter Robins Watson
Ph: 252-559-2200

Peter Robins Watson
Principal Investigator

Statesville

Iredell Memorial Hospital

Ruby Ann Grimm
Ph: 704-873-5661

Ruby Ann Grimm
Principal Investigator

Ohio
Akron

Akron General Medical Center

Esther Hoogland Rehmus
Ph: 330-344-6348

Esther Hoogland Rehmus
Principal Investigator

Belpre

Strecker Cancer Center-Belpre

John Philip Kuebler
Ph: 614-566-3275

John Philip Kuebler
Principal Investigator

Chillicothe

Adena Regional Medical Center

John Philip Kuebler
Ph: 614-566-3275

John Philip Kuebler
Principal Investigator

Cincinnati

Oncology Hematology Care Inc - Anderson

Howard M. Gross
Ph: 937-775-1350

Howard M. Gross
Principal Investigator

Oncology Hematology Care Inc - Kenwood

Howard M. Gross
Ph: 937-775-1350

Howard M. Gross
Principal Investigator

Oncology Hematology Care Inc-Blue Ash

Howard M. Gross
Ph: 937-775-1350

Howard M. Gross
Principal Investigator

Oncology Hematology Care Inc-Eden Park

Howard M. Gross
Ph: 937-775-1350

Howard M. Gross
Principal Investigator

Oncology Hematology Care Inc-Mercy West

Howard M. Gross
Ph: 937-775-1350

Howard M. Gross
Principal Investigator

University of Cincinnati

Olugbenga Olowokure (Gbenga)
Ph: 513-558-4553
Email: uchealthnews@uc.edu

Olugbenga Olowokure (Gbenga)
Principal Investigator

Cleveland

Case Western Reserve University

Jennifer Rachel Eads
Ph: 800-641-2422

Jennifer Rachel Eads
Principal Investigator

Columbus

Columbus Oncology and Hematology Associates Inc

John Philip Kuebler
Ph: 614-566-3275

John Philip Kuebler
Principal Investigator

Doctors Hospital

John Philip Kuebler
Ph: 614-566-3275

John Philip Kuebler
Principal Investigator

Grant Medical Center

John Philip Kuebler
Ph: 614-566-3275

John Philip Kuebler
Principal Investigator

Mount Carmel Health Center West

John Philip Kuebler
Ph: 614-566-3275

John Philip Kuebler
Principal Investigator

Ohio State University Comprehensive Cancer Center

Manisha H. Shah
Ph: 800-293-5066
Email: Jamesline@osumc.edu

Manisha H. Shah
Principal Investigator

Riverside Methodist Hospital

John Philip Kuebler
Ph: 614-566-3275

John Philip Kuebler
Principal Investigator

The Mark H Zangmeister Center

John Philip Kuebler
Ph: 614-566-3275

John Philip Kuebler
Principal Investigator

Dayton

Good Samaritan Hospital - Dayton

Howard M. Gross
Ph: 937-775-1350

Howard M. Gross
Principal Investigator

Miami Valley Hospital

Howard M. Gross
Ph: 937-775-1350

Howard M. Gross
Principal Investigator

Samaritan North Health Center

Howard M. Gross
Ph: 937-775-1350

Howard M. Gross
Principal Investigator

Delaware

Delaware Health Center-Grady Cancer Center

John Philip Kuebler
Ph: 614-566-3275

John Philip Kuebler
Principal Investigator

Delaware Radiation Oncology

John Philip Kuebler
Ph: 614-566-3275

John Philip Kuebler
Principal Investigator

Grady Memorial Hospital

John Philip Kuebler
Ph: 614-566-3275

John Philip Kuebler
Principal Investigator

Fairfield

Oncology Hematology Care Inc-Healthplex

Howard M. Gross
Ph: 937-775-1350

Howard M. Gross
Principal Investigator

Findlay

Blanchard Valley Hospital

Howard M. Gross
Ph: 937-775-1350

Howard M. Gross
Principal Investigator

Franklin

Atrium Medical Center-Middletown Regional Hospital

Howard M. Gross
Ph: 937-775-1350

Howard M. Gross
Principal Investigator

Greenville

Wayne Hospital

Howard M. Gross
Ph: 937-775-1350

Howard M. Gross
Principal Investigator

Kettering

Kettering Medical Center

Howard M. Gross
Ph: 937-775-1350

Howard M. Gross
Principal Investigator

Lancaster

Fairfield Medical Center

John Philip Kuebler
Ph: 614-566-3275

John Philip Kuebler
Principal Investigator

Lima

Saint Rita's Medical Center

Henry Gerad
Ph: 419-226-9617

Henry Gerad
Principal Investigator

Marietta

Marietta Memorial Hospital

John Philip Kuebler
Ph: 614-566-3275

John Philip Kuebler
Principal Investigator

Mount Vernon

Knox Community Hospital

John Philip Kuebler
Ph: 614-566-3275

John Philip Kuebler
Principal Investigator

Newark

Licking Memorial Hospital

John Philip Kuebler
Ph: 614-566-3275

John Philip Kuebler
Principal Investigator

Newark Radiation Oncology

John Philip Kuebler
Ph: 614-566-3275

John Philip Kuebler
Principal Investigator

Portsmouth

Southern Ohio Medical Center

John Philip Kuebler
Ph: 614-566-3275

John Philip Kuebler
Principal Investigator

Springfield

Springfield Regional Medical Center

John Philip Kuebler
Ph: 614-488-2745
Email: sheree@columbusccop.org

John Philip Kuebler
Principal Investigator

Sylvania

Flower Hospital

Rex B. Mowat
Ph: 800-444-3561

Rex B. Mowat
Principal Investigator

Toledo

Toledo Community Hospital Oncology Program CCOP

Rex B. Mowat
Ph: 800-444-3561

Rex B. Mowat
Principal Investigator

University of Toledo

Rex B. Mowat
Ph: 800-444-3561

Rex B. Mowat
Principal Investigator

Troy

Upper Valley Medical Center

Howard M. Gross
Ph: 937-775-1350

Howard M. Gross
Principal Investigator

West Chester

University Pointe

Olugbenga Olowokure (Gbenga)
Ph: 513-558-4553
Email: uchealthnews@uc.edu

Olugbenga Olowokure (Gbenga)
Principal Investigator

Westerville

Saint Ann's Hospital

John Philip Kuebler
Ph: 614-566-3275

John Philip Kuebler
Principal Investigator

Zanesville

Genesis HealthCare System

John Philip Kuebler
Ph: 614-488-2745
Email: sheree@columbusccop.org

John Philip Kuebler
Principal Investigator

Oklahoma
Oklahoma City

University of Oklahoma Health Sciences Center

Shubham Pant
Ph: 405-271-4272
Email: julie-traylor@ouhsc.edu

Shubham Pant
Principal Investigator

Tulsa

Tulsa Cancer Institute

Shubham Pant
Ph: 405-271-4272
Email: julie-traylor@ouhsc.edu

Shubham Pant
Principal Investigator

Oregon
Portland

Kaiser Permanente

Nagendra Ranganatha Tirumali
Ph: 503-335-2400

Nagendra Ranganatha Tirumali
Principal Investigator

Pennsylvania
Danville

Geisinger Medical Center

Maged F. Khalil
Ph: 610-402-2273

Maged F. Khalil
Principal Investigator

Hazleton

Geisinger Medical Center-Cancer Center Hazleton

Maged F. Khalil
Ph: 610-402-2273

Maged F. Khalil
Principal Investigator

Hershey

Penn State Milton S Hershey Medical Center

Nelson Shu-Sang Yee
Ph: 717-531-3779
Email: CTO@hmc.psu.edu

Nelson Shu-Sang Yee
Principal Investigator

Lewisburg

Geisinger Medical Oncology at Evangelical Community Hospital

Ying Maggie Zeng
Ph: 570-271-5251

Ying Maggie Zeng
Principal Investigator

Lewistown

Lewistown Hospital

Ying Maggie Zeng
Ph: 570-271-5251

Ying Maggie Zeng
Principal Investigator

Philadelphia

Fox Chase Cancer Center

Paul F. Engstrom
Ph: 215-728-4790

Paul F. Engstrom
Principal Investigator

Thomas Jefferson University Hospital

Ashwin Reddy Sama
Ph: 215-955-6084

Ashwin Reddy Sama
Principal Investigator

University of Pennsylvania/Abramson Cancer Center

Peter James O'Dwyer
Ph: 800-474-9892

Peter James O'Dwyer
Principal Investigator

Pittsburgh

University of Pittsburgh Cancer Institute (UPCI)

Nathan Bahary
Ph: 412-647-8073

Nathan Bahary
Principal Investigator

Pottsville

Geisinger Medical Oncology-Pottsville

Ying Maggie Zeng
Ph: 570-271-5251

Ying Maggie Zeng
Principal Investigator

State College

Geisinger Medical Group

Maged F. Khalil
Ph: 610-402-2273

Maged F. Khalil
Principal Investigator

West Reading

Reading Hospital

Terrence Paul Cescon
Ph: 610-988-9323

Terrence Paul Cescon
Principal Investigator

Wilkes-Barre

Geisinger Wyoming Valley/Henry Cancer Center

Maged F. Khalil
Ph: 610-402-2273

Maged F. Khalil
Principal Investigator

South Carolina
Greenville

Greenville Health System Cancer Institute-Butternut

Jeffrey K. Giguere
Ph: 864-241-6251

Jeffrey K. Giguere
Principal Investigator

Greenville Health System Cancer Institute-Eastside

Jeffrey K. Giguere
Ph: 864-241-6251

Jeffrey K. Giguere
Principal Investigator

Greenville Health System Cancer Institute-Faris

Jeffrey K. Giguere
Ph: 864-241-6251

Jeffrey K. Giguere
Principal Investigator

Greenville Memorial Hospital

Jeffrey K. Giguere
Ph: 864-241-6251

Jeffrey K. Giguere
Principal Investigator

Greer

Greenville Health System Cancer Institute-Greer

Jeffrey K. Giguere
Ph: 864-241-6251

Jeffrey K. Giguere
Principal Investigator

Seneca

Greenville Health System Cancer Institute-Seneca

Jeffrey K. Giguere
Ph: 864-241-6251

Jeffrey K. Giguere
Principal Investigator

Spartanburg

Greenville Health System Cancer Institute-Spartanburg

Jeffrey K. Giguere
Ph: 864-241-6251

Jeffrey K. Giguere
Principal Investigator

Tennessee
Franklin

Vanderbilt-Ingram Cancer Center Cool Springs

Dana Backlund Cardin
Ph: 800-811-8480

Dana Backlund Cardin
Principal Investigator

Nashville

Vanderbilt Breast Center at One Hundred Oaks

Dana Backlund Cardin
Ph: 800-811-8480

Dana Backlund Cardin
Principal Investigator

Vanderbilt University/Ingram Cancer Center

Dana Backlund Cardin
Ph: 800-811-8480

Dana Backlund Cardin
Principal Investigator

Virginia
Charlottesville

University of Virginia Cancer Center

William Wangerin Grosh
Ph: 434-243-6143

William Wangerin Grosh
Principal Investigator

Washington
Auburn

MultiCare Auburn Medical Center

John A. Keech
Ph: 907-458-5380

John A. Keech
Principal Investigator

Bellevue

Overlake Hospital Medical Center

John A. Keech
Ph: 907-458-5380

John A. Keech
Principal Investigator

Centralia

Providence Regional Cancer System-Centralia

John A. Keech
Ph: 907-458-5380

John A. Keech
Principal Investigator

Everett

Providence Regional Cancer Partnership

John A. Keech
Ph: 907-458-5380

John A. Keech
Principal Investigator

Federal Way

Saint Francis Hospital

John A. Keech
Ph: 907-458-5380

John A. Keech
Principal Investigator

Lacey

Providence Regional Cancer System-Lacey

John A. Keech
Ph: 907-458-5380

John A. Keech
Principal Investigator

Lakewood

Saint Clare Hospital

John A. Keech
Ph: 907-458-5380

John A. Keech
Principal Investigator

Puyallup

MultiCare Good Samaritan Hospital

John A. Keech
Ph: 907-458-5380

John A. Keech
Principal Investigator

Tacoma

Multicare Health System

John A. Keech
Ph: 907-458-5380

John A. Keech
Principal Investigator

Northwest Medical Specialties PLLC

John A. Keech
Ph: 907-458-5380

John A. Keech
Principal Investigator

West Virginia
Charleston

West Virginia University Charleston

Steven James Jubelirer
Ph: 304-344-3457

Steven James Jubelirer
Principal Investigator

Wisconsin
Burlington

Aurora Cancer Care-Burlington

Dhimant R. Patel
Ph: 800-252-2990

Dhimant R. Patel
Principal Investigator

Elkhorn

Aurora Cancer Care-Southern Lakes

Dhimant R. Patel
Ph: 800-252-2990

Dhimant R. Patel
Principal Investigator

Fond Du Lac

Aurora Health Center-Fond du Lac

Dhimant R. Patel
Ph: 800-252-2990

Dhimant R. Patel
Principal Investigator

Grafton

Aurora Cancer Care-Grafton

Dhimant R. Patel
Ph: 800-252-2990

Dhimant R. Patel
Principal Investigator

Green Bay

Aurora BayCare Medical Center

Dhimant R. Patel
Ph: 800-252-2990

Dhimant R. Patel
Principal Investigator

Kenosha

Aurora Cancer Care-Kenosha South

Dhimant R. Patel
Ph: 800-252-2990

Dhimant R. Patel
Principal Investigator

La Crosse

Gundersen Lutheran Medical Center

Kurt Oettel
Ph: 608-775-2385
Email: cancerctr@gundluth.org

Kurt Oettel
Principal Investigator

Marinette

Vince Lombardi Cancer Clinic-Marinette

Dhimant R. Patel
Ph: 800-252-2990

Dhimant R. Patel
Principal Investigator

Menomonee Falls

Aurora Advanced Healthcare Inc-Menomonee Falls

Dhimant R. Patel
Ph: 800-252-2990

Dhimant R. Patel
Principal Investigator

Milwaukee

Aurora Cancer Care-Milwaukee

Dhimant R. Patel
Ph: 800-252-2990

Dhimant R. Patel
Principal Investigator

Aurora Saint Luke's Medical Center

Dhimant R. Patel
Ph: 800-252-2990

Dhimant R. Patel
Principal Investigator

Aurora Sinai Medical Center

Dhimant R. Patel
Ph: 800-252-2990

Dhimant R. Patel
Principal Investigator

Froedtert and the Medical College of Wisconsin

Ben George
Ph: 414-805-4380

Ben George
Principal Investigator

New Richmond

Cancer Center of Western Wisconsin

Joseph W. Leach
Ph: 952-993-1517
Email: MMCCOP@parknicollet.com

Joseph W. Leach
Principal Investigator

Oshkosh

Vince Lombardi Cancer Clinic - Oshkosh

Dhimant R. Patel
Ph: 800-252-2990

Dhimant R. Patel
Principal Investigator

Racine

Aurora Cancer Care-Racine

Dhimant R. Patel
Ph: 800-252-2990

Dhimant R. Patel
Principal Investigator

Sheboygan

Vince Lombardi Cancer Clinic-Sheboygan

Dhimant R. Patel
Ph: 800-252-2990

Dhimant R. Patel
Principal Investigator

Summit

Aurora Medical Center in Summit

Dhimant R. Patel
Ph: 800-252-2990

Dhimant R. Patel
Principal Investigator

Two Rivers

Vince Lombardi Cancer Clinic

Dhimant R. Patel
Ph: 800-252-2990

Dhimant R. Patel
Principal Investigator

Waukesha

Aurora Cancer Care-Waukesha

Dhimant R. Patel
Ph: 800-252-2990

Dhimant R. Patel
Principal Investigator

Wauwatosa

Aurora Cancer Care-Milwaukee West

Dhimant R. Patel
Ph: 800-252-2990

Dhimant R. Patel
Principal Investigator

West Allis

Aurora West Allis Medical Center

Dhimant R. Patel
Ph: 800-252-2990

Dhimant R. Patel
Principal Investigator

Wyoming
Cheyenne

Cheyenne Regional Medical Center-West

Keren Sturtz
Ph: 888-785-6789

Keren Sturtz
Principal Investigator

Link to the current ClinicalTrials.gov record.
NLM Identifer NCT01824875

Note: Information about participating sites on pharmaceutical industry trials may be incomplete. Please visit the ClinicalTrials.gov record via the link above for more information about participating sites.