Rituximab and Combination Chemotherapy With or Without Lenalidomide in Treating Patients With Newly Diagnosed Stage II-IV Diffuse Large B Cell Lymphoma

  • Resize font
  • Print
  • Email
  • Facebook
  • Twitter
  • Google+
  • Pinterest

Basic Trial Information

PhaseTypeStatusAgeSponsorProtocol IDs
Phase IIBiomarker/Laboratory analysis, TreatmentActive18 and overNCINCI-2013-00959
ECOG-E1412, E1412, U10CA180820, U10CA021115, NCT01856192

Trial Description

Summary

This randomized phase II trial studies how well rituximab and combination chemotherapy with or without lenalidomide work in treating patients with newly diagnosed stage II-IV diffuse large B cell lymphoma. Monoclonal antibodies, such as rituximab, may interfere with the ability of cancer cells to grow and spread. Drugs used in chemotherapy, such as cyclophosphamide, doxorubicin hydrochloride, vincristine sulfate, and prednisone, work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Lenalidomide may stimulate the immune system in different ways and stop cancer cells from growing. It is not yet known whether rituximab and combination chemotherapy are more effective when given with or without lenalidomide in treating patients with diffuse large B cell lymphoma.

Further Study Information

PRIMARY OBJECTIVES:

I. Progression-free survival (PFS).

SECONDARY OBJECTIVES:

I. Response rate (RR). II. Complete remission (CR) rate as defined by positron emission tomography (PET)-computed tomography (CT) criteria.

III. Overall survival (OS).

TERTIARY OBJECTIVES:

I. Impact of diffuse large B cell lymphoma (DLBCL) molecular subtype on outcome.

II. Interim PET scan results in relation to treatment outcome.

OUTLINE: Patients are randomized to 1 of 2 treatment arms.

ARM A: Patients receive rituximab intravenously (IV), cyclophosphamide IV, doxorubicin hydrochloride IV, and vincristine sulfate IV on day 1; prednisone orally (PO) on days 1-5; and lenalidomide PO on days 1-10. Treatment repeats every 21 days for 6 courses in the absence of disease progression or unacceptable toxicity.

ARM B: Patients receive rituximab, cyclophosphamide, doxorubicin hydrochloride, vincristine sulfate, and prednisone as in Arm A. Treatment repeats every 21 days for 6 courses in the absence of disease progression or unacceptable toxicity.

After completion of study treatment, patient are followed up every 3 months for 2 years, every 6 months for 1 year, and then annually for up to 7 years.

Eligibility Criteria

Inclusion Criteria:

  • Histologically confirmed DLBCL expressing cluster of differentiation (CD)20 antigen; patients with transform lymphoma are excluded; in this regard, patients with composite lymphoma in the diagnostic tissue (concomitant DLBCL and follicular or other low-grade lymphoma component) are excluded; however, patients with DLBCL in primary diagnostic tissue but a bone marrow that shows low grade or indeterminate lymphoma are eligible; patients with known primary mediastinal large B-cell lymphoma (PMLBCL) are excluded; similarly, patients with known v-myc myelocytomatosis viral oncogene homolog (avian) (c-myc) translocation (by fluorescence in situ hybridization) positive DLBCL are encouraged to participate in trials specifically designed for these patients; however patients with known c-myc positive are NOT excluded from this study; c-myc testing prior to study enrollment is NOT required
  • Stages II bulky disease (defined as mass size of more than 10 cm), stage III, or IV (Ann Arbor staging); patients with stage I and stage II non-bulky disease are excluded from this study
  • A tumor tissue specimen from the initial diagnostic biopsy has been located and ready to ship to the Eastern Cooperative Oncology Group (ECOG)-American College of Radiology Imaging Network (ACRIN) Central Biorepository and Pathology Facility within 30 days following registration; patients must have paraffin-embedded tumor specimen available for central pathology review and defined laboratory research studies; archived formalin fixed paraffin embedded (FFPE) tumor tissue block is required; if the block is unavailable for submission, please submit the below alternative requirements:
  • One (1) hematoxylin & eosin (H&E) slide, and
  • Twenty (20) 4 um unstained air-dried plus slides, and
  • One (1) or more core punches (minimum of 4 mm diameter)
  • International Prognostic Index (IPI) of 2 or greater
  • ECOG performance status 0-2
  • Patients must have measurable disease (at least 1 lesion of >= 1.5 cm in one diameter) as detected by CT or the CT images of the PET/CT
  • Previously untreated and not receiving any other agent that would be considered as a treatment for the lymphoma
  • No known central nervous system (CNS) lymphoma or cerebrospinal fluid involvement with malignant lymphoma cells; these patients are usually treated with CNS directed therapy; screening for cerebrospinal fluid (CSF)/CNS involvement is NOT required but can be performed per treating medical doctor (MD) discretion; intrathecal (IT) methotrexate or IT cytarabine prophylaxis in patients with negative CSF who are felt to be at high risk of CNS relapse is allowed per local MD discretion; this should be noted on the treatment form
  • Absolute neutrophil count (ANC) >= 1500
  • Platelets (PLT) >= 100,000
  • Total bilirubin =< 1.5 x upper limit of normal (ULN) or if total bilirubin is > 1.5 x ULN, the direct bilirubin must be normal
  • Alkaline (Alk.) phosphatase =< 3 x ULN unless evidence of the direct liver involvement by lymphoma--then =< 5 x ULN
  • Aspartate aminotransferase (AST) =< 3 x ULN unless evidence of the direct liver involvement by lymphoma-then =< 5 x ULN
  • Creatinine =< 2 x ULN or creatinine clearance (CrCl) > 30 ml/min
  • Ejection fraction of >= 45% by either multi gated acquisition scan (MUGA) or echocardiogram (ECHO)
  • Absence of co-morbid systemic illnesses or other severe concurrent disease which, in the judgment of the investigator, would make the patient inappropriate for entry into this study or interfere significantly with the proper assessment of safety and toxicity of the prescribed regimens, including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements
  • Absence of history of myocardial infarction =< 6 months, or congestive heart failure requiring use of ongoing maintenance therapy for life-threatening ventricular arrhythmias
  • Absence of history of deep venous thrombosis/embolism, threatening thromboembolism or known thrombophilia; patients with a history of deep vein thrombosis(DVT)/pulmonary embolism (PE) or thrombophilia may participate if they are willing to be on full anticoagulation during the treatment if randomized to rituximab, cyclophosphamide, doxorubicin hydrochloride, vincristine sulfate, and prednisone (R2CHOP) arm A; full anticoagulation is defined as warfarin, factor X inhibitors, or low molecular weight heparin at therapeutic doses
  • Patient must be able and willing to receive anticoagulation therapy with aspirin 70-325 mg daily prophylaxis, low molecular weight heparin, factor X inhibitors or warfarin; patients unable or unwilling to take any prophylaxis are NOT eligible
  • Absence of history of acquired immune deficiency syndrome (AIDS)-related conditions (other than the presenting DLBCL) or post-transplant lymphoproliferative disorder (PTLD) in immunocompromised patients; patients with human immunodeficiency virus (HIV) on antiretroviral therapy other than zidovudine (AZT) and/or stavudine and without prior AIDS defining conditions and adequate CD4 count (> 400) are eligible
  • No other active malignancy requiring therapy such as radiation, chemotherapy, or immunotherapy; exceptions to this are as follows: localized non-melanotic skin cancer and any cancer that in the judgment of the investigator has been treated with curative intent and will not interfere with the study treatment plan and response assessment
  • No history of radiation therapy to >= 25% of the bone marrow for other diseases or history of anthracycline therapy
  • Patients must not be receiving erythroid stimulating agents (erythropoietin [EPO]: Procrit, Aranesp)
  • Patient must be willing to provide informed written consent and to return to enrolling institution for follow-up
  • Women must not be pregnant or breast-feeding
  • Females of childbearing potential (FCBP) must have a negative serum or urine pregnancy test with a sensitivity of at least 25 mIU/mL within 10-14 days prior to and again within 24 hours of starting lenalidomide and must either commit to continued abstinence from heterosexual intercourse or begin TWO acceptable methods of birth control, one highly effective method and one additional effective method AT THE SAME TIME, at least 28 days before she starts taking lenalidomide; FCBP must also agree to ongoing pregnancy testing; a female of childbearing potential is any woman, regardless of sexual orientation or whether they have undergone tubal ligation, who meets the following criteria: 1) has not undergone a hysterectomy or bilateral oophorectomy; or 2) has not been naturally postmenopausal for at least 24 consecutive months (i.e., has had menses at any time in the preceding 24 consecutive months)
  • Men must agree to use a latex condom during sexual contact with a FCBP even if they have had a successful vasectomy; all patients must be counseled at a minimum of every 28 days about pregnancy precautions and risks of fetal exposure

Trial Contact Information

Trial Lead Organizations/Sponsors

National Cancer Institute

    Grzegorz Nowakowski, Principal Investigator

    Trial Sites

    U.S.A.

    Alaska
    Anchorage

    Alaska Breast Care and Surgery LLC

    Keith S. Lanier
    Ph: 503-215-6412

    Alaska Women's Cancer Care

    Keith S. Lanier
    Ph: 503-215-6412

    Anchorage Oncology Centre

    Keith S. Lanier
    Ph: 503-215-6412

    Katmai Oncology Group

    Keith S. Lanier
    Ph: 503-215-6412

    Providence Cancer Center

    Keith S. Lanier
    Ph: 503-215-6412

    Arizona
    Scottsdale

    Mayo Clinic Scottsdale

    Grzegorz S Nowakowski
    Ph: 507-538-7623

    Tucson

    Arizona Cancer Center at University of Arizona Health Sciences Center

    Daniel O Persky
    Ph: 520-626-9008

    Arkansas
    Little Rock

    Veterans Affairs Medical Center - Little Rock

    Zhifu Xiang
    Ph: 501-686-8274

    California
    Antioch

    Kaiser Permanente - Deer Valley

    Tatjana Kolevska
    Ph: 626-564-3455

    Baldwin Park

    Kaiser Permanente Medical Center - Baldwin Park

    Han A Koh
    Ph: 626-564-3455

    Burbank

    Roy and Patricia Disney Family Cancer Center at Providence Saint Joseph Medical Center

    Keith S. Lanier
    Ph: 503-215-6412

    Irvine

    Kaiser Permanente - Irvine

    Han A Koh
    Ph: 626-564-3455

    Loma Linda

    Loma Linda University Cancer Institute at Loma Linda University Medical Center

    Chien-Shing ( Chen
    Ph: 909-558-3375

    Modesto

    Memorial Medical Center

    David A Shiba
    Ph: 415-209-2686
    Email: bernicl@sutterhealth.org

    Mountain View

    Palo Alto Medical Foundation

    David A Shiba
    Ph: 415-209-2686
    Email: bernicl@sutterhealth.org

    Oakland

    Kaiser Permanente-Oakland

    Tatjana Kolevska
    Ph: 626-564-3455

    Orange

    Chao Family Comprehensive Cancer Center at University of California Irvine Medical Center

    Deepa Jeyakumar
    Ph: 877-827-8839
    Email: ucstudy@uci.edu

    Palo Alto

    Palo Alto Medical Foundation - Palo Alto

    David A Shiba
    Ph: 415-209-2686
    Email: bernicl@sutterhealth.org

    Panorama City

    Kaiser Permanente Medical Group

    Han A Koh
    Ph: 626-564-3455

    Richmond

    Kaiser Permanente Medical Center - Richmond

    Tatjana Kolevska
    Ph: 626-564-3455

    Sacramento

    Kaiser Permanente Medical Center - Sacramento

    Tatjana Kolevska
    Ph: 626-564-3455

    South Sacramento Kaiser-Permanente Medical Center

    Tatjana Kolevska
    Ph: 626-564-3455

    San Diego

    Kaiser Permanente Medical Center - Kaiser Foundation Hospital - San Diego

    Han A Koh
    Ph: 626-564-3455

    Kaiser Permanente Medical Office -Vandever Medical Office

    Han A Koh
    Ph: 626-564-3455

    San Francisco

    Kaiser Permanente Medical Center - San Francisco Geary Campus

    Tatjana Kolevska
    Ph: 626-564-3455

    San Jose

    Kaiser Permanente Medical Center - Santa Teresa

    Tatjana Kolevska
    Ph: 626-564-3455

    San Marcos

    Kaiser Permanente Health Care

    Han A Koh
    Ph: 626-564-3455

    San Rafael

    Kaiser Foundation Hospital - San Rafael

    Tatjana Kolevska
    Ph: 626-564-3455

    Santa Clara

    Kaiser Permanente Medical Center - Santa Clara Homestead Campus

    Tatjana Kolevska
    Ph: 626-564-3455

    Santa Rosa

    Kaiser Permanente Medical Center - Santa Rosa

    Tatjana Kolevska
    Ph: 626-564-3455

    Sutter Pacific Medical Foundation

    David A Shiba
    Ph: 415-209-2686
    Email: bernicl@sutterhealth.org

    South San Francisco

    Kaiser Permanente Medical Center - South San Francisco

    Tatjana Kolevska
    Ph: 626-564-3455

    Sunnyvale

    Palo Atlo Medical Foundation-Sunnyvale

    David A Shiba
    Ph: 415-209-2686
    Email: bernicl@sutterhealth.org

    Walnut Creek

    Kaiser Permanente Medical Center - Walnut Creek

    Tatjana Kolevska
    Ph: 626-564-3455

    Woodland Hills

    Kaiser Permanente Medical Cener - Woodland Hills

    Han A Koh
    Ph: 626-564-3455

    Colorado
    Aurora

    Medical Center of Aurora - South Campus

    Keren Sturtz
    Ph: 888-785-6789

    Rocky Mountain Cancer Centers - Aurora

    Keren Sturtz
    Ph: 888-785-6789

    Boulder

    Boulder Community Hospital

    Keren Sturtz
    Ph: 888-785-6789

    Colorado Springs

    Penrose Cancer Center at Penrose Hospital

    Keren Sturtz
    Ph: 888-785-6789

    Rocky Mountain Cancer Centers at the Pavilion

    Keren Sturtz
    Ph: 888-785-6789

    Denver

    CCOP - Colorado Cancer Research Program

    Keren Sturtz
    Ph: 888-785-6789

    Colorado Blood Cancer Institute

    Keren Sturtz
    Ph: 888-785-6789

    Kaiser Permanente of Colorado

    Alexander Menter
    Ph: 303-614-1300

    Porter Adventist Hospital

    Keren Sturtz
    Ph: 888-785-6789

    Presbyterian - St. Luke's Medical Center

    Keren Sturtz
    Ph: 888-785-6789

    Rocky Mountain Cancer Centers - Denver Midtown

    Keren Sturtz
    Ph: 888-785-6789

    Rocky Mountain Cancer Centers-Rose

    Keren Sturtz
    Ph: 888-785-6789

    Rose Medical Center

    Keren Sturtz
    Ph: 888-785-6789

    St. Joseph Hospital

    Keren Sturtz
    Ph: 888-785-6789

    Durango

    Mercy Medical Center

    Keren Sturtz
    Ph: 888-785-6789

    Englewood

    Comprehensive Cancer Care and Research Institute of Colorado LLC

    Keren Sturtz
    Ph: 888-785-6789

    Swedish Medical Center

    Keren Sturtz
    Ph: 888-785-6789

    Golden

    Mountain Blue Cancer Care Center

    Keren Sturtz
    Ph: 888-785-6789

    Greeley

    North Colorado Medical Center

    Keren Sturtz
    Ph: 888-785-6789

    Greenwood Village

    Breast Cancer Care Consultants

    Keren Sturtz
    Ph: 888-785-6789

    Lafayette

    Kaiser Permanente - Lafayette

    Alexander Menter
    Ph: 303-614-1300

    Lakewood

    Rocky Mountain Cancer Centers-Lakewood

    Keren Sturtz
    Ph: 888-785-6789

    St. Anthony Central Hospital

    Keren Sturtz
    Ph: 888-785-6789

    Littleton

    Littleton Adventist Hospital

    Keren Sturtz
    Ph: 888-785-6789

    Rocky Mountain Cancer Centers - Littleton

    Keren Sturtz
    Ph: 888-785-6789

    Lone Tree

    Rocky Mountain Cancer Centers - Lone Tree

    Keren Sturtz
    Ph: 888-785-6789

    Sky Ridge Medical Center

    Keren Sturtz
    Ph: 888-785-6789

    Longmont

    Hope Cancer Care Center at Longmont United Hospital

    Keren Sturtz
    Ph: 888-785-6789

    Loveland

    McKee Medical Center

    Keren Sturtz
    Ph: 888-785-6789

    Parker

    Parker Adventist Hospital

    Keren Sturtz
    Ph: 888-785-6789

    Rocky Mountain Cancer Centers - Parker

    Keren Sturtz
    Ph: 888-785-6789

    Pueblo

    St. Mary - Corwin Regional Medical Center

    Keren Sturtz
    Ph: 888-785-6789

    Thornton

    Rocky Mountain Cancer Centers - Thornton

    Keren Sturtz
    Ph: 888-785-6789

    Wheat Ridge

    Exempla Lutheran Medical Center

    Keren Sturtz
    Ph: 888-785-6789

    Connecticut
    Hartford

    Saint Francis/Mount Sinai Regional Cancer Center at Saint Francis Hospital and Medical Center

    Christopher M Reynolds
    Ph: 734-712-4673

    New Britain

    George Bray Cancer Center at the Hospital of Central Connecticut - New Britain Campus

    Brian J Byrne
    Ph: 860-224-5660

    Delaware
    Dover

    Kent General Hospital

    Iftekhar A. Khan
    Ph: 302-744-6755
    Email: mary_ella_quillen@bayhealth.org

    Lewes

    Tunnell Cancer Center at Beebe Medical Center

    Gregory A. Masters
    Ph: 302-733-6227

    Newark

    Delaware Clinical and Laboratory Physicians

    Gregory A. Masters
    Ph: 302-733-6227

    Helen F. Graham Cancer Center at Christiana Hospital

    Gregory A. Masters
    Ph: 302-733-6227

    Gregory A. Masters
    Ph: 302-733-6227

    Medical Oncology Hematology Consultants, PA at Helen F. Graham Cancer Center

    Gregory A. Masters
    Ph: 302-733-6227

    Regional Hematology/Oncology, PA - Newark

    Gregory A. Masters
    Ph: 302-733-6227

    Rehoboth Beach

    Beebe Health Campus

    Gregory A. Masters
    Ph: 302-733-6227

    Seaford

    Nanticoke Memorial Hospital

    Gregory A. Masters
    Ph: 302-733-6227

    Georgia
    Atlanta

    Winship Cancer Institute of Emory University

    Jonathon B Cohen
    Ph: 404-778-1868

    Savannah

    Nancy N. and J. C. Lewis Cancer and Research Pavilion at St. Joseph's/Candler

    Grant C Lewis
    Ph: 912-350-8568

    Hawaii
    Honolulu

    Cancer Research Center of Hawaii

    Jeffrey L. Berenberg
    Ph: 808-586-2979

    Hawaii Medical Center - East

    Jeffrey L. Berenberg
    Ph: 808-586-2979

    Kaiser Permanente - Moanalua Medical Center and Clinic

    Tatjana Kolevska
    Ph: 626-564-3455

    OnCare Hawaii, Incorporated - Kuakini

    Jeffrey L. Berenberg
    Ph: 808-586-2979

    OnCare Hawaii, Incorporated - Lusitana

    Jeffrey L. Berenberg
    Ph: 808-586-2979

    Straub Clinic and Hospital, Incorporated

    Jeffrey L. Berenberg
    Ph: 808-586-2979

    Idaho
    Boise

    Saint Alphonsus Cancer Care Center at Saint Alphonsus Regional Medical Center

    Christopher M Reynolds
    Ph: 734-712-4673

    Illinois
    Canton

    Illinois CancerCare - Canton

    Nguyet A Le-Lindqwister
    Ph: 800-793-2262

    Carthage

    Illinois CancerCare - Carthage

    Nguyet A Le-Lindqwister
    Ph: 800-793-2262

    Chicago

    Robert H. Lurie Comprehensive Cancer Center at Northwestern University

    Adam M Petrich
    Ph: 312-695-1301
    Email: cancer@northwestern.edu

    Decatur

    Cancer Care Center of Decatur

    James L. Wade
    Ph: 217-876-4740
    Email: kcheek@dmhhs.org

    Decatur Memorial Hospital Cancer Care Institute

    James L. Wade
    Ph: 217-876-4740
    Email: kcheek@dmhhs.org

    Eureka

    Illinois CancerCare - Eureka

    Nguyet A Le-Lindqwister
    Ph: 800-793-2262

    Galesburg

    Medical and Surgical Specialists, LLC

    Nguyet A Le-Lindqwister
    Ph: 800-793-2262

    Harvey

    Ingalls Cancer Care Center at Ingalls Memorial Hospital

    Mark F. Kozloff
    Ph: 708-915-4673
    Email: clinicaltrials@ingalls.org

    Hinsdale

    Hinsdale Hematology Oncology Associates

    Elyse Cheryl Schneiderman
    Ph: 630-654-1790
    Email: info@hhoaltd.com

    Joliet

    Joliet Oncology-Hematology Associates, Limited - West

    Kulumani M Sivarajan
    Ph: 815-730-3098
    Email: maureenc@jolietoncology.com

    Kewanee

    Illinois CancerCare - Kewanee Clinic

    Nguyet A Le-Lindqwister
    Ph: 800-793-2262

    Macomb

    Illinois CancerCare - Macomb

    Nguyet A Le-Lindqwister
    Ph: 800-793-2262

    Moline

    Trinity Cancer Center at Trinity Medical Center - 7th Street Campus

    David M Spector
    Ph: 309-779-4200

    Niles

    Cancer Care and Hematology Specialists of Chicagoland - Niles

    Adam M Petrich
    Ph: 312-695-1301
    Email: cancer@northwestern.edu

    Ottawa

    Illinois CancerCare - Ottawa

    Nguyet A Le-Lindqwister
    Ph: 800-793-2262

    Pekin

    Illinois CancerCare - Pekin

    Nguyet A Le-Lindqwister
    Ph: 800-793-2262

    Peoria

    Illinois CancerCare - Peoria

    Nguyet A Le-Lindqwister
    Ph: 800-793-2262

    Peru

    Illinois CancerCare - Princeton

    Nguyet A Le-Lindqwister
    Ph: 800-793-2262

    Princeton

    Illinois CancerCare - Princeton

    Nguyet A Le-Lindqwister
    Ph: 800-793-2262

    Rockford

    Advanced Care and Treatment Medical Group, PC

    Harvey Eric Einhorn
    Ph: 779-696-9400
    Email: cancercare@swedishamerican.org

    Springfield

    Central Illinois Hematology Oncology Center

    James L. Wade
    Ph: 217-876-4740
    Email: kcheek@dmhhs.org

    Regional Cancer Center at Memorial Medical Center

    James L. Wade
    Ph: 217-876-4740
    Email: kcheek@dmhhs.org

    Warrenville

    Central Dupage Cancer Center

    Robert A. Bayer
    Ph: 630-208-4563
    Email: kevin.tomczyk@delnor.com

    Indiana
    Elkhart

    Michiana Hematology-Oncology, PC - Elkhart

    Jose A. Bufill
    Ph: 574-237-1328

    Indianapolis

    Central Indiana Cancer Centers - East

    Michael J. Robertson
    Ph: 317-274-2552

    Indiana University Melvin and Bren Simon Cancer Center

    Michael J. Robertson
    Ph: 317-274-2552

    Lafayette

    Clarian Arnett Cancer Care

    Michael J. Robertson
    Ph: 317-274-2552

    Mishawaka

    Michiana Hematology-Oncology, PC - Mishawaka

    Jose A. Bufill
    Ph: 574-237-1328

    Saint Joseph's Medical Center

    Jose A. Bufill
    Ph: 574-237-1328

    Muncie

    Cancer Center at Ball Memorial Hospital

    Michael J Williamson
    Ph: 765-751-5850

    Plymouth

    Michiana Hematology Oncology PC - Plymouth

    Jose A. Bufill
    Ph: 574-237-1328

    Richmond

    Reid Hospital & Health Care Services

    Howard M. Gross
    Ph: 937-775-1350

    South Bend

    CCOP - Northern Indiana CR Consortium

    Jose A. Bufill
    Ph: 574-237-1328

    Michiana Hematology-Oncology, PC - South Bend

    Jose A. Bufill
    Ph: 574-237-1328

    Westville

    Michiana Hematology Oncology-PC Westville

    Jose A. Bufill
    Ph: 574-237-1328

    Iowa
    Ames

    McFarland Clinic, PC

    Joseph James Merchant
    Ph: 515-239-2621

    Cedar Rapids

    Cedar Rapids Oncology Associates

    Deborah W Wilbur
    Ph: 319-363-2690

    Des Moines

    Medical Oncology and Hematology Associates at John Stoddard Cancer Center

    Robert J Behrens
    Ph: 515-282-2921

    Mason City

    Mercy Cancer Center at Mercy Medical Center - North Iowa

    Arvind Y Vemula
    Ph: 800-433-3883

    Sioux City

    Siouxland Hematology-Oncology Associates, LLP

    Donald Bruce Wender
    Ph: 712-252-0088

    Kansas
    Lawrence

    Lawrence Memorial Hospital

    Shaker R. Dakhil
    Ph: 316-262-4467

    Wichita

    Wesley Medical Center

    Shaker R. Dakhil
    Ph: 316-262-4467

    Louisiana
    Baton Rouge

    Ochsner Health Center - Bluebonnet

    Robert V. Emmons
    Ph: 888-562-4763

    New Orleans

    Ochsner Cancer Institute at Ochsner Clinic Foundation

    Robert V. Emmons
    Ph: 888-562-4763

    Maine
    Augusta

    Harold Alfond Center for Cancer Care

    Thomas Henry Openshaw
    Ph: 207-973-4274

    Bangor

    CancerCare of Maine at Eastern Maine Medical Center

    Thomas Henry Openshaw
    Ph: 207-973-4274

    Maryland
    Baltimore

    Greater Baltimore Medical Center Cancer Center

    Gary I. Cohen
    Ph: 443-849-3706

    Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

    Lode J. Swinnen
    Ph: 410-955-8804
    Email: jhcccro@jhmi.edu

    Salisbury

    Peninsula Regional Medical Center

    Paul E Zorsky
    Ph: 410-543-7017
    Email: sandra.heineken@peninsula.org

    Massachusetts
    Boston

    Boston University Cancer Research Center

    John M Sloan
    Ph: 617-638-8265

    Tufts Medical Center Cancer Center

    Andrew M Evens
    Ph: 617-636-5000
    Email: ContactUsCancerCenter@TuftsMedicalCenter.org

    Springfield

    Baystate Medical Center

    Syed S Ali
    Ph: 413-794-3565
    Email: tamara.wrenn@baystatehealth.org

    Worcester

    UMASS Memorial Cancer Center - University Campus

    Alan Glen Rosmarin
    Ph: 508-856-3216
    Email: cancer.research@umassmed.edu

    Michigan
    Ann Arbor

    Saint Joseph Mercy Cancer Center

    Christopher M Reynolds
    Ph: 734-712-4673

    Battle Creek

    Battle Creek Health System Cancer Care Center

    Gilbert D Padula
    Ph: 616-685-5225
    Email: connie.szczepanek@grcop.org

    Dearborn

    Oakwood Cancer Center at Oakwood Hospital and Medical Center

    Christopher M Reynolds
    Ph: 734-712-4673

    Detroit

    Van Elslander Cancer Center at St. John Hospital and Medical Center

    Christopher M Reynolds
    Ph: 734-712-4673

    Wayne State University

    Jay Yang
    Ph: 313-576-9363

    Escanaba

    Green Bay Oncology, Limited - Escanaba

    Brian L Burnette
    Ph: 800-432-6049

    Flint

    Genesys Hurley Cancer Institute

    Christopher M Reynolds
    Ph: 734-712-4673

    Grand Rapids

    Butterworth Hospital at Spectrum Health

    Gilbert D Padula
    Ph: 616-685-5225
    Email: connie.szczepanek@grcop.org

    Lacks Cancer Center at Saint Mary's Health Care

    Gilbert D Padula
    Ph: 616-685-5225
    Email: connie.szczepanek@grcop.org

    Iron Mountain

    Green Bay Oncology - Iron Mountain

    Brian L Burnette
    Ph: 800-432-6049

    Jackson

    Gayle M. Jacob Cancer Center at Allegiance Health

    Christopher M Reynolds
    Ph: 734-712-4673

    Kalamazoo

    West Michigan Cancer Center

    Raymond Sterling Lord
    Ph: 269-373-7458

    Livonia

    St. Mary Mercy Hospital

    Christopher M Reynolds
    Ph: 734-712-4673

    Muskegon

    Mercy General Health Partners

    Gilbert D Padula
    Ph: 616-685-5225
    Email: connie.szczepanek@grcop.org

    Pontiac

    St. Joseph Mercy Oakland

    Christopher M Reynolds
    Ph: 734-712-4673

    Port Huron

    Mercy Regional Cancer Center at Mercy Hospital

    Christopher M Reynolds
    Ph: 734-712-4673

    Reed City

    Spectrum Health Reed City Hospital

    Gilbert D Padula
    Ph: 616-685-5225
    Email: connie.szczepanek@grcop.org

    Saginaw

    Seton Cancer Institute at Saint Mary's - Saginaw

    Christopher M Reynolds
    Ph: 734-712-4673

    Saint Joseph

    Lakeside Cancer Specialists, PLLC

    Gilbert D Padula
    Ph: 616-685-5225
    Email: connie.szczepanek@grcop.org

    St. Joseph

    Lakeland Regional Cancer Care Center - St. Joseph

    Gilbert D Padula
    Ph: 616-685-5225
    Email: connie.szczepanek@grcop.org

    Traverse City

    Munson Medical Center

    Gilbert D Padula
    Ph: 616-685-5225
    Email: connie.szczepanek@grcop.org

    Warren

    St. John Macomb Hospital

    Christopher M Reynolds
    Ph: 734-712-4673

    Minnesota
    Bemidji

    MeritCare Bemidji

    Preston D. Steen
    Ph: 701-234-6161

    Burnsville

    Fairview Ridges Hospital

    Joseph W Leach
    Ph: 952-993-1517
    Email: MMCCOP@parknicollet.com

    Coon Rapids

    Mercy and Unity Cancer Center at Mercy Hospital

    Joseph W Leach
    Ph: 952-993-1517
    Email: MMCCOP@parknicollet.com

    Duluth

    CCOP - Duluth

    Bret E Friday
    Ph: 888-203-7267

    St. Luke's Hospital Cancer Care Center

    Basem S Goueli
    Ph: 888-823-5923
    Email: ctsucontact@westat.com

    Edina

    Fairview Southdale Hospital

    Joseph W Leach
    Ph: 952-993-1517
    Email: MMCCOP@parknicollet.com

    Fergus Falls

    Lake Region Healthcare Corporation-Cancer Care

    Bret E Friday
    Ph: 888-203-7267

    Fridley

    Mercy and Unity Cancer Center at Unity Hospital

    Joseph W Leach
    Ph: 952-993-1517
    Email: MMCCOP@parknicollet.com

    Hutchinson

    Hutchinson Area Health Care

    Joseph W Leach
    Ph: 952-993-1517
    Email: MMCCOP@parknicollet.com

    Maplewood

    HealthEast Cancer Care at St. John's Hospital

    Joseph W Leach
    Ph: 952-993-1517
    Email: MMCCOP@parknicollet.com

    Minnesota Oncology - Maplewood

    Joseph W Leach
    Ph: 952-993-1517
    Email: MMCCOP@parknicollet.com

    Minneapolis

    Health Partners Inc

    Joseph W Leach
    Ph: 952-993-1517
    Email: MMCCOP@parknicollet.com

    Hennepin County Medical Center - Minneapolis

    Joseph W Leach
    Ph: 952-993-1517
    Email: MMCCOP@parknicollet.com

    Virginia Piper Cancer Institute at Abbott - Northwestern Hospital

    Joseph W Leach
    Ph: 952-993-1517
    Email: MMCCOP@parknicollet.com

    Robbinsdale

    Humphrey Cancer Center at North Memorial Outpatient Center

    Joseph W Leach
    Ph: 952-993-1517
    Email: MMCCOP@parknicollet.com

    Rochester

    Mayo Clinic Cancer Center

    Grzegorz S Nowakowski
    Ph: 507-538-7623

    Saint Cloud

    CentraCare Clinic - Women and Children

    Donald J Jurgens
    Ph: 877-229-4907
    Email: coborncancercenter@centracare.com

    Saint Louis Park

    Park Nicollet Cancer Center

    Joseph W Leach
    Ph: 952-993-1517
    Email: MMCCOP@parknicollet.com

    Saint Paul

    Regions Hospital Cancer Care Center

    Joseph W Leach
    Ph: 952-993-1517
    Email: MMCCOP@parknicollet.com

    United Hospital

    Joseph W Leach
    Ph: 952-993-1517
    Email: MMCCOP@parknicollet.com

    Shakopee

    St. Francis Cancer Center at St. Francis Medical Center

    Joseph W Leach
    Ph: 952-993-1517
    Email: MMCCOP@parknicollet.com

    Waconia

    Ridgeview Medical Center

    Joseph W Leach
    Ph: 952-993-1517
    Email: MMCCOP@parknicollet.com

    Willmar

    Willmar Cancer Center at Rice Memorial Hospital

    Joseph W Leach
    Ph: 952-993-1517
    Email: MMCCOP@parknicollet.com

    Woodbury

    Minnesota Oncology - Woodbury

    Joseph W Leach
    Ph: 952-993-1517
    Email: MMCCOP@parknicollet.com

    Missouri
    Bolivar

    Central Care Cancer Center at Carrie J. Babb Cancer Center

    Jay W Carlson
    Ph: 800-821-7532

    Cape Girardeau

    Saint Francis Medical Center

    James L. Wade
    Ph: 217-876-4740
    Email: kcheek@dmhhs.org

    Southeast Cancer Center

    James L. Wade
    Ph: 217-876-4740
    Email: kcheek@dmhhs.org

    Chesterfield

    Saint Luke's Hospital

    Donald F. Busiek
    Ph: 314-205-6936

    Jefferson City

    Goldschmidt Cancer Center

    Bryan A Faller
    Ph: 800-392-0936

    Kansas City

    Saint Luke's Hospital

    Rakesh Gaur
    Ph: 913-948-5588
    Email: aroland@kccop.org

    Saint Louis

    David C. Pratt Cancer Center at St. John's Mercy

    Jay W Carlson
    Ph: 800-821-7532

    Mercy Clinic St. Louis Cancer and Breast Institute

    Jay W Carlson
    Ph: 800-821-7532

    Missouri Baptist Cancer Center

    Bryan A Faller
    Ph: 800-392-0936

    Montana
    Billings

    Billings Clinic Cancer Center - 801 N 29th Street

    Benjamin Thomas Marchello
    Ph: 800-648-6274

    Bozeman

    Bozeman Deaconess Cancer Center

    Benjamin Thomas Marchello
    Ph: 800-648-6274

    Butte

    St. James Healthcare Cancer Care

    Benjamin Thomas Marchello
    Ph: 800-648-6274

    Great Falls

    Benefis Sletten Cancer Institute

    Benjamin Thomas Marchello
    Ph: 800-648-6274

    Nebraska
    Lincoln

    Cancer Resource Center - Lincoln

    Gamini S. Soori
    Ph: 402-991-8070ext202
    Email: mwilwerding@mvcc.cc

    Omaha

    Fred and Pamela Buffett Cancer Center

    Philip J. Bierman
    Ph: 402-559-6941
    Email: unmcrsa@unmc.edu

    Nevada
    Las Vegas

    Cancer and Blood Specialists-Fort Apache

    John Allan Ellerton
    Ph: 702-384-0013

    CCOP - Nevada Cancer Research Foundation

    John Allan Ellerton
    Ph: 702-384-0013

    University Medical Center of Southern Nevada

    John Allan Ellerton
    Ph: 702-384-0013

    New Hampshire
    Concord

    New Hampshire Oncology - Hematology, PA at Payson Center for Cancer Care

    Frederick M. Briccetti
    Ph: 800-339-6484

    Dover

    Seacoast Cancer Center at Wentworth - Douglass Hospital

    Taylor M Ortiz
    Ph: 603-740-2150

    Hooksett

    New Hampshire Oncology - Hematology, PA - Hooksett

    Frederick M. Briccetti
    Ph: 800-339-6484

    Laconia

    Lakes Region General Hospital

    Frederick M. Briccetti
    Ph: 800-339-6484

    Lebanon

    Norris Cotton Cancer Center at Dartmouth-Hitchcock Medical Center

    Frederick Lansigan
    Ph: 800-639-6918
    Email: cancer.research.nurse@dartmouth.edu

    New Jersey
    Livingston

    St. Barnabas Medical Center Cancer Center

    Miguel A. Conde
    Ph: 973-322-2470

    Mount Holly

    Virtua Fox Chase Health Cancer Program at Virtua Memorial Hospital Burlington County

    Michael S. Entmacher
    Ph: 888-847-8823

    Vineland

    Frank and Edith Scarpa Regional Cancer Pavillion at South Jersey Healthcare

    Ramakrishna Sudhindra
    Ph: 856-641-7933

    New York
    Bronx

    Albert Einstein Cancer Center at Albert Einstein College of Medicine

    Ramakrishna Battini
    Ph: 718-904-2730
    Email: aecc@aecom.yu.edu

    Jack D. Weiler Hospital at Montefiore Medical Center - East Campus

    Ramakrishna Battini
    Ph: 718-904-2730
    Email: aecc@aecom.yu.edu

    Montefiore Medical Center

    Ramakrishna Battini
    Ph: 718-904-2730
    Email: aecc@aecom.yu.edu

    Brooklyn

    Kings County Hospital Center

    Jason P Gonsky
    Ph: 718-245-3131

    SUNY Downstate Medical Center

    Jason P Gonsky
    Ph: 718-245-3131

    Buffalo

    Roswell Park Cancer Institute

    Francisco J Hernandez-ILizaliturri
    Ph: 877-275-7724

    East Syracuse

    CCOP - Hematology-Oncology Associates of Central New York

    Jeffrey J. Kirshner
    Ph: 315-472-7504

    New York

    Herbert Irving Comprehensive Cancer Center at Columbia University Medical Center

    Jennifer E Amengual
    Ph: 212-305-8615

    New York University Medical Center

    Catherine S Diefenbach
    Ph: 212-263-4434
    Email: prmc.coordinator@nyumc.org

    Plattsburgh

    Fitzpatrick Cancer Center at Champlain Valley Physicians Hospital Medical Center

    Jan Erik Duus
    Ph: 518-561-2000

    Rochester

    James P. Wilmot Cancer Center at University of Rochester Medical Center

    Jonathan W Friedberg
    Ph: 585-275-5830

    Syracuse

    SUNY Upstate Medical University Hospital

    Teresa C. Gentile
    Ph: 315-464-5476

    North Carolina
    Asheboro

    Randolph Hospital

    James M Granfortuna
    Ph: 336-832-0821

    Chapel Hill

    Lineberger Comprehensive Cancer Center at University of North Carolina - Chapel Hill

    Steven I Park
    Ph: 877-668-0683
    Email: cancerclinicaltrials@med.unc.edu

    Clinton

    Southeastern Medical Oncology Center-Clinton

    James N. Atkins
    Ph: 919-580-0000

    Goldsboro

    Southeastern Medical Oncology Center - Goldsboro

    James N. Atkins
    Ph: 919-580-0000

    Wayne Memorial Hospital, Incorporated

    James N. Atkins
    Ph: 919-580-0000

    Greensboro

    Moses Cone Regional Cancer Center at Wesley Long Community Hospital

    James M Granfortuna
    Ph: 336-832-0821

    Hendersonville

    Comprehensive Cancer Center at Pardee Hospital

    James E. Radford
    Ph: 828-696-4716

    Jacksonville

    Southeastern Medical Oncology Center-Jacksonville

    James N. Atkins
    Ph: 919-580-0000

    Kinston

    Kinston Medical Specialists

    Peter R. Watson
    Ph: 252-559-2200

    Reidsville

    Annie Penn Cancer Center

    James M Granfortuna
    Ph: 336-832-0821

    Statesville

    Iredell Memorial Hospital

    Ruby A. Grimm
    Ph: 704-873-5661

    Washington

    Marion L. Shepard Cancer Center at Beaufort County Hospital

    John J Inzerillo
    Ph: 252-975-4308

    Wilson

    Southeastern Medical Oncology Center - Wilson

    James N. Atkins
    Ph: 919-580-0000

    Winston-Salem

    Wake Forest University Comprehensive Cancer Center

    Zanetta S Lamar
    Ph: 336-713-6771

    North Dakota
    Bismarck

    Medcenter One Hospital Cancer Care Center

    Preston D. Steen
    Ph: 701-234-6161

    Fargo

    Roger Maris Cancer Center at MeritCare Hospital

    Preston D. Steen
    Ph: 701-234-6161

    Preston D. Steen
    Ph: 701-234-6161

    Sanford Clinic North-Fargo

    Preston D. Steen
    Ph: 701-234-6161

    Ohio
    Akron

    Summa Center for Cancer Care at Akron City Hospital

    Jennifer E Payne
    Ph: 330-375-6101

    Barberton

    Barberton Citizens Hospital

    Jennifer E Payne
    Ph: 330-375-6101

    Canton

    Mercy Cancer Center at Mercy Medical Center

    Mitchell Haut
    Ph: 888-293-4673

    Cincinnati

    Good Samaritan Hospital Cancer Treatment Center

    Ranga S Brahmamdam
    Ph: 513-862-2230

    TriHealth Cancer Institute-Anderson

    Ranga S Brahmamdam
    Ph: 513-862-2230

    TriHealth Cancer Institute-Westside

    Ranga S Brahmamdam
    Ph: 513-862-2230

    University of Cincinnati

    Stephen C Medlin
    Ph: 513-558-4553
    Email: uchealthnews@uc.edu

    Cleveland

    Case Comprehensive Cancer Center

    Paolo F Caimi
    Ph: 800-641-2422

    Columbus

    Arthur G. James Cancer Hospital and Richard J. Solove Research Institute at Ohio State University Comprehensive Cancer Center

    Kami J Maddocks
    Ph: 800-293-5066
    Email: Jamesline@osumc.edu

    Columbus Oncology Associates, Incorporated

    J. Philip Kuebler
    Ph: 614-566-3275

    Mount Carmel Health - West Hospital

    J. Philip Kuebler
    Ph: 614-566-3275

    Riverside Methodist Hospital Cancer Care

    J. Philip Kuebler
    Ph: 614-566-3275

    Zangmeister Center

    J. Philip Kuebler
    Ph: 614-566-3275

    Dayton

    David L. Rike Cancer Center at Miami Valley Hospital

    Howard M. Gross
    Ph: 937-775-1350

    Good Samaritan Hospital

    Howard M. Gross
    Ph: 937-775-1350

    Samaritan North Cancer Care Center

    Howard M. Gross
    Ph: 937-775-1350

    Findlay

    Blanchard Valley Regional Cancer Center

    Howard M. Gross
    Ph: 937-775-1350

    Lima

    St. Rita's Medical Center

    Henry Gerad
    Ph: 419-226-9617

    Marietta

    Strecker Cancer Center at Marietta Memorial Hospital

    J. Philip Kuebler
    Ph: 614-566-3275

    Newark

    Licking Memorial Cancer Care Program at Licking Memorial Hospital

    J. Philip Kuebler
    Ph: 614-566-3275

    Springfield

    Community Hospital of Springfield and Clark County

    J. Philip Kuebler
    Ph: 614-566-3275

    Toledo

    Toledo Clinic, Incorporated - Main Clinic

    Rex B Mowat
    Ph: 800-444-3561

    Westerville

    Mount Carmel St. Ann's Cancer Center

    J. Philip Kuebler
    Ph: 614-566-3275

    Oregon
    Newberg

    Providence Newberg Medical Center

    Keith S. Lanier
    Ph: 503-215-6412

    Oregon City

    Willamette Falls Hospital

    Keith S. Lanier
    Ph: 503-215-6412

    Portland

    Providence Cancer Center at Providence Portland Medical Center

    Keith S. Lanier
    Ph: 503-215-6412

    Providence St. Vincent Medical Center

    Keith S. Lanier
    Ph: 503-215-6412

    Pennsylvania
    Allentown

    Morgan Cancer Center at Lehigh Valley Hospital - Cedar Crest

    Eliot Lawrence Friedman
    Ph: 610-402-2273

    Bethlehem

    St. Luke's Cancer Network at St. Luke's Hospital

    Neil D Belman
    Ph: 610-954-3582
    Email: infolink@slhn.org

    Bryn Mawr

    Bryn Mawr Hospital

    Albert S DeNittis
    Ph: 866-225-5654

    Danville

    Geisinger Cancer Institute at Geisinger Health

    Edward J Gorak
    Ph: 570-271-5251

    Doylestown

    Doylestown Hospital Cancer Center

    Mitchell Alden
    Ph: 215-345-2378
    Email: lheacock@dh.org

    Drexel Hill

    Delaware County Regional Cancer Center at Delaware County Memorial Hospital

    Michael M Mikhail
    Ph: 610-284-8237
    Email: jolene.garney@crozer.org

    Ephrata

    Ephrata Cancer Center at Ephrata Community Hospital

    Amir Tabatabai
    Ph: 877-441-7957

    Amir Tabatabai
    Ph: 877-441-7957

    Gettysburg

    Adams Cancer Center

    Amir Tabatabai
    Ph: 877-441-7957

    Hanover

    Cherry Tree Cancer Center

    Amir Tabatabai
    Ph: 877-441-7957

    Hazleton

    Geisinger Hazleton Cancer Center

    Edward J Gorak
    Ph: 570-271-5251

    Hershey

    Penn State Hershey Cancer Institute at Milton S. Hershey Medical Center

    Witold Boleslaw Rybka
    Ph: 717-531-3779
    Email: CTO@hmc.psu.edu

    Paoli

    Cancer Center of Paoli Memorial Hospital

    Albert S DeNittis
    Ph: 866-225-5654

    Philadelphia

    Abramson Cancer Center of the University of Pennsylvania

    Daniel J Landsburg
    Ph: 800-474-9892

    Fox Chase Cancer Center - Philadelphia

    Nadia Khan
    Ph: 215-728-4790

    Kimmel Cancer Center at Thomas Jefferson University - Philadelphia

    Barbara Pro
    Ph: 215-955-6084

    Temple Cancer Center at Temple University Hospital

    Nadia Khan
    Ph: 215-728-4790

    Pottstown

    Pottstown Memorial Regional Cancer Center

    Wei Song
    Ph: 610-327-7544

    Scranton

    Hematology and Oncology Associates of North East Pennsylvania

    Barbara Pro
    Ph: 215-955-6084

    State College

    Mount Nittany Medical Center

    Witold Boleslaw Rybka
    Ph: 717-531-3779
    Email: CTO@hmc.psu.edu

    West Chester

    Cancer Center of Chester County

    William E. Luginbuhl
    Ph: 610-431-5297

    West Reading

    McGlinn Family Regional Cancer Center at Reading Hospital and Medical Center

    Terrence P. Cescon
    Ph: 610-988-9323

    Wilkes-Barre

    Frank M. and Dorothea Henry Cancer Center at Geisinger Wyoming Valley Medical Center

    Edward J Gorak
    Ph: 570-271-5251

    Wynnewood

    Lankenau Cancer Center at Lankenau Hospital

    Albert S DeNittis
    Ph: 866-225-5654

    York

    WellSpan Health

    Amir Tabatabai
    Ph: 877-441-7957

    South Carolina
    Easley

    Cancer Centers of the Carolinas - Easley

    Jeffrey Kent Giguere
    Ph: 864-241-6251

    Greenville

    Cancer Centers of the Carolinas - Andrews

    Jeffrey Kent Giguere
    Ph: 864-241-6251

    Cancer Centers of the Carolinas - Faris Road

    Jeffrey Kent Giguere
    Ph: 864-241-6251

    Cancer Centers of the Carolinas - Grove Commons

    Jeffrey Kent Giguere
    Ph: 864-241-6251

    CCOP - Greenville

    Jeffrey Kent Giguere
    Ph: 864-241-6251

    Greenville Memorial Hospital

    Jeffrey Kent Giguere
    Ph: 864-241-6251

    Greer

    Cancer Centers of the Carolinas - Greer Radiation Oncology

    Jeffrey Kent Giguere
    Ph: 864-241-6251

    Seneca

    Cancer Centers of the Carolinas - Seneca

    Jeffrey Kent Giguere
    Ph: 864-241-6251

    Spartanburg

    Cancer Centers of the Carolinas - Spartanburg

    Jeffrey Kent Giguere
    Ph: 864-241-6251

    South Dakota
    Rapid City

    Rapid City Regional Hospital

    Mark T Schroeder
    Ph: 605-716-3982
    Email: research@rcrh.org

    Sioux Falls

    Avera Cancer Institute

    Addison R Tolentino
    Ph: 800-657-4377
    Email: Jan.Healy@avera.org

    Sanford Cancer Center at Sanford USD Medical Center

    Preston D. Steen
    Ph: 701-234-6161

    Preston D. Steen
    Ph: 701-234-6161

    Tennessee
    Nashville

    Vanderbilt-Ingram Cancer Center

    Nishitha Reddy
    Ph: 800-811-8480

    Texas
    Austin

    University Medical Center Brackenridge

    Alka Mallik
    Ph: 512-324-7991

    Dallas

    Simmons Comprehensive Cancer Center at University of Texas Southwestern Medical Center - Dallas

    Harris V Naina
    Ph: 214-648-7097

    Fort Sam Houston

    Brooke Army Medical Center

    John S Renshaw
    Ph: 210-916-4837

    Lubbock

    Covenant Medical Center

    Donald P Quick
    Ph: 806-725-8000
    Email: jaccresearch@covhs.org

    Texas Tech University Health Sciences Center

    Nicholas C D'Cunha
    Ph: 806-775-8590

    Virginia
    Charlottesville

    University of Virginia Cancer Center

    Michael Eugene Williams
    Ph: 434-243-6143

    Martinsville

    Ravenel Oncology Center at Memorial Hospital of Martinsville and Henry County

    Sreedhar Katragadda
    Ph: 276-666-7827

    Washington
    Longview

    Lower Columbia Regional Cancer Center at PeaceHealth-St. John Medical Center

    Keith S. Lanier
    Ph: 503-215-6412

    Vancouver

    Southwest Washington Medical Center Cancer Center

    Keith S. Lanier
    Ph: 503-215-6412

    West Virginia
    Charleston

    West Virginia University Medical School - Charleston

    Steven J. Jubelirer
    Ph: 304-344-3457

    Wisconsin
    Antigo

    Langlade Memorial Hospital

    Hamied R. Rezazadeh
    Ph: 877-405-6866

    Burlington

    Aurora Cancer Care-Burlington

    Rubina Qamar
    Ph: 888-709-2080

    Eau Claire

    Center for Cancer Treatment & Prevention at Sacred Heart Hospital

    Ali W. Bseiso
    Ph: 715-389-4457

    Marshfield Clinic Cancer Care at Regional Cancer Center

    Ali W. Bseiso
    Ph: 715-389-4457

    Elkhorn

    Vince Lombardi Cancer Center at Aurora Lakeland Medical Center - Elkhorn

    Rubina Qamar
    Ph: 888-709-2080

    Grafton

    Aurora Cancer Care-Grafton

    Rubina Qamar
    Ph: 888-709-2080

    Green Bay

    Bellin Memorial Hospital

    Patrick J Mansky
    Ph: 240-566-3584
    Email: clinicaltrials@fmh.org

    Green Bay Oncology, Limited at St. Mary's Hospital

    Brian L Burnette
    Ph: 800-432-6049

    Green Bay Oncology, Limited at St. Vincent Hospital Regional Cancer Center

    Brian L Burnette
    Ph: 800-432-6049

    St. Mary's Hospital Medical Center - Green Bay

    Brian L Burnette
    Ph: 800-432-6049

    St. Vincent Hospital Regional Cancer Center

    Brian L Burnette
    Ph: 800-432-6049

    Vince Lombardi Cancer Clinic - Green Bay at Aurora BayCare Medical Center

    Rubina Qamar
    Ph: 888-709-2080

    Johnson Creek

    UW Cancer Center Johnson Creek

    Brad S. Kahl
    Ph: 877-405-6866

    Kenosha

    Oncology Alliance - Kenosha South

    Rubina Qamar
    Ph: 888-709-2080

    La Crosse

    Gundersen Lutheran Center for Cancer and Blood

    Kurt Oettel
    Ph: 608-775-2385
    Email: cancerctr@gundluth.org

    Madison

    Dean Hematology & Oncology Clinic

    Amit Sanyal
    Ph: 608-410-2700

    University of Wisconsin Paul P. Carbone Comprehensive Cancer Center

    Brad S. Kahl
    Ph: 877-405-6866

    Marinette

    Bay Area Cancer Care Center at Bay Area Medical Center

    Brian L Burnette
    Ph: 800-432-6049

    Vince Lombardi Cancer Clinic - Marinette

    Rubina Qamar
    Ph: 888-709-2080

    Marshfield

    Marshfield Clinic - Marshfield Center

    Ali W. Bseiso
    Ph: 715-389-4457

    Saint Joseph's Hospital

    Ali W. Bseiso
    Ph: 715-389-4457

    Menomonee Falls

    Aurora Advanced Healthcare Inc-Menomonee Falls

    Rubina Qamar
    Ph: 888-709-2080

    Milwaukee

    Aurora Cancer Care-Milwaukee

    Rubina Qamar
    Ph: 888-709-2080

    Aurora Sinai Medical Center

    Rubina Qamar
    Ph: 888-709-2080

    Froedtert Hospital and Medical College of Wisconsin

    Timothy S Fenske
    Ph: 414-805-4380

    Oncology Alliance, SC - Milwaukee - South

    Rubina Qamar
    Ph: 888-709-2080

    Vince Lombardi Cancer Clinic at Aurora St. Luke's Medical Center

    Rubina Qamar
    Ph: 888-709-2080

    Minocqua

    Marshfield Clinic - Lakeland Center

    Ali W. Bseiso
    Ph: 715-389-4457

    Oconomowoc

    Regional Cancer Center at Oconomowoc Memorial Hospital

    Timothy R Wassenaar
    Ph: 262-928-7878

    Oconto Falls

    Green Bay Oncology, Limited - Oconto Falls

    Brian L Burnette
    Ph: 800-432-6049

    Oshkosh

    Vince Lombardi Cancer Clinic - Oshkosh

    Rubina Qamar
    Ph: 888-709-2080

    Racine

    Aurora Health Center - Racine

    Rubina Qamar
    Ph: 888-709-2080

    Rhinelander

    Ministry Medical Group at Saint Mary's Hospital

    Ali W. Bseiso
    Ph: 715-389-4457

    Ali W. Bseiso
    Ph: 715-389-4457

    Rice Lake

    Marshfield Clinic - Indianhead Center

    Ali W. Bseiso
    Ph: 715-389-4457

    Ali W. Bseiso
    Ph: 715-389-4457

    Sheboygan

    Vince Lombardi Cancer Clinic - Sheboygan

    Rubina Qamar
    Ph: 888-709-2080

    Stevens Point

    Marshfield Clinic at Saint Michael's Hospital

    Ali W. Bseiso
    Ph: 715-389-4457

    Saint Michael's Hospital Cancer Center

    Ali W. Bseiso
    Ph: 715-389-4457

    Sturgeon Bay

    Green Bay Oncology, Limited - Sturgeon Bay

    Brian L Burnette
    Ph: 800-432-6049

    Summit

    Aurora Medical Center

    Rubina Qamar
    Ph: 888-709-2080

    Two Rivers

    Vince Lombardi Cancer Clinic - Two Rivers

    Rubina Qamar
    Ph: 888-709-2080

    Waukesha

    Aurora Cancer Care-Waukesha

    Rubina Qamar
    Ph: 888-709-2080

    Waukesha Memorial Hospital Regional Cancer Center

    Timothy R Wassenaar
    Ph: 262-928-7878

    Wausau

    Marshfield Clinic - Wausau Center

    Ali W. Bseiso
    Ph: 715-389-4457

    University of Wisconcin Cancer Center at Aspirus Wausau Hospital

    Hamied R. Rezazadeh
    Ph: 877-405-6866

    Wauwatosa

    Oncology Alliance, SC - Milwaukee - West

    Rubina Qamar
    Ph: 888-709-2080

    West Allis

    Aurora Women's Pavilion of West Allis Memorial Hospital

    Rubina Qamar
    Ph: 888-709-2080

    Weston

    Diagnostic and Treatment Center

    Ali W. Bseiso
    Ph: 715-389-4457

    Marshfield Clinic - Weston Center

    Ali W. Bseiso
    Ph: 715-389-4457

    Wisconsin Rapids

    Marshfield Clinic - Wisconsin Rapids Center

    Ali W. Bseiso
    Ph: 715-389-4457

    Riverview UW Cancer Center at Riverview Hospital

    Ron James Kirschling
    Ph: 877-405-6866

    Link to the current ClinicalTrials.gov record.
    NLM Identifier NCT01856192
    ClinicalTrials.gov processed this data on May 21, 2015

    Note: Information about this trial is from the ClinicalTrials.gov database. The versions designated for health professionals and patients contain the same text. Minor changes may be made to the ClinicalTrials.gov record to standardize the names of study sponsors, sites, and contacts. Cancer.gov only lists sites that are recruiting patients for active trials, whereas ClinicalTrials.gov lists all sites for all trials. Questions and comments regarding the presented information should be directed to ClinicalTrials.gov.