Comparison of Axillary Lymph Node Dissection With Axillary Radiation for Patients With Node-Positive Breast Cancer Treated With Chemotherapy

  • Resize font
  • Print
  • Email
  • Facebook
  • Twitter
  • Google+
  • Pinterest

Basic Trial Information

PhaseTypeStatusAgeSponsorProtocol IDs
Phase IIITreatmentActive18 and overNCI, OtherA011202
U10CA031946, NCI-2013-00875, NCT01901094

Trial Description

Summary

This randomized phase III trial studies axillary lymph node dissection to see how well it works compared to axillary radiation therapy in treating patients with node-positive breast cancer treated with neoadjuvant chemotherapy followed by surgery. Lymph node dissection may remove cancer cells that have spread to nearby lymph nodes in patients with breast cancer. Radiation therapy uses high-energy x-rays to kill tumor cells. This study will evaluate whether radiation therapy is as effective as lymph node dissection.

Further Study Information

Study Outline:

  • All patients will undergo surgery to identify sentinel lymph node(s). If a lymph node (sentinel or non-sentinel) is determined to be positive on intra-operative pathology the patient will be registered/randomized intra-operatively.
  • Patients who do not have a sentinel lymph node identified will not be registered/randomized to the study.
  • Patients whose sentinel lymph node status is cannot be/is not determined intra- operatively, and have not undergone ALND, but had at least one lymph node (sentinel or non-sentinel) found to be positive on final pathology review will be registered/randomized post-operatively.
  • Patients whose sentinel lymph node status is found to be negative intra-operatively and have not undergone ALND, but had at least one lymph node (sentinel or non-sentinel) found to be positive on final pathology review will be registered/randomized post-operatively.
  • ALND is not to be performed prior to registration/randomization.
  • Patients who are determined to have negative lymph nodes on final pathology will not be registered/randomized, but can be offered participation in another cooperative group trial.

The primary and secondary objectives of the study are described below. Please see the "Arms" section for a detailed description of the treatment regimens.

Primary Objective:

  • To evaluate whether radiation to the undissected axilla and regional lymph nodes is not inferior to axillary lymph node dissection with radiation to the regional lymph nodes but not to the dissected axilla in terms of invasive breast cancer recurrence-free interval in patients with positive SLN(s) after completion of neoadjuvant chemotherapy

Secondary Objectives:

  • To evaluate whether radiation to the undissected axilla and regional lymph nodes is not inferior to axillary lymph node dissection with radiation to the regional lymph nodes but not to the dissected axilla in terms of the incidence of invasive loco-regional recurrences in patients with a positive SLN(s) after completion of neoadjuvant chemotherapy
  • To obtain an estimate of the distribution of residual disease burden scores for each treatment arm
  • To estimate the distribution of overall survival for each treatment arm

Patients may receive adjuvant and ancillary therapy as appropriate per the protocol.

Adjuvant Therapy:

  • Adjuvant endocrine therapy: Patients with hormone receptor (ER and/or PR) positive disease should receive a minimum of 5 years of standard endocrine therapy (experimental agents/regimens are not permitted). Endocrine therapy should begin following completion of neoadjuvant chemotherapy and surgery, either before, during or after radiation therapy at the discretion of the oncologist. Selection of the agents is at the treating physician's discretion.
  • Patients with HER 2 positive disease should complete a total of one year of trastuzumab therapy (over the neoadjuvant and adjuvant period).
  • Chemotherapy, biologic therapy or vaccine therapy in the adjuvant setting is not allowed.

Patients who wish to receive any of these therapies after surgery must go off study at the time of their initiation.

Ancillary Therapy:

  • Patients should receive full supportive care, including transfusions of blood and blood products, erythropoetin (unless otherwise specified in the protocol), antibiotics, antiemetics, etc. when appropriate.

Patients are followed up for 5 years after completion of radiation therapy.

Eligibility Criteria

Pre-Registration Eligibility Criteria:

1. Patients ≥ 18 years of age

2. Clinical stage T1-3 N1 M0 breast cancer at diagnosis (prior to the start of neoadjuvant chemotherapy) by American Joint Committee on Cancer (AJCC) staging 7th edition

3. No inflammatory breast cancer

4. No other malignancy within 5 years of registration with the exception of basal cell or squamous cell carcinoma of the skin treated with local resection only or carcinoma in situ of the cervix

5. All patients must have had an axillary ultrasound with fine needle aspiration (FNA) or core needle biopsy of axillary lymph nodes documenting axillary metastasis at the time of diagnosis, prior to or at most 14 days after starting neoadjuvant chemotherapy. Note: Biopsy of intramammary nodes does not fulfill eligibility criteria.

6. Patients must have had estrogen receptor, progesterone receptor and human epidermal growth factor receptor 2 (HER2) status by immunohistochemistry [IHC] and/or fluorescence in situ hybridization [FISH] evaluated on diagnostic core biopsy prior to start of neoadjuvant chemotherapy. Note: If HER2 status has not been clearly determined (ie equivocal/indeterminate), then patients should not be enrolled.

7. Patients must have completed all planned chemotherapy prior to surgery. Sandwich chemotherapy is not allowed (i.e. chemotherapy planned to be given after surgery). Patients must have completed at least 6 cycles of neoadjuvant chemotherapy consisting of an anthracycline and/or taxane-based regimen without evidence of disease progression in the breast or the lymph nodes. NOTE: Delays/dose modifications due to toxicities/adverse events are allowed as long as a minimum of 6 cycles of neoadjuvant chemotherapy is administered. More than 6 cycles of NAC may be administered at the discretion of the treating medical oncologist.

8. Patients with HER-2 positive tumors must have received neoadjuvant trastuzumab, trastuzumab + pertuzumab, or other approved anti-HER-2 therapy (either with all or with a portion of the neoadjuvant chemotherapy regimen). Therapy must be Food and Drug Administration (FDA)-approved targeted anti-HER2 therapy, but additional therapies are allowed as are non-trastuzumab regimens if administered in the context of an Institutional Review Board (IRB)-approved clinical trial.

9. All patients must have a clinically negative axilla (no palpable lymph nodes or bulky adenopathy) on physical examination documented at the completion of neoadjuvant chemotherapy. NOTE: An ultrasound of the axilla is not required at completion of neoadjuvant chemotherapy. If performed, its findings do NOT impact eligibility.

10. No neoadjuvant endocrine therapy

11. No neoadjuvant radiation therapy

12. No sentinel lymph node (SLN) surgery/excisional biopsy for pathological confirmation of axillary status prior to or during neoadjuvant chemotherapy

13. No prior history of ipsilateral breast cancer (invasive disease or ductal carcinoma in situ [DCIS]). Lobular carcinoma in situ (LCIS) and benign breast disease is allowed.

14. No prior ipsilateral axillary surgery, such as excisional biopsy of lymph node(s) or treatment of hidradenitis.

15. No history of prior or concurrent contralateral invasive breast cancer. Benign breast disease, LCIS or DCIS of contralateral breast is allowed.

16. Patients must not be pregnant or nursing. A negative pregnancy test is required prior to registration for women of childbearing potential. Note: Peri-menopausal women must be amenorrheic for > 12 months to be considered not of childbearing potential.

17. Eastern Cooperative Oncology Group (ECOG) (Zubrod) performance status 0-1.

18. Required Pre-Registration Laboratory Values:

  • Serum or urine beta-human chorionic gonadotropin (ß-HCG)
  • Negative in women of child-bearing potential

Intra-Operative Registration/Randomization Criteria:

1. Breast surgery (lumpectomy or mastectomy) and sentinel lymph node surgery must be completed within 56 days of the completion of neoadjuvant chemotherapy.

2. A minimum of 1 sentinel node and a maximum of 6 total nodes (sentinel + non-sentinel) are identified and excised by the surgeon. Patients who do not have an identifiable sentinel lymph node will not proceed to Registration/Randomization.

3. At least one lymph node (sentinel or non-sentinel) with a metastasis greater than 0.2 mm in greatest dimension identified on intra-operative pathologic assessment. Note: Isolated tumor cells (metastases less than or equal to 0.2 mm) will be treated as node negative disease (N0i+). Axillary lymph node dissection [ALND] is not to be performed prior to Registration/Randomization.

Post-Operative Registration/Randomization Criteria:

1. For cases where ALND has not been performed and one of the following is true:

  • intra-operative evaluation of sentinel lymph node could not be/was not performed and final pathology identified a positive lymph node (sentinel or non-sentinel) with metastasis greater than 0.2 mm on hematoxylin and eosin stain (H & E) OR
  • lymph node (sentinel or non-sentinel) considered negative on intra-operative evaluation was found to be positive on final pathology (with metastasis greater than 0.2 mm on H & E)
  • Breast surgery (lumpectomy or mastectomy) and sentinel lymph node surgery must be completed within 56 days of the completion of neoadjuvant chemotherapy.
  • At least one lymph node (sentinel or non-sentinel) with a metastasis greater than 0.2 mm in greatest dimension identified by H&E staining on final pathology (for cases where intra-operative evaluation was not performed, or was negative and completion dissection was not performed).
  • Among the minimum of 1 and the maximum of 6 nodes (sentinel or non-sentinel) identified and excised by the surgeon, no more than 8 lymph nodes (sentinel and non-sentinel) were found by the pathologists to have been actually excised. Note: Isolated tumor cells (metastases less than or equal to 0.2 mm) will be treated as node negative disease (N0i+).
  • For those patients who also undergo contralateral breast surgery, if invasive disease is found in the contralateral breast, the patient is not eligible for registration/randomization.

Trial Contact Information

Trial Lead Organizations/Sponsors

Alliance for Clinical Trials in Oncology

  • National Cancer Institute
Judy Boughey, Study Chair

Trial Sites

U.S.A.

Alaska
Anchorage

Alaska Breast Care and Surgery LLC

Keith S. Lanier
Ph: 503-215-6412

Alaska Women's Cancer Care

Keith S. Lanier
Ph: 503-215-6412

Anchorage Oncology Centre

Keith S. Lanier
Ph: 503-215-6412

Katmai Oncology Group

Keith S. Lanier
Ph: 503-215-6412

Providence Cancer Center

Keith S. Lanier
Ph: 503-215-6412

Fairbanks

Fairbanks Cancer Treatment Center at Fairbanks Memorial Hospital

John A Keech
Ph: 907-458-5380

Arizona
Tucson

Arizona Cancer Center at University Medical Center North

Michele L Ley
Ph: 520-626-9008

Arizona Cancer Center at University of Arizona Health Sciences Center

Michele L Ley
Ph: 520-626-9008

Arkansas
Little Rock

Arkansas Cancer Research Center at University of Arkansas for Medical Sciences

V. Suzanne Klimberg
Ph: 501-686-8274

California
Auburn

Auburn Radiation Oncology

Peter P. Yu
Ph: 415-209-2686
Email: bernicl@sutterhealth.org

Berkeley

Alta Bates Summit Comprehensive Cancer Center

Peter P. Yu
Ph: 415-209-2686
Email: bernicl@sutterhealth.org

Burbank

Roy and Patricia Disney Family Cancer Center at Providence Saint Joseph Medical Center

Keith S. Lanier
Ph: 503-215-6412

Burlingame

Peninsula Medical Center

Peter P. Yu
Ph: 415-209-2686
Email: bernicl@sutterhealth.org

Cameron Park

Radiation Oncology Centers - Cameron Park

Peter P. Yu
Ph: 415-209-2686
Email: bernicl@sutterhealth.org

Concord

Cancer Care Center at John Muir Health - Concord Campus

Deborah L. Kerlin
Ph: 925-674-2580

Dublin

Epic Care-Dublin

Jon M Greif
Ph: 510-835-9900

Emeryville

Bay Area Breast Surgeons, Incorporated

Jon M Greif
Ph: 510-835-9900

Epic Care - Oakland

Jon M Greif
Ph: 510-835-9900

Fresno

California Cancer Center - Woodward Park Office

Uzair B. Chaudhary
Ph: 559-447-4050

University Oncology Associates

Uzair B. Chaudhary
Ph: 559-447-4050

Loma Linda

Loma Linda University Cancer Institute at Loma Linda University Medical Center

Sharon S Lum
Ph: 909-558-3375

Los Angeles

Samuel Oschin Comprehensive Cancer Institute at Cedars-Sinai Medical Center

Armando E Giuliano
Ph: 310-423-8965

USC/Norris Comprehensive Cancer Center and Hospital

Heather R Macdonald
Ph: 323-865-0451

Heather R Macdonald
Ph: 323-865-0451

Martinez

Contra Costa Regional Medical Center

Jon M Greif
Ph: 510-835-9900

Modesto

Memorial Medical Center

Peter P. Yu
Ph: 415-209-2686
Email: bernicl@sutterhealth.org

Monterey

Community Hospital of the Monterey Peninsula Comprehensive Cancer Center

John Hausdorff
Ph: 831-625-4753

Mountain View

Palo Alto Medical Foundation

Peter P. Yu
Ph: 415-209-2686
Email: bernicl@sutterhealth.org

Novato

Sutter Health Western Division Cancer Research Group

Peter P. Yu
Ph: 415-209-2686
Email: bernicl@sutterhealth.org

Oakland

Alta Bates Summit Medical Center - Summit Campus

Jon M Greif
Ph: 510-835-9900

CCOP - Bay Area Tumor Institute

Jon M Greif
Ph: 510-835-9900

Kaiser Permanente-Oakland

Louis Fehrenbacher
Ph: 626-564-3455

Larry G Strieff MD Medical Corporation

Jon M Greif
Ph: 510-835-9900

Palo Alto

Palo Alto Medical Foundation - Palo Alto

Peter P. Yu
Ph: 415-209-2686
Email: bernicl@sutterhealth.org

Stanford Cancer Center

Frederick M Dirbas
Ph: 650-498-7061
Email: ccto-office@stanford.edu

Pasadena

Huntington OutPatient Surgery Center

Jeannie Shen
Ph: 626-535-2420

Pleasanton

Valley Medical Oncology Consultants - Pleasanton

Jon M Greif
Ph: 510-835-9900

Redwood City

Kaiser Permanente Medical Center - Redwood City

Louis Fehrenbacher
Ph: 626-564-3455

Richmond

Kaiser Permanente Medical Center - Richmond

Louis Fehrenbacher
Ph: 626-564-3455

Roseville

Kaiser Permanente Medical Center - Roseville

Louis Fehrenbacher
Ph: 626-564-3455

Radiation Oncology Center - Roseville

Peter P. Yu
Ph: 415-209-2686
Email: bernicl@sutterhealth.org

Sutter Cancer Center at Roseville Medical Center

Peter P. Yu
Ph: 415-209-2686
Email: bernicl@sutterhealth.org

Sacramento

Kaiser Permanente Medical Center - Sacramento

Louis Fehrenbacher
Ph: 626-564-3455

South Sacramento Kaiser-Permanente Medical Center

Louis Fehrenbacher
Ph: 626-564-3455

Sutter Cancer Center

Peter P. Yu
Ph: 415-209-2686
Email: bernicl@sutterhealth.org

Salinas

Salinas Valley Memorial Hospital

Laura V. Stampleman
Ph: 831-759-1838
Email: tnielsen2@svmh.com

San Francisco

California Pacific Medical Center - California Campus

Peter P. Yu
Ph: 415-209-2686
Email: bernicl@sutterhealth.org

Kaiser Permanente Medical Center - San Francisco Geary Campus

Louis Fehrenbacher
Ph: 626-564-3455

San Jose

Kaiser Permanente Medical Center - Santa Teresa

Louis Fehrenbacher
Ph: 626-564-3455

San Leandro

Kaiser Permanente Medical Center - Hayward

Louis Fehrenbacher
Ph: 626-564-3455

San Rafael

Kaiser Foundation Hospital - San Rafael

Louis Fehrenbacher
Ph: 626-564-3455

Santa Clara

Kaiser Permanente Medical Center - Santa Clara Homestead Campus

Louis Fehrenbacher
Ph: 626-564-3455

Santa Cruz

Palo Alto Medical Foundation-Santa Cruz

Peter P. Yu
Ph: 415-209-2686
Email: bernicl@sutterhealth.org

Santa Rosa

Kaiser Permanente Medical Center - Santa Rosa

Louis Fehrenbacher
Ph: 626-564-3455

South San Francisco

Kaiser Permanente Medical Center - South San Francisco

Louis Fehrenbacher
Ph: 626-564-3455

Stockton

Kaiser Permanente Medical Facility - Stockton

Louis Fehrenbacher
Ph: 626-564-3455

Sunnyvale

Palo Atlo Medical Foundation-Sunnyvale

Peter P. Yu
Ph: 415-209-2686
Email: bernicl@sutterhealth.org

Vacaville

Kaiser Permanente Medical Center - Vacaville

Louis Fehrenbacher
Ph: 626-564-3455

Solano Radiation Oncology Center

Peter P. Yu
Ph: 415-209-2686
Email: bernicl@sutterhealth.org

Vallejo

Kaiser Permanente Medical Center - Vallejo

Louis Fehrenbacher
Ph: 626-564-3455

Sutter Solano Medical Center

Peter P. Yu
Ph: 415-209-2686
Email: bernicl@sutterhealth.org

Walnut Creek

John Muir/Mt. Diablo Comprehensive Cancer Center

Deborah L. Kerlin
Ph: 925-674-2580

Kaiser Permanente Medical Center - Walnut Creek

Louis Fehrenbacher
Ph: 626-564-3455

Colorado
Aurora

Medical Center of Aurora - South Campus

Keren Sturtz
Ph: 888-785-6789

Rocky Mountain Cancer Centers - Aurora

Keren Sturtz
Ph: 888-785-6789

University of Colorado Cancer Center at UC Health Sciences Center

Nicole Kounalakis
Ph: 720-848-0650

Boulder

Boulder Community Hospital

Keren Sturtz
Ph: 888-785-6789

Rocky Mountain Cancer Centers-Boulder

Keren Sturtz
Ph: 888-785-6789

Colorado Springs

Memorial Hospital Cancer Center - Colorado Springs

Laura K Pomerenke
Ph: 719-365-2406

Penrose Cancer Center at Penrose Hospital

Keren Sturtz
Ph: 888-785-6789

Rocky Mountain Cancer Centers at the Pavilion

Keren Sturtz
Ph: 888-785-6789

Denver

Colorado Blood Cancer Institute

Keren Sturtz
Ph: 888-785-6789

Porter Adventist Hospital

Keren Sturtz
Ph: 888-785-6789

Presbyterian - St. Luke's Medical Center

Keren Sturtz
Ph: 888-785-6789

Rocky Mountain Cancer Centers - Denver Midtown

Keren Sturtz
Ph: 888-785-6789

Rocky Mountain Cancer Centers-Rose

Keren Sturtz
Ph: 888-785-6789

Rose Medical Center

Keren Sturtz
Ph: 888-785-6789

St. Joseph Hospital

Keren Sturtz
Ph: 888-785-6789

Durango

Mercy Medical Center

Keren Sturtz
Ph: 888-785-6789

Englewood

Comprehensive Cancer Care and Research Institute of Colorado LLC

Keren Sturtz
Ph: 888-785-6789

Swedish Medical Center

Keren Sturtz
Ph: 888-785-6789

Fort Collins

Poudre Valley Hospital

Regina J Brown
Ph: 970-297-6150

Golden

Mountain Blue Cancer Care Center

Keren Sturtz
Ph: 888-785-6789

National Jewish Health-Western Hematology Oncology

Keren Sturtz
Ph: 888-785-6789

Greeley

North Colorado Medical Center

Keren Sturtz
Ph: 888-785-6789

Greenwood Village

Breast Cancer Care Consultants

Keren Sturtz
Ph: 888-785-6789

Lakewood

Rocky Mountain Cancer Centers-Lakewood

Keren Sturtz
Ph: 888-785-6789

St. Anthony Central Hospital

Keren Sturtz
Ph: 888-785-6789

Littleton

Littleton Adventist Hospital

Keren Sturtz
Ph: 888-785-6789

Rocky Mountain Cancer Centers - Littleton

Keren Sturtz
Ph: 888-785-6789

Lone Tree

Rocky Mountain Cancer Centers - Lone Tree

Keren Sturtz
Ph: 888-785-6789

Sky Ridge Medical Center

Keren Sturtz
Ph: 888-785-6789

Longmont

Hope Cancer Care Center at Longmont United Hospital

Keren Sturtz
Ph: 888-785-6789

Rocky Mountain Cancer Centers - Longmont

Keren Sturtz
Ph: 888-785-6789

Loveland

McKee Medical Center

Keren Sturtz
Ph: 888-785-6789

Parker

Parker Adventist Hospital

Keren Sturtz
Ph: 888-785-6789

Rocky Mountain Cancer Centers - Parker

Keren Sturtz
Ph: 888-785-6789

Pueblo

Rocky Mountain Cancer Centers - Pueblo

Keren Sturtz
Ph: 888-785-6789

St. Mary - Corwin Regional Medical Center

Keren Sturtz
Ph: 888-785-6789

Thornton

Rocky Mountain Cancer Centers - Thornton

Keren Sturtz
Ph: 888-785-6789

Wheat Ridge

Exempla Lutheran Medical Center

Keren Sturtz
Ph: 888-785-6789

Connecticut
Hartford

Saint Francis/Mount Sinai Regional Cancer Center at Saint Francis Hospital and Medical Center

Philip J. Stella
Ph: 734-712-4673

Middletown

Middlesex Hospital Cancer Center

Susanna Hong
Ph: 860-358-2058

Norwalk

Norwalk Hospital

Richard C. Frank
Ph: 203-852-2996
Email: jennifer.long@norwalkhealth.org

District of Columbia
Washington

Lombardi Comprehensive Cancer Center at Georgetown University Medical Center

Shawna C Willey
Ph: 202-444-0381

Sibley Memorial Hospital

Lisa K. Jacobs
Ph: 410-955-8804
Email: jhcccro@jhmi.edu

Washington Cancer Institute at Washington Hospital Center

Shawna C Willey
Ph: 202-444-0381

Florida
Altamonte Springs

Florida Hospital - Altamonte

Lee M. Zehngebot
Ph: 407-303-5623

Jacksonville

Mayo Clinic - Jacksonville

Judy C Boughey
Ph: 507-538-7623

Kissimmee

Florida Hospital Kissimmee

Lee M. Zehngebot
Ph: 407-303-5623

Miami Beach

CCOP - Mount Sinai Medical Center

Michael Schwartz
Ph: 305-674-2625
Email: info@msccop.com

Orlando

Florida Hospital Cancer Institute at Florida Hospital Orlando

Lee M. Zehngebot
Ph: 407-303-5623

Florida Hospital East Orlando

Lee M. Zehngebot
Ph: 407-303-5623

Florida Urology Associates-Orlando

Lee M. Zehngebot
Ph: 407-303-5623

M.D. Anderson Cancer Center at Orlando

Terry Mamounas
Ph: 321-841-7246
Email: CancerClinicalTrials@orlandohealth.com

Stuart

Robert and Carol Weissman Cancer Center at Martin Memorial

James J. Vopal
Ph: 772-288-5858ext4

James J. Vopal
Ph: 772-288-5858ext4

Winter Park

Florida Hospital Cancer Institute at Winter Park

Lee M. Zehngebot
Ph: 407-303-5623

Georgia
Columbus

John B. Amos Cancer Center

Kenneth L Smith
Ph: 706-660-6404

Gainesville

Northeast Georgia Medical Center

Pierce K. Dixon
Ph: 770-219-8800
Email: cancerpatient.navigator@nghs.com

Savannah

Curtis and Elizabeth Anderson Cancer Institute at Memorial Health University Medical Center

William E. Burak
Ph: 912-350-8568

Low Country Cancer Care Associates, PC

William E. Burak
Ph: 912-350-8568

Summit Cancer Care-Memorial

William E. Burak
Ph: 912-350-8568

Hawaii
Honolulu

Kaiser Permanente - Moanalua Medical Center and Clinic

Louis Fehrenbacher
Ph: 626-564-3455

Idaho
Boise

Saint Alphonsus Cancer Care Center at Saint Alphonsus Regional Medical Center

Philip J. Stella
Ph: 734-712-4673

Illinois
Aurora

Rush-Copley Cancer Care Center

Maria T Grosse-Perdekamp
Ph: 800-446-5532

Bloomington

Illinois CancerCare - Bloomington

James L. Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

St. Joseph Medical Center

James L. Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

Canton

Illinois CancerCare - Canton

James L. Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

Carbondale

Memorial Hospital of Carbondale

James L. Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

Carthage

Illinois CancerCare - Carthage

James L. Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

Centralia

Centralia Oncology Clinic

James L. Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

Chicago

Creticos Cancer Center at Advocate Illinois Masonic Medical Center

Ann M. Mauer
Ph: 773-296-5360

John H. Stroger, Jr. Hospital of Cook County

Thomas E. Lad
Ph: 312-864-6000

Mount Sinai Hospital Medical Center

Pam G. Khosla
Ph: 773-257-5960
Email: suhi@sinai.org

Swedish Covenant Hospital

Elyse A Lambiase
Ph: 847-316-6994

University of Chicago Cancer Research Center

Swati A Kulkarni
Ph: 773-834-7424

Danville

Carle on Vermilion

Maria T Grosse-Perdekamp
Ph: 800-446-5532

Decatur

Cancer Care Center of Decatur

James L. Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

Decatur Memorial Hospital Cancer Care Institute

James L. Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

Effingham

Carle Physician Group-Effingham

Maria T Grosse-Perdekamp
Ph: 800-446-5532

Crossroads Cancer Center

James L. Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

Eureka

Illinois CancerCare - Eureka

James L. Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

Evanston

St. Francis Hospital

Elyse A Lambiase
Ph: 847-316-6994

Galesburg

Galesburg Clinic, PC

James L. Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

InterCommunity Cancer Center of Western Illinois

James L. Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

Harvey

Ingalls Cancer Care Center at Ingalls Memorial Hospital

Mark F. Kozloff
Ph: 708-915-4673
Email: clinicaltrials@ingalls.org

Kewanee

Illinois CancerCare - Kewanee Clinic

James L. Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

Macomb

Illinois CancerCare - Macomb

James L. Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

Mattoon

Carle Physician Group-Mattoon/Charleston

Maria T Grosse-Perdekamp
Ph: 800-446-5532

Mount Vernon

Good Samaritan Regional Health Center

Jay W Carlson
Ph: 800-821-7532

Naperville

Edward Hospital Cancer Center

Vasudha Lingareddy
Ph: 630-646-6075

Ottawa

Illinois CancerCare - Ottawa

James L. Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

Radiation Oncology of Northern Illinois

James L. Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

Pekin

Cancer Treatment Center at Pekin Hospital

James L. Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

Illinois CancerCare - Pekin

James L. Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

Peoria

Illinois CancerCare - Peoria

James L. Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

Methodist Medical Center of Illinois

James L. Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

OSF Saint Francis Medical Center Radiation Oncology Service at the Central Illinois Comprehensive CC

James L. Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

OSF St. Francis Medical Center

James L. Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

Peru

Illinois CancerCare - Princeton

James L. Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

Valley Cancer Center

James L. Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

Princeton

Illinois CancerCare - Princeton

James L. Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

Springfield

Central Illinois Hematology Oncology Center

James L. Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

Regional Cancer Center at Memorial Medical Center

James L. Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

Simmons Cooper Cancer Institute

James L. Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

Springfield Clinic - Main Campus

James L. Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

Swansea

Cancer Care Specialists of Illinois-Swansea

James L. Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

Urbana

Carle Cancer Center at Carle Foundation Hospital

Maria T Grosse-Perdekamp
Ph: 800-446-5532

Maria T Grosse-Perdekamp
Ph: 800-446-5532

Warrenville

Central Dupage Cancer Center

Christy M Kesslering
Ph: 630-352-5300

Yorkville

Rush-Copley Healthcare Center

Maria T Grosse-Perdekamp
Ph: 800-446-5532

Indiana
Avon

Clarian West Medical Center

Linda K Han
Ph: 317-274-2552

Carmel

IU Health North Hospital

Linda K Han
Ph: 317-274-2552

Elkhart

Michiana Hematology-Oncology, PC - Elkhart

Robin Zon
Ph: 574-234-5123

Indianapolis

Indiana University Melvin and Bren Simon Cancer Center

Linda K Han
Ph: 317-274-2552

Methodist Cancer Center at Methodist Hospital

Linda K Han
Ph: 317-274-2552

William N. Wishard Memorial Hospital

Linda K Han
Ph: 317-274-2552

Michigan City

Saint Anthony Memorial Health Centers

Maria T Grosse-Perdekamp
Ph: 800-446-5532

Woodland Cancer Care Center

Maria T Grosse-Perdekamp
Ph: 800-446-5532

Mishawaka

Michiana Hematology-Oncology, PC - Mishawaka

Robin Zon
Ph: 574-234-5123

Saint Joseph's Medical Center

Robin Zon
Ph: 574-234-5123

Plymouth

Michiana Hematology Oncology PC - Plymouth

Robin Zon
Ph: 574-234-5123

South Bend

CCOP - Northern Indiana CR Consortium

Robin Zon
Ph: 574-234-5123

Memorial Hospital of South Bend

Robin Zon
Ph: 574-234-5123

Michiana Hematology-Oncology, PC - South Bend

Robin Zon
Ph: 574-234-5123

Westville

Michiana Hematology Oncology-PC Westville

Robin Zon
Ph: 574-234-5123

Iowa
Clive

Medical Oncology and Hematology Associates-West Des Moines

Mehmet S. Copur
Ph: 800-998-2119

Mercy Cancer Center - West Lakes

Mehmet S. Copur
Ph: 800-998-2119

Des Moines

Medical Oncology and Hematology Associates at Mercy Cancer Center

Mehmet S. Copur
Ph: 800-998-2119

Mercy Cancer Center at Mercy Medical Center - Des Moines

Mehmet S. Copur
Ph: 800-998-2119

Sioux City

Siouxland Hematology-Oncology Associates, LLP

Donald Bruce Wender
Ph: 712-252-0088

West Des Moines

Methodist West Hospital

Mehmet S. Copur
Ph: 800-998-2119

Kansas
Chanute

Cancer Center of Kansas, PA - Chanute

Shaker R. Dakhil
Ph: 316-262-4467

Dodge City

Cancer Center of Kansas, PA - Dodge City

Shaker R. Dakhil
Ph: 316-262-4467

El Dorado

Cancer Center of Kansas, PA - El Dorado

Shaker R. Dakhil
Ph: 316-262-4467

Emporia

Newman Regional Health

Jamie L Wagner
Ph: 913-588-4709

Fort Scott

Cancer Center of Kansas - Fort Scott

Shaker R. Dakhil
Ph: 316-262-4467

Garden City

St. Catherine Hospital Cancer Center

Jamie L Wagner
Ph: 913-588-4709

Great Bend

St. Rose Ambulatory and Surgery Center

Jamie L Wagner
Ph: 913-588-4709

Hays

Hays Medical Center

Jamie L Wagner
Ph: 913-588-4709

Independence

Cancer Center of Kansas-Independence

Shaker R. Dakhil
Ph: 316-262-4467

Kansas City

Kansas Masonic Cancer Research Institute at the University of Kansas Medical Center

Jamie L Wagner
Ph: 913-588-4709

Kingman

Cancer Center of Kansas, PA - Kingman

Shaker R. Dakhil
Ph: 316-262-4467

Lawrence

Lawrence Memorial Hospital

Shaker R. Dakhil
Ph: 316-262-4467

Liberal

Cancer Center of Kansas, PA - Liberal

Shaker R. Dakhil
Ph: 316-262-4467

Newton

Cancer Center of Kansas, PA - Newton

Shaker R. Dakhil
Ph: 316-262-4467

Overland Park

Kansas City Cancer Centers - Southwest

Jamie L Wagner
Ph: 913-588-4709

Menorah Medical Center

Rakesh Gaur
Ph: 913-948-5588
Email: aroland@kccop.org

Saint Luke's Hospital - South

Rakesh Gaur
Ph: 913-948-5588
Email: aroland@kccop.org

Parsons

Cancer Center of Kansas, PA - Parsons

Shaker R. Dakhil
Ph: 316-262-4467

Pittsburg

Mount Carmel Regional Cancer Center

Jamie L Wagner
Ph: 913-588-4709

Pratt

Cancer Center of Kansas, PA - Pratt

Shaker R. Dakhil
Ph: 316-262-4467

Salina

Cancer Center of Kansas, PA - Salina

Shaker R. Dakhil
Ph: 316-262-4467

Tammy Walker Cancer Center at Salina Regional Health Center

Jamie L Wagner
Ph: 913-588-4709

Topeka

Cotton-O'Neil Cancer Center

Muhammad A Salamat
Ph: 785-270-4963

St. Francis Comprehensive Cancer Center

Jamie L Wagner
Ph: 913-588-4709

Wellington

Cancer Center of Kansas, PA - Wellington

Shaker R. Dakhil
Ph: 316-262-4467

Wichita

Associates in Women's Health, PA - North Hillside

Shaker R. Dakhil
Ph: 316-262-4467

Cancer Center of Kansas, PA - Medical Arts Tower

Shaker R. Dakhil
Ph: 316-262-4467

Cancer Center of Kansas, PA - Wichita

Shaker R. Dakhil
Ph: 316-262-4467

Via Christi Cancer Center at Via Christi Regional Medical Center

Shaker R. Dakhil
Ph: 316-262-4467

Wesley Medical Center

Shaker R. Dakhil
Ph: 316-262-4467

Winfield

Cancer Center of Kansas, PA - Winfield

Shaker R. Dakhil
Ph: 316-262-4467

Kentucky
Lexington

Saint Joseph East

Mehmet S. Copur
Ph: 800-998-2119

United Radiation Oncology - Bob-O-Link Drive Office

Mehmet S. Copur
Ph: 800-998-2119

Louisville

Jewish Hospital

Mehmet S. Copur
Ph: 800-998-2119

Jewish Hospital Medical Center Northeast

Mehmet S. Copur
Ph: 800-998-2119

University of Louisville School of Medicine

Nicolas Ajkay
Ph: 866-530-5516

Owensboro

Mitchell Memorial Cancer Center at Owensboro Medical Health System

Alan P Mullins
Ph: 270-688-3691
Email: shawns@omhs.org

Louisiana
New Orleans

Ochsner Cancer Institute at Ochsner Clinic Foundation

Ralph L Corsetti
Ph: 888-562-4763

Maine
Augusta

Harold Alfond Center for Cancer Care

Thomas Henry Openshaw
Ph: 207-973-4274

Bangor

CancerCare of Maine at Eastern Maine Medical Center

Thomas Henry Openshaw
Ph: 207-973-4274

Brewer

Lafayette Family Cancer Center-EMMC

Thomas Henry Openshaw
Ph: 207-973-4274

Rockport

Penobscot Bay Medical Center Cancer Care Center

Thomas Henry Openshaw
Ph: 207-973-4274

Maryland
Baltimore

Harry and Jeanette Weinberg Cancer Institute at Franklin Square Hospital Center

Shawna C Willey
Ph: 202-444-0381

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

Lisa K. Jacobs
Ph: 410-955-8804
Email: jhcccro@jhmi.edu

Union Memorial Hospital

Shawna C Willey
Ph: 202-444-0381

Towson

Cancer Institute at St. Joseph Medical Center

Michael J Schultz
Ph: 410-337-4569
Email: patriciajohnson@catholichealth.net

Massachusetts
Boston

Boston University Cancer Research Center

Maureen T. Kavanah
Ph: 617-638-8265

Dana-Farber/Brigham and Women's Cancer Center

Laura S Dominici
Ph: 866-790-4500

Dana-Farber/Harvard Cancer Center at Dana-Farber Cancer Institute

Laura S Dominici
Ph: 866-790-4500

Fitchburg

Simonds-Sinon Regional Cancer Center at HealthAlliance Hospital - Burbank Campus

James E. Liebmann
Ph: 508-856-3216
Email: cancer.research@umassmed.edu

Springfield

Baystate Medical Center

Seth A Kaufman
Ph: 413-794-9338

Worcester

UMASS Memorial Cancer Center - University Campus

James E. Liebmann
Ph: 508-856-3216
Email: cancer.research@umassmed.edu

Michigan
Ann Arbor

Saint Joseph Mercy Cancer Center

Philip J. Stella
Ph: 734-712-4673

Dearborn

Oakwood Cancer Center at Oakwood Hospital and Medical Center

Philip J. Stella
Ph: 734-712-4673

Detroit

Van Elslander Cancer Center at St. John Hospital and Medical Center

Philip J. Stella
Ph: 734-712-4673

Wayne State University

Lydia W Choi
Ph: 313-576-9363

Farmington

Botsford Oncology Practice at Botsford General Hospital

Eric A Brown
Ph: 248-551-7695

Flint

Genesys Hurley Cancer Institute

Philip J. Stella
Ph: 734-712-4673

Hurley Medical Center

Philip J. Stella
Ph: 734-712-4673

Jackson

Gayle M. Jacob Cancer Center at Allegiance Health

Philip J. Stella
Ph: 734-712-4673

Lansing

Sparrow Regional Cancer Center

Philip J. Stella
Ph: 734-712-4673

Livonia

St. Mary Mercy Hospital

Philip J. Stella
Ph: 734-712-4673

Niles

Lakeland Hospital - Niles

Robin Zon
Ph: 574-234-5123

Pontiac

St. Joseph Mercy Oakland

Philip J. Stella
Ph: 734-712-4673

Port Huron

Mercy Regional Cancer Center at Mercy Hospital

Philip J. Stella
Ph: 734-712-4673

Roseville

Michigan Cancer Specialists

Eric A Brown
Ph: 248-551-7695

Royal Oak

Cancer Care Associates - Royal Oak

Eric A Brown
Ph: 248-551-7695

Comprehensive Medical Center PLLC

Eric A Brown
Ph: 248-551-7695

Hematology-Oncology Consultants - Royal Oak

Eric A Brown
Ph: 248-551-7695

Oakland Colon and Rectal Associates, PC

Eric A Brown
Ph: 248-551-7695

Oakland Medical Group

Eric A Brown
Ph: 248-551-7695

William Beaumont Hospital - Royal Oak Campus

Eric A Brown
Ph: 248-551-7695

Saginaw

Seton Cancer Institute at Saint Mary's - Saginaw

Philip J. Stella
Ph: 734-712-4673

Southfield

Providence Hospital - Southfield

Susan E Lyons
Ph: 248-849-5337
Email: jaswinder.grewal@stjohn.org

St. Joseph

Lakeland Regional Cancer Care Center - St. Joseph

Robin Zon
Ph: 574-234-5123

Sterling Heights

Mitchell Folbe MD PC

Eric A Brown
Ph: 248-551-7695

Premier Hematology Oncology Care

Eric A Brown
Ph: 248-551-7695

Troy

Claudia BR Herke MD PC

Eric A Brown
Ph: 248-551-7695

Hematology Oncology Consultants - Troy

Eric A Brown
Ph: 248-551-7695

Michigan Institute of Urology, PC - Troy

Eric A Brown
Ph: 248-551-7695

William Beaumont Hospital - Troy Campus

Eric A Brown
Ph: 248-551-7695

Warren

St. John Macomb Hospital

Philip J. Stella
Ph: 734-712-4673

Minnesota
Bemidji

MeritCare Bemidji

Preston D. Steen
Ph: 701-234-6161

Burnsville

Fairview Ridges Hospital

Daniel M Anderson
Ph: 952-993-1517
Email: MMCCOP@parknicollet.com

Coon Rapids

Mercy and Unity Cancer Center at Mercy Hospital

Daniel M Anderson
Ph: 952-993-1517
Email: MMCCOP@parknicollet.com

Edina

Fairview Southdale Hospital

Daniel M Anderson
Ph: 952-993-1517
Email: MMCCOP@parknicollet.com

Fridley

Mercy and Unity Cancer Center at Unity Hospital

Daniel M Anderson
Ph: 952-993-1517
Email: MMCCOP@parknicollet.com

Hutchinson

Hutchinson Area Health Care

Daniel M Anderson
Ph: 952-993-1517
Email: MMCCOP@parknicollet.com

Maplewood

HealthEast Cancer Care at St. John's Hospital

Daniel M Anderson
Ph: 952-993-1517
Email: MMCCOP@parknicollet.com

Minnesota Oncology - Maplewood

Daniel M Anderson
Ph: 952-993-1517
Email: MMCCOP@parknicollet.com

Minneapolis

Health Partners Inc

Daniel M Anderson
Ph: 952-993-1517
Email: MMCCOP@parknicollet.com

Hennepin County Medical Center - Minneapolis

Daniel M Anderson
Ph: 952-993-1517
Email: MMCCOP@parknicollet.com

Virginia Piper Cancer Institute at Abbott - Northwestern Hospital

Daniel M Anderson
Ph: 952-993-1517
Email: MMCCOP@parknicollet.com

New Ulm

New Ulm Medical Center

Daniel M Anderson
Ph: 952-993-1517
Email: MMCCOP@parknicollet.com

Robbinsdale

Humphrey Cancer Center at North Memorial Outpatient Center

Daniel M Anderson
Ph: 952-993-1517
Email: MMCCOP@parknicollet.com

Rochester

Mayo Clinic Cancer Center

Judy C Boughey
Ph: 507-538-7623

Saint Cloud

CentraCare Clinic - Women and Children

Donald J Jurgens
Ph: 877-229-4907
Email: coborncancercenter@centracare.com

Coborn Cancer Center

Donald J Jurgens
Ph: 877-229-4907
Email: coborncancercenter@centracare.com

Saint Louis Park

Park Nicollet Cancer Center

Daniel M Anderson
Ph: 952-993-1517
Email: MMCCOP@parknicollet.com

Saint Paul

Regions Hospital Cancer Care Center

Daniel M Anderson
Ph: 952-993-1517
Email: MMCCOP@parknicollet.com

United Hospital

Daniel M Anderson
Ph: 952-993-1517
Email: MMCCOP@parknicollet.com

Shakopee

St. Francis Cancer Center at St. Francis Medical Center

Daniel M Anderson
Ph: 952-993-1517
Email: MMCCOP@parknicollet.com

Stillwater

Lakeview Hospital

Daniel M Anderson
Ph: 952-993-1517
Email: MMCCOP@parknicollet.com

Waconia

Ridgeview Medical Center

Daniel M Anderson
Ph: 952-993-1517
Email: MMCCOP@parknicollet.com

Willmar

Willmar Cancer Center at Rice Memorial Hospital

Daniel M Anderson
Ph: 952-993-1517
Email: MMCCOP@parknicollet.com

Woodbury

Minnesota Oncology - Woodbury

Daniel M Anderson
Ph: 952-993-1517
Email: MMCCOP@parknicollet.com

Missouri
Bolivar

Central Care Cancer Center at Carrie J. Babb Cancer Center

Jay W Carlson
Ph: 800-821-7532

Bonne Terre

Parkland Health Center-Bonne Terre

Alan Philip Lyss
Ph: 800-392-0936

Branson

Skaggs Cancer Center at Skaggs Regional Medical Center

Jay W Carlson
Ph: 800-821-7532

Cape Girardeau

Saint Francis Medical Center

James L. Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

Southeast Cancer Center

Alan Philip Lyss
Ph: 800-392-0936

Independence

Independence Regional Health Center

Rakesh Gaur
Ph: 913-948-5588
Email: aroland@kccop.org

Jefferson City

Goldschmidt Cancer Center

Alan Philip Lyss
Ph: 800-392-0936

Joplin

Freeman Cancer Institute at Freeman Health System

Jay W Carlson
Ph: 800-821-7532

St. John's Regional Medical Center

Jay W Carlson
Ph: 800-821-7532

Kansas City

Heartland Hematology Oncology Associates, Incorporated

Rakesh Gaur
Ph: 913-948-5588
Email: aroland@kccop.org

Kansas City Cancer Centers - North

Jamie L Wagner
Ph: 913-588-4709

Kansas City Cancer Centers - South

Jamie L Wagner
Ph: 913-588-4709

North Kansas City Hospital

Jamie L Wagner
Ph: 913-588-4709

Research Medical Center

Rakesh Gaur
Ph: 913-948-5588
Email: aroland@kccop.org

Saint Luke's Hospital

Rakesh Gaur
Ph: 913-948-5588
Email: aroland@kccop.org

Lee's Summit

Kansas City Cancer Centers - East

Jamie L Wagner
Ph: 913-588-4709

Saint Luke's East - Lee's Summit

Rakesh Gaur
Ph: 913-948-5588
Email: aroland@kccop.org

Liberty

Parvin Radiation Oncology

Rakesh Gaur
Ph: 913-948-5588
Email: aroland@kccop.org

Rolla

Mercy Clinic Cancer and Hematology - Rolla

Jay W Carlson
Ph: 800-821-7532

Phelps County Regional Medical Center

Jay W Carlson
Ph: 800-821-7532

Saint Joseph

Heartland Regional Medical Center

Rakesh Gaur
Ph: 913-948-5588
Email: aroland@kccop.org

Saint Louis

Barnes-Jewish West County Hospital

Amy E Cyr
Ph: 800-600-3606
Email: info@siteman.wustl.edu

David C. Pratt Cancer Center at St. John's Mercy

Jay W Carlson
Ph: 800-821-7532

Mercy Clinic St. Louis Cancer and Breast Institute

Jay W Carlson
Ph: 800-821-7532

Missouri Baptist Cancer Center

Alan Philip Lyss
Ph: 800-392-0936

Siteman Cancer Center at Barnes-Jewish Hospital - Saint Louis

Amy E Cyr
Ph: 800-600-3606
Email: info@siteman.wustl.edu

Saint Peters

Siteman Cancer Center at Barnes-Jewish St. Peters Hospital - St. Peters

Amy E Cyr
Ph: 800-600-3606
Email: info@siteman.wustl.edu

Sainte Genevieve

Sainte Genevieve County Memorial Hospital

Alan Philip Lyss
Ph: 800-392-0936

Springfield

Hulston Cancer Center at Cox Medical Center South

Jay W Carlson
Ph: 800-821-7532

St. John's Regional Health Center

Jay W Carlson
Ph: 800-821-7532

Sullivan

Missouri Baptist Sullivan Hospital

Alan Philip Lyss
Ph: 800-392-0936

Sunset Hills

Missouri Baptist Outpatient Center-Sunset Hills

Alan Philip Lyss
Ph: 800-392-0936

Nebraska
Grand Island

Saint Francis Cancer Treatment Center at Saint Francis Memorial Health Center

Mehmet S. Copur
Ph: 800-998-2119

Kearney

Good Samaritan Cancer Center at Good Samaritan Hospital

Mehmet S. Copur
Ph: 800-998-2119

Omaha

Alegant Health Cancer Center at Bergan Mercy Medical Center

Mehmet S. Copur
Ph: 800-998-2119

Creighton University Medical Center

Mehmet S. Copur
Ph: 800-998-2119

Fred and Pamela Buffett Cancer Center

Elizabeth C. Reed
Ph: 402-559-6941
Email: unmcrsa@unmc.edu

Immanuel Medical Center

Mehmet S. Copur
Ph: 800-998-2119

Lakeside Hospital

Mehmet S. Copur
Ph: 800-998-2119

Papillion

Midlands Cancer Center at Midlands Community Hospital

Mehmet S. Copur
Ph: 800-998-2119

New Jersey
Basking Ridge

Memorial Sloan-Kettering Cancer Center - Basking Ridge

Tari A King
Ph: 212-639-7202

Paterson

St. Joseph's Hospital and Medical Center

Michael Maroules
Ph: 973-754-2909

New Mexico
Albuquerque

University of New Mexico Cancer Center

John C Russell
Ph: 505-272-6972

Las Cruces

Memorial Medical Center

Fa-Chyi Lee
Ph: 505-272-6972

New York
Buffalo

Roswell Park Cancer Institute

Ellis G. Levine
Ph: 877-275-7724

Carmel

Putnam Hospital Center

Gregory J Zanieski
Ph: 845-483-6483

Commack

Memorial Sloan-Kettering Cancer Center

Tari A King
Ph: 212-639-7202

Fishkill

Fishkill Radiation Oncology Center

Gregory J Zanieski
Ph: 845-483-6483

Kingston

Ulster Radiation Oncology Center

Gregory J Zanieski
Ph: 845-483-6483

New York

Beth Israel Medical Center - Petrie Division

Aye M Ma
Ph: 212-523-4000

Herbert Irving Comprehensive Cancer Center at Columbia University Medical Center

Bret Taback
Ph: 212-305-8615

Memorial Sloan-Kettering Cancer Center

Tari A King
Ph: 212-639-7202

St. Luke's - Roosevelt Hospital Center - St.Luke's Division

Aye M Ma
Ph: 212-523-4000

Poughkeepsie

Dyson Center for Cancer Care at Vassar Brothers Medical Center

Gregory J Zanieski
Ph: 845-483-6483

Rockville Centre

Memorial Sloan-Kettering Cancer Center - Rockville Centre

Tari A King
Ph: 212-639-7202

Sleepy Hollow

Memorial Sloan-Kettering Cancer Center at Phelps Memorial Hospital Center

Tari A King
Ph: 212-639-7202

Stony Brook

Stony Brook University Cancer Center

Brian J O'Hea
Ph: 800-862-2215

West Harrison

Memorial Sloan-Kettering Cancer Center West Harrison

Tari A King
Ph: 212-639-7202

North Carolina
Asheboro

Randolph Hospital

James M Granfortuna
Ph: 336-832-0821

Burlington

Alamance Cancer Center at Alamance Regional Medical Center

James M Granfortuna
Ph: 336-832-0821

Charlotte

Blumenthal Cancer Center at Carolinas Medical Center

Richard L. White
Ph: 704-355-2884

Levine Cancer Institute-Ballantyne

Richard L. White
Ph: 704-355-2884

Levine Cancer Institute-Pineville

Richard L. White
Ph: 704-355-2884

Levine Cancer Institute-Tryon

Richard L. White
Ph: 704-355-2884

Levine Cancer Institute-University

Richard L. White
Ph: 704-355-2884

Mecklenburg Medical Group

Richard L. White
Ph: 704-355-2884

Pineville Radiation Therapy Center

Richard L. White
Ph: 704-355-2884

University Radiation Oncology

Richard L. White
Ph: 704-355-2884

Concord

Batte Cancer Center at Northeast Medical Center

Richard L. White
Ph: 704-355-2884

Durham

Duke Cancer Institute

Jeffrey Crawford
Ph: 888-275-3853

Greensboro

Moses Cone Regional Cancer Center at Wesley Long Community Hospital

James M Granfortuna
Ph: 336-832-0821

Greenville

Leo W. Jenkins Cancer Center at ECU Medical School

Eleanor E.R. Harris
Ph: 252-744-2391

Mebane

Cone Heath Cancer Center at Mebane

James M Granfortuna
Ph: 336-832-0821

Monroe

Edwards Cancer Center at Union Regional Medical Center

Richard L. White
Ph: 704-355-2884

Reidsville

Annie Penn Cancer Center

James M Granfortuna
Ph: 336-832-0821

Statesville

Iredell Memorial Hospital

Ruby A. Grimm
Ph: 704-873-5661

Winston-Salem

Wake Forest University Comprehensive Cancer Center

Marissa M Howard-McNatt
Ph: 336-713-6771

North Dakota
Bismarck

Medcenter One Hospital Cancer Care Center

Preston D. Steen
Ph: 701-234-6161

Fargo

Roger Maris Cancer Center at MeritCare Hospital

Preston D. Steen
Ph: 701-234-6161

Preston D. Steen
Ph: 701-234-6161

Sanford Clinic North-Fargo

Preston D. Steen
Ph: 701-234-6161

Ohio
Akron

McDowell Cancer Center at Akron General Medical Center

Esther H. Rehmus
Ph: 330-344-6348

Centerville

Miami Valley Hospital South

Howard M. Gross
Ph: 937-775-1350

Cincinnati

Bethesda North Hospital

Mehmet S. Copur
Ph: 800-998-2119

Christ Hospital Cancer Center

Jennifer B Manders
Ph: 513-585-2859

Good Samaritan Hospital Cancer Treatment Center

Mehmet S. Copur
Ph: 800-998-2119

University of Cincinnati

Elizabeth Shaughnessy
Ph: 513-558-4553
Email: uchealthnews@uc.edu

Cleveland

Case Comprehensive Cancer Center

Robert R Shenk
Ph: 800-641-2422

Columbus

Arthur G. James Cancer Hospital and Richard J. Solove Research Institute at Ohio State University Comprehensive Cancer Center

Doreen M Agnese
Ph: 800-293-5066
Email: Jamesline@osumc.edu

West Chester

University Pointe

Elizabeth Shaughnessy
Ph: 513-558-4553
Email: uchealthnews@uc.edu

Oklahoma
Oklahoma City

Stephenson Cancer Center at the University of Oklahoma

William C Dooley
Ph: 405-271-4272
Email: julie-traylor@ouhsc.edu

Oregon
Clackamas

Clackamas Radiation Oncology Center

Keith S. Lanier
Ph: 503-215-6412

Providence Oncology and Hematology Care Southeast

Keith S. Lanier
Ph: 503-215-6412

Newberg

Providence Newberg Medical Center

Keith S. Lanier
Ph: 503-215-6412

Oregon City

Willamette Falls Hospital

Keith S. Lanier
Ph: 503-215-6412

Portland

Providence Cancer Center at Providence Portland Medical Center

Keith S. Lanier
Ph: 503-215-6412

Providence St. Vincent Medical Center

Keith S. Lanier
Ph: 503-215-6412

Pennsylvania
Beaver

UPMC Cancer Center at Beaver Medical Center

Gretchen M. Ahrendt
Ph: 412-647-2811

Clairton

UPMC Cancer Center at Jefferson Regional Medical Center

Gretchen M. Ahrendt
Ph: 412-647-2811

Danville

Geisinger Cancer Institute at Geisinger Health

Victor Gerald Vogel
Ph: 570-271-5251

Greensburg

UPMC Cancer Center - Arnold Palmer Pavilion

Gretchen M. Ahrendt
Ph: 412-647-2811

Hazleton

Geisinger Hazleton Cancer Center

Victor Gerald Vogel
Ph: 570-271-5251

Hershey

Penn State Hershey Cancer Institute at Milton S. Hershey Medical Center

Anna M Leung
Ph: 717-531-3779
Email: CTO@hmc.psu.edu

Johnstown

UPMC Cancer Center at the John P. Murtha Pavilion

Gretchen M. Ahrendt
Ph: 412-647-2811

Lancaster

Lancaster General Hospital

Daleela G Dodge
Ph: 717-544-0511

McKeesport

UPMC Cancer Center at UPMC McKeesport

Gretchen M. Ahrendt
Ph: 412-647-2811

Meadowbrook

Charles A. & Betty Bott Cancer Center at Holy Redeemer Hospital

Sheena K Jain
Ph: 215-938-3551

Monroeville

Forbes Regional Hospital

Thomas B Julian
Ph: 877-284-2000

Moon Township

UPMC - Moon

Gretchen M. Ahrendt
Ph: 412-647-2811

Natrona Heights

Alle-Kiski Medical Center

Thomas B Julian
Ph: 877-284-2000

Philadelphia

Kimmel Cancer Center at Thomas Jefferson University - Philadelphia

Melissa A Lazar
Ph: 215-955-6084

Pittsburgh

Allegheny Cancer Center at Allegheny General Hospital

Thomas B Julian
Ph: 877-284-2000

St. Clair Memorial Hospital Cancer Center

Gretchen M. Ahrendt
Ph: 412-647-2811

UPMC - Shadyside

Gretchen M. Ahrendt
Ph: 412-647-2811

UPMC Cancer Center at Magee-Womens Hospital

Gretchen M. Ahrendt
Ph: 412-647-2811

UPMC Cancer Center at UPMC Passavant

Gretchen M. Ahrendt
Ph: 412-647-2811

UPMC Cancer Center at UPMC Presbyterian

Gretchen M. Ahrendt
Ph: 412-647-2811

UPMC Cancer Center at UPMC St. Margaret

Gretchen M. Ahrendt
Ph: 412-647-2811

UPMC Cancer Centers

Gretchen M. Ahrendt
Ph: 412-647-2811

Seneca

UPMC Cancer Center at UPMC Northwest

Gretchen M. Ahrendt
Ph: 412-647-2811

Uniontown

UPMC Cancer Center - Uniontown

Gretchen M. Ahrendt
Ph: 412-647-2811

Washington

Washington Hospital Cancer Center

Gretchen M. Ahrendt
Ph: 412-647-2811

Wexford

Allegheny Health Network

Thomas B Julian
Ph: 877-284-2000

Wilkes-Barre

Frank M. and Dorothea Henry Cancer Center at Geisinger Wyoming Valley Medical Center

Victor Gerald Vogel
Ph: 570-271-5251

Rhode Island
Providence

Women and Infants Hospital of Rhode Island

William M. Sikov
Ph: 401-274-1122

South Carolina
Charleston

Hollings Cancer Center at Medical University of South Carolina

Nancy DeMore
Ph: 843-792-9321

Greenville

Bon Secours St. Francis Health System

James Dewitt Bearden
Ph: 800-486-5941

Cancer Centers of the Carolinas - Faris Road

Jeffrey Kent Giguere
Ph: 864-241-6251

Cancer Centers of the Carolinas - Grove Commons

Jeffrey Kent Giguere
Ph: 864-241-6251

CCOP - Greenville

Jeffrey Kent Giguere
Ph: 864-241-6251

Greenville Memorial Hospital

Jeffrey Kent Giguere
Ph: 864-241-6251

Saint Francis Cancer Center

Robert D. Siegel
Ph: 864-255-1713

Greer

Cancer Centers of the Carolinas - Greer Radiation Oncology

Jeffrey Kent Giguere
Ph: 864-241-6251

Rock Hill

Carolina Cancer Specialists

Richard L. White
Ph: 704-355-2884

Rock Hill Radiation Therapy Center

Richard L. White
Ph: 704-355-2884

Seneca

Cancer Centers of the Carolinas - Seneca

Jeffrey Kent Giguere
Ph: 864-241-6251

Spartanburg

Cancer Centers of the Carolinas - Spartanburg

Jeffrey Kent Giguere
Ph: 864-241-6251

South Dakota
Sioux Falls

Sanford Cancer Center at Sanford USD Medical Center

Preston D. Steen
Ph: 701-234-6161

Preston D. Steen
Ph: 701-234-6161

Tennessee
Chattanooga

H. Clay Evans Johnson Cancer Center at Memorial Hospital

Mehmet S. Copur
Ph: 800-998-2119

Jackson

West Tennessee Cancer Center at Jackson-Madison County General Hospital

Dwight C Kaufman
Ph: 731-425-6865

Memphis

Baptist Centers for Cancer Care

Lindi H VanderWalde
Ph: 901-226-3077

Nashville

MBCCOP - Meharry Medical College - Nashville

Philip E Lammers
Ph: 615-327-5724
Email: jmurray@mmc.edu

Texas
Amarillo

Harrington Cancer Center

Daniel Arsenault
Ph: 806-359-4673
Email: ryokubaitis@harringtoncc.org

Dallas

Baylor University Medical Center - Dallas

Jeffrey P Lamont
Ph: 800-422-9567

Parkland Memorial Hospital

Ann Marilyn Leitch
Ph: 214-648-7097

Simmons Comprehensive Cancer Center at University of Texas Southwestern Medical Center - Dallas

Ann Marilyn Leitch
Ph: 214-648-7097

Houston

Univeristy of Texas M.D. Anderson Cancer Center

Elizabeth A Mittendorf
Ph: 713-792-3245

Laredo

Doctor's Hospital of Laredo

Gary W. Unzeitig
Ph: 888-823-5923
Email: ctsucontact@westat.com

Utah
Salt Lake City

Huntsman Cancer Institute at University of Utah

Matthew M Poppe
Ph: 801-581-4477
Email: clinical.trials@hci.utah.edu

Virginia
Alexandria

INOVA Alexandria Hospital

Costanza Cocilovo
Ph: 703-208-6650

Charlottesville

University of Virginia Cancer Center

Shayna L Showalter
Ph: 434-243-6143

Fairfax

INOVA Fair Oaks Hospital

Costanza Cocilovo
Ph: 703-208-6650

Falls Church

Inova Fairfax Hospital

Costanza Cocilovo
Ph: 703-208-6650

Fredericksburg

Hematology Oncology Associates of Fredericksburg Inc

Harry D. Bear
Ph: 804-628-1939

Hampton

Sentara Cancer Institute at Sentara CarePlex Hospital

Eric C Feliberti
Ph: 757-388-2406

Mechanicsville

Memorial Regional Medical Center

William J Irvin
Ph: 804-594-4900

Midlothian

Bon Secours Cancer Institute - Virginia Breast Center

William J Irvin
Ph: 804-594-4900

Norfolk

Sentara Cancer Institute at Sentara Norfolk General Hospital

Eric C Feliberti
Ph: 757-388-2406

Sentara Leigh Hospital

Eric C Feliberti
Ph: 757-388-2406

Richmond

Bon Secours Cancer Institute at St. Mary's Hospital

William J Irvin
Ph: 804-594-4900

Virginia Commonwealth University Massey Cancer Center

Harry D. Bear
Ph: 804-628-1939

Virginia Beach

Coastal Cancer Center at Sentara Virginia Beach General Hospital

Eric C Feliberti
Ph: 757-388-2406

Washington
Auburn

Auburn Regional Center for Cancer Care

John A Keech
Ph: 907-458-5380

Bainbridge Island

Virginia Mason Bainbridge Island Medical Center

John A Keech
Ph: 907-458-5380

Bellevue

Overlake Cancer Center at Overlake Hospital Medical Center

John A Keech
Ph: 907-458-5380

Bremerton

Harrison Medical Center

Mehmet S. Copur
Ph: 800-998-2119

Olympic Hematology and Oncology

Mehmet S. Copur
Ph: 800-998-2119

Burien

Highline Medical Center Cancer Center

Mehmet S. Copur
Ph: 800-998-2119

Federal Way

Virginia Mason Federal Way Medical Center

John A Keech
Ph: 907-458-5380

Gig Harbor

MultiCare Gig Harbor Medical Park

John A Keech
Ph: 907-458-5380

Tacoma/Valley Radiation Oncology Centers-Gig Harbor

John A Keech
Ph: 907-458-5380

Kennewick

Northwest Cancer Clinic

John A Keech
Ph: 907-458-5380

Longview

Lower Columbia Regional Cancer Center at PeaceHealth-St. John Medical Center

Keith S. Lanier
Ph: 503-215-6412

Lynnwood

Virginia Mason Lynnwood Medical Center

John A Keech
Ph: 907-458-5380

Poulsbo

Harrison Poulsbo Hematology and Onocology

Mehmet S. Copur
Ph: 800-998-2119

Peninsula Cancer Center

John A Keech
Ph: 907-458-5380

Puyallup

Good Samaritan Cancer Center

John A Keech
Ph: 907-458-5380

Takoma/Valley Radiation Oncology Center at Good Samaritan

John A Keech
Ph: 907-458-5380

Seattle

Virginia Mason Medical Center

John A Keech
Ph: 907-458-5380

Tacoma

MultiCare Regional Cancer Center at Tacoma General Hospital

John A Keech
Ph: 907-458-5380

Northwest Medical Specialties, PLLC - Tacoma

Mehmet S. Copur
Ph: 800-998-2119

Tacoma/Valley Radiation Oncology Center - St. Joseph

John A Keech
Ph: 907-458-5380

Tacoma/Valley Radiation Oncology Centers-Jackson Hall

John A Keech
Ph: 907-458-5380

Vancouver

Southwest Washington Medical Center Cancer Center

Keith S. Lanier
Ph: 503-215-6412

West Virginia
Morgantown

Mary Babb Randolph Cancer Center at West Virginia University Hospitals

Jessica F Partin
Ph: 304-293-2745
Email: sfilburn@hsc.wvu.edu

Wisconsin
Appleton

Fox Valley Surgical Associates at Appleton Medical Center

Honnie R Bermas
Ph: 800-574-3872

Honnie R Bermas
Ph: 800-574-3872

Burlington

Aurora Cancer Care-Burlington

Judy A Tjoe
Ph: 800-252-2990

Eau Claire

Center for Cancer Treatment & Prevention at Sacred Heart Hospital

Jessica A Wernberg
Ph: 715-389-4457

Elkhorn

Vince Lombardi Cancer Center at Aurora Lakeland Medical Center - Elkhorn

Judy A Tjoe
Ph: 800-252-2990

Grafton

Aurora Cancer Care-Grafton

Judy A Tjoe
Ph: 800-252-2990

Green Bay

St. Mary's Hospital Medical Center - Green Bay

Anthony J. Jaslowski
Ph: 800-432-6049

St. Vincent Hospital Regional Cancer Center

Anthony J. Jaslowski
Ph: 800-432-6049

Vince Lombardi Cancer Clinic - Green Bay at Aurora BayCare Medical Center

Judy A Tjoe
Ph: 800-252-2990

Kenosha

Oncology Alliance - Kenosha South

Judy A Tjoe
Ph: 800-252-2990

La Crosse

Gundersen Lutheran Center for Cancer and Blood

Kurt Oettel
Ph: 608-775-2385
Email: cancerctr@gundluth.org

Marinette

Vince Lombardi Cancer Clinic - Marinette

Judy A Tjoe
Ph: 800-252-2990

Marshfield

Marshfield Clinic - Marshfield Center

Jessica A Wernberg
Ph: 715-389-4457

Saint Joseph's Hospital

Jessica A Wernberg
Ph: 715-389-4457

Menomonee Falls

Aurora Advanced Healthcare Inc-Menomonee Falls

Judy A Tjoe
Ph: 800-252-2990

Milwaukee

Aurora Cancer Care-Milwaukee

Judy A Tjoe
Ph: 800-252-2990

Aurora Sinai Medical Center

Judy A Tjoe
Ph: 800-252-2990

Froedtert Hospital and Medical College of Wisconsin

Amanda L Kong
Ph: 414-805-3666

Vince Lombardi Cancer Clinic at Aurora St. Luke's Medical Center

Judy A Tjoe
Ph: 800-252-2990

Minocqua

Marshfield Clinic - Lakeland Center

Jessica A Wernberg
Ph: 715-389-4457

Neenah

Surgical Associates of Neenah, SC

Honnie R Bermas
Ph: 800-574-3872

New Richmond

Cancer Center of Western Wisconsin

Daniel M Anderson
Ph: 952-993-1517
Email: MMCCOP@parknicollet.com

Oshkosh

Vince Lombardi Cancer Clinic - Oshkosh

Judy A Tjoe
Ph: 800-252-2990

Racine

Aurora Health Center - Racine

Judy A Tjoe
Ph: 800-252-2990

Rice Lake

Marshfield Clinic - Indianhead Center

Jessica A Wernberg
Ph: 715-389-4457

Sheboygan

Vince Lombardi Cancer Clinic - Sheboygan

Judy A Tjoe
Ph: 800-252-2990

Stevens Point

Saint Michael's Hospital Cancer Center

Jessica A Wernberg
Ph: 715-389-4457

Summit

Aurora Medical Center

Judy A Tjoe
Ph: 800-252-2990

Two Rivers

Vince Lombardi Cancer Clinic - Two Rivers

Judy A Tjoe
Ph: 800-252-2990

Waukesha

Aurora Cancer Care-Waukesha

Judy A Tjoe
Ph: 800-252-2990

Wauwatosa

Oncology Alliance, SC - Milwaukee - West

Judy A Tjoe
Ph: 800-252-2990

West Allis

Aurora Women's Pavilion of West Allis Memorial Hospital

Judy A Tjoe
Ph: 800-252-2990

Weston

Diagnostic and Treatment Center

Jessica A Wernberg
Ph: 715-389-4457

Wyoming
Cheyenne

Cheyenne Regional Medical Center

Keren Sturtz
Ph: 888-785-6789

Canada

Ontario
Toronto

Princess Margaret Hospital

Christine A Koch
Ph: 416-946-4501
Email: clinical.trials@uhn.on.ca

Saskatchewan
Regina

Allan Blair Cancer Centre at Pasqua Hospital

Muhammad Salim
Ph: 306-766-2213

Link to the current ClinicalTrials.gov record.
NLM Identifier NCT01901094
ClinicalTrials.gov processed this data on November 12, 2014

Note: Information about this trial is from the ClinicalTrials.gov database. The versions designated for health professionals and patients contain the same text. Minor changes may be made to the ClinicalTrials.gov record to standardize the names of study sponsors, sites, and contacts. Cancer.gov only lists sites that are recruiting patients for active trials, whereas ClinicalTrials.gov lists all sites for all trials. Questions and comments regarding the presented information should be directed to ClinicalTrials.gov.