Exemestane With or Without Entinostat in Treating Postmenopausal Patients With Recurrent Hormone Receptor-Positive Breast Cancer That is Locally Advanced or Metastatic

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Basic Trial Information

PhaseTypeStatusAgeSponsorProtocol IDs
Phase IIIBiomarker/Laboratory analysis, TreatmentActive18 and overNCINCI-2014-00746
ECOG-E2112, E2112, U10CA180820, U10CA021115, NCT02115282

Trial Description

Summary

This randomized phase III trial studies exemestane and entinostat to see how well they work compared to exemestane alone in treating postmenopausal patients with hormone receptor-positive breast cancer that has spread to nearby tissue or lymph nodes or another place in the body. Estrogen can cause the growth of breast cancer cells. Endocrine therapy using exemestane may fight breast cancer by lowering the amount of estrogen the body makes. Entinostat may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. It is not yet known whether exemestane is more effective with or without entinostat in treating breast cancer.

Further Study Information

PRIMARY OBJECTIVES:

I. To evaluate whether the addition of entinostat to endocrine therapy (exemestane) improves progression-free survival (PFS) and/or overall survival (OS) in postmenopausal patients with hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative locally advanced or metastatic breast cancer who have previously progressed on a non-steroidal aromatase inhibitor (Al).

SECONDARY OBJECTIVES:

I. To evaluate the safety and tolerability of entinostat in combination with exemestane, and to compare the safety profile to that of endocrine therapy with placebo.

II. To evaluate the objective response rate of exemestane in combination with entinostat or placebo.

III. To evaluate whether the efficacy of exemestane with entinostat varies with changes in acetylation status in peripheral blood mononuclear cells (PBMCs).

IV. To evaluate the time to treatment deterioration (as defined by decrease in health-related quality of life [HRQL], progression, death) of exemestane + entinostat versus exemestane + placebo arms.

V. To evaluate the differences in overall health-related quality of life (HRQL) between the exemestane + entinostat versus exemestane + placebo arms.

VI. To evaluate the difference with respect to specific symptoms that are associated with entinostat, i.e., fatigue, nausea, anorexia and diarrhea, between the exemestane + entinostat versus exemestane + placebo arms.

VII. To measure adherence to protocol therapy.

TERTIARY OBJECTIVES:

I. To collect archival tumor samples and germline deoxyribonucleic acid (DNA) to explore other potential biomarkers of therapeutic efficacy.

II. To collect patient ratings of adverse events (AEs) using select patient-reported outcomes (PRO)-Common Terminology Criteria for Adverse Events (CTCAE) items to evaluate the psychometric properties of PRO-CTCAE items and explore the incorporation of PRO-CTCAE items into a phase III double-blind placebo-controlled trial.

OUTLINE: Patients are randomized to 1 of 2 treatment arms.

ARM A: Patients receive exemestane orally (PO) once daily (QD) on days 1-28 and entinostat PO on days 1, 8, 15, and 22. Courses repeat every 28 days in the absence of disease progression or unacceptable toxicity.

ARM B: Patients receive exemestane as in Arm A and placebo PO on days 1, 8, 15, and 22. Courses repeat every 28 days in the absence of disease progression or unacceptable toxicity.

In both arms, male patients also receive goserelin acetate subcutaneously (SC) on day 1.

After completion of study treatment, patients are followed up every 3 months for 2 years, every 6 months for 3 years, and then annually for 5 years.

Eligibility Criteria

Inclusion Criteria:

  • Estrogen receptor (ER) and/or progesterone receptor (PR) positive histologically confirmed adenocarcinoma of the breast with staining of >= 1% cells will be considered positive; receptor status may be based on any time during treatment prior to study randomization, and from any site (i.e. primary, recurrent, or metastatic)
  • Patients whose tumors have HER2 immunohistochemistry (IHC) 3+, in situ hybridization (ISH) >= 2.0, or average HER2 copy number >= 6.0 signals per cell are not eligible; receptor status may be based on any time during treatment prior to study randomization, and from any site (i.e. primary, recurrent, or metastatic)
  • Patients must have measurable or non-measurable stage III/locally advanced or metastatic carcinoma of the breast where local therapy with curative intent is not possible; lesions must be evaluated =< 4 weeks prior to study randomization; diagnostic-quality computed tomography (CT) scans with both oral and intravenous (IV) contrast are the expected radiologic method, unless an alternative is approved
  • NOTE: Where baseline imaging has already been performed =< 6 weeks prior to study randomization, repeat imaging may not be required
  • Postmenopausal women and all men are eligible for this trial; postmenopausal is defined as:
  • Age >= 55 years and one year or more of amenorrhea
  • Age < 55 years and one year or more of amenorrhea, with estradiol < 20 pg/ml
  • Age < 55 with prior hysterectomy but intact ovaries, with estradiol < 20 pg/ml
  • Prior bilateral oophorectomy NOTE: Men can enroll provided they agree to receive concomitant luteinizing hormone-releasing hormone (LHRH) agonist; LHRH agonist use is not permitted for female patients
  • Sexually active males must be strongly advised to use an accepted and effective method of contraception or to abstain from sexual intercourse for the duration of their participation in the study and for 3 months after discontinuation of therapy
  • Patients must not have known central nervous system metastasis or a history of central nervous system (CNS) metastases; patients with leptomeningeal disease are not eligible
  • Patients must be disease-free of prior invasive malignancies for > 5 years with the exception of curatively-treated basal cell or squamous cell carcinoma of the skin or carcinoma in situ of the cervix; NOTE: if there is a history of prior malignancy, patients must not be receiving other specific treatment for that cancer
  • Patients must meet at least one of the following criteria:
  • Disease progression any time after non-steroidal aromatase inhibitor (AI) use in the advanced disease setting
  • Relapse while on or within =< 12 months of end of adjuvant non-steroidal AI therapy with no prior endocrine therapy for advanced disease
  • NOTE: Treatment with any prior endocrine therapy must be completed >= 2 weeks prior to randomization, with the exception of exemestane which is allowed in the advanced disease setting for =< 4 weeks immediately prior to study entry (defined as date of randomization); prior exemestane (other than =< 4 weeks as above) or fulvestrant in any setting is not allowed; prior everolimus therapy is allowed and must have been completed 2 weeks prior to randomization
  • Patients may have received one prior chemotherapy regimen for metastatic disease provided treatment was completed >= 3 weeks prior to randomization
  • Patients may be treated with bone modifying agents such as bisphosphonates or receptor activator of nuclear factor kappa-B (RANK)-ligand agents (e.g. denosumab) per American Society of Clinical Oncology (ASCO) guidelines; whenever possible, patients requiring bone modifying agents should start treatment >= 7 days prior to study therapy and should continue the same agent throughout study unless clinically compelled to change
  • Prior radiotherapy must in general have been completed >= 2 weeks prior to randomization and patients must have recovered from the toxicity of the radiation; NOTE: patients may receive concurrent radiation therapy to painful sites of bony disease or areas of impending fracture as long as sites of measurable or non-measurable disease outside the radiation therapy port are available to follow
  • Patients must NOT receive concurrent anti-cancer therapy or investigational agent unless specified in protocol
  • Patients must NOT be receiving valproic acid, an histone deacetylase (HDAC) inhibitor, and may not have previously received any HDAC inhibitor prior to enrollment (e.g. valproic acid, entinostat, vorinostat)
  • Patients must have no known allergies to imidazole drugs (e.g. clotrimazole, ketoconazole, miconazole, econazole, sulconazole, ticonazole, or terconazole), exemestane or entinostat
  • Patients must NOT suffer from medical or psychiatric conditions that would interfere with protocol compliance, the ability to provide informed consent, or assessment of response or anticipated toxicities; this includes uncontrolled intercurrent illness including, but not limited to ongoing or active infection
  • Patients must have recovered from all clinically relevant adverse events to grade 1 or baseline due to previous agents administered (except alopecia)
  • Patients must have adequate hematologic, liver and renal function =< 28 days prior to randomization; NOTE: it is preferred that laboratory values for eligibility be assessed after the last dose of prior treatment, especially in cases where most-recent treatment prior to study entry is chemotherapy
  • Hemoglobin (HgB) >= 9.0 g/dL
  • Platelet count >= 100,000/mcL
  • Absolute neutrophil count >= 1,500/mcL
  • Creatinine =< 2.0 mg/dL
  • Total bilirubin < 1.5 x institutional upper limit of normal (=< 3 mg/dL in case of Gilbert's syndrome)
  • Transaminases (alanine aminotransferase [ALT], aspartate aminotransferase [AST]) =< 2.5 x institutional upper limit normal
  • Known human immunodeficiency virus (HIV)-positive patients should have a cluster of differentiation (CD)4 count > 250/mm^3
  • Patients must have Eastern Cooperative Oncology Group (ECOG) performance status 0-1
  • Patients must have a life expectancy >= 12 weeks
  • Patients must be able to swallow tablets

Trial Contact Information

Trial Lead Organizations/Sponsors

National Cancer Institute

    Roisin Connolly, Principal Investigator

    Trial Sites

    U.S.A.

    Alabama
    Birmingham

    UAB Comprehensive Cancer Center

    Carla I. Falkson
    Ph: 205-934-0309

    California
    Paradise

    Feather River Hospital Cancer Center

    Sam Mazj
    Ph: 530-876-7995
    Email: haleew@ah.org

    Saint Helena

    Saint Helena Hospital

    Gregory B Smith
    Ph: 707-967-3698

    Colorado
    Aurora

    Medical Center of Aurora - South Campus

    Keren Sturtz
    Ph: 888-785-6789

    Rocky Mountain Cancer Centers - Aurora

    Keren Sturtz
    Ph: 888-785-6789

    Boulder

    Boulder Community Hospital

    Keren Sturtz
    Ph: 888-785-6789

    Rocky Mountain Cancer Centers-Boulder

    Keren Sturtz
    Ph: 888-785-6789

    Colorado Springs

    Memorial Hospital Cancer Center - Colorado Springs

    Anthony D. Elias
    Ph: 720-848-0650

    Penrose Cancer Center at Penrose Hospital

    Keren Sturtz
    Ph: 888-785-6789

    Rocky Mountain Cancer Centers at the Pavilion

    Keren Sturtz
    Ph: 888-785-6789

    Denver

    CCOP - Colorado Cancer Research Program

    Keren Sturtz
    Ph: 888-785-6789

    Colorado Blood Cancer Institute

    Keren Sturtz
    Ph: 888-785-6789

    Porter Adventist Hospital

    Keren Sturtz
    Ph: 888-785-6789

    Presbyterian - St. Luke's Medical Center

    Keren Sturtz
    Ph: 888-785-6789

    Rocky Mountain Cancer Centers - Denver Midtown

    Keren Sturtz
    Ph: 888-785-6789

    Rocky Mountain Cancer Centers-Rose

    Keren Sturtz
    Ph: 888-785-6789

    Rose Medical Center

    Keren Sturtz
    Ph: 888-785-6789

    St. Joseph Hospital

    Keren Sturtz
    Ph: 888-785-6789

    Durango

    Mercy Medical Center

    Keren Sturtz
    Ph: 888-785-6789

    Englewood

    Comprehensive Cancer Care and Research Institute of Colorado LLC

    Keren Sturtz
    Ph: 888-785-6789

    Swedish Medical Center

    Keren Sturtz
    Ph: 888-785-6789

    Golden

    Mountain Blue Cancer Care Center

    Keren Sturtz
    Ph: 888-785-6789

    Greeley

    North Colorado Medical Center

    Keren Sturtz
    Ph: 888-785-6789

    Greenwood Village

    Breast Cancer Care Consultants

    Keren Sturtz
    Ph: 888-785-6789

    Lakewood

    Rocky Mountain Cancer Centers-Lakewood

    Keren Sturtz
    Ph: 888-785-6789

    St. Anthony Central Hospital

    Keren Sturtz
    Ph: 888-785-6789

    Littleton

    Littleton Adventist Hospital

    Keren Sturtz
    Ph: 888-785-6789

    Rocky Mountain Cancer Centers - Littleton

    Keren Sturtz
    Ph: 888-785-6789

    Lone Tree

    Rocky Mountain Cancer Centers - Lone Tree

    Keren Sturtz
    Ph: 888-785-6789

    Sky Ridge Medical Center

    Keren Sturtz
    Ph: 888-785-6789

    Longmont

    Hope Cancer Care Center at Longmont United Hospital

    Keren Sturtz
    Ph: 888-785-6789

    Rocky Mountain Cancer Centers - Longmont

    Keren Sturtz
    Ph: 888-785-6789

    Loveland

    McKee Medical Center

    Keren Sturtz
    Ph: 888-785-6789

    Parker

    Parker Adventist Hospital

    Keren Sturtz
    Ph: 888-785-6789

    Rocky Mountain Cancer Centers - Parker

    Keren Sturtz
    Ph: 888-785-6789

    Pueblo

    Rocky Mountain Cancer Centers - Pueblo

    Keren Sturtz
    Ph: 888-785-6789

    St. Mary - Corwin Regional Medical Center

    Keren Sturtz
    Ph: 888-785-6789

    Thornton

    Rocky Mountain Cancer Centers - Thornton

    Keren Sturtz
    Ph: 888-785-6789

    Wheat Ridge

    Exempla Lutheran Medical Center

    Keren Sturtz
    Ph: 888-785-6789

    Connecticut
    Hartford

    Saint Francis/Mount Sinai Regional Cancer Center at Saint Francis Hospital and Medical Center

    Christopher M Reynolds
    Ph: 734-712-4673

    Middletown

    Middlesex Hospital Cancer Center

    Susanna Hong
    Ph: 860-358-2058

    New Britain

    George Bray Cancer Center at the Hospital of Central Connecticut - New Britain Campus

    Brian J Byrne
    Ph: 860-224-5660

    Delaware
    Lewes

    Tunnell Cancer Center at Beebe Medical Center

    Stephen Scott Grubbs
    Ph: 302-733-6227

    Newark

    Helen F. Graham Cancer Center at Christiana Hospital

    Stephen Scott Grubbs
    Ph: 302-733-6227

    Stephen Scott Grubbs
    Ph: 302-733-6227

    Medical Oncology Hematology Consultants, PA at Helen F. Graham Cancer Center

    Stephen Scott Grubbs
    Ph: 302-733-6227

    Regional Hematology/Oncology, PA - Newark

    Stephen Scott Grubbs
    Ph: 302-733-6227

    Rehoboth Beach

    Beebe Health Campus

    Stephen Scott Grubbs
    Ph: 302-733-6227

    Seaford

    Nanticoke Memorial Hospital

    Stephen Scott Grubbs
    Ph: 302-733-6227

    Wilmington

    Christiana Care Health System-Wilmington Hospital

    Stephen Scott Grubbs
    Ph: 302-733-6227

    District of Columbia
    Washington

    Sibley Memorial Hospital

    Roisin M Connolly
    Ph: 410-955-8804
    Email: jhcccro@jhmi.edu

    Washington Cancer Institute at Washington Hospital Center

    Pia M Herbolsheimer
    Ph: 202-877-8839

    Florida
    Deerfield Beach

    University of Miami/Deerfield Beach

    Joyce M Slingerland
    Ph: 866-574-5124
    Email: Sylvester@emergingmed.com

    Jacksonville

    Baptist Cancer Institute - Jacksonville

    Troy Hancil Guthrie
    Ph: 904-202-7051

    Miami

    University of Miami Sylvester Comprehensive Cancer Center - Miami

    Joyce M Slingerland
    Ph: 866-574-5124
    Email: Sylvester@emergingmed.com

    Georgia
    Atlanta

    Georgia Cancer Center for Excellence at Grady Memorial Hospital

    Jane L Meisel
    Ph: 404-778-1868

    Winship Cancer Institute of Emory University

    Jane L Meisel
    Ph: 404-778-1868

    Jane L Meisel
    Ph: 404-778-1868

    Columbus

    John B. Amos Cancer Center

    Andrew W. Pippas
    Ph: 706-660-6404

    Hawaii
    Aiea

    Kapiolani Medical Center at Pali Momi

    Jeffrey L. Berenberg
    Ph: 808-586-2979

    Jeffrey L. Berenberg
    Ph: 808-586-2979

    Honolulu

    Cancer Research Center of Hawaii

    Jeffrey L. Berenberg
    Ph: 808-586-2979

    OnCare Hawaii, Incorporated - Kuakini

    Jeffrey L. Berenberg
    Ph: 808-586-2979

    Jeffrey L. Berenberg
    Ph: 808-586-2979

    OnCare Hawaii, Incorporated - Lusitana

    Jeffrey L. Berenberg
    Ph: 808-586-2979

    Queen's Cancer Institute at Queen's Medical Center

    Jeffrey L. Berenberg
    Ph: 808-586-2979

    Straub Clinic and Hospital, Incorporated

    Jeffrey L. Berenberg
    Ph: 808-586-2979

    Idaho
    Boise

    Saint Alphonsus Cancer Care Center at Saint Alphonsus Regional Medical Center

    Christopher M Reynolds
    Ph: 734-712-4673

    Coeur D'Alene

    Kootenai Medical Center

    Benjamin Thomas Marchello
    Ph: 800-648-6274

    Post Falls

    Kootenai Cancer Center - Post Falls

    Benjamin Thomas Marchello
    Ph: 800-648-6274

    Sandpoint

    Kootenai Cancer

    Benjamin Thomas Marchello
    Ph: 800-648-6274

    Illinois
    Aurora

    Rush-Copley Cancer Care Center

    Kendrith M. Rowland
    Ph: 800-446-5532

    Bloomington

    Illinois CancerCare - Bloomington

    Nguyet A Le-Lindqwister
    Ph: 800-793-2262

    St. Joseph Medical Center

    Nguyet A Le-Lindqwister
    Ph: 800-793-2262

    Canton

    Illinois CancerCare - Canton

    Nguyet A Le-Lindqwister
    Ph: 800-793-2262

    Carbondale

    Memorial Hospital of Carbondale

    James L. Wade
    Ph: 217-876-4740
    Email: kcheek@dmhhs.org

    Carthage

    Illinois CancerCare - Carthage

    Nguyet A Le-Lindqwister
    Ph: 800-793-2262

    Centralia

    Centralia Oncology Clinic

    James L. Wade
    Ph: 217-876-4740
    Email: kcheek@dmhhs.org

    Chicago

    John H. Stroger, Jr. Hospital of Cook County

    Thomas E. Lad
    Ph: 312-864-6000

    Swedish Covenant Hospital

    Elyse A Lambiase
    Ph: 847-316-6994

    Danville

    Carle on Vermilion

    Kendrith M. Rowland
    Ph: 800-446-5532

    Decatur

    Cancer Care Center of Decatur

    James L. Wade
    Ph: 217-876-4740
    Email: kcheek@dmhhs.org

    Decatur Memorial Hospital Cancer Care Institute

    James L. Wade
    Ph: 217-876-4740
    Email: kcheek@dmhhs.org

    Effingham

    Carle Physician Group-Effingham

    Kendrith M. Rowland
    Ph: 800-446-5532

    Crossroads Cancer Center

    James L. Wade
    Ph: 217-876-4740
    Email: kcheek@dmhhs.org

    Elk Grove Village

    Cancer Institute at Alexian Brothers

    Bruce B. Bank
    Ph: 847-952-7164
    Email: fredianc@alexian.net

    Eureka

    Illinois CancerCare - Eureka

    Nguyet A Le-Lindqwister
    Ph: 800-793-2262

    Evanston

    St. Francis Hospital

    Elyse A Lambiase
    Ph: 847-316-6994

    Galesburg

    Galesburg Clinic, PC

    Nguyet A Le-Lindqwister
    Ph: 800-793-2262

    InterCommunity Cancer Center of Western Illinois

    Nguyet A Le-Lindqwister
    Ph: 800-793-2262

    Joliet

    Joliet Oncology-Hematology Associates, Limited - West

    Kulumani M Sivarajan
    Ph: 815-730-3098
    Email: maureenc@jolietoncology.com

    Kankakee

    Provena St. Mary's Regional Cancer Center - Kankakee

    Silviya V Velinova
    Ph: 815-937-8780

    Kewanee

    Illinois CancerCare - Kewanee Clinic

    Nguyet A Le-Lindqwister
    Ph: 800-793-2262

    Macomb

    Illinois CancerCare - Macomb

    Nguyet A Le-Lindqwister
    Ph: 800-793-2262

    Mattoon

    Carle Physician Group-Mattoon/Charleston

    Kendrith M. Rowland
    Ph: 800-446-5532

    Mount Vernon

    Good Samaritan Regional Health Center

    Jay W Carlson
    Ph: 800-821-7532

    Ottawa

    Illinois CancerCare - Ottawa

    Nguyet A Le-Lindqwister
    Ph: 800-793-2262

    Radiation Oncology of Northern Illinois

    Nguyet A Le-Lindqwister
    Ph: 800-793-2262

    Pekin

    Cancer Treatment Center at Pekin Hospital

    Nguyet A Le-Lindqwister
    Ph: 800-793-2262

    Illinois CancerCare - Pekin

    Nguyet A Le-Lindqwister
    Ph: 800-793-2262

    Peoria

    Illinois CancerCare - Peoria

    Nguyet A Le-Lindqwister
    Ph: 800-793-2262

    Methodist Medical Center of Illinois

    Nguyet A Le-Lindqwister
    Ph: 800-793-2262

    OSF Saint Francis Medical Center Radiation Oncology Service at the Central Illinois Comprehensive CC

    Nguyet A Le-Lindqwister
    Ph: 800-793-2262

    OSF St. Francis Medical Center

    Nguyet A Le-Lindqwister
    Ph: 800-793-2262

    Peru

    Illinois CancerCare - Princeton

    Nguyet A Le-Lindqwister
    Ph: 800-793-2262

    Valley Cancer Center

    Nguyet A Le-Lindqwister
    Ph: 800-793-2262

    Princeton

    Illinois CancerCare - Princeton

    Nguyet A Le-Lindqwister
    Ph: 800-793-2262

    Rockford

    Advanced Care and Treatment Medical Group, PC

    Harvey Eric Einhorn
    Ph: 779-696-9400
    Email: cancercare@swedishamerican.org

    Springfield

    Central Illinois Hematology Oncology Center

    James L. Wade
    Ph: 217-876-4740
    Email: kcheek@dmhhs.org

    Regional Cancer Center at Memorial Medical Center

    James L. Wade
    Ph: 217-876-4740
    Email: kcheek@dmhhs.org

    Urbana

    Carle Cancer Center at Carle Foundation Hospital

    Kendrith M. Rowland
    Ph: 800-446-5532

    Kendrith M. Rowland
    Ph: 800-446-5532

    Warrenville

    Central Dupage Cancer Center

    Dragana Tomic
    Ph: 630-352-5300

    Yorkville

    Rush-Copley Healthcare Center

    Kendrith M. Rowland
    Ph: 800-446-5532

    Indiana
    Carmel

    IU Health North Hospital

    Kathy Miller
    Ph: 317-274-2552

    Fishers

    Central Indiana Cancer Centers - North

    Keith W Logie
    Ph: 317-356-2422

    Fort Wayne

    Fort Wayne Medical Oncology and Hematology

    Sreenivasa Rao Nattam
    Ph: 260-484-8830
    Email: ledgar@fwmoh.com

    Indianapolis

    Central Indiana Cancer Centers - East

    Keith W Logie
    Ph: 317-356-2422

    Indiana University Melvin and Bren Simon Cancer Center

    Kathy Miller
    Ph: 317-274-2552

    Methodist Cancer Center at Methodist Hospital

    Kathy Miller
    Ph: 317-274-2552

    Spring Mill Medical Center

    Kathy Miller
    Ph: 317-274-2552

    William N. Wishard Memorial Hospital

    Kathy Miller
    Ph: 317-274-2552

    Lafayette

    Clarian Arnett Cancer Care

    Bamidele A Adesunloye
    Ph: 317-356-2422
    Email: thimes@iuhealth.org

    Michigan City

    Woodland Cancer Care Center

    Kendrith M. Rowland
    Ph: 800-446-5532

    Muncie

    Cancer Center at Ball Memorial Hospital

    Michael J Williamson
    Ph: 765-751-5850

    Richmond

    Reid Hospital & Health Care Services

    Howard M. Gross
    Ph: 937-775-1350

    Iowa
    Ames

    McFarland Clinic, PC

    Joseph James Merchant
    Ph: 515-239-2621

    William R. Bliss Cancer Center at Mary Greeley Medical Center

    Joseph James Merchant
    Ph: 515-239-2621

    Bettendorf

    Hematology Oncology Associates of the Quad Cities

    Shobha R. Chitneni
    Ph: 563-355-7733
    Email: kedaprile@rccqc.com

    Boone

    McFarland Clinic PC-Boone

    Joseph James Merchant
    Ph: 515-239-2621

    Cedar Rapids

    Cedar Rapids Oncology Associates

    Deborah W Wilbur
    Ph: 319-363-2690

    Mercy Regional Cancer Center at Mercy Medical Center

    Deborah W Wilbur
    Ph: 319-363-2690

    Clive

    Medical Oncology and Hematology Associates-West Des Moines

    Mehmet S. Copur
    Ph: 800-998-2119

    Mercy Cancer Center - West Lakes

    Mehmet S. Copur
    Ph: 800-998-2119

    Davenport

    Genesis Regional Cancer Center at Genesis Medical Center

    George Kovach
    Ph: 800-446-6088
    Email: werners@genesishealth.com

    Des Moines

    John Stoddard Cancer Center at Iowa Methodist Medical Center

    Robert J Behrens
    Ph: 515-282-2921

    Medical Oncology and Hematology Associates at John Stoddard Cancer Center

    Robert J Behrens
    Ph: 515-282-2921

    Medical Oncology and Hematology Associates at Mercy Cancer Center

    Mehmet S. Copur
    Ph: 800-998-2119

    Mercy Cancer Center at Mercy Medical Center - Des Moines

    Mehmet S. Copur
    Ph: 800-998-2119

    Fort Dodge

    Trinity Regional Medical Center

    Joseph James Merchant
    Ph: 515-239-2621

    Jefferson

    McFarland Clinic PC-Jefferson

    Joseph James Merchant
    Ph: 515-239-2621

    Marshalltown

    McFarland Clinic PC-Marshalltown

    Joseph James Merchant
    Ph: 515-239-2621

    Mason City

    Mercy Cancer Center at Mercy Medical Center - North Iowa

    Arvind Y Vemula
    Ph: 800-433-3883

    Sioux City

    Siouxland Hematology-Oncology Associates, LLP

    Donald Bruce Wender
    Ph: 712-252-0088

    West Des Moines

    Methodist West Hospital

    Mehmet S. Copur
    Ph: 800-998-2119

    Kansas
    Chanute

    Cancer Center of Kansas, PA - Chanute

    Shaker R. Dakhil
    Ph: 316-262-4467

    Dodge City

    Cancer Center of Kansas, PA - Dodge City

    Shaker R. Dakhil
    Ph: 316-262-4467

    El Dorado

    Cancer Center of Kansas, PA - El Dorado

    Shaker R. Dakhil
    Ph: 316-262-4467

    Fort Scott

    Cancer Center of Kansas - Fort Scott

    Shaker R. Dakhil
    Ph: 316-262-4467

    Independence

    Cancer Center of Kansas-Independence

    Shaker R. Dakhil
    Ph: 316-262-4467

    Kingman

    Cancer Center of Kansas, PA - Kingman

    Shaker R. Dakhil
    Ph: 316-262-4467

    Lawrence

    Lawrence Memorial Hospital

    Shaker R. Dakhil
    Ph: 316-262-4467

    Liberal

    Cancer Center of Kansas, PA - Liberal

    Shaker R. Dakhil
    Ph: 316-262-4467

    Newton

    Cancer Center of Kansas, PA - Newton

    Shaker R. Dakhil
    Ph: 316-262-4467

    Parsons

    Cancer Center of Kansas, PA - Parsons

    Shaker R. Dakhil
    Ph: 316-262-4467

    Pratt

    Cancer Center of Kansas, PA - Pratt

    Shaker R. Dakhil
    Ph: 316-262-4467

    Salina

    Cancer Center of Kansas, PA - Salina

    Shaker R. Dakhil
    Ph: 316-262-4467

    Wellington

    Cancer Center of Kansas, PA - Wellington

    Shaker R. Dakhil
    Ph: 316-262-4467

    Wichita

    Associates in Women's Health, PA - North Hillside

    Shaker R. Dakhil
    Ph: 316-262-4467

    Cancer Center of Kansas, PA - Medical Arts Tower

    Shaker R. Dakhil
    Ph: 316-262-4467

    Cancer Center of Kansas, PA - Wichita

    Shaker R. Dakhil
    Ph: 316-262-4467

    Via Christi Cancer Center at Via Christi Regional Medical Center

    Shaker R. Dakhil
    Ph: 316-262-4467

    Winfield

    Cancer Center of Kansas, PA - Winfield

    Shaker R. Dakhil
    Ph: 316-262-4467

    Kentucky
    Corbin

    Baptist Regional Medical Center

    Firas B Badin
    Ph: 859-260-6425

    Crestview Hills

    Oncology Hematology Care, Incorporated - Crestview Hills

    Howard M. Gross
    Ph: 937-775-1350

    Elizabethtown

    Hardin Memorial Hospital

    Firas B Badin
    Ph: 859-260-6425

    Lexington

    Central Baptist Hospital

    Firas B Badin
    Ph: 859-260-6425

    Saint Joseph East

    Mehmet S. Copur
    Ph: 800-998-2119

    United Radiation Oncology - Bob-O-Link Drive Office

    Mehmet S. Copur
    Ph: 800-998-2119

    Louisville

    Jewish Hospital

    Mehmet S. Copur
    Ph: 800-998-2119

    Jewish Hospital Medical Center Northeast

    Mehmet S. Copur
    Ph: 800-998-2119

    Madisonville

    Merle M. Mahr Cancer Center at Regional Medical Center of Hopkins County

    Firas B Badin
    Ph: 859-260-6425

    Paducah

    Western Baptist Hospital

    Firas B Badin
    Ph: 859-260-6425

    Louisiana
    Baton Rouge

    Earl K. Long Medical Center

    Augusto C Ochoa
    Ph: 504-568-2428
    Email: emede1@lsuhsc.edu

    Hematology-Oncology Clinic

    Hana F Safah
    Ph: 504-988-6121

    Mary Bird Perkins Cancer Center - Baton Rouge

    Augusto C Ochoa
    Ph: 504-568-2428
    Email: emede1@lsuhsc.edu

    Medical Oncology, LLC

    Augusto C Ochoa
    Ph: 504-568-2428
    Email: emede1@lsuhsc.edu

    Houma

    Terrebonne General Medical Center

    Augusto C Ochoa
    Ph: 504-568-2428
    Email: emede1@lsuhsc.edu

    New Orleans

    Medical Center of Louisiana - New Orleans

    Augusto C Ochoa
    Ph: 504-568-2428
    Email: emede1@lsuhsc.edu

    Stanley S. Scott Cancer Center at Louisiana State University Medical Center - New Orleans

    Augusto C Ochoa
    Ph: 504-568-2428
    Email: emede1@lsuhsc.edu

    Maine
    Augusta

    Harold Alfond Center for Cancer Care

    Thomas Henry Openshaw
    Ph: 207-973-4274

    Bangor

    CancerCare of Maine at Eastern Maine Medical Center

    Thomas Henry Openshaw
    Ph: 207-973-4274

    Brewer

    Lafayette Family Cancer Center-EMMC

    Thomas Henry Openshaw
    Ph: 207-973-4274

    Rockport

    Penobscot Bay Medical Center Cancer Care Center

    Thomas Henry Openshaw
    Ph: 207-973-4274

    York

    York Hospital's Oncology Treatment Center

    Marilyn A McLaughlin
    Ph: 207-351-3777

    Maryland
    Annapolis

    DeCesaris Cancer Institute at Anne Arundel Medical Center

    Jeanine L. Werner
    Ph: 443-481-1320
    Email: kbodenhorn@aahs.org

    Baltimore

    Greenebaum Cancer Center at University of Maryland Medical Center

    Katherine Tkaczuk
    Ph: 800-888-8823

    Harry and Jeanette Weinberg Cancer Institute at Franklin Square Hospital Center

    Pia M Herbolsheimer
    Ph: 202-877-8839

    Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

    Roisin M Connolly
    Ph: 410-955-8804
    Email: jhcccro@jhmi.edu

    Bel Air

    Upper Chesapeake Medical Center

    Katherine Tkaczuk
    Ph: 800-888-8823

    Easton

    Shore Regional Cancer Center at Memorial Hospital - Easton

    Mary S. DeShields
    Ph: 410-820-6800ext108
    Email: srichter@shorehealth.org

    Olney

    Montgomery General Hospital

    Pia M Herbolsheimer
    Ph: 202-877-8839

    Massachusetts
    Fall River

    Hudner Oncology Center at Saint Anne's Hospital - Fall River

    Peter R Ward
    Ph: 508-674-5600ext2515

    Pittsfield

    Berkshire Hematology Oncology, PC

    Harvey Zimbler
    Ph: 413-496-8205
    Email: ggero@bhs1.org

    Michigan
    Adrian

    Hickman Cancer Center at Bixby Medical Center

    Rex B Mowat
    Ph: 800-444-3561

    Ann Arbor

    Saint Joseph Mercy Cancer Center

    Christopher M Reynolds
    Ph: 734-712-4673

    Dearborn

    Oakwood Cancer Center at Oakwood Hospital and Medical Center

    Christopher M Reynolds
    Ph: 734-712-4673

    Detroit

    Josephine Ford Cancer Center at Henry Ford Hospital

    Robert Anthony Chapman
    Ph: 313-916-1784

    Van Elslander Cancer Center at St. John Hospital and Medical Center

    Christopher M Reynolds
    Ph: 734-712-4673

    Wayne State University

    Michael S. Simon
    Ph: 313-576-9363

    Escanaba

    Green Bay Oncology, Limited - Escanaba

    Brian L Burnette
    Ph: 800-432-6049

    Farmington Hills

    Weisberg Cancer Treatment Center

    Michael S. Simon
    Ph: 313-576-9363

    Flint

    Genesys Hurley Cancer Institute

    Christopher M Reynolds
    Ph: 734-712-4673

    Hurley Medical Center

    Christopher M Reynolds
    Ph: 734-712-4673

    Iron Mountain

    Green Bay Oncology - Iron Mountain

    Brian L Burnette
    Ph: 800-432-6049

    Jackson

    Gayle M. Jacob Cancer Center at Allegiance Health

    Christopher M Reynolds
    Ph: 734-712-4673

    Livonia

    St. Mary Mercy Hospital

    Christopher M Reynolds
    Ph: 734-712-4673

    Pontiac

    St. Joseph Mercy Oakland

    Christopher M Reynolds
    Ph: 734-712-4673

    Port Huron

    Mercy Regional Cancer Center at Mercy Hospital

    Christopher M Reynolds
    Ph: 734-712-4673

    Royal Oak

    William Beaumont Hospital - Royal Oak Campus

    Naveed Aslam
    Ph: 248-551-7695

    Saginaw

    Seton Cancer Institute at Saint Mary's - Saginaw

    Christopher M Reynolds
    Ph: 734-712-4673

    Troy

    William Beaumont Hospital - Troy Campus

    Naveed Aslam
    Ph: 248-551-7695

    Warren

    St. John Macomb Hospital

    Christopher M Reynolds
    Ph: 734-712-4673

    Minnesota
    Bemidji

    MeritCare Bemidji

    Preston D. Steen
    Ph: 701-234-6161

    Brainerd

    St. Joseph's Medical Center

    Bret E Friday
    Ph: 888-203-7267

    Duluth

    CCOP - Duluth

    Bret E Friday
    Ph: 888-203-7267

    Fergus Falls

    Lake Region Healthcare Corporation-Cancer Care

    Bret E Friday
    Ph: 888-203-7267

    Mississippi
    Hattiesburg

    Forrest General Cancer Center at Forrest General Hospital

    Augusto C Ochoa
    Ph: 504-568-2428
    Email: emede1@lsuhsc.edu

    Hattiesburg Clinic, PA at Forrest General

    Augusto C Ochoa
    Ph: 504-568-2428
    Email: emede1@lsuhsc.edu

    Jackson

    University of Mississippi Cancer Clinic

    Barbara S Craft
    Ph: 601-815-6700

    Missouri
    Bonne Terre

    Parkland Health Center-Bonne Terre

    Alan Philip Lyss
    Ph: 800-392-0936

    Branson

    Skaggs Cancer Center at Skaggs Regional Medical Center

    Jay W Carlson
    Ph: 800-821-7532

    Cape Girardeau

    Saint Francis Medical Center

    James L. Wade
    Ph: 217-876-4740
    Email: kcheek@dmhhs.org

    Southeast Cancer Center

    Alan Philip Lyss
    Ph: 800-392-0936

    Chesterfield

    Saint Luke's Hospital

    Donald F. Busiek
    Ph: 314-205-6936

    Jefferson City

    Goldschmidt Cancer Center

    Alan Philip Lyss
    Ph: 800-392-0936

    Saint Louis

    David C. Pratt Cancer Center at St. John's Mercy

    Jay W Carlson
    Ph: 800-821-7532

    Mercy Clinic St. Louis Cancer and Breast Institute

    Jay W Carlson
    Ph: 800-821-7532

    Missouri Baptist Cancer Center

    Alan Philip Lyss
    Ph: 800-392-0936

    Sainte Genevieve

    Sainte Genevieve County Memorial Hospital

    Alan Philip Lyss
    Ph: 800-392-0936

    Springfield

    Hulston Cancer Center at Cox Medical Center South

    Jay W Carlson
    Ph: 800-821-7532

    St. John's Regional Health Center

    Jay W Carlson
    Ph: 800-821-7532

    Sullivan

    Missouri Baptist Sullivan Hospital

    Alan Philip Lyss
    Ph: 800-392-0936

    Sunset Hills

    Missouri Baptist Outpatient Center-Sunset Hills

    Alan Philip Lyss
    Ph: 800-392-0936

    Montana
    Billings

    St. Vincent Healthcare Cancer Care Services

    Benjamin Thomas Marchello
    Ph: 800-648-6274

    Bozeman

    Bozeman Deaconess Cancer Center

    Benjamin Thomas Marchello
    Ph: 800-648-6274

    Butte

    St. James Healthcare Cancer Care

    Benjamin Thomas Marchello
    Ph: 800-648-6274

    Great Falls

    Benefis Sletten Cancer Institute

    Benjamin Thomas Marchello
    Ph: 800-648-6274

    Helena

    St. Peter's Hospital

    Benjamin Thomas Marchello
    Ph: 800-648-6274

    Kalispell

    Kalispell Regional Medical Center

    Benjamin Thomas Marchello
    Ph: 800-648-6274

    Missoula

    Montana Cancer Center at St. Patrick Hospital and Health Sciences Center

    Benjamin Thomas Marchello
    Ph: 800-648-6274

    Nebraska
    Grand Island

    Saint Francis Cancer Treatment Center at Saint Francis Memorial Health Center

    Mehmet S. Copur
    Ph: 800-998-2119

    Kearney

    Good Samaritan Cancer Center at Good Samaritan Hospital

    Mehmet S. Copur
    Ph: 800-998-2119

    Omaha

    Alegant Health Cancer Center at Bergan Mercy Medical Center

    Mehmet S. Copur
    Ph: 800-998-2119

    Creighton University Medical Center

    Mehmet S. Copur
    Ph: 800-998-2119

    Lakeside Hospital

    Mehmet S. Copur
    Ph: 800-998-2119

    New Hampshire
    Dover

    Seacoast Cancer Center at Wentworth - Douglass Hospital

    Barbara Shea
    Ph: 603-740-2150

    New Jersey
    Hackensack

    CCOP - Northern New Jersey

    Donna T McNamara
    Ph: 201-996-2879

    Hackensack University Medical Center Cancer Center

    Donna T McNamara
    Ph: 201-996-2879

    Long Branch

    Monmouth Medical Center

    Seth D Cohen
    Ph: 732-923-7689

    Somerville

    Somerset Medical Center

    Kathleen C Toomey
    Ph: 908-685-2481

    Vineland

    Frank and Edith Scarpa Regional Cancer Pavillion at South Jersey Healthcare

    Carl J. Minniti
    Ph: 856-641-7933

    New Mexico
    Albuquerque

    New Mexico Cancer Center

    Ursa A Brown-Glaberman
    Ph: 505-272-6972

    University of New Mexico Cancer Center

    Ursa A Brown-Glaberman
    Ph: 505-272-6972

    Las Cruces

    Memorial Medical Center

    Ursa A Brown-Glaberman
    Ph: 505-272-6972

    Santa Fe

    New Mexico Cancer Care Associates

    Ursa A Brown-Glaberman
    Ph: 505-272-6972

    New York
    Auburn

    Hematology Oncology Associates of Central New York-Auburn

    Jeffrey J. Kirshner
    Ph: 315-472-7504

    Bronx

    Albert Einstein Cancer Center at Albert Einstein College of Medicine

    Christine M. Pellegrino
    Ph: 718-904-2730
    Email: aecc@aecom.yu.edu

    Jack D. Weiler Hospital at Montefiore Medical Center - East Campus

    Christine M. Pellegrino
    Ph: 718-904-2730
    Email: aecc@aecom.yu.edu

    Montefiore Medical Center

    Christine M. Pellegrino
    Ph: 718-904-2730
    Email: aecc@aecom.yu.edu

    Brooklyn

    Kings County Hospital Center

    Evelyn O Taiwo
    Ph: 718-270-8216
    Email: sima.terebelo@downstate.edu

    SUNY Downstate Medical Center

    Evelyn O Taiwo
    Ph: 718-270-8216
    Email: sima.terebelo@downstate.edu

    Buffalo

    Roswell Park Cancer Institute

    Ellis G. Levine
    Ph: 877-275-7724

    East Syracuse

    CCOP - Hematology-Oncology Associates of Central New York

    Jeffrey J. Kirshner
    Ph: 315-472-7504

    Elmira

    Falck Cancer Center at Arnot Ogden Medical Center

    William T Muuse
    Ph: 607-271-7000

    Syracuse

    Hematology Oncology Associates of Central New York-Onondaga Hill

    Jeffrey J. Kirshner
    Ph: 315-472-7504

    White Plains

    Dickstein Cancer Treatment Center at White Plains Hospital Center

    Karen B Green
    Ph: 914-681-2290

    North Carolina
    Asheboro

    Randolph Hospital

    James M Granfortuna
    Ph: 336-832-0821

    Asheville

    Cancer Care of Western North Carolina

    Cameron B Harkness
    Ph: 828-670-8403

    Hope A Women's Cancer Center

    Cameron B Harkness
    Ph: 828-670-8403

    Mission Hospitals - Memorial Campus

    Cameron B Harkness
    Ph: 828-670-8403

    Burlington

    Alamance Cancer Center at Alamance Regional Medical Center

    James M Granfortuna
    Ph: 336-832-0821

    Greensboro

    Moses Cone Regional Cancer Center at Wesley Long Community Hospital

    James M Granfortuna
    Ph: 336-832-0821

    Hendersonville

    Comprehensive Cancer Center at Pardee Hospital

    James E. Radford
    Ph: 828-696-4716

    Hendersonville Hematology and Oncology

    James E. Radford
    Ph: 828-696-4716

    Kinston

    Kinston Medical Specialists

    Peter R. Watson
    Ph: 252-559-2200

    Mebane

    Cone Heath Cancer Center at Mebane

    James M Granfortuna
    Ph: 336-832-0821

    Reidsville

    Annie Penn Cancer Center

    James M Granfortuna
    Ph: 336-832-0821

    Washington

    Marion L. Shepard Cancer Center at Beaufort County Hospital

    John J Inzerillo
    Ph: 252-975-4308

    North Dakota
    Bismarck

    Medcenter One Hospital Cancer Care Center

    Preston D. Steen
    Ph: 701-234-6161

    Fargo

    Roger Maris Cancer Center at MeritCare Hospital

    Preston D. Steen
    Ph: 701-234-6161

    Preston D. Steen
    Ph: 701-234-6161

    Sanford Clinic North-Fargo

    Preston D. Steen
    Ph: 701-234-6161

    Minot

    Trinity CancerCare Center

    Stephen N Makoni
    Ph: 800-862-0005

    Ohio
    Akron

    McDowell Cancer Center at Akron General Medical Center

    Esther H. Rehmus
    Ph: 330-344-6348

    Summa Center for Cancer Care at Akron City Hospital

    Jennifer E Payne
    Ph: 330-375-6101

    Belpre

    Strecker Cancer Center-Belpre

    J. Philip Kuebler
    Ph: 614-566-3275

    Chillicothe

    Adena Regional Medical Center

    J. Philip Kuebler
    Ph: 614-566-3275

    Cincinnati

    Oncology Hematology Care Inc - Western Hills

    Howard M. Gross
    Ph: 937-775-1350

    Oncology Hematology Care, Incorporated - Anderson

    Howard M. Gross
    Ph: 937-775-1350

    Oncology Hematology Care, Incorporated - Blue Ash

    Howard M. Gross
    Ph: 937-775-1350

    Oncology Hematology Care, Incorporated - Kenwood

    Howard M. Gross
    Ph: 937-775-1350

    Oncology Hematology Care, Incorporated - Mt. Auburn/Taft Road

    Howard M. Gross
    Ph: 937-775-1350

    Columbus

    Columbus Oncology Associates, Incorporated

    J. Philip Kuebler
    Ph: 614-566-3275

    Doctors Hospital at Ohio Health

    J. Philip Kuebler
    Ph: 614-566-3275

    Grant Medical Center Cancer Care

    J. Philip Kuebler
    Ph: 614-566-3275

    Mount Carmel Health - West Hospital

    J. Philip Kuebler
    Ph: 614-566-3275

    Riverside Methodist Hospital Cancer Care

    J. Philip Kuebler
    Ph: 614-566-3275

    Zangmeister Center

    J. Philip Kuebler
    Ph: 614-566-3275

    Delaware

    Delaware Health Center

    J. Philip Kuebler
    Ph: 614-566-3275

    Delaware Radiation Oncology

    J. Philip Kuebler
    Ph: 614-566-3275

    Grady Memorial Hospital

    J. Philip Kuebler
    Ph: 614-566-3275

    Fairfield

    Oncology Hematology Care, Incorporated - Fairfield Healthplex

    Howard M. Gross
    Ph: 937-775-1350

    Lancaster

    Fairfield Medical Center

    J. Philip Kuebler
    Ph: 614-566-3275

    Lima

    St. Rita's Medical Center

    Henry Gerad
    Ph: 419-226-9617

    Marietta

    Strecker Cancer Center at Marietta Memorial Hospital

    J. Philip Kuebler
    Ph: 614-566-3275

    Maumee

    Northwest Ohio Oncology Center

    Rex B Mowat
    Ph: 800-444-3561

    Mount Vernon

    Knox Community Hospital

    J. Philip Kuebler
    Ph: 614-566-3275

    Newark

    Licking Memorial Cancer Care Program at Licking Memorial Hospital

    J. Philip Kuebler
    Ph: 614-566-3275

    Newark Radiation Oncology

    J. Philip Kuebler
    Ph: 614-566-3275

    Oregon

    St. Charles Mercy Hospital

    Rex B Mowat
    Ph: 800-444-3561

    Portsmouth

    Southern Ohio Medical Center Cancer Center

    J. Philip Kuebler
    Ph: 614-566-3275

    Springfield

    Community Hospital of Springfield and Clark County

    J. Philip Kuebler
    Ph: 614-566-3275

    Sylvania

    Flower Hospital Cancer Center

    Rex B Mowat
    Ph: 800-444-3561

    Toledo

    CCOP - Toledo Community Hospital

    Rex B Mowat
    Ph: 800-444-3561

    St. Anne Mercy Hospital

    Rex B Mowat
    Ph: 800-444-3561

    Toledo Clinic, Incorporated - Main Clinic

    Rex B Mowat
    Ph: 800-444-3561

    Troy

    UVMC Cancer Care Center at Upper Valley Medical Center

    Howard M. Gross
    Ph: 937-775-1350

    Westerville

    Mount Carmel St. Ann's Cancer Center

    J. Philip Kuebler
    Ph: 614-566-3275

    Zanesville

    Genesis - Good Samaritan Hospital

    J. Philip Kuebler
    Ph: 614-488-2745
    Email: sheree@columbusccop.org

    Oklahoma
    Lawton

    Cancer Centers of Southwest Oklahoma, LLC - Lawton

    Nadim F. Nimeh
    Ph: 877-231-4440

    Pennsylvania
    Chadds Ford

    Christiana Care Concord Health Center

    Stephen Scott Grubbs
    Ph: 302-733-6227

    Doylestown

    Doylestown Hospital Cancer Center

    Mitchell Alden
    Ph: 215-345-2378
    Email: lheacock@dh.org

    Harrisburg

    PinnacleHealth Regional Cancer Center at Polyclinic Hospital

    Kit Y Lu
    Ph: 717-724-6765
    Email: klitchfield@PINNACLEHEALTH.org

    Hershey

    Penn State Hershey Cancer Institute at Milton S. Hershey Medical Center

    Cristina I. Truica
    Ph: 410-601-6120
    Email: CTO@hmc.psu.edu

    Lancaster

    Lancaster General Hospital

    Elizabeth Horenkamp
    Ph: 717-544-5511

    Philadelphia

    Fox Chase Cancer Center - Philadelphia

    Jennifer S Winn
    Ph: 215-728-4790

    Pittsburgh

    UPMC Cancer Centers

    Shannon L Puhalla
    Ph: 412-647-2811

    West Chester

    Cancer Center of Chester County

    William E. Luginbuhl
    Ph: 610-431-5297

    West Reading

    McGlinn Family Regional Cancer Center at Reading Hospital and Medical Center

    Terrence P. Cescon
    Ph: 610-988-9323

    Williamsport

    Susquehanna Cancer Center at Divine Providence Hospital

    Warren L Robinson
    Ph: 800-598-4282

    South Carolina
    Easley

    Cancer Centers of the Carolinas - Easley

    Jeffrey Kent Giguere
    Ph: 864-241-6251

    Greenville

    Cancer Centers of the Carolinas - Faris Road

    Jeffrey Kent Giguere
    Ph: 864-241-6251

    Cancer Centers of the Carolinas - Grove Commons

    Jeffrey Kent Giguere
    Ph: 864-241-6251

    CCOP - Greenville

    Jeffrey Kent Giguere
    Ph: 864-241-6251

    Greer

    Cancer Centers of the Carolinas - Greer Radiation Oncology

    Jeffrey Kent Giguere
    Ph: 864-241-6251

    Seneca

    Cancer Centers of the Carolinas - Seneca

    Jeffrey Kent Giguere
    Ph: 864-241-6251

    Spartanburg

    Cancer Centers of the Carolinas - Spartanburg

    Jeffrey Kent Giguere
    Ph: 864-241-6251

    South Dakota
    Aberdeen

    Conklin Regional Cancer Center

    Addison R Tolentino
    Ph: 800-657-4377
    Email: Jan.Healy@avera.org

    Rapid City

    Rapid City Regional Hospital

    Joshua C Lukenbill
    Ph: 605-716-3982
    Email: research@rcrh.org

    Sioux Falls

    Avera Cancer Institute

    Addison R Tolentino
    Ph: 800-657-4377
    Email: Jan.Healy@avera.org

    Sanford Cancer Center at Sanford USD Medical Center

    Preston D. Steen
    Ph: 701-234-6161

    Preston D. Steen
    Ph: 701-234-6161

    Tennessee
    Kingsport

    Christine LaGuardia Phillips Cancer Center at Wellmont Holston Valley Medical Center

    Asheesh Shipstone
    Ph: 423-578-8538

    Kingsport Hematology-Oncology Associates

    Asheesh Shipstone
    Ph: 423-578-8538

    Texas
    Dallas

    Simmons Comprehensive Cancer Center at University of Texas Southwestern Medical Center - Dallas

    Barbara B. Haley
    Ph: 214-648-7097

    Tyler

    University of Texas Health Center at Tyler

    Hitesh Singh
    Ph: 888-823-5923
    Email: ctsucontact@westat.com

    Virginia
    Fredericksburg

    Hematology Oncology Associates of Fredericksburg Inc

    Hetal R Vachhani
    Ph: 804-628-1939

    Lynchburg

    Lynchburg Hematology-Oncology Clinic

    Hetal R Vachhani
    Ph: 804-628-1939

    Martinsville

    Ravenel Oncology Center at Memorial Hospital of Martinsville and Henry County

    Sreedhar Katragadda
    Ph: 276-666-7827

    Norton

    Southwest Virginia Regional Cancer Center at Wellmonth Health

    Asheesh Shipstone
    Ph: 423-578-8538

    Richmond

    Virginia Cancer Institute - West End

    Hetal R Vachhani
    Ph: 804-628-1939

    Virginia Commonwealth University Massey Cancer Center

    Hetal R Vachhani
    Ph: 804-628-1939

    Winchester

    Shenandoah Oncology Associates, PC

    Hetal R Vachhani
    Ph: 804-628-1939

    Washington
    Bremerton

    Harrison Medical Center

    Mehmet S. Copur
    Ph: 800-998-2119

    Olympic Hematology and Oncology

    Mehmet S. Copur
    Ph: 800-998-2119

    Burien

    Highline Medical Center Cancer Center

    Mehmet S. Copur
    Ph: 800-998-2119

    Edmonds

    Swedish Cancer Institute at Stevens Hospital

    Gary E Goodman
    Ph: 206-386-2323
    Email: patra.grevstad@swedish.org

    Issaquah

    Swedish Medical Center - Issaquah Campus

    Gary E Goodman
    Ph: 206-386-2323
    Email: patra.grevstad@swedish.org

    Poulsbo

    Harrison Poulsbo Hematology and Onocology

    Mehmet S. Copur
    Ph: 800-998-2119

    Seattle

    Group Health Central Hospital

    Gary E Goodman
    Ph: 206-386-2323
    Email: patra.grevstad@swedish.org

    Minor and James Medical, PLLC

    Gary E Goodman
    Ph: 206-386-2323
    Email: patra.grevstad@swedish.org

    Swedish Cancer Institute at Swedish Medical Center - First Hill Campus

    Gary E Goodman
    Ph: 206-386-2323
    Email: patra.grevstad@swedish.org

    Swedish Medical Center-Ballard Campus

    Gary E Goodman
    Ph: 206-386-2323
    Email: patra.grevstad@swedish.org

    Tacoma

    Franciscan Research Center-Northwest Medical Plaza

    Mehmet S. Copur
    Ph: 800-998-2119

    Northwest Medical Specialties, PLLC - Tacoma

    Mehmet S. Copur
    Ph: 800-998-2119

    West Virginia
    Huntington

    Edwards Comprehensive Cancer Center at Cabell Huntington Hospital

    Maria-Rosalia B. Tria Tirona
    Ph: 304-399-6617

    Wisconsin
    Antigo

    Langlade Memorial Hospital

    Hamied R. Rezazadeh
    Ph: 877-405-6866

    Burlington

    Aurora Cancer Care-Burlington

    Rubina Qamar
    Ph: 888-709-2080

    Elkhorn

    Vince Lombardi Cancer Center at Aurora Lakeland Medical Center - Elkhorn

    Rubina Qamar
    Ph: 888-709-2080

    Fond Du Lac

    Aurora Health Center-Fond du Lac

    Rubina Qamar
    Ph: 888-709-2080

    Grafton

    Aurora Cancer Care-Grafton

    Rubina Qamar
    Ph: 888-709-2080

    Green Bay

    Bellin Memorial Hospital

    Patrick J Mansky
    Ph: 240-566-3584
    Email: clinicaltrials@fmh.org

    Green Bay Oncology, Limited at St. Mary's Hospital

    Brian L Burnette
    Ph: 800-432-6049

    Green Bay Oncology, Limited at St. Vincent Hospital Regional Cancer Center

    Brian L Burnette
    Ph: 800-432-6049

    St. Mary's Hospital Medical Center - Green Bay

    Brian L Burnette
    Ph: 800-432-6049

    St. Vincent Hospital Regional Cancer Center

    Brian L Burnette
    Ph: 800-432-6049

    Vince Lombardi Cancer Clinic - Green Bay at Aurora BayCare Medical Center

    Rubina Qamar
    Ph: 888-709-2080

    Johnson Creek

    UW Cancer Center Johnson Creek

    Amye J Tevaarwerk
    Ph: 877-405-6866

    Kenosha

    Oncology Alliance - Kenosha South

    Rubina Qamar
    Ph: 888-709-2080

    La Crosse

    Gundersen Lutheran Center for Cancer and Blood

    Kurt Oettel
    Ph: 608-775-2385
    Email: cancerctr@gundluth.org

    Madison

    University of Wisconsin Paul P. Carbone Comprehensive Cancer Center

    Amye J Tevaarwerk
    Ph: 877-405-6866

    Marinette

    Vince Lombardi Cancer Clinic - Marinette

    Rubina Qamar
    Ph: 888-709-2080

    Menomonee Falls

    Aurora Advanced Healthcare Inc-Menomonee Falls

    Rubina Qamar
    Ph: 888-709-2080

    Milwaukee

    Aurora Cancer Care-Milwaukee

    Rubina Qamar
    Ph: 888-709-2080

    Aurora Sinai Medical Center

    Rubina Qamar
    Ph: 888-709-2080

    Vince Lombardi Cancer Clinic at Aurora St. Luke's Medical Center

    Rubina Qamar
    Ph: 888-709-2080

    Mukwonago

    D.N. Greenwald Center

    Timothy R Wassenaar
    Ph: 262-928-7878

    Oconomowoc

    Regional Cancer Center at Oconomowoc Memorial Hospital

    Timothy R Wassenaar
    Ph: 262-928-7878

    Oconto Falls

    Green Bay Oncology, Limited - Oconto Falls

    Brian L Burnette
    Ph: 800-432-6049

    Oshkosh

    Vince Lombardi Cancer Clinic - Oshkosh

    Rubina Qamar
    Ph: 888-709-2080

    Racine

    Aurora Health Center - Racine

    Rubina Qamar
    Ph: 888-709-2080

    Sheboygan

    Vince Lombardi Cancer Clinic - Sheboygan

    Rubina Qamar
    Ph: 888-709-2080

    Sturgeon Bay

    Green Bay Oncology, Limited - Sturgeon Bay

    Brian L Burnette
    Ph: 800-432-6049

    Summit

    Aurora Medical Center

    Rubina Qamar
    Ph: 888-709-2080

    Two Rivers

    Vince Lombardi Cancer Clinic - Two Rivers

    Rubina Qamar
    Ph: 888-709-2080

    Waukesha

    Aurora Cancer Care-Waukesha

    Rubina Qamar
    Ph: 888-709-2080

    Waukesha Memorial Hospital Regional Cancer Center

    Timothy R Wassenaar
    Ph: 262-928-7878

    Wausau

    University of Wisconcin Cancer Center at Aspirus Wausau Hospital

    Hamied R. Rezazadeh
    Ph: 877-405-6866

    Wauwatosa

    Oncology Alliance, SC - Milwaukee - West

    Rubina Qamar
    Ph: 888-709-2080

    West Allis

    Aurora Women's Pavilion of West Allis Memorial Hospital

    Rubina Qamar
    Ph: 888-709-2080

    Wyoming
    Cheyenne

    Cheyenne Regional Medical Center

    Keren Sturtz
    Ph: 888-785-6789

    Link to the current ClinicalTrials.gov record.
    NLM Identifier NCT02115282
    ClinicalTrials.gov processed this data on May 25, 2015

    Note: Information about this trial is from the ClinicalTrials.gov database. The versions designated for health professionals and patients contain the same text. Minor changes may be made to the ClinicalTrials.gov record to standardize the names of study sponsors, sites, and contacts. Cancer.gov only lists sites that are recruiting patients for active trials, whereas ClinicalTrials.gov lists all sites for all trials. Questions and comments regarding the presented information should be directed to ClinicalTrials.gov.