General Information About Liver (Hepatocellular) Cancer
Liver cancer is a disease in which malignant (cancer) cells form in the tissues of the liver.
The liver is one of the largest organs in the body. It has four lobes and fills the upper right side of the abdomen inside the rib cage. The liver has many important functions, including:
- Filtering harmful substances from the blood so they can be passed from the body in stools and urine.
- Making bile to help digest fats from food.
- Storing glycogen (sugar), which the body uses for energy.
See the following PDQ summaries for more information about liver (hepatocellular) cancer:
- Liver (Hepatocellular) Cancer Screening 1
- Adult Primary Liver Cancer Treatment 2
- Childhood Liver Cancer Treatment 3
Liver cancer is not common in the United States.
Liver cancer is the fourth most common cancer and the third leading cause of cancer death in the world. In the United States, men, especially Chinese American men, have an increased risk of liver cancer. The number of new cases of liver cancer and the number of deaths from liver cancer continue to increase, especially among middle-aged black, Hispanic, and white men. People are usually older than 40 years when they develop this cancer.
Finding and treating liver cancer early may prevent death from liver cancer.
Being infected with certain types of the hepatitis virus can cause hepatitis and increase the risk of liver cancer.
Hepatitis is most commonly caused by the hepatitis virus. Hepatitis is a disease that causes inflammation (swelling) of the liver. Damage to the liver from hepatitis that lasts a long time can increase the risk of liver cancer.
There are six types of the hepatitis virus. Hepatitis A (HAV), hepatitis B (HBV), and hepatitis C (HCV) are the three most common types. These three viruses cause similar symptoms, but the ways they spread and affect the liver are different.
The Hepatitis A vaccine and the hepatitis B vaccine prevent infection with hepatitis A and hepatitis B. There is no vaccine to prevent infection with hepatitis C. If a person has had one type of hepatitis in the past, it is still possible to get the other types.
Hepatitis viruses include:
Hepatitis A is caused by eating food or drinking water infected with hepatitis A virus. It does not lead to chronic disease. People with hepatitis A usually get better without treatment.
Hepatitis B is caused by contact with the blood, semen, or other body fluid of a person infected with hepatitis B virus. It is a serious infection that may become chronic and cause scarring of the liver (cirrhosis). This may lead to liver cancer. Blood banks test all donated blood for hepatitis B, which greatly lowers the risk of getting the virus from blood transfusions.
Hepatitis C is caused by contact with the blood of a person infected with hepatitis C virus. Hepatitis C may range from a mild illness that lasts a few weeks to a serious, lifelong illness. Most people who have hepatitis C develop a chronic infection that may cause scarring of the liver (cirrhosis). This may lead to liver cancer. Blood banks test all donated blood for hepatitis C, which greatly lowers the risk of getting the virus from blood transfusions.
Hepatitis D develops in people already infected with hepatitis B. It is caused by hepatitis D virus (HDV) and is spread through contact with infected blood or dirty needles, or by having unprotected sex with a person infected with HDV. Hepatitis D causes acute hepatitis.
Hepatitis E is caused by hepatitis E virus (HEV). Hepatitis E can be spread through oral- anal contact or by drinking infected water. Hepatitis E is rare in the United States.
Being infected with hepatitis G virus (HGV) has not been shown to cause liver cancer.
Glossary Termsabdomen (AB-doh-men)The area of the body that contains the pancreas, stomach, intestines, liver, gallbladder, and other organs.acute (uh-KYOOT) Symptoms or signs that begin and worsen quickly; not chronic.anal (AY-nul) Having to do with the anus. The anus is the opening of the rectum (last part of the large intestine) to the outside of the body.bile (bile) A fluid made by the liver and stored in the gallbladder. Bile is excreted into the small intestine, where it helps digest fat.blood (blud) A tissue with red blood cells, white blood cells, platelets, and other substances suspended in fluid called plasma. Blood takes oxygen and nutrients to the tissues, and carries away wastes.blood transfusion (blud tranz-FYOO-zhun) A procedure in which a person is given an infusion of whole blood or parts of blood. The blood may be donated by another person, or it may have been taken from the patient earlier and stored until needed. Also called transfusion.cancer (KAN-ser) A term for diseases in which abnormal cells divide without control and can invade nearby tissues. Cancer cells can also spread to other parts of the body through the blood and lymph systems. There are several main types of cancer. Carcinoma is a cancer that begins in the skin or in tissues that line or cover internal organs. Sarcoma is a cancer that begins in bone, cartilage, fat, muscle, blood vessels, or other connective or supportive tissue. Leukemia is a cancer that starts in blood-forming tissue such as the bone marrow, and causes large numbers of abnormal blood cells to be produced and enter the blood. Lymphoma and multiple myeloma are cancers that begin in the cells of the immune system. Central nervous system cancers are cancers that begin in the tissues of the brain and spinal cord. Also called malignancy.chronic (KRAH-nik) A disease or condition that persists or progresses over a long period of time.cirrhosis (seh-ROH-sis) A type of chronic, progressive liver disease in which liver cells are replaced by scar tissue.fluid (FLOO-id) A substance that flows smoothly and takes the shape of its container. Liquids and gases are fluids.hepatitis (HEH-puh-TY-tis) Disease of the liver causing inflammation. Symptoms include an enlarged liver, fever, nausea, vomiting, abdominal pain, and dark urine.hepatitis A vaccine (HEH-puh-TY-tis ... vak-SEEN) A vaccine used to prevent infection with the hepatitis A virus, which causes a serious liver disease. The vaccine is made of a weakened form of the virus that cannot cause disease but causes the body’s immune system to make antibodies that destroy the hepatitis A virus.hepatitis A virus (HEH-puh-TY-tis ... VY-rus) A virus that causes a serious liver disease. It is usually spread by contact with an infected person’s stool by eating food he or she has handled after not washing hands, but it can be spread in other ways. Symptoms of infection include jaundice, dark urine, and fever and other flu-like symptoms.hepatitis B virus (HEH-puh-TY-tis ... VY-rus) A virus that causes hepatitis (inflammation of the liver). It is carried and passed to others through the blood and other body fluids. Different ways the virus is spread include sharing needles with an infected person and being stuck accidentally by a needle contaminated with the virus. Infants born to infected mothers may also become infected with the virus. Although many patients who are infected with hepatitis B virus may not have symptoms, long-term infection may lead to cirrhosis (scarring of the liver) and liver cancer. Also called HBV.hepatitis C virus (HEH-puh-TY-tis ... VY-rus) A virus that causes hepatitis (inflammation of the liver). It is carried and passed to others through the blood and other body fluids. Different ways the virus is spread include sharing needles with an infected person and being stuck accidentally by a needle contaminated with the virus. Infants born to infected mothers may also become infected with the virus. Although patients who are infected with hepatitis C virus may not have symptoms, long-term infection may lead to cirrhosis (scarring of the liver) and liver cancer. These patients may also have an increased risk for certain types of non-Hodgkin lymphoma. Also called HCV.hepatitis D virus (HEH-puh-TY-tis … VY-rus) A type of hepatitis virus that may be present in the body at the same time as the hepatitis B virus. It makes the hepatitis (inflammation of the liver) caused by hepatitis B much worse. The hepatitis D virus and the hepatitis B virus are spread to others through blood or sexual contact. Infants born to infected mothers may also become infected with the virus. Also called hepatitis delta virus.hepatitis E virus (HEH-puh-TY-tis … VY-rus) A virus that causes hepatitis (inflammation of the liver). It is usually spread through food that has been handled by an infected person, or through drinking water that is contaminated with human waste.hepatitis G virus (HEH-puh-TY-tis … VY-rus) A virus that may be found in patients with hepatitis (inflammation of the liver). It is spread to others through blood or sexual contact. Infants born to infected mothers may also become infected with the virus.infection (in-FEK-shun) Invasion and multiplication of germs in the body. Infections can occur in any part of the body and can spread throughout the body. The germs may be bacteria, viruses, yeast, or fungi. They can cause a fever and other problems, depending on where the infection occurs. When the body’s natural defense system is strong, it can often fight the germs and prevent infection. Some cancer treatments can weaken the natural defense system.inflammation (IN-fluh-MAY-shun) Redness, swelling, pain, and/or a feeling of heat in an area of the body. This is a protective reaction to injury, disease, or irritation of the tissues.liver (LIH-ver) A large organ located in the upper abdomen. The liver cleanses the blood and aids in digestion by secreting bile.liver cancer (LIH-ver KAN-ser) Primary liver cancer is cancer that forms in the tissues of the liver. Secondary liver cancer is cancer that spreads to the liver from another part of the body.lobe (lobe) A portion of an organ, such as the liver, lung, breast, thyroid, or brain.oral (OR-ul) By or having to do with the mouth.organ (OR-gun) A part of the body that performs a specific function. For example, the heart is an organ.PDQ PDQ is an online database developed and maintained by the National Cancer Institute. Designed to make the most current, credible, and accurate cancer information available to health professionals and the public, PDQ contains peer-reviewed summaries on cancer treatment, screening, prevention, genetics, complementary and alternative medicine, and supportive care; a registry of cancer clinical trials from around the world; and directories of physicians, professionals who provide genetics services, and organizations that provide cancer care. Most of this information, and more specific information about PDQ, can be found on the NCI's Web site at http://www.cancer.gov/cancertopics/pdq. Also called Physician Data Query.semen (SEE-men) The fluid that is released through the penis during orgasm. Semen is made up of sperm from the testicles and fluid from the prostate and other sex glands.stool (stool) The material in a bowel movement. Stool is made up of undigested food, bacteria, mucus, and cells from the lining of the intestines. Also called feces.symptom (SIMP-tum) An indication that a person has a condition or disease. Some examples of symptoms are headache, fever, fatigue, nausea, vomiting, and pain.urine (YOOR-in) Fluid containing water and waste products. Urine is made by the kidneys, stored in the bladder, and leaves the body through the urethra.vaccine (vak-SEEN) A substance or group of substances meant to cause the immune system to respond to a tumor or to microorganisms, such as bacteria or viruses. A vaccine can help the body recognize and destroy cancer cells or microorganisms.virus (VY-rus) In medicine, a very simple microorganism that infects cells and may cause disease. Because viruses can multiply only inside infected cells, they are not considered to be alive. |
