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Childhood Liver Cancer Treatment (PDQ®)

  • Last Modified: 05/28/2014

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Treatment Options for Childhood Liver Cancer

Hepatoblastoma
Hepatocellular Carcinoma
Undifferentiated Embryonal Sarcoma of the Liver
Infantile Choriocarcinoma of the Liver
Recurrent Childhood Liver Cancer
Treatment Options in Clinical Trials



Hepatoblastoma

Treatment of stages I and II hepatoblastoma may include the following:

Treatment of stage III hepatoblastoma may include the following:

The treatment of stage IV hepatoblastoma often includes chemotherapy and surgery. Combination chemotherapy is given to shrink the cancer in the liver and cancer that has spread to other parts of the body, such as the lungs or brain. After chemotherapy, imaging tests are done to check whether the cancer can be removed by surgery. Treatment may include one or more of the following:

  • If the cancer in the liver and other parts of the body can be completely removed, the treatment is surgery to remove the tumor followed by chemotherapy to kill any cancer cells that may remain.
  • If the cancer in the liver cannot be removed by surgery and there are no signs of cancer in other parts of the body, the treatment is a liver transplant. If a liver transplant is not possible, treatment may include one or more of the following:
  • A clinical trial of new combinations of chemotherapy, surgery to remove the tumor, and liver transplant.
Hepatocellular Carcinoma

Treatment of stages I and II hepatocellular carcinoma may include the following:

Treatment of stage III hepatocellular carcinoma and PRETEXT stage 4 hepatocellular carcinoma may include the following:

Treatment of stage IV hepatocellular carcinoma that was staged after surgery may include the following:

Undifferentiated Embryonal Sarcoma of the Liver

Treatment of undifferentiated embryonal sarcoma of the liver may include the following:

Infantile Choriocarcinoma of the Liver

Treatment of choriocarcinoma of the liver in infants may include the following:

Recurrent Childhood Liver Cancer

Treatment of recurrent hepatoblastoma may include the following:

Treatment of recurrent hepatocellular carcinoma may include the following:

Treatment Options in Clinical Trials

Check for U.S. clinical trials from NCI's list of cancer clinical trials that are now accepting patients with childhood liver cancer. For more specific results, refine the search by using other search features, such as the location of the trial, the type of treatment, or the name of the drug. Talk with your child's doctor about clinical trials that may be right for your child. General information about clinical trials is available from the NCI Web site.