1.	Radial Reload Laparoscopic Case Series Phase: Phase IV Type: Treatment Status: Active Age: 18 to 85 Sponsor: Other Protocol IDs: COVLARL0287, NCT01706822
2.	RObotic Versus LAparoscopic Resection for Rectal Cancer Phase: Phase IV Type: Treatment Status: Active Age: 18 and over Sponsor: Other Protocol IDs: HS#2011-8537, NCT01736072
3.	Chemotherapy Alone or Chemotherapy Plus Radiation Therapy in Treating Patients With Locally Advanced Rectal Cancer Undergoing Surgery Phase: Phase III, Phase II Type: Biomarker/Laboratory analysis, Treatment Status: Active Age: 18 and over Sponsor: NCI, Other Protocol IDs: CDR0000715321, NCCTG-N1048, N1048, NCT01515787
4.	Laparoscopic-Assisted Resection or Open Resection in Treating Patients With Stage IIA, Stage IIIA, or Stage IIIB Rectal Cancer Phase: Phase III Type: Treatment Status: Active Age: 18 and over Sponsor: NCI, Other Protocol IDs: CDR0000601816, ACOSOG-Z6051, Z6051, NCT00726622
5.	Dose-Escalation and Safety Trial of YN968D1 Phase: Phase II, Phase I Type: Biomarker/Laboratory analysis, Treatment Status: Active Age: 18 and over Sponsor: Pharmaceutical / Industry Protocol IDs: BK-LSK-AM101, NCT01497704
6.	A Study of Neoadjuvant Photodynamic Immunomodulation for Colon Cancer Phase: Phase II, Phase I Type: Biomarker/Laboratory analysis, Treatment Status: Active Age: 18 and over Sponsor: NCI, Other Protocol IDs: 108643, 1R21CA153594, NCT01522677
7.	Phase II Study of Neoadjuvant Modified FOLFOX 6 Chemotherapy Followed by Total Mesorectal Excision and Adjuvant Modified FOLFOX 6 Chemotherapy in Patients With Rectal Cancer Phase: Phase II Type: Treatment Status: Active Age: 18 and over Sponsor: Pharmaceutical / Industry Protocol IDs: BIMCP-OX-08-006, OX-08-006, AVENTIS-BIMCP-OX-08-006, NCT00831181
8.	Phase II Study of Neoadjuvant Chemoradiotherapy Comprising Capecitabine, Panitumumab, and Radiotherapy With or Without Irinotecan Hydrochloride in Patients With Localized Rectal Cancer. Note: The information about this trial has not been updated by the sponsor/principal investigator/lead organization. Cancer.gov cannot verify the accuracy of the information. Phase: Phase II Type: Treatment Status: Active Age: 18 and over Sponsor: Other Protocol IDs: LLOMGI-20050743, 20050743, MALIK 012009, NCT00967655
9.	Exercise and Metformin in Colorectal and Breast Cancer Survivors Phase: Phase II Type: Biomarker/Laboratory analysis, Educational/Counseling/Training, Treatment Status: Active Age: 18 and over Sponsor: Other Protocol IDs: 11-009, NCT01340300
10.	Memantine Hydrochloride in Helping Cancer Survivors Stop Smoking Phase: Phase II Type: Biomarker/Laboratory analysis, Treatment Status: Active Age: 18 and over Sponsor: NCI, Other Protocol IDs: CCCWFU 99311, U10CA081851, WFU 09-10-14, NCT01535040
11.	Maintenance Chemotherapy After Neoadjuvant Chemoradiation Therapy for Distal Rectal Cancer Phase: Phase II Type: Treatment Status: Active Age: 18 and over Sponsor: Other Protocol IDs: R12-3092L, NCT01613469
12.	Effect of Metformin on Biomarkers of Colorectal Tumor Cell Growth Phase: Phase II Type: Biomarker/Laboratory analysis, Treatment Status: Active Age: 18 and over Sponsor: Other Protocol IDs: 134190, NCT01632020
13.	Phase II Trial of Preoperative High-dose-rate Endorectal Brachytherapy and FOLFOX Chemotherapy for Rectal Cancer Phase: Phase II Type: Treatment Status: Active Age: 18 and over Sponsor: Other Protocol IDs: HDRBT for Rectal cancer, NCT01659424
14.	Doxorubicin With or Without Sildenafil, With Analysis of Cardiac Markers Phase: Phase I Type: Biomarker/Laboratory analysis, Supportive care, Treatment Status: Active Age: 18 and over Sponsor: Other Protocol IDs: MCC-13419, NCI-2011-0098, NCT01375699
15.	Dose Escalation Trial of Nitroglycerin, 5-flourouracil and Rad Therapy for Rectal Cancer Phase: Phase I Type: Treatment Status: Active Age: 18 to 90 Sponsor: Other Protocol IDs: VA10-100, NCT01407107
16.	Impact of Pretreatment With Metformin on Colorectal Cancer Stem Cells (CCSC) and Related Pharmacodynamic Markers Phase: Phase I Type: Biomarker/Laboratory analysis, Treatment Status: Active Age: 18 to 79 Sponsor: Other Protocol IDs: Metformin CCSC, NCT01440127
17.	Dose Escalation Study of I-131-CLR1404 in Subjects With Cancer That Does Not Respond to Treatment or Has Returned Phase: Phase I Type: Biomarker/Laboratory analysis, Treatment Status: Active Age: 18 and over Sponsor: Pharmaceutical / Industry Protocol IDs: DCL-10-001, NCT01495663
18.	Vaccine Therapy With or Without Sirolimus in Treating Patients With NY-ESO-1 Expressing Solid Tumors Phase: Phase I Type: Biomarker/Laboratory analysis, Treatment Status: Active Age: 18 and over Sponsor: Other Protocol IDs: I 191511, NCI-2011-03568, NCT01522820
19.	STA9090: Phase I Trial of Ganetespib, Capecitabine, and Radiation in Rectal Cancer Phase: Phase I Type: Biomarker/Laboratory analysis, Treatment Status: Active Age: 18 and over Sponsor: Other Protocol IDs: STA 9090, NCT01554969
20.	A Phase I Study of Bavituximab, Capecitabine, and Radiation for the Treatment of Rectal Adenocarcinoma Phase: Phase I Type: Treatment Status: Active Age: 18 and over Sponsor: Other Protocol IDs: STU 032012-025, NCT01634685
21.	Safety of Labeled Dendritic Cell (DC) Vaccines and Feasibility of Tracking by Magnetic Resonance Imaging (MRI) Phase: Phase I Type: Diagnostic, Treatment Status: Active Age: 18 and over Sponsor: NCI Protocol IDs: 10-052, R01CA134633, NCT01671592
22.	Trametinib, Fluorouracil, and Radiation Therapy Before Surgery in Treating Patients With Stage II-III Rectal Cancer Phase: Phase I Type: Biomarker/Laboratory analysis, Treatment Status: Active Age: 18 and over Sponsor: Other Protocol IDs: OSU-12054, NCI-2012-02158, NCT01740648
23.	An Open-Labeled Pilot Study of Biomarker Response Following Short-Term Exposure to Metformin Phase: Phase I Type: Biomarker/Laboratory analysis, Treatment Status: Active Age: 18 to 75 Sponsor: Other Protocol IDs: 2012-1150, NCT01816659
24.	Biomarkers in Patients With Rectal Cancer Undergoing Chemotherapy and Radiation Therapy Phase: No phase specified Type: Biomarker/Laboratory analysis, Treatment Status: Active Age: 18 and over Sponsor: NCI, Other Protocol IDs: LCCC 0216, P30CA016086, CDR0000561688, UNC-LCCC-0216, NCT00280761
25.	Hand Assisted Versus "Pure" Laparoscopic Assisted Proctectomy for Rectal Cancer Phase: No phase specified Type: Health services research, Treatment Status: Active Age: 18 and over Sponsor: Other Protocol IDs: MITT02, NCT00651677