1.	Phase II/III Randomized Comparison of Two Schedules of TMTX vs 5-FU in Patients with Colorectal Carcinoma (Summary Last Modified 11/88) Phase: Phase III, Phase II Type: Treatment Status: Closed Age: 18 and over Sponsor: NCI Protocol IDs: SWOG-8611
2.	Phase I/II Chemotherapy with Trimetrexate in Children with Solid Tumors Phase: Phase II, Phase I Type: Treatment Status: Closed Age: 21 and under Sponsor: NCI Protocol IDs: POG-8591
3.	Phase I/II Pilot Study of Chemotherapy with CDDP/TMTX or TMTX/VP-16 in Patients with non-Small Cell Lung Cancer (Summary Last Modified 09/88) Phase: Phase II, Phase I Type: Treatment Status: Closed Age: 18 to 80 Sponsor: Protocol IDs: YALE-HIC-4467, NCI-V88-0377
4.	Phase II Study of TMTX/5-FU/CF in Recurrent or Refractory Metastatic Urothelial Tract Cancer (Summary Last Modified 07/97) Phase: Phase II Type: Treatment Status: Completed Age: over 18 Sponsor: Other Protocol IDs: MSKCC-93150, NCI-V94-0477
5.	Phase II Study of TMTX/5-FU/CF for Previously Untreated, Unresectable or Metastatic Gastric Cancer (Summary Last Modified 05/97) Phase: Phase II Type: Treatment Status: Completed Age: 18 and over Sponsor: Pharmaceutical / Industry Protocol IDs: USB-TMTX-B018, UPCC-1294, NCI-V94-0528
6.	Combination Chemotherapy in Treating Children With Acute Lymphoblastic Leukemia, Osteosarcoma, or Non-Hodgkin's Lymphoma Phase: Phase II Type: Treatment Status: Completed Age: 21 and under at diagnosis Sponsor: NCI, Other Protocol IDs: 95-093, P30CA008748, MSKCC-95093, NCI-V96-0840, NCT00002738
7.	Phase II Study of Trimetrexate for Advanced, Persistent, or Recurrent Mixed Mesodermal Tumors of the Uterus Phase: Phase II Type: Treatment Status: Completed Age: 18 and over Sponsor: NCI Protocol IDs: GOG-130C
8.	Phase II Study of Trimetrexate in Refractory Leiomyosarcoma of the Uterus Phase: Phase II Type: Treatment Status: Completed Age: 18 and over Sponsor: NCI Protocol IDs: GOG-131D
9.	Phase II Study of Trimetrexate, Fluorouracil, and Leucovorin in Unresectable or Metastatic Adenocarcinoma of the Stomach (Summary Last Modified 12/98) Phase: Phase II Type: Treatment Status: Closed Age: 18 and over Sponsor: NCI Protocol IDs: SWOG-9511
10.	Combination Chemotherapy in Treating Patients With Advanced Cancer of the Pancreas Phase: Phase II Type: Treatment Status: Completed Age: 18 and over Sponsor: NCI, Other Protocol IDs: CDR0000065428 (3P-95-1), LAC-USC-3P951, NCI-G97-1173, NCT00002955
11.	Phase II Study of Trimetrexate Glucuronate and Continuous Infusion Fluorouracil in Previously Untreated Patients with Locally Advanced or Metastatic Pancreatic Cancer (Summary Last Modified 11/1999) Phase: Phase II Type: Treatment Status: Closed Age: 18 and over Sponsor: Pharmaceutical / Industry Protocol IDs: UCLA-HSPC-971201401, USB-UCLA-HSPC-971201401, NCI-V98-1409
12.	Phase II Study of Trimetrexate Glucuronate, Fluorouracil, and Leucovorin Calcium in Patients With Recurrent or Metastatic Colorectal Carcinoma (Summary Last Modified 09/2001). Note: The information about this trial has not been updated by the sponsor/principal investigator/lead organization. Cancer.gov cannot verify the accuracy of the information. Phase: Phase II Type: Treatment Status: Completed Age: 18 to 74 Sponsor: Other Protocol IDs: GOCS-12-CR-97, NCI-V98-1457, NCT00003446
13.	Phase II Study of Trimetrexate Glucuronate with Leucovorin Calcium Protection, Surgery, and Chemotherapy in Patients with Newly Diagnosed Metastatic Osteosarcoma (Summary Last Modified 06/2000). Note: The information about this trial has not been updated by the sponsor/principal investigator/lead organization. Cancer.gov cannot verify the accuracy of the information. Phase: Phase II Type: Treatment Status: Completed Age: 30 and under Sponsor: NCI Protocol IDs: MSKCC-98102, NCI-G99-1507, NCT00003776
14.	Phase II Chemotherapy with Trimetrexate in Patients with Advanced Sarcomas (Summary Last Modified 11/90) Phase: Phase II Type: Treatment Status: Completed Age: over 18 Sponsor: NCI Protocol IDs: DFCI-87083, NCI-T88-0015D, T88-0015
15.	Phase II Study of TMTX in Patients with Metastatic Breast or Head and Neck Tumors Refractory to Conventional Therapy or for Whom No Conventional Therapy Exists Phase: Phase II Type: Treatment Status: Completed Age: 18 to 80 Sponsor: Protocol IDs: WL/PD-898, AECM-8509201, BGSM-99885, NCI-V85-0228
16.	Phase II Master Protocol for Single-Agent or Combination Chemotherapy in Patients with Refractory non-Hodgkin's Lymphoma --- TMTX (Summary Last Modified 11/87) Phase: Phase II Type: Treatment Status: Closed Age: over 15 Sponsor: NCI Protocol IDs: CLB-8651, CALGB-8651
17.	Phase II Chemotherapy with TMTX in Patients with Endocrine Therapy-Resistant Metastatic Adenocarcinoma of the Prostate (Summary Last Modified 12/87) Phase: Phase II Type: Treatment Status: Completed Age: any age Sponsor: NCI Protocol IDs: UMCC-8525, MSKCC-86100, NCI-T85-0265C, T85-0265
18.	Phase II Chemotherapy with TMTX in Patients with Advanced Ovarian Cancer Who Have Failed Prior Chemotherapy (Summary Last Modified 03/88) Phase: Phase II Type: Treatment Status: Completed Age: any age Sponsor: NCI Protocol IDs: UMCC-8603, NCI-T86-0047C, T86-0047
19.	Phase II Chemotherapy with Trimetrexate in Patients with Advanced Uterine Carcinoma Phase: Phase II Type: Treatment Status: Completed Age: no age specified Sponsor: NCI Protocol IDs: UMCC-8604, NCI-T86-0048C, T86-0048
20.	Phase II Master Protocol for Controlled Studies in the Treatment of Advanced Renal Cell Cancer --- Trimetrexate Phase: Phase II Type: Treatment Status: Completed Age: 18 and over Sponsor: NCI Protocol IDs: EST-2885
21.	Phase II Chemotherapy with Trimetrexate in Patients with Soft Tissue Sarcoma Phase: Phase II Type: Treatment Status: Closed Age: 16 and over Sponsor: Protocol IDs: CAN-NCIC-IND28, NCI-T86-0130W, T86-0130, IND28
22.	Phase II Chemotherapy with Trimetrexate in Patients with Advanced Colorectal Carcinoma Phase: Phase II Type: Treatment Status: Completed Age: 18 and over Sponsor: NCI Protocol IDs: JHOC-85070801, NCI-T86-0071D, T86-0071
23.	Phase II Chemotherapy with TMTX in Patients with Advanced Unresectable Renal Cell Carcinoma Phase: Phase II Type: Treatment Status: Closed Age: 18 and over Sponsor: NCI Protocol IDs: MSKCC-8650, NCI-T85-0223C, T85-0223
24.	Phase II Chemotherapy with Trimetrexate in Patients with Metastatic Malignant Melanoma Phase: Phase II Type: Treatment Status: Completed Age: 18 and over Sponsor: NCI Protocol IDs: CAN-NCIC-IND26, NCI-T86-0128W, T86-0128, IND26
25.	Phase II Chemotherapy with Trimetrexate in Patients with Malignant Glioma Phase: Phase II Type: Treatment Status: Completed Age: no age specified Sponsor: NCI Protocol IDs: CAN-NCIC-IND27, NCI-T86-0129W, T86-0129, IND27