1.	An Endometrial Cancer Chemoprevention Study of Metformin Phase: Phase III Type: Behavioral study, Biomarker/Laboratory analysis, Prevention Status: Active Age: 50 to 60 Sponsor: Other Protocol IDs: 2011-0739, NCT01697566
2.	Gemcitabine+Nab-paclitaxel and FOLFIRINOX and Molecular Profiling for Patients With Advanced Pancreatic Cancer Phase: Phase II, Phase I Type: Biomarker/Laboratory analysis, Treatment Status: Active Age: 18 and over Sponsor: Other Protocol IDs: PCRT 11-002, NCT01488552
3.	A Phase I/II Trial of Vemurafenib and Metformin to Melanoma Patients Phase: Phase II, Phase I Type: Treatment Status: Active Age: 18 and over Sponsor: Other Protocol IDs: BCC-MEL-11-03, NCT01638676
4.	Efficacy and Safety of Adjuvant Metformin for Operable Breast Cancer Patients Phase: Phase II Type: Treatment Status: Active Age: 20 and over Sponsor: Other Protocol IDs: adjuvant metformin for BC, NCT00909506
5.	Combination Chemotherapy With or Without Metformin Hydrochloride in Treating Patients With Metastatic Pancreatic Cancer Phase: Phase II Type: Treatment Status: Active Age: 18 to 75 Sponsor: Other Protocol IDs: CDR0000681691, PACT-17, 2010-020979-23, SRSI-PACT-17, EUDRACT-2010-020979-23, EU-21052, NCT01167738
6.	Metformin Combined With Chemotherapy for Pancreatic Cancer Phase: Phase II Type: Treatment Status: Active Age: 18 to 80 Sponsor: Other Protocol IDs: AMCmedonc10/003, NCT01210911
7.	Effect of Metformin on Breast Cancer Metabolism Phase: Phase II Type: Biomarker/Laboratory analysis, Treatment Status: Active Age: 18 and over Sponsor: Other Protocol IDs: EP-TSC-647, NCT01266486
8.	A Trial of Standard Chemotherapy With Metformin (vs Placebo) in Women With Metastatic Breast Cancer Phase: Phase II Type: Biomarker/Laboratory analysis, Treatment Status: Active Age: 18 to 75 Sponsor: Other Protocol IDs: OZM-027, NCT01310231
9.	A Trial of Metformin for Colorectal Cancer Risk Reduction Among Patients With a History of Colorectal Adenomas and Elevated Body Mass Index Phase: Phase II Type: Biomarker/Laboratory analysis, Prevention Status: Active Age: 35 to 80 Sponsor: NCI Protocol IDs: NCI-2011-01744, 2010-7705, UCI 10-31, UCI09-13-01, N01CN35160, NCT01312467
10.	Metformin Plus Paclitaxel for Metastatic or Recurrent Head and Neck Cancer Phase: Phase II Type: Treatment Status: Active Age: 18 and over Sponsor: Other Protocol IDs: METTAX200901, NCT01333852
11.	Exercise and Metformin in Colorectal and Breast Cancer Survivors Phase: Phase II Type: Biomarker/Laboratory analysis, Educational/Counseling/Training, Treatment Status: Active Age: 18 and over Sponsor: Other Protocol IDs: 11-009, NCT01340300
12.	Metformin Hydrochloride in Treating Patients With Prostate Cancer Undergoing Surgery Phase: Phase II Type: Biomarker/Laboratory analysis, Treatment Status: Active Age: 19 and over Sponsor: NCI Protocol IDs: NCI-2012-00243, 11-0211-04, CDR0000712087, UARIZ-UAZ10-16-01, N01CN35158, NCT01433913
13.	Phase II Short-term Adjuvant Therapy and Biomarker Studies With Targeted Agents in Women With Estrogen Receptor Negative Breast Cancer Phase: Phase II Type: Biomarker/Laboratory analysis, Prevention Status: Approved-not yet active Age: 18 and over Sponsor: Other Protocol IDs: 2010-0794, NCT01471106
14.	Modulation of Response to Hormonal Therapy With Lapatinib and/or Metformin in Patients With Metastatic Breast Cancer Phase: Phase II Type: Treatment Status: Active Age: 18 and over Sponsor: Other Protocol IDs: CROLT/02, 2011-000155-16, NCT01477060
15.	A Randomized, Placebo-controlled, Double-blind Phase II Study Evaluating if Glucophage Can Avoid Liver Injury Due to Chemotherapy Associated Steatosis Phase: Phase II Type: Treatment Status: Active Age: 18 and over Sponsor: Other Protocol IDs: G-LUCAS, 200084-610, 2011-001010-34, NCT01523639
16.	Study of Metformin With Simvastatin for Men With Prostate Carcinoma Phase: Phase II Type: Treatment Status: Active Age: 18 and over Sponsor: Other Protocol IDs: H-28936, NCT01561482
17.	Metformin Plus Neoadjuvant Chemotherapy in Breast Cancer Phase: Phase II Type: Treatment Status: Approved-not yet active Age: 18 to 70 Sponsor: Other Protocol IDs: MET-INCAN-1, NCT01566799
18.	Evaluation of Metformin, Targeting Cancer Stem Cells for Prevention of Relapse in GYN Patients Phase: Phase II Type: Treatment Status: Active Age: 19 to 79 Sponsor: Other Protocol IDs: UMCC 2011.037, HUM 47900, NCT01579812
19.	Neoadjuvant Letrozole Plus Metformin vs Letrozole Plus Placebo for ER-positive Postmenopausal Breast Cancer Phase: Phase II Type: Treatment Status: Active Age: 18 to 80 Sponsor: Other Protocol IDs: KBCSG 013, NCT01589367
20.	Castration Compared to Castration Plus Metformin as First Line Treatment for Patients With Advanced Prostate Cancer Phase: Phase II Type: Treatment Status: Active Age: 18 and over Sponsor: Other Protocol IDs: CTRC 10-21, HSC20110273H, NCT01620593
21.	FJE_Exemestane-RAD001-Metformin Phase: Phase II Type: Treatment Status: Active Age: 18 and over Sponsor: Other Protocol IDs: 2011-1239, NCT01627067
22.	Effect of Metformin on Biomarkers of Colorectal Tumor Cell Growth Phase: Phase II Type: Biomarker/Laboratory analysis, Treatment Status: Active Age: 18 and over Sponsor: Other Protocol IDs: 134190, NCT01632020
23.	Dimethyldiguanide Combined With Aromatase Inhibitor (AI) in Metastatic Breast Cancer Phase: Phase II Type: Treatment Status: Active Age: 18 and over Sponsor: Other Protocol IDs: Fudan BR2012-12, NCT01654185
24.	Metformin Plus Modified FOLFOX 6 in Metastatic Pancreatic Cancer Phase: Phase II Type: Biomarker/Laboratory analysis, Treatment Status: Active Age: 18 and over Sponsor: NCI, Other Protocol IDs: CASE1212, NCI-2012-01322, NCT01666730
25.	Impact of the Addition of Metformin to Abiraterone in Metastatic Prostate Cancer Patients Phase: Phase II Type: Treatment Status: Approved-not yet active Age: 18 to 90 Sponsor: Other Protocol IDs: MetAb-Pro, NCT01677897