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Clinical Trials (PDQ®)

Clinical Trials (PDQ®)

Prostate Radiation Therapy or Short-Term Androgen Deprivation Therapy and Pelvic Lymph Node Radiation Therapy With or Without Prostate Radiation Therapy in Treating Patients With a Rising Prostate Specific Antigen (PSA) After Surgery for Prostate Cancer

Basic Trial Information
Trial Description
     Summary
     Further Trial Information
     Eligibility Criteria
Trial Contact Information

Basic Trial Information

PhaseTypeStatusAgeSponsorProtocol IDs
Phase IIIBiomarker/Laboratory analysis, Supportive care, TreatmentActive18 and overNCI, OtherRTOG 0534
CDR0000577574, NCI-2009-00733, NCT00567580

Trial Description

Summary

RATIONALE: Radiation therapy uses high-energy x-rays to kill tumor cells. Androgens can cause the growth of prostate cancer cells. Antihormone therapy, such as flutamide, bicalutamide, and luteinizing hormone-releasing hormone agonist, may lessen the amount of androgens made by the body. It is not yet known which regimen of radiation therapy with or without androgen-deprivation therapy is more effective for prostate cancer.

PURPOSE: This randomized phase III trial is studying prostate radiation therapy to see how well it works compared with short-term androgen deprivation therapy given together with pelvic lymph node radiation therapy with or without prostate radiation therapy in treating patients with a rising PSA after surgery for prostate cancer.

Further Study Information

OBJECTIVES:

Primary

  • To determine whether the addition of short-term androgen deprivation (STAD) to prostate bed radiotherapy (PBRT) improves freedom from progression (FFP) (i.e., maintenance of a prostate-specific antigen [PSA] less than the nadir+2 ng/mL, absence of clinical failure, and absence of death from any cause) for 5 years, over that of PBRT alone in men treated with salvage radiotherapy after radical prostatectomy.
  • To determine whether STAD, pelvic lymph node radiotherapy (PLNRT), and PBRT improves FFP over that of STAD+PBRT and PBRT alone in men treated with salvage radiotherapy after radical prostatectomy.

Secondary

  • To compare the rates of a PSA ≥ 0.4 ng/mL and rising at 5 years after randomization (secondary biochemical failure endpoint), the development of hormone-refractory disease (3 rises in PSA during treatment with salvage androgen-deprivation therapy), distant metastasis, cause-specific mortality, and overall mortality.
  • To compare acute and late morbidity based on Common Toxicity Criteria for Adverse Effects (CTCAE), v. 3.0.
  • To measure the expression of cell kinetic, apoptotic pathway, and angiogenesis-related genes in archival diagnostic tissue to better define the risk of FFP, distant failure, cause-specific mortality, and overall mortality after salvage radiotherapy for prostate cancer, independently of conventional clinical parameters now used.
  • To quantify blood product-based proteomic and genomic (single nucleotide polymorphisms) patterns and urine-based genomic patterns before and at different times after treatment to better define the risk of FFP, distant failure, cause-specific mortality, and overall mortality after salvage radiotherapy for prostate cancer, independently of conventional clinical parameters now used.
  • To assess the degree, duration, and significant differences of disease-specific health-related quality of life (HRQOL) decrements among treatment arms.
  • To assess whether mood is improved and depression is decreased with the more aggressive therapy if it improves FFP.
  • To collect paraffin-embedded tissue blocks, serum, plasma, urine, and buffy coat cells for future translational research analyses.

Tertiary

  • To assess whether an incremental gain in FFP and survival with more aggressive therapy outweighs decrements in the primary generic domains of HRQOL (i.e., mobility, self care, usual activities, pain/discomfort, and anxiety/depression).
  • To evaluate the cost-utility of the treatment arm demonstrating the most significant benefit (in terms of the primary outcome) in comparison with other widely accepted cancer and non-cancer therapies.
  • To assess associations between serum levels of beta-amyloid and measures of cognition and mood and depression.
  • An exploratory aim is to assess the relationship(s) between the American Urological Association Symptom Index (AUA SI) and urinary morbidity using the CTCAE v. 3.0 grading system.

OUTLINE: Patients are stratified according to seminal vesicle involvement (yes vs no), prostatectomy Gleason score (≤ 7 vs 8-9), pre-radiotherapy PSA (≥ 0.1 and ≤ 1.0 ng/mL vs > 1.0 and < 2.0 ng/mL), and pathology stage (pT2 and margin negative vs all others). Patients are randomized to 1 of 3 treatment arms.

  • Arm I (prostate bed radiotherapy [PBRT] alone): Patients undergo PBRT once daily, 5 days a week, Monday through Friday, for approximately 7-8 weeks (36 to 39 fractions).
  • Arm II (PBRT and short-term androgen-deprivation [STAD]): Beginning 2 months before the start of PBRT, patients undergo STAD, using a combination of antiandrogen and luteinizing hormone-releasing hormone (LHRH) agonist therapy, for a total of 4-6 months. Patients receive antiandrogen therapy comprising either oral flutamide 3 times daily or oral bicalutamide once daily for at least 4 months (started within 1-14 days prior to the LHRH agonist and ending the last day of radiotherapy ± 14 days). Patients receive LHRH agonist injection beginning concurrently with or 2 weeks after the start of antiandrogen therapy. LHRH agonist injection consists of analogs approved by the FDA (or by Health Canada for Canadian institutions) (e.g., leuprolide, goserelin, buserelin, or triptorelin) and may be given in any possible combination (may be given as a single 4-month injection and one to two 1-month injection[s], two 3-month injections, or a 6-month injection), such that the total LHRH agonist treatment time is 4-6 months. Approximately 2 months after beginning of STAD, patients undergo PBRT as in arm I.
  • Arm III (Pelvic lymph node radiotherapy [PLNRT], PBRT, and STAD): Beginning 2 months before the start of radiotherapy, patients receive STAD therapy as in arm II. Approximately 2 months after beginning of STAD, patients undergo PBRT and PLNRT once daily, 5 days a week, Monday through Friday, for approximately 5 weeks (25 fractions) followed by PBRT only once daily, 5 days a week for approximately 2-3 weeks (11-14 fractions).

Patients complete the American Urological Association Symptom Index (AUA SI) questionnaire prior to protocol treatment, at week 6 of radiotherapy, and then periodically after completion of study therapy.

After completion of study therapy, patients are followed up every 3 months for 1 year, every 6 months for 4 years, and then annually thereafter.

Eligibility Criteria

DISEASE CHARACTERISTICS:

  • Adenocarcinoma of the prostate treated primarily with radical prostatectomy
  • Pathologically proven to be lymph node-negative by pelvic lymphadenectomy (N0) or lymph node status pathologically unknown (Nx [undissected pelvic lymph nodes because lymph node dissection is not required])
  • Any type of radical prostatectomy allowed, including retropubic, perineal, laparoscopic, or robotically assisted
  • Meets 1 of the following pathologic classifications:
  • T3 N0/Nx disease with or without positive prostatectomy margins
  • T2 N0/Nx disease with or without positive prostatectomy margins
  • N1 patients are ineligible, as are those with pelvic lymph node enlargement ≥ 1.5 cm in greatest dimension by CT scan or MRI of the pelvis, unless the enlarged lymph node is negative
  • Prostatectomy Gleason score of 9 or less
  • A post-radical prostatectomy entry PSA of ≥ 0.1 and ≤ 1.0 ng/mL at least 6 weeks after prostatectomy and within 30 days of registration
  • Serum total testosterone ≥ 40% of the lower limit of normal (patients who have had a unilateral orchiectomy are eligible as long as this requirement is met)
  • No distant metastases based on history/physical examination, CT scan or MRI of the abdomen and pelvis, and bone scan
  • No palpable prostatic fossa abnormality/mass suggestive of recurrence, unless shown by biopsy under ultrasound guidance not to contain cancer

PATIENT CHARACTERISTICS:

  • Zubrod performance status 0-1
  • Platelets ≥ 100,000/mm^3
  • Hemoglobin ≥ 10.0 g/dL (the use of transfusion or other intervention to achieve this is allowed)
  • Aspartate aminotransferase (AST) or alanine aminotransferase (ALT) < 2 x upper limit of normal
  • No prior invasive malignancy (except nonmelanoma skin cancer) or superficial bladder cancer unless disease free for a minimum of 5 years (e.g., carcinoma in situ of the oral cavity is permissible)
  • No severe, active co-morbidity, including any of the following:
  • History of inflammatory bowel disease
  • History of hepatitis B or C
  • Unstable angina and/or congestive heart failure requiring hospitalization within the past 6 months
  • Transmural myocardial infarction within the past 6 months
  • Acute bacterial or fungal infection requiring intravenous antibiotics at the time of registration
  • Chronic obstructive pulmonary disease exacerbation or other respiratory illness requiring hospitalization or precluding study therapy at the time of registration
  • Hepatic insufficiency resulting in clinical jaundice and/or coagulation defects
  • Acquired immune deficiency syndrome (AIDS) based upon current Centers for Disease Control (CDC) definition
  • HIV testing is not required for entry
  • No prior allergic reaction to the study drug(s) involved in this protocol

PRIOR CONCURRENT THERAPY:

  • See Disease Characteristics
  • More than 5 years since prior chemotherapy for any other disease site
  • No androgen-deprivation therapy started prior to prostatectomy for > 6 months duration
  • The use of finasteride or dutasteride (± tamsulosin) for longer periods prior to prostatectomy is acceptable
  • No androgen-deprivation therapy started after prostatectomy and prior to registration
  • The use of finasteride or dutasteride (± tamsulosin) after prostatectomy is not acceptable, it must be stopped within 3 months after prostatectomy
  • No neoadjuvant chemotherapy before or after prostatectomy
  • No prior cryosurgery or brachytherapy of the prostate (prostatectomy should be the primary treatment and not a salvage procedure)
  • No prior pelvic radiotherapy

Trial Contact Information

Trial Lead Organizations/Sponsors

Radiation Therapy Oncology Group

National Cancer Institute

Cancer and Leukemia Group B

NRG Oncology

Alan PollackPrincipal Investigator

Leonard G. GomellaStudy Chair

Joycelyn L. SpeightStudy Chair

Trial Sites

U.S.A.
Alabama
  Birmingham
 Kirklin Clinic at Acton Road
 Michael C Dobelbower Ph: 205-934-0309
 UAB Comprehensive Cancer Center
 Michael C Dobelbower Ph: 205-934-0309
Alaska
  Fairbanks
 Fairbanks Cancer Treatment Center at Fairbanks Memorial Hospital
 Huong T. Pham Ph: 800-354-9527
Arizona
  Peoria
 Arizona Center for Cancer Care - Peoria
 Terry T Lee Ph: 623-773-2873
  Scottsdale
 Arizona Oncology Services Foundation
 David G. Brachman Ph: 800-360-6371
  Tucson
 Arizona Oncology - Tucson
 Vivek S Kavadi Ph: 281-277-5200
Arkansas
  Hot Springs
 St. Joseph's Mercy Cancer Center
 David E. Pruitt Ph: 501-686-8274
California
  Auburn
 Auburn Radiation Oncology
 Christopher Jones Ph: 916-454-6500
  Email: cancerinfo@sutterhealth.org
  Burlingame
 Peninsula Medical Center
 Ari D Baron Ph: 415-600-1182
  Email: SchmidtJ@cpmcri.org
  Cameron Park
 Radiation Oncology Centers - Cameron Park
 Christopher Jones Ph: 916-454-6500
  Email: cancerinfo@sutterhealth.org
  Chico
 Enloe Cancer Center at Enloe Medical Center
 Grace E Yuh Ph: 530-332-3808
  Duarte
 City of Hope Comprehensive Cancer Center
 Alan Pollack
  Email: Sylvester@emergingmed.com
  Fullerton
 Virginia K. Crosson Cancer Center at St. Jude Medical Center
 William Eyre Lawler Ph: 714-446-5642
  La Jolla
 Rebecca and John Moores UCSD Cancer Center
 Alan Pollack
  Email: Sylvester@emergingmed.com
  Los Angeles
 Samuel Oschin Comprehensive Cancer Institute at Cedars-Sinai Medical Center
 Howard Mark Sandler Ph: 310-423-8965
 USC/Norris Comprehensive Cancer Center and Hospital
 Leslie Ballas Ph: 323-865-0451
 Leslie Ballas Ph: 323-865-0451
  Modesto
 Memorial Medical Center
 Jorge A Garcia-Young Ph: 209-572-7116
  Oakland
 Alta Bates Summit Medical Center - Summit Campus
 James H. Feusner Ph: 510-450-7600
 Kaiser Permanente-Oakland
 Louis Fehrenbacher Ph: 626-564-3455
  Orange
 St. Joseph Hospital Regional Cancer Center - Orange
 Robert B Ash Ph: 714-734-6220
  Palo Alto
 Palo Alto Medical Foundation - Palo Alto
 Ari D Baron Ph: 888-823-5923
  Email: ctsucontact@westat.com
  Paradise
 Feather River Hospital Cancer Center
 Sam Mazj Ph: 530-876-7995
  Email: haleew@ah.org
  Pomona
 Robert and Beverly Lewis Family Cancer Care Center at Pomona Valley Hospital Medical Center
 Yallapragada S. Rao Ph: 909-865-9555
  Rancho Cardova
 Kaiser Permanente Medical Center - Rancho Cordova
 Louis Fehrenbacher Ph: 626-564-3455
  Rohnert Park
 Rohnert Park Cancer Center
 Louis Fehrenbacher Ph: 626-564-3455
  Roseville
 Radiation Oncology Center - Roseville
 Christopher Jones Ph: 916-454-6500
  Email: cancerinfo@sutterhealth.org
 The Permanente Medical Group-Roseville Radiation Oncology
 Louis Fehrenbacher Ph: 626-564-3455
  Sacramento
 South Sacramento Cancer Center
 Louis Fehrenbacher Ph: 626-564-3455
 Sutter Cancer Center
 Christopher Jones Ph: 916-454-6500
  Email: cancerinfo@sutterhealth.org
 University of California Davis Cancer Center
 Richard K. Valicenti Ph: 916-734-3089
  Saint Helena
 Saint Helena Hospital
 David J Tate Ph: 707-967-3698
  San Diego
 Rebecca and John Moores UCSD Cancer Center
 Loren K Mell Ph: 858-822-5354
  Email: cancercto@ucsd.edu
  San Francisco
 California Pacific Medical Center - California Campus
 Ari D Baron Ph: 415-600-1182
  Email: SchmidtJ@cpmcri.org
  Santa Clara
 Kaiser Permanente Medical Center - Santa Clara Homestead Campus
 Louis Fehrenbacher Ph: 626-564-3455
 Louis Fehrenbacher Ph: 626-564-3455
  South San Francisco
 Kaiser Permanente Cancer Treatment Center
 Louis Fehrenbacher Ph: 626-564-3455
  Stanford
 Stanford Cancer Center
 Mark K Buyyounouski Ph: 650-498-7061
  Email: ccto-office@stanford.edu
  Vacaville
 Solano Radiation Oncology Center
 Christopher Jones Ph: 916-454-6500
  Email: cancerinfo@sutterhealth.org
  Vallejo
 Sutter Solano Medical Center
 Ari D Baron Ph: 415-600-1182
  Email: SchmidtJ@cpmcri.org
Colorado
  Aurora
 Rocky Mountain Cancer Centers - Aurora
 Keren Sturtz Ph: 888-785-6789
 University of Colorado Cancer Center at UC Health Sciences Center
 Brian D Kavanagh Ph: 720-848-0650
  Boulder
 Boulder Community Hospital
 Keren Sturtz Ph: 888-785-6789
  Denver
 Porter Adventist Hospital
 Keren Sturtz Ph: 888-785-6789
  Englewood
 Swedish Medical Center
 Keren Sturtz Ph: 888-785-6789
  Greeley
 North Colorado Medical Center
 Keren Sturtz Ph: 888-785-6789
  Littleton
 Rocky Mountain Cancer Centers - Littleton
 Keren Sturtz Ph: 888-785-6789
  Longmont
 Hope Cancer Care Center at Longmont United Hospital
 Keren Sturtz Ph: 888-785-6789
  Loveland
 McKee Medical Center
 Keren Sturtz Ph: 888-785-6789
  Thornton
 Rocky Mountain Cancer Centers - Thornton
 Keren Sturtz Ph: 888-785-6789
  Wheat Ridge
 Exempla Lutheran Medical Center
 Keren Sturtz Ph: 888-785-6789
Connecticut
  Hartford
 Saint Francis/Mount Sinai Regional Cancer Center at Saint Francis Hospital and Medical Center
 Samir Narayan Ph: 734-712-4673
  Middletown
 Middlesex Hospital Cancer Center
 Joseph B. Weissberg Ph: 860-358-2058
  Email: beth_slifer@midhosp.org
  New Britain
 George Bray Cancer Center at the Hospital of Central Connecticut - New Britain Campus
 Neal B Goldberg Ph: 860-224-5660
Delaware
  Newark
 Helen F. Graham Cancer Center at Christiana Hospital
 Adam Raben Ph: 302-733-6227
 Adam Raben Ph: 302-733-6227
Florida
  Jacksonville
 Baptist Cancer Institute - Jacksonville
 Mark E Augspurger Ph: 904-202-7051
 University of Florida Health Science Center - Jacksonville
 R. Charles Nichols Ph: 877-686-6009
  Jascksonville
 Integrated Community Oncology Network - Baptist South
 Mark E Augspurger Ph: 904-202-7051
  Miami Beach
 CCOP - Mount Sinai Medical Center
 Michael Schwartz Ph: 305-674-2625
  Email: info@msccop.com
  Orange Park
 Integrated Community Oncology Network - Orange Park
 Mark E Augspurger Ph: 904-202-7051
  Palatka
 Cancer Specialists of North Florida-Putnam
 Mark E Augspurger Ph: 904-202-7051
  Saint Augustine
 Integrated Community Oncology Network at St. Augustine Cancer Center
 Mark E Augspurger Ph: 904-202-7051
  Tampa
 Veterans Affairs Medical Center - Tampa
 Babu Zachariah Ph: 800-456-7121
  Email: canceranswers@moffitt.org
Georgia
  Atlanta
 Emory University Hospital Midtown
 Alan Pollack
  Email: Sylvester@emergingmed.com
 Northside Hospital Cancer Center
 Sahar E Rosenbaum Ph: 404-303-3355
 Piedmont Hospital
 Adam W Nowlan Ph: 404-425-7943
  Email: ORS@piedmont.org
 Saint Joseph's Hospital of Atlanta
 Peter J Rossi Ph: 404-778-1868
 Winship Cancer Institute of Emory University
 Peter J Rossi Ph: 404-778-1868
  Columbus
 John B. Amos Cancer Center
 Douglas F. Ciuba Ph: 706-660-6404
  Cumming
 Northside Hospital-Forsyth
 Sahar E Rosenbaum Ph: 404-303-3355
  Gainesville
 Northeast Georgia Medical Center
 Frank G. Lake Ph: 770-219-8800
  Email: cancerpatient.navigator@nghs.com
  Savannah
 Nancy N. and J. C. Lewis Cancer and Research Pavilion at St. Joseph's/Candler
 John A Pablo Ph: 800-622-6877
Hawaii
  Ewa Beach
 Leeward Radiation Oncology
 Paul A. DeMare Ph: 808-545-8548
  Honolulu
 Queen's Cancer Institute at Queen's Medical Center
 Paul A. DeMare Ph: 808-545-8548
Idaho
  Boise
 Saint Alphonsus Cancer Care Center at Saint Alphonsus Regional Medical Center
 Samir Narayan Ph: 734-712-4673
  Post Falls
 Kootenai Cancer Center - Post Falls
 Benjamin Thomas Marchello Ph: 800-648-6274
Illinois
  Chicago
 Creticos Cancer Center at Advocate Illinois Masonic Medical Center
 Santosh V Yajnik Ph: 773-296-5360
 John H. Stroger, Jr. Hospital of Cook County
 Thomas E. Lad Ph: 312-864-6000
 Rush Cancer Institute at Rush University Medical Center
 Dian Wang Ph: 312-942-5498
  Email: clinical_trials@rush.edu
 University of Chicago Cancer Research Center
 Stanley L Liauw Ph: 773-834-7424
 University of Illinois Cancer Center
 Matthew Koshy Ph: 312-355-3046
  Decatur
 Decatur Memorial Hospital Cancer Care Institute
 James L. Wade Ph: 217-876-4740
  Email: kcheek@dmhhs.org
  Effingham
 Crossroads Cancer Center
 James L. Wade Ph: 217-876-4740
  Email: kcheek@dmhhs.org
  Elk Grove Village
 Cancer Institute at Alexian Brothers
 Martin J. Boyer Ph: 847-952-7164
  Email: fredianc@alexian.net
  Harvey
 Ingalls Cancer Care Center at Ingalls Memorial Hospital
 Sulochana D Yalavarthi Ph: 708-915-4673
  Email: clinicaltrials@ingalls.org
  Hines
 Veterans Affairs Medical Center - Hines
 Nirmala Bhoopalam Ph: 708-202-8387
  Rockford
 Advanced Care and Treatment Medical Group, PC
 Harvey Eric Einhorn Ph: 779-696-9400
  Email: cancercare@swedishamerican.org
  Springfield
 Cancer Institute at St. John's Hospital
 Laurent Brard Ph: 217-545-7929
 Regional Cancer Center at Memorial Medical Center
 James L. Wade Ph: 217-876-4740
  Email: kcheek@dmhhs.org
Indiana
  Beech Grove
 St. Francis Hospital and Health Centers - Beech Grove Campus
 Howard M. Gross Ph: 765-983-3000
  Fort Wayne
 Parkview Regional Cancer Center at Parkview Health
 Brian K Chang Ph: 260-373-8888
  Email: parkviewresearch@parkview.com
 Radiation Oncology Associates Southwest
 Brian K Chang Ph: 260-373-8888
  Email: parkviewresearch@parkview.com
  Goshen
 Center for Cancer Care at Goshen General Hospital
 James A. Wheeler Ph: 574-535-2858
  Indianapolis
 Indiana University Melvin and Bren Simon Cancer Center
 Peter A. Johnstone Ph: 317-274-2552
 Methodist Cancer Center at Methodist Hospital
 Alexander M. Yeh Ph: 765-646-8358
  South Bend
 Memorial Hospital of South Bend
 David A. Hornback Ph: 800-284-7370
Iowa
  Des Moines
 John Stoddard Cancer Center at Iowa Methodist Medical Center
 Robert J Behrens Ph: 888-244-6061
  Email: sherrijr@iora.org
 Mercy Cancer Center at Mercy Medical Center - Des Moines
 Robert J Behrens Ph: 888-244-6061
  Email: sherrijr@iora.org
Kansas
  Lawrence
 Lawrence Memorial Hospital
 Shaker R. Dakhil Ph: 316-262-4467
  Wichita
 Via Christi Cancer Center at Via Christi Regional Medical Center
 Shaker R. Dakhil Ph: 316-262-4467
Kentucky
  Lexington
 University of Kentucky Chandler Medical Center
 William H St. Clair Ph: 859-257-3379
  Louisville
 Louisville Oncology at Norton Cancer Institute - Louisville
 Aaron C Spalding Ph: 502-629-2500
 Norton Suburban Hospital
 Aaron C Spalding Ph: 502-629-2500
  Owensboro
 Mitchell Memorial Cancer Center at Owensboro Medical Health System
 Samuel R Faught Ph: 270-688-3691
  Email: shawns@omhs.org
Louisiana
  Baton Rouge
 Mary Bird Perkins Cancer Center - Baton Rouge
 Augusto C Ochoa Ph: 504-568-2428
  Email: emede1@lsuhsc.edu
  New Orleans
 Ochsner Cancer Institute at Ochsner Clinic Foundation
 Troy G. Scroggins Ph: 888-562-4763
 Touro Infirmary
 Augusto C Ochoa Ph: 504-568-2428
  Email: emede1@lsuhsc.edu
 Tulane Cancer Center at Tulane University Hospital and Clinic
 William R. Robinson Ph: 504-988-6121
Maine
  Lewiston
 Central Maine Comprehensive Cancer Center at Central Maine Medical Center
 Michael W Brown Ph: 207-795-8250
  Email: benderli@cmhc.org
Maryland
  Annapolis
 DeCesaris Cancer Institute at Anne Arundel Medical Center
 Angel E. Torano Ph: 443-481-1320
  Email: kbodenhorn@aahs.org
  Baltimore
 Greater Baltimore Medical Center Cancer Center
 Robert K. Brookland Ph: 443-849-3706
 Greenebaum Cancer Center at University of Maryland Medical Center
 Young Kwok Ph: 800-888-8823
  Columbia
 Central Maryland Oncology Center
 Young Kwok Ph: 800-888-8823
  Easton
 Shore Regional Cancer Center at Memorial Hospital - Easton
 John Philip Mastandrea Ph: 410-820-6800ext108
  Email: srichter@shorehealth.org
  Glen Burnie
 Tate Cancer Center at Baltimore Washington Medical Center
 Young Kwok Ph: 800-888-8823
Massachusetts
  Boston
 Beth Israel Deaconess Medical Center
 William U. Shipley Ph: 877-726-5130
 Boston University Cancer Research Center
 Ariel E Hirsch Ph: 617-638-8265
 Dana-Farber/Brigham and Women's Cancer Center
 William U. Shipley Ph: 877-726-5130
 Massachusetts General Hospital
 William U. Shipley Ph: 877-726-5130
  Fall River
 Hudner Oncology Center at Saint Anne's Hospital - Fall River
 Michele Albert Ph: 508-674-5600ext2515
  Hyannis
 Davenport-Mugar Cancer Center at Cape Cod Hospital
 Daniel J Canaday Ph: 508-862-5799
  Lowell
 Lowell General Hospital
 William U. Shipley Ph: 877-726-5130
  Milford
 Dana-Farber/Brigham and Women's Cancer Center at Milford Regional Medical Center
 William U. Shipley Ph: 877-726-5130
  Plymouth
 Jordan Hospital Club Cancer Center
 James M Koomey Ph: 508-830-2390
  Email: cancerinfo@jordanhospital.org
  South Weymouth
 Dana-Farber/Brigham and Women's Cancer Center at South Shore
 William U. Shipley Ph: 877-726-5130
Michigan
  Adrian
 Hickman Cancer Center at Bixby Medical Center
 Rex B Mowat Ph: 517-265-0116
 Rex B Mowat Ph: 517-265-0116
  Ann Arbor
 Saint Joseph Mercy Cancer Center
 Samir Narayan Ph: 734-712-4673
 University of Michigan Comprehensive Cancer Center
 Alan Pollack
  Email: Sylvester@emergingmed.com
 Daniel A Hamstra Ph: 800-865-1125
  Clinton Township
 Henry Ford Macomb Hospital
 Eleanor M. Walker Ph: 313-916-1784
  Dearborn
 Oakwood Cancer Center at Oakwood Hospital and Medical Center
 Samir Narayan Ph: 734-712-4673
  Detroit
 Josephine Ford Cancer Center at Henry Ford Hospital
 Eleanor M. Walker Ph: 313-916-1784
 Van Elslander Cancer Center at St. John Hospital and Medical Center
 Samir Narayan Ph: 734-712-4673
 Wayne State University
 Jordan M Maier Ph: 313-576-9363
  Flint
 McLaren Cancer Institute
 Hesham E. Gayar Ph: 810-342-4071
  Kalamazoo
 West Michigan Cancer Center
 Raymond Sterling Lord Ph: 269-373-7458
  Lansing
 Sparrow Regional Cancer Center
 Samir Narayan Ph: 734-712-4673
  Lapeer
 Great Lakes Cancer Institute - Lapeer Campus
 Hesham E. Gayar Ph: 810-342-4071
  Mount Pleasant
 Norval K. Morey Cancer Center at Central Michigan Community Hospital
 Thomas P Boike Ph: 800-248-6777
  Owosso
 Great Lakes Cancer Institute - Owosso
 Hesham E. Gayar Ph: 810-342-4071
  Petoskey
 Northern Michigan Hospital
 Thomas P Boike Ph: 800-248-6777
  Pontiac
 St. Joseph Mercy Oakland
 Samir Narayan Ph: 734-712-4673
  Port Huron
 Mercy Regional Cancer Center at Mercy Hospital
 Samir Narayan Ph: 734-712-4673
  Royal Oak
 William Beaumont Hospital - Royal Oak Campus
 Daniel J Krauss Ph: 248-551-7695
  Saginaw
 Seton Cancer Institute at Saint Mary's - Saginaw
 Samir Narayan Ph: 734-712-4673
  Troy
 William Beaumont Hospital - Troy Campus
 Daniel J Krauss Ph: 248-551-7695
  Warren
 St. John Macomb Hospital
 Samir Narayan Ph: 734-712-4673
Minnesota
  Bemidji
 MeritCare Bemidji
 Preston D. Steen Ph: 701-234-6161
  Coon Rapids
 Mercy and Unity Cancer Center at Mercy Hospital
 Paul Sperduto Ph: 952-993-1517
  Email: MMCCOP@parknicollet.com
  Duluth
 St. Luke's Hospital Cancer Care Center
 Basem S Goueli Ph: 888-823-5923
  Email: ctsucontact@westat.com
  Edina
 Fairview Southdale Hospital
 Paul Sperduto Ph: 952-993-1517
  Email: MMCCOP@parknicollet.com
  Fridley
 Mercy and Unity Cancer Center at Unity Hospital
 Paul Sperduto Ph: 952-993-1517
  Email: MMCCOP@parknicollet.com
  Maplewood
 Minnesota Oncology - Maplewood
 Paul Sperduto Ph: 952-993-1517
  Email: MMCCOP@parknicollet.com
  Minneapolis
 Hennepin County Medical Center - Minneapolis
 Paul Sperduto Ph: 952-993-1517
  Email: MMCCOP@parknicollet.com
 Virginia Piper Cancer Institute at Abbott - Northwestern Hospital
 Paul Sperduto Ph: 952-993-1517
  Email: MMCCOP@parknicollet.com
  Robbinsdale
 Humphrey Cancer Center at North Memorial Outpatient Center
 Paul Sperduto Ph: 952-993-1517
  Email: MMCCOP@parknicollet.com
  Rochester
 Mayo Clinic Cancer Center
 Richard (Chunhee) Choo Ph: 507-538-7623
  Saint Louis Park
 CCOP - Metro-Minnesota
 Paul Sperduto Ph: 952-993-1517
  Email: MMCCOP@parknicollet.com
  Saint Paul
 Regions Hospital Cancer Care Center
 Paul Sperduto Ph: 952-993-1517
  Email: MMCCOP@parknicollet.com
 United Hospital
 Paul Sperduto Ph: 952-993-1517
  Email: MMCCOP@parknicollet.com
  Waconia
 Ridgeview Medical Center
 Paul Sperduto Ph: 952-993-1517
  Email: MMCCOP@parknicollet.com
Mississippi
  Jackson
 University of Mississippi Cancer Clinic
 Srinivasan Vijayakumar Ph: 601-815-6700
  Pascagoula
 Regional Cancer Center at Singing River Hospital
 James E. Clarkson Ph: 228-809-5292
Missouri
  Cape Girardeau
 Southeast Cancer Center
 Alan Philip Lyss Ph: 800-392-0936
  Columbia
 Ellis Fischel Cancer Center at University of Missouri - Columbia
 Akm Mosharraf Hossain Ph: 573-882-7440
  Saint Louis
 Barnes-Jewish West County Hospital
 Jeff M. Michalski Ph: 800-600-3606
  Email: info@siteman.wustl.edu
 Missouri Baptist Cancer Center
 Alan Philip Lyss Ph: 800-392-0936
 Siteman Cancer Center at Barnes-Jewish Hospital - Saint Louis
 Jeff M. Michalski Ph: 800-600-3606
  Email: info@siteman.wustl.edu
  Saint Peters
 Siteman Cancer Center at Barnes-Jewish St. Peters Hospital - St. Peters
 Jeff M. Michalski Ph: 800-600-3606
  Email: info@siteman.wustl.edu
  Springfield
 Hulston Cancer Center at Cox Medical Center South
 Jay W Carlson Ph: 800-821-7532
  Email: sherrijr@iora.org
 St. John's Regional Health Center
 Jay W Carlson Ph: 800-821-7532
  Email: sherrijr@iora.org
Montana
  Billings
 Billings Clinic Cancer Center - 801 N 29th Street
 Benjamin Thomas Marchello Ph: 800-648-6274
 CCOP - Montana Cancer Consortium
 Benjamin Thomas Marchello Ph: 800-648-6274
  Great Falls
 Benefis Sletten Cancer Institute
 Benjamin Thomas Marchello Ph: 800-648-6274
Nebraska
  Omaha
 Immanuel Medical Center
 Gamini S. Soori Ph: 402-280-4100
 Methodist Estabrook Cancer Center
 Tien-Shew W Huang Ph: 402-354-5144
 UNMC Eppley Cancer Center at the University of Nebraska Medical Center
 Andrew O Wahl Ph: 800-999-5465
Nevada
  Henderson
 Comprehensive Cancer Centers of Nevada - Henderson
 John Allan Ellerton Ph: 702-384-0013
  Las Vegas
 Comprehensive Cancer Centers of Nevada - Central Valley
 John Allan Ellerton Ph: 702-384-0013
 Comprehensive Cancer Centers of Nevada - Southwest
 John Allan Ellerton Ph: 702-384-0013
 Radiation Oncology Centers of Las Vegas - Downtown Location
 John Allan Ellerton Ph: 702-384-0013
New Hampshire
  Exeter
 Center for Cancer Care at Exeter Hospital
 Gary Miller Proulx Ph: 800-439-3837
  Keene
 Kingsbury Center for Cancer Care at Cheshire Medical Center
 Alan C. Hartford Ph: 800-639-6918
  Email: cancer.research.nurse@dartmouth.edu
  Lebanon
 Norris Cotton Cancer Center at Dartmouth-Hitchcock Medical Center
 Alan C. Hartford Ph: 800-639-6918
  Email: cancer.research.nurse@dartmouth.edu
New Jersey
  Basking Ridge
 Memorial Sloan-Kettering Cancer Center - Basking Ridge
 Michael J Zelefsky Ph: 212-639-7202
  Camden
 Cancer Institute of New Jersey at Cooper University Hospital - Camden
 Ashraf F Youssef Ph: 856-325-6757
  Egg Harbor Township
 AtlantiCare Surgery Center
 James C Wurzer Ph: 609-748-7200
  Mount Holly
 Virtua Fox Chase Health Cancer Program at Virtua Memorial Hospital Burlington County
 Lemuel S. Ariaratnam Ph: 888-847-8823
  New Brunswick
 Cancer Institute of New Jersey at UMDNJ - Robert Wood Johnson Medical School
 Molly Gabel Ph: 732-235-8675
 Saint Peter's University Hospital
 Gopal R Desai Ph: 732-745-8600ext6163
  Email: kcovert@saintpetersuh.com
  Pennington
 Capital Health Medical Center-Hopewell
 Shirnett Karean Williamson Ph: 800-255-3440
  Princeton
 University Medical Center at Princeton
 Joseph M Pepek Ph: 609-497-4475
  Somerville
 Somerset Medical Center
 Joel K Braver Ph: 908-685-2481
  Sparta
 Frederick R. and Betty M. Smith Cancer Treatment Center
 Adam P. Dicker Ph: 215-955-6084
  Voorhees
 Cancer Institute of New Jersey at Cooper - Voorhees
 Ashraf F Youssef Ph: 856-325-6757
New Mexico
  Albuquerque
 New Mexico Cancer Center
 Gregg E Franklin Ph: 505-243-4039
 University of New Mexico Cancer Center
 Benny J. Liem Ph: 505-272-6972
 Alan Pollack
  Email: Sylvester@emergingmed.com
  Las Cruces
 Memorial Medical Center
 Benny J. Liem Ph: 505-272-6972
New York
  Brooklyn
 New York Methodist Hospital
 Sameer Rafla-Demetrious Ph: 718-780-5240
  Buffalo
 Roswell Park Cancer Institute
 Michael R. Kuettel Ph: 877-275-7724
  Canandiaqua
 Sands Cancer Center
 Yuhchyau Chen Ph: 585-275-5830
  Commack
 Memorial Sloan-Kettering Cancer Center
 Michael J Zelefsky Ph: 212-639-7202
  New York
 Herbert Irving Comprehensive Cancer Center at Columbia University Medical Center
 Israel Deutsch Ph: 212-305-8615
 Memorial Sloan-Kettering Cancer Center
 Michael J Zelefsky Ph: 212-639-7202
 New York Weill Cornell Cancer Center at Cornell University
 Michael J Smith Ph: 212-746-1848
 St. Luke's - Roosevelt Hospital Center - St.Luke's Division
 Ronald D Ennis Ph: 212-523-4000
  Poughkeepsie
 Dyson Center for Cancer Care at Vassar Brothers Medical Center
 Edward M Farhangi Ph: 845-483-6483
 Hudson Valley Oncology Associates
 Adam P. Dicker Ph: 215-955-6084
  Rochester
 Daisy Marquis Jones Radiation Oncology Center at Highland Hospital of Rochester
 Yuhchyau Chen Ph: 585-275-5830
 James P. Wilmot Cancer Center at University of Rochester Medical Center
 Yuhchyau Chen Ph: 585-275-5830
 Lipson Cancer and Blood Center at Rochester General Hospital
 Meri Atanas Ph: 585-922-3536
  Email: tia.derosa@rochestergeneral.org
 University Radiation Oncology at Parkridge Hospital
 Yuhchyau Chen Ph: 585-275-5830
  Rockville Centre
 Memorial Sloan-Kettering Cancer Center - Rockville Centre
 Michael J Zelefsky Ph: 212-639-7202
  Sleepy Hollow
 Memorial Sloan-Kettering Cancer Center at Phelps Memorial Hospital Center
 Michael J Zelefsky Ph: 212-639-7202
  Syracuse
 SUNY Upstate Medical University Hospital
 Jeffrey A. Bogart Ph: 315-464-5476
North Carolina
  Asheboro
 Randolph Hospital
 Sandra E Mitchell Ph: 336-832-0821
  Asheville
 Mission Hospitals - Memorial Campus
 Christopher H Chay Ph: 828-213-4150
  Charlotte
 Blumenthal Cancer Center at Carolinas Medical Center
 Michael Haake Ph: 704-355-2884
 Presbyterian Cancer Center at Presbyterian Hospital
 Justin P Favaro Ph: 704-384-5369
  Matthews
 Southeast Radiation Oncology Group, PA at Matthews Radiation Oncology Center
 Justin P Favaro Ph: 704-384-5369
  Morehead City
 Coleman Radiation Oncology Center at Carter General Hospital
 Michael A Papagikos Ph: 910-251-1839
  New Bern
 CarolinaEast Cancer Care
 Michael A Papagikos Ph: 910-251-1839
  Pinehurst
 FirstHealth Moore Regional Community Hospital Comprehensive Cancer Center
 Stephen C King Ph: 910-715-2200
  Raleigh
 Rex Cancer Center at Rex Hospital
 Leroy G Hoffman Ph: 919-784-7209
  Supply
 South Atlantic Radiation Oncology, LLC
 Michael A Papagikos Ph: 910-251-1839
  Wilmington
 Coastal Carolina Radiation Oncology Center
 Michael A Papagikos Ph: 910-251-1839
  Winston-Salem
 Wake Forest University Comprehensive Cancer Center
 Bart Frizzell Ph: 336-713-6771
North Dakota
  Fargo
 Roger Maris Cancer Center at MeritCare Hospital
 Preston D. Steen Ph: 701-234-6161
 Preston D. Steen Ph: 701-234-6161
Ohio
  Akron
 Summa Center for Cancer Care at Akron City Hospital
 Charles A Kunos Ph: 330-375-6101
  Barberton
 Barberton Citizens Hospital
 Charles A Kunos Ph: 330-375-6101
  Canton
 Aultman Cancer Center at Aultman Hospital
 Laird E Olson Ph: 330-363-6891
  Cleveland
 Case Comprehensive Cancer Center
 Rodney J Ellis Ph: 800-641-2422
 Cleveland Clinic Cancer Center at Fairview Hospital
 Rahul D Tendulkar Ph: 866-223-8100
 Cleveland Clinic Taussig Cancer Center
 Rahul D Tendulkar Ph: 866-223-8100
  Columbus
 Arthur G. James Cancer Hospital and Richard J. Solove Research Institute at Ohio State University Comprehensive Cancer Center
 Alan Pollack
  Email: Sylvester@emergingmed.com
 Douglas David Martin Ph: 866-627-7616
  Email: osu@emergingmed.com
 Doctors Hospital at Ohio Health
 J. Philip Kuebler Ph: 800-446-5532
 Riverside Methodist Hospital Cancer Care
 J. Philip Kuebler Ph: 800-446-5532
  Elyria
 Mercy Cancer Center - Elyria
 Rodney J Ellis Ph: 800-641-2422
  Independence
 Cleveland Clinic Taussig Cancer Center
 Rahul D Tendulkar Ph: 866-223-8100
  Maumee
 Northwest Ohio Oncology Center
 Rex B Mowat Ph: 517-265-0116
  Mayfield Heights
 Hillcrest Cancer Center at Hillcrest Hospital
 Rahul D Tendulkar Ph: 866-223-8100
  Medina
 Summa Health Center at Lake Medina
 Charles A Kunos Ph: 330-375-6101
  Mentor
 Lake/University Ireland Cancer Center
 Rodney J Ellis Ph: 800-641-2422
  Middleburg Heights
 Southwest General Health Center
 Rodney J Ellis Ph: 800-641-2422
  Orange Village
 UHHS Chagrin Highlands Medical Center
 Rodney J Ellis Ph: 800-641-2422
  Oregon
 St. Charles Mercy Hospital
 Rex B Mowat Ph: 517-265-0116
  Portsmouth
 Southern Ohio Medical Center Cancer Center
 J. Philip Kuebler Ph: 800-446-5532
  Ravenna
 Robinson Radiation Oncology
 Mitchell Lee Fromm Ph: 330-344-6348
  Sandusky
 North Coast Cancer Care, Incorporated
 Rahul D Tendulkar Ph: 866-223-8100
 University Hospitals Ireland Cancer Center at Firelands Regional Medical Center
 Rodney J Ellis Ph: 800-641-2422
  Strongsville
 Cleveland Clinic Foundation - Strongsville
 Rahul D Tendulkar Ph: 866-223-8100
  Sylvania
 Flower Hospital Cancer Center
 Rex B Mowat Ph: 517-265-0116
  Toledo
 St. Anne Mercy Hospital
 Rex B Mowat Ph: 517-265-0116
 University of Toledo Medical Center
 Rex B Mowat Ph: 517-265-0116
  Westlake
 UHHS Westlake Medical Center
 Rodney J Ellis Ph: 800-641-2422
  Wooster
 Cleveland Clinic - Wooster
 Rahul D Tendulkar Ph: 866-223-8100
  Zanesville
 Genesis - Good Samaritan Hospital
 J. Philip Kuebler Ph: 800-446-5532
Oklahoma
  Oklahoma City
 Oklahoma University Cancer Institute
 Terence S. Herman Ph: 405-271-4272
  Email: julie-traylor@ouhsc.edu
Oregon
  Coos Bay
 Bay Area Hospital
 Leo Kusuda Ph: 541-269-8392
  Email: cherie.cox@bayareahospital.org
  Eugene
 Willamette Valley Cancer Center - Eugene
 Vivek S Kavadi Ph: 281-277-5200
  Grants Pass
 Three Rivers Community Hospital
 Gordon L. Metz Ph: 541-789-6176
  Gresham
 Legacy Mount Hood Medical Center
 Andrew Y Kee Ph: 507-538-7623
  Medford
 Dubs Cancer Center at Rogue Valley Medical Center
 Gordon L. Metz Ph: 541-789-6176
 Providence Cancer Center at PMCC
 Gordon L. Metz Ph: 541-789-6176
  Portland
 Legacy Good Samaritan Hospital & Comprehensive Cancer Center
 Andrew Y Kee Ph: 507-538-7623
Pennsylvania
  Abington
 Rosenfeld Cancer Center at Abington Memorial Hospital
 Wayne H Pinover Ph: 215-481-2402
  Bethlehem
 St. Luke's Cancer Network at St. Luke's Hospital
 Nimisha Deb Ph: 610-954-3582
  Email: infolink@slhn.org
  Danville
 Geisinger Cancer Institute at Geisinger Health
 Thomas J Gergel Ph: 570-271-5251
  Dunmore
 Northeast Radiation Oncology Center
 Adam P. Dicker Ph: 215-955-6084
  Furlong
 Fox Chase Cancer Center Buckingham
 Eric Horwitz Ph: 215-728-4790
  Gettysburg
 Adams Cancer Center
 Amit B. Shah Ph: 877-441-7957
  Hershey
 Penn State Hershey Cancer Institute at Milton S. Hershey Medical Center
 Justin J Juliano Ph: 717-531-3779
  Email: CTO@hmc.psu.edu
  Lancaster
 Lancaster General Hospital
 Jeffery S Eshleman Ph: 717-544-5511
  Langhorne
 St. Mary Regional Cancer Center
 Robert C. Reilly Ph: 215-710-4585
  Milford
 Upper Delaware Valley Cancer Center
 Adam P. Dicker Ph: 215-955-6084
  Philadelphia
 American College of Radiology Imaging Network
 Alan Pollack
  Email: Sylvester@emergingmed.com
 Fox Chase Cancer Center - Philadelphia
 Eric Horwitz Ph: 215-728-4790
 Kimmel Cancer Center at Thomas Jefferson University - Philadelphia
 Adam P. Dicker Ph: 215-955-6084
  Pittsburgh
 UPMC Cancer Center at Magee-Womens Hospital
 Ryan P. Smith Ph: 412-621-2334
  Reading
 St. Joseph Medical Center
 Leonard C Tuanquin Ph: 610-378-2336
  Email: danielward2@catholichealth.net
  West Reading
 McGlinn Family Regional Cancer Center at Reading Hospital and Medical Center
 Albert Yuen Ph: 610-988-9323
  York
 WellSpan Health
 Amit B. Shah Ph: 877-441-7957
South Carolina
  Anderson
 AnMed Cancer Center
 Patricia C Griffin Ph: 800-486-5941
 Patricia C Griffin Ph: 800-486-5941
  Charleston
 Hollings Cancer Center at Medical University of South Carolina
 David T Marshall Ph: 843-792-9321
 Roper St. Francis Cancer Center at Roper Hospital
 James Michael Orcutt Ph: 843-720-8386
  Email: elizabeth.strojny@roperstfrancis.com
  Greenville
 Cancer Centers of the Carolinas - Faris Road
 Jeffrey Kent Giguere Ph: 864-241-6251
 CCOP - Greenville
 Jeffrey Kent Giguere Ph: 864-241-6251
  Greer
 Cancer Centers of the Carolinas - Greer Radiation Oncology
 Jeffrey Kent Giguere Ph: 864-241-6251
 Gibbs Cancer Center-Pelham
 Patricia C Griffin Ph: 800-486-5941
  Hilton Head Island
 Hilton Head Radiation Oncology Center
 John A Pablo Ph: 800-622-6877
  Seneca
 Cancer Centers of the Carolinas - Seneca
 Jeffrey Kent Giguere Ph: 864-241-6251
  Spartanburg
 Cancer Centers of the Carolinas - Spartanburg
 Jeffrey Kent Giguere Ph: 864-241-6251
 Gibbs Regional Cancer Center at Spartanburg Regional Medical Center
 Patricia C Griffin Ph: 800-486-5941
South Dakota
  Rapid City
 Rapid City Regional Hospital
 Michael J Swartz Ph: 605-716-3982
  Email: research@rcrh.org
Texas
  Austin
 Texas Oncology, PA at South Austin Cancer Center
 Vivek S Kavadi Ph: 281-277-5200
  Bedford
 Texas Oncology, PA at Harris Center HEB
 Vivek S Kavadi Ph: 281-277-5200
  Dallas
 Simmons Comprehensive Cancer Center at University of Texas Southwestern Medical Center - Dallas
 David A. Pistenmaa Ph: 214-648-7097
  Denton
 Texas Oncology, PA at Texas Cancer Center - Denton South
 Vivek S Kavadi Ph: 281-277-5200
  Fort Worth
 Klabzuba Cancer Center at Harris Methodist Fort Worth Hospital
 Vivek S Kavadi Ph: 281-277-5200
  Houston
 Memorial Hermann Hospital - Memorial City
 Vivek S Kavadi Ph: 281-277-5200
  Longview
 Longview Cancer Center
 Vivek S Kavadi Ph: 281-277-5200
  Round Rock
 Texas Oncology, PA - Seton Williamson
 Vivek S Kavadi Ph: 281-277-5200
  Sherman
 Texas Oncology, PA at Texas Cancer Center - Sherman
 Vivek S Kavadi Ph: 281-277-5200
  Sugar Land
 Texas Oncology, PA at Texas Oncology Cancer Center Sugar Land
 Vivek S Kavadi Ph: 281-277-5200
  Tyler
 Tyler Cancer Center
 Vivek S Kavadi Ph: 281-277-5200
Utah
  Logan
 Logan Regional Hospital
 R. Jeffrey Lee Ph: 801-507-3950
  Murray
 Jon and Karen Huntsman Cancer Center at Intermountain Medical Center
 R. Jeffrey Lee Ph: 801-507-3950
  Ogden
 Val and Ann Browning Cancer Center at McKay-Dee Hospital Center
 R. Jeffrey Lee Ph: 801-507-3950
  Provo
 Utah Valley Regional Medical Center - Provo
 R. Jeffrey Lee Ph: 801-507-3950
  Saint George
 Dixie Regional Medical Center - East Campus
 R. Jeffrey Lee Ph: 801-507-3950
  Salt Lake City
 Huntsman Cancer Institute at University of Utah
 Jonathan D Tward Ph: 801-581-4477
  Email: clinical.trials@hci.utah.edu
 LDS Hospital
 R. Jeffrey Lee Ph: 801-507-3950
 Utah Cancer Specialists at UCS Cancer Center
 R. Jeffrey Lee Ph: 801-507-3950
Vermont
  Berlin
 Mountainview Medical
 Harold James Wallace Ph: 802-656-8990
  Burlington
 Fletcher Allen Health Care - Medical Center Campus
 Harold James Wallace Ph: 802-656-8990
  Rutland
 Community Cancer Center at Rutland Regional Medical Center
 Richard D. Lovett Ph: 802-775-7111
  Saint Johnsbury
 Norris Cotton Cancer Center - North
 Alan C. Hartford Ph: 800-639-6918
  Email: cancer.research.nurse@dartmouth.edu
Virginia
  Alexandria
 INOVA Alexandria Hospital
 Matthew M Poggi Ph: 703-776-2580
  Email: research@inova.org
  Charlottesville
 Martha Jefferson Hospital Cancer Care Center
 Sylvia Sutton Hendrix Ph: 434-654-8400
  Hampton
 Sentara Cancer Institute at Sentara CarePlex Hospital
 Mark E Shaves Ph: 757-388-2406
  Norfolk
 Sentara Cancer Institute at Sentara Norfolk General Hospital
 Mark E Shaves Ph: 757-388-2406
  Portsmouth
 Naval Medical Center - Portsmouth
 Edward F Miles Ph: 757-953-5939
  Roanoke
 Blue Ridge Cancer Care - Roanoke
 Vivek S Kavadi Ph: 281-277-5200
  Virginia Beach
 Coastal Cancer Center at Sentara Virginia Beach General Hospital
 Mark E Shaves Ph: 757-388-2406
Washington
  Bremerton
 Harrison Medical Center
 Stephen C Springate Ph: 866-844-9355
  Federal Way
 St. Francis Hospital
 Yoshio Inoue Ph: 253-403-2394
  Kennewick
 Northwest Cancer Clinic
 Huong T. Pham Ph: 800-354-9527
  Mount Vernon
 Skagit Valley Hospital Cancer Care Center
 George E. Laramore Ph: 206-616-8289
  Seattle
 CCOP - Virginia Mason Research Center
 Huong T. Pham Ph: 800-354-9527
 Seattle Cancer Care Alliance
 George E. Laramore Ph: 206-616-8289
 University Cancer Center at University of Washington Medical Center
 George E. Laramore Ph: 206-616-8289
  Spokane
 Cancer Care Northwest - North
 Vivek S Kavadi Ph: 281-277-5200
 Cancer Care Northwest - Spokane South
 Vivek S Kavadi Ph: 281-277-5200
  Wenatchee
 Confluence Health - Wenatchee Valley Medical Center
 George E. Laramore Ph: 206-616-8289
  Yakima
 North Star Lodge Cancer Center at Yakima Valley Memorial Hospital
 Sean F. Cleary Ph: 877-902-3324
West Virginia
  Charleston
 West Virginia University Medical School - Charleston
 Steven J. Jubelirer Ph: 304-344-3457
Wisconsin
  Antigo
 Langlade Memorial Hospital
 Darryl R. Barton Ph: 877-405-6866
  Appleton
 Fox Valley Hematology and Oncology - East Grant Street
 Robert R Kohl Ph: 920-433-8889
 Fox Valley Surgical Associates at Appleton Medical Center
 Michael E Ray Ph: 920-380-1500
  Fond Du Lac
 Central Wisconsin Cancer Program at Agnesian HealthCare
 Timothy P Korytko Ph: 607-547-3073
  Email: diana.crean@bassett.org
  Green Bay
 Bellin Memorial Hospital
 Charlie C Pan Ph: 800-865-1125
 St. Mary's Hospital Medical Center - Green Bay
 James L Leenstra Ph: 920-433-8889
 St. Vincent Hospital Regional Cancer Center
 James L Leenstra Ph: 920-433-8889
  Johnson Creek
 UW Cancer Center Johnson Creek
 Mark A Ritter Ph: 877-405-6866
  La Crosse
 Franciscan Skemp Healthcare - La Crosse Campus
 David J Schwartz Ph: 608-392-9462
  Email: MMCCOP@parknicollet.com
 Gundersen Lutheran Center for Cancer and Blood
 Collin D Driscoll Ph: 608-775-2385
  Email: cancerctr@gundluth.org
  Madison
 University of Wisconsin Paul P. Carbone Comprehensive Cancer Center
 Mark A Ritter Ph: 877-405-6866
  Marinette
 Bay Area Cancer Care Center at Bay Area Medical Center
 James L Leenstra Ph: 920-433-8889
  Mequon
 Columbia Saint Mary's Hospital - Ozaukee
 Craig A Schulz Ph: 414-326-2675
  Email: clinicaltrials@columbia-stmarys.org
  Milwaukee
 Columbia-Saint Mary's Cancer Care Center
 Craig A Schulz Ph: 414-326-2675
  Email: clinicaltrials@columbia-stmarys.org
 Froedtert Hospital and Medical College of Wisconsin
 Colleen A. Lawton Ph: 414-805-4380
 Veterans Affairs Medical Center - Milwaukee
 Elizabeth M. Gore Ph: 414-805-4380
 Vince Lombardi Cancer Clinic at Aurora St. Luke's Medical Center
 Mitchell H. Pincus Ph: 800-252-2990
  Oconomowoc
 Regional Cancer Center at Oconomowoc Memorial Hospital
 Wingate F. Clapper Ph: 262-928-7632
  Racine
 All Saints Cancer Center at Wheaton Franciscan Healthcare
 James H. Taylor Ph: 414-874-4541
  Email: Kelli.holton@wfhc.org
  Sheboygan
 Vince Lombardi Cancer Clinic - Sheboygan
 Mitchell H. Pincus Ph: 800-252-2990
  Sturgeon Bay
 Door County Cancer Center at Door County Memorial Hospital
 James L Leenstra Ph: 920-433-8889
  Summit
 Aurora Medical Center
 Mitchell H. Pincus Ph: 800-252-2990
  Waukesha
 Waukesha Memorial Hospital Regional Cancer Center
 Wingate F. Clapper Ph: 262-928-7632
  Wausau
 University of Wisconcin Cancer Center at Aspirus Wausau Hospital
 Darryl R. Barton Ph: 877-405-6866
  West Allis
 Aurora Women's Pavilion of West Allis Memorial Hospital
 Mitchell H. Pincus Ph: 800-252-2990
  Wisconsin Rapids
 Riverview UW Cancer Center at Riverview Hospital
 Mark A Ritter Ph: 877-405-6866
Canada
Alberta
  Calgary
 Tom Baker Cancer Centre - Calgary
 Alexander G Balogh Ph: 403-521-3433
  Edmonton
 Cross Cancer Institute at University of Alberta
 Nawaid Usmani Ph: 780-432-8500
New Brunswick
  Saint John
 Saint John Regional Hospital
 Holly Campbell Ph: 506-648-6890
Ontario
  Hamilton
 Margaret and Charles Juravinski Cancer Centre
 Himanshu R Lukka Ph: 905-387-9495
  London
 London Regional Cancer Program at London Health Sciences Centre
 Tracy L Sexton Ph: 519-685-8600
Quebec
  Montreal
 Hopital Notre-Dame du CHUM
 Marie-Claude Beauchemin Ph: 514-890-8000ext23611
  Email: sylvie.beaudoin.chum@ssss.gouv.qc.ca
 Maisonneuve-Rosemont Hospital
 Nader Khaouam Ph: 514-252-3400ext3329
 McGill Cancer Centre at McGill University
 Marie Duclos Ph: 514-398-1444
  Email: penny.chipman@mcgill.ca
  Quebec City
 Centre Hospitalier Universitaire de Quebec
 Andre-Guy Martin Ph: 418-525-4444
Saskatchewan
  Regina
 Allan Blair Cancer Centre at Pasqua Hospital
 Evgeny Sadikov Ph: 306-766-2213
  Saskatoon
 Saskatoon Cancer Centre at the University of Saskatchewan
 Ali A El-Gayed Ph: 306-655-2914
Hong Kong
  Chai Wan
 Pamela Youde Nethersole Eastern Hospital
 Inda Sung Soong Ph: 888-823-5923
  Email: ctsucontact@westat.com
Israel
  Petach Tikva
 Rabin Medical Center - Beilinson Campus
 Aaron M Allen Ph: (866) 790-4500
  Tel Aviv
 Tel-Aviv Sourasky Medical Center
 Eliahu Gez Ph: 011-972-3-6974761
  Email: mop@tasmc.health.gov.il

Link to the current ClinicalTrials.gov record.
NLM Identifer NCT00567580
ClinicalTrials.gov processed this data on September 29, 2014

Note: Information about this trial is from the ClinicalTrials.gov database. The versions designated for health professionals and patients contain the same text. Minor changes may be made to the ClinicalTrials.gov record to standardize the names of study sponsors, sites, and contacts. Cancer.gov only lists sites that are recruiting patients for active trials, whereas ClinicalTrials.gov lists all sites for all trials. Questions and comments regarding the presented information should be directed to ClinicalTrials.gov.