Alternate Title
Basic Trial Information
Trial Description
     Purpose
     Eligibility
     Treatment/Intervention
Trial Contact Information
Related Information
Registry Information

Alternate Title

Phase II Study of Cisplatin and Flavopiridol in Patients With Advanced Ovarian Epithelial or Primary Peritoneal Cancer (Group 2 closed to accrual as of 3/10/06)

Basic Trial Information

Special Category: NCI Web site featured trial

Trial Description

Purpose:

Drugs used in chemotherapy, such as cisplatin and flavopiridol, work in different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells.

This phase II trial is studying how well giving cisplatin together with flavopiridol works in treating patients with advanced ovarian epithelial cancer or primary peritoneal cancer.

Eligibility:

Eligibility criteria include the following:

• At least 18 years old
• Measurable or evaluable disease
• No more than one previous chemotherapy regimen
• No CNS metastases
• More than 3 weeks since chemotherapy or radiation therapy
• For more information about the eligibility criteria for this trial, refer to the Health Professional version.

Final eligibility for a clinical trial is determined by the health professionals conducting the trial.

Treatment/Intervention:

Patients will receive an infusion of cisplatin and a 24-hour continuous infusion of flavopiridol. Treatment may be repeated every 3 weeks for as long as benefit is shown. Patients will be evaluated every 3 months for up to 3 years.

Important:

For more details about this trial, refer to the Health Professional version of the trial summary.

If you are interested in participating in a clinical trial, contact your doctor for a referral or call a trial contact person listed below. You may see the same contact person listed at more than one site, however, if you call the number listed you can ask to speak to the study coordinator or person involved with the specific trial you are interested in. If you have questions about cancer or clinical trials, call the Cancer Information Service at 1-800-4-CANCER (1-800-422-6237). General information about clinical trials, including risks, benefits, and costs, can be found on NCI's Web site.

Trial Contact Information

Trial Lead Organizations

Mayo Clinic Cancer Center

Keith Bible, MD, PhD, Protocol chair		Ph: 507-284-2511 Email: bible.keith@mayo.edu

Related Information

Featured trial article

Registry Information
Official Title		Phase II Trial Of Flavopiridol And Cisplatin In Advanced Epithelial Ovarian And Primary Peritoneal Carcinomas
Trial Start Date		2004-04-20
Trial Completion Date		2010-03-04 (estimated)
Registered in ClinicalTrials.gov		NCT00083122
Date Submitted to PDQ		2004-03-18
Information Last Verified		2009-07-05
NCI Grant/Contract Number		CM17104, CA15083

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