Alternate Title
Basic Trial Information
Objectives
Entry Criteria
Expected Enrollment
Outcomes
Outline
Trial Contact Information
Related Information
Registry Information

Alternate Title

Surgery With or Without Docetaxel and Leuprolide or Goserelin in Treating Patients With High-Risk Localized Prostate Cancer

Basic Trial Information

Special Category: CTSU trial, NCI Web site featured trial

Objectives

Primary

1. Compare the rate of 3-year biochemical progression-free survival (bPFS) in patients with high-risk, clinically localized prostate cancer treated with radical prostatectomy with vs without neoadjuvant chemohormonal therapy comprising docetaxel and androgen-deprivation therapy with leuprolide acetate or goserelin.

Secondary

1. Compare the 5-year bPFS rate, bPFS, disease progression, disease-free survival, and overall survival of patients treated with these regimens.
2. Determine the safety and tolerability of neoadjuvant docetaxel and androgen-deprivation therapy in these patients.
3. Compare the time to clinically apparent local disease recurrence and metastatic disease in patients treated with these regimens.
4. Compare pathologic tumor stage, frequency of lymph node metastases, and positive margin rates in patients treated with these regimens.
5. Determine if changes in serum testosterone levels will predict bPFS in these patients.
6. Determine, prospectively, whether prostate-specific antigen doubling time is a surrogate endpoint for time to clinical metastases and overall survival in these patients.

Entry Criteria

Disease Characteristics:

• Histologically confirmed adenocarcinoma of the prostate
  • No small cell, neuroendocrine, or transitional cell carcinoma

• Clinically localized, stage T1-3a disease

• No radiographic evidence of metastatic disease*, as demonstrated by all of the following:
  • No pelvic lymph nodes > 1.5 cm by CT scan or MRI of the abdomen and pelvis or endorectal MRI of the pelvis
    • A negative biopsy required for lymph node(s) that measure > 1.5 cm
      • If > 1 lymph node is > 1.5 cm, the largest or most accessible node is biopsied
  • Negative bone scan with plain films and/or MRI/CT scan confirmation, if necessary

   [Note: *Positive positron emission tomography scan and Prostascint scans are not considered proof of metastatic disease]

• Serum prostate-specific antigen level ≤ 100 ng/mL within the past 6 weeks

• Patients must have a known Gleason sum based on biopsy or TURP at study entry

• High-risk disease, meeting 1 of the following criteria:
  • Probability of biochemical progression-free survival at 5 years after surgery < 60% by Kattan nomogram prediction
  • Biopsy Gleason score 8 to 10

• Deemed an appropriate candidate for radical prostatectomy

Prior/Concurrent Therapy:

• No prior treatment for prostate cancer, including surgery, pelvic lymph node dissection, radiotherapy, or chemotherapy
  • Prior transurethral resection of prostate allowed
• Prior androgen-deprivation therapy (e.g., luteinizing hormone-releasing hormone agonists, antiandrogens, or both) lasting ≤ 4 months allowed
• Concurrent systemic anticoagulation allowed
• No other concurrent systemic therapy, including androgen-deprivation therapy for the treatment of the prostate cancer
• No concurrent oral antiandrogens
• No concurrent aprepitant
• No other concurrent chemotherapeutic agents except for any of the following:
  • Steroids given for adrenal failure
  • Hormones administered for nondisease-related conditions (e.g., insulin for diabetes)
  • Intermittent use of dexamethasone as an antiemetic or as pretreatment for patients receiving docetaxel

Patient Characteristics:

• ECOG performance status 0-2
• Life expectancy > 10 years
• Absolute neutrophil count ≥ 1,500/mm³
• Platelet count ≥ 150,000/mm³
• Creatinine ≤ 2.0 mg/dL
• Bilirubin normal (≤ 2.5 times upper limit of normal [ULN] for patients with Gilbert’s disease)
• AST and ALT ≤ 1.5 times ULN
• Fertile patients must use effective contraception during and for ≥ 2 months after completion of study treatment
• Not at high risk for cardiac complications
  • Prior deep venous thrombosis, pulmonary embolism, and/or cerebrovascular accident allowed

Expected Enrollment

A total of 750 patients will be accrued for this study.

Outcomes

3-year biochemical progression-free survival (bPFS) rate

5-year bPFS rate and bPFS
Time to clinical local recurrence
Time to metastatic disease progression
Unacceptable toxicity
Prostate cancer-specific-free survival
Disease progression
Overall survival
Death

Outline

This is a multicenter, randomized study. Patients are stratified according to nomogram-predicted biochemical progression-free survival at 5 years (0-20.9% vs 21-39.9% vs 40-59.9% vs ≥ 60%) and androgen-deprivation therapy in the past 3 months (no vs yes). Patients are randomized to 1 of 2 treatment arms.

• Arm I: Patients receive goserelin subcutaneously or leuprolide acetate intramuscularly once every 4 or 12 weeks for 18-24 weeks (measured from the date of starting docetaxel). They also receive docetaxel IV over 1 hour on day 1. Treatment with docetaxel repeats every 3 weeks for up to 6 courses. Within 60 days after completion of chemohormonal therapy, patients undergo radical prostatectomy with staging pelvic lymphadenectomy.

• Arm II: Within 60 days after randomization, patients undergo radical prostatectomy with staging pelvic lymphadenectomy.

After completion of study therapy, patients are followed at 1 and 3 months and then periodically for up to 15 years.

Trial Contact Information

Trial Lead Organizations

Cancer and Leukemia Group B

James Eastham, MD, Protocol chair		Ph: 646-422-4390; 800-525-2225

Eastern Cooperative Oncology Group

Martin Sanda, MD, Protocol chair		Ph: 617-667-2960

NCIC-Clinical Trials Group

Martin Gleave, MD, Protocol chair		Ph: 604-875-5003

U.S.A.
Alaska
	Anchorage
	Providence Cancer Center
		Clinical Trials Office - Providence Cancer Center	Ph:  907-261-3109
	Fairbanks
	Fairbanks Cancer Treatment Center at Fairbanks Memorial Hospital
		Craig Nichols, MD	Ph:  503-494-6346
Arkansas
	Little Rock
	Arkansas Cancer Research Center at University of Arkansas for Medical Sciences
		Clinical Trial Office - Arkansas Cancer Research Center at University of Arkansas for Medical Sciences	Ph:  501-686-8274
California
	Berkeley
	Alta Bates Summit Comprehensive Cancer Center
		Clinical Trials Office - Alta Bates Summit Comprehensive Cancer Center	Ph:  510-204-3428
	Burlingame
	Peninsula Medical Center
		David Irwin, MD	Ph:  510-204-1591
	La Jolla
	Rebecca and John Moores UCSD Cancer Center
		Clinical Trials Office - Rebecca and John Moores UCSD Cancer Center	Ph:  858-822-5354
			Email: cancercto@ucsd.edu
	Los Angeles
	USC/Norris Comprehensive Cancer Center and Hospital
		Clinical Trials Office - USC/Norris Comprehensive Cancer Center and Hospital	Ph:  323-865-0451
	Novato
	Sutter Health - Western Division Cancer Research Group
		David Irwin, MD	Ph:  510-204-1591
	Sacramento
	University of California Davis Cancer Center
		Clinical Trials Office - University of California Davis Cancer Center	Ph:  916-734-3089
	Saint Helena
	Saint Helena Hospital
		Gregory Smith	Ph:  707-963-3611
	San Diego
	Naval Medical Center - San Diego
		Preston Gable, MD, FACP	Ph:  619-532-7319
	San Francisco
	California Pacific Medical Center - California Campus
		David Irwin, MD	Ph:  510-204-1591
	Truckee
	Tahoe Forest Cancer Center
		Primo Lara, MD	Ph:  916-734-3771
	Vallejo
	Sutter Solano Medical Center
		David Irwin, MD	Ph:  510-204-1591
Connecticut
	Hartford
	Saint Francis/Mount Sinai Regional Cancer Center at Saint Francis Hospital and Medical Center
		Philip Stella, MD	Ph:  734-712-1000
	Norwich
	Eastern Connecticut Hematology and Oncology Associates
		Dennis Slater, MD	Ph:  860-886-8362
	West Haven
	Veterans Affairs Medical Center - West Haven
		Edward Uchio	Ph:  203-937-3421
Delaware
	Lewes
	Tunnell Cancer Center at Beebe Medical Center
		Clinical Trials Office - Tunnell Cancer Center	Ph:  302-645-3171
	Newark
	CCOP - Christiana Care Health Services
		Clinical Trial Office - CCOP - Christiana Care Health Services	Ph:  302-623-4450
Florida
	Fort Lauderdale
	Michael and Dianne Bienes Comprehensive Cancer Center at Holy Cross Hospital
		Clinical Trials Office - Michael and Dianne Bienes Comprehensive Cancer Center	Ph:  954-776-3239
	Jupiter
	Ella Milbank Foshay Cancer Center at Jupiter Medical Center
		Clinical Trials Office - Ella Milbank Foshay Cancer Center	Ph:  561-745-5768
	Miami Beach
	CCOP - Mount Sinai Medical Center
		Michael Schwartz, MD	Ph:  305-535-3310
	Orlando
	Florida Hospital Cancer Institute at Florida Hospital Orlando
		Clinical Trials Office - Florida Hospital Cancer Institute	Ph:  407-303-5623
	Tampa
	H. Lee Moffitt Cancer Center and Research Institute at University of South Florida
		Clinical Trials Office - H. Lee Moffitt Cancer Center and Reseach Institute	Ph:  800-456-7121
			Email: canceranswers@moffitt.org
	Weston
	Cleveland Clinic Florida - Weston
		Clinical Trials Office - Cleveland Clinic Florida - Weston	Ph:  954-659-5705
Hawaii
	Aiea
	Kapiolani Medical Center at Pali Momi
		Jeffrey Berenberg, MD	Ph:  808-433-4089
	Honolulu
	Cancer Research Center of Hawaii
		Clinical Trials Office - Cancer Research Center of Hawaii	Ph:  808-586-2979
	Hawaii Medical Center - East
		Jeffrey Berenberg, MD	Ph:  808-433-4089
	Kapiolani Medical Center for Women and Children
		Jeffrey Berenberg, MD	Ph:  808-433-4089
	OnCare Hawaii, Incorporated - Kuakini
		Jeffrey Berenberg, MD	Ph:  808-433-4089
	OnCare Hawaii, Incorporated - Lusitana
		Jeffrey Berenberg, MD	Ph:  808-433-4089
	Queen's Cancer Institute at Queen's Medical Center
		Jeffrey Berenberg, MD	Ph:  808-433-4089
	Straub Clinic and Hospital, Incorporated
		Jeffrey Berenberg, MD	Ph:  808-433-4089
	Kailua
	Castle Medical Center
		Jeffrey Berenberg, MD	Ph:  808-433-4089
	Lihue
	Kauai Medical Clinic
		Jeffrey Berenberg, MD	Ph:  808-433-4089
	Wailuku
	Maui Memorial Medical Center
		Jeffrey Berenberg, MD	Ph:  808-433-4089
	Pacific Cancer Institute - Maui
		Jeffrey Berenberg, MD	Ph:  808-433-4089
Idaho
	Boise
	Saint Alphonsus Cancer Care Center at Saint Alphonsus Regional Medical Center
		Clinical Trials Office - Saint Alphonsus Cancer Care Center	Ph:  208-367-7954
Illinois
	Chicago
	Louis A. Weiss Memorial Hospital
		Clinical Trials Office - Louis A. Weiss Memorial Hospital	Ph:  773- 564-5044
	University of Chicago Cancer Research Center
		Clinical Trials Office - University of Chicago Cancer Research Center	Ph:  773-834-7424
	Hines
	Veterans Affairs Medical Center - Hines
		Nirmala Bhoopalam, MD	Ph:  708-202-2782
	Maywood
	Cardinal Bernardin Cancer Center at Loyola University Medical Center
		Clinical Trials Office - Cardinal Bernardin Cancer Center	Ph:  708-226-4357
Indiana
	Elkhart
	Elkhart Clinic, LLC
		Rafat Ansari, MD, FACP	Ph:  574-234-5123
	Elkhart General Hospital
		Rafat Ansari, MD, FACP	Ph:  574-234-5123
	Michiana Hematology-Oncology, PC - Elkhart
		Rafat Ansari, MD, FACP	Ph:  574-234-5123
	Kokomo
	Howard Community Hospital
		Rafat Ansari, MD, FACP	Ph:  574-234-5123
	La Porte
	Center for Cancer Therapy at LaPorte Hospital and Health Services
		Rafat Ansari, MD, FACP	Ph:  574-234-5123
	Mishawaka
	Michiana Hematology-Oncology, PC - South Bend
		Rafat Ansari, MD, FACP	Ph:  574-234-5123
	Saint Joseph Regional Medical Center
		Rafat Ansari, MD, FACP	Ph:  574-234-5123
	Plymouth
	Michiana Hematology Oncology PC - Plymouth
		Rafat Ansari, MD, FACP	Ph:  574-234-5123
	South Bend
	CCOP - Northern Indiana CR Consortium
		Rafat Ansari, MD, FACP	Ph:  574-234-5123
	Memorial Hospital of South Bend
		Clinical Trials Office - Memorial Hospital of South Bend	Ph:  800-284-7370
	Michiana Hematology-Oncology, PC - South Bend
		Rafat Ansari, MD, FACP	Ph:  574-234-5123
	Westville
	Michiana Hematology Oncology PC - La Porte
		Rafat Ansari, MD, FACP	Ph:  574-234-5123
Iowa
	Bettendorf
	Hematology Oncology Associates of the Quad Cities
		Shobha Chitneni, MD, MBBS	Ph:  563-355-7733
	Davenport
	Genesis Regional Cancer Center at Genesis Medical Center
		George Kovach, MD	Ph:  563-421-1960
	Iowa City
	Holden Comprehensive Cancer Center at University of Iowa
		Cancer Information Service	Ph:  800-237-1225
Kansas
	Hays
	Hays Medical Center
		Peter VanVeldhuizen, MD	Ph:  816-861-4700ext.56775
	Hutchinson
	Hutchinson Hospital Corporation
		Peter VanVeldhuizen, MD	Ph:  816-861-4700ext.56775
	Kansas City
	Kansas Masonic Cancer Research Institute at the University of Kansas Medical Center
		Clinical Trials Office - Kansas Masonic Cancer Research Institute at the University of Kansas Medical Center	Ph:  913-588-4709
	Pittsburg
	Mount Carmel Regional Cancer Center
		Peter VanVeldhuizen, MD	Ph:  816-861-4700ext.56775
	Salina
	Tammy Walker Cancer Center at Salina Regional Health Center
		Peter VanVeldhuizen, MD	Ph:  816-861-4700ext.56775
	Topeka
	St. Francis Comprehensive Cancer Center
		Peter VanVeldhuizen, MD	Ph:  816-861-4700ext.56775
Louisiana
	Alexandria
	Tulane Cancer Center Office of Clinical Research
		Clinical Trials Office - Tulane Cancer Center	Ph:  504-988-6121
	Baton Rouge
	Mary Bird Perkins Cancer Center - Baton Rouge
		Robert Veith	Ph:  225-767-0847
	New Orleans
	MBCCOP - LSU Health Sciences Center
		Robert Veith	Ph:  504-568-5151
	Medical Center of Louisiana - New Orleans
		Robert Veith	Ph:  504-903-2311
Maine
	Scarborough
	Maine Center for Cancer Medicine and Blood Disorders - Scarborough
		Frederick Aronson, MD	Ph:  207-885-7600
Maryland
	Elkton MD
	Union Hospital of Cecil County
		Stephen Grubbs, MD	Ph:  302-366-1200
	Salisbury
	Peninsula Regional Medical Center
		Clinical Trials Office - Peninsula Regional Medical Center	Ph:  410-543-7000
Massachusetts
	Pittsfield
	Berkshire Hematology Oncology, PC
		Harvey Zimbler, MD	Ph:  413-496-8205
Michigan
	Ann Arbor
	CCOP - Michigan Cancer Research Consortium
		Philip Stella, MD	Ph:  734-712-1000
	Saint Joseph Mercy Cancer Center
		Philip Stella, MD	Ph:  734-712-1000
	Battle Creek
	Battle Creek Health System Cancer Care Center
		Martin Bury	Ph:  616-966-8000
	Big Rapids
	Mecosta County Medical Center
		Martin Bury	Ph:  231-796-8691
	Dearborn
	Oakwood Cancer Center at Oakwood Hospital and Medical Center
		Clinical Trials Office - Oakwood Cancer Center at Oakwood Hospital and Medical Center	Ph:  313-593-8090
	Detroit
	Josephine Ford Cancer Center at Henry Ford Hospital
		Robert Chapman, MD	Ph:  313-916-1332
	Flint
	Genesys Hurley Cancer Institute
		Clinical Trials Office - Genesys Hurley Cancer Institute	Ph:  810-762-8057
	Hurley Medical Center
		Clinical Trials Office - Hurley Medical Center	Ph:  810-762-8057
	Grand Rapids
	Butterworth Hospital at Spectrum Health
		Martin Bury	Ph:  616-391-2799
	CCOP - Grand Rapids
		Martin Bury	Ph:  616-391-1230
	Lacks Cancer Center at Saint Mary's Health Care
		Martin Bury	Ph:  616-752-5222
	Grosse Pointe Woods
	Van Elslander Cancer Center at St. John Hospital and Medical Center
		Clincial Trials Office - Van Elslander Cancer Center at St. John Hospital and Medical Center	Ph:  313-343-3166
	Jackson
	Foote Memorial Hospital
		Philip Stella, MD	Ph:  734-712-1000
	Lansing
	Sparrow Regional Cancer Center
		Clinical Trials Office - Sparrow Regional Cancer Center	Ph:  517-364-2890
	Livonia
	St. Mary Mercy Hospital
		Philip Stella, MD	Ph:  734-712-1000
	Muskegon
	Mercy General Health Partners
		Martin Bury	Ph:  231-672-2000
	Niles
	Michiana Hematology Oncology PC - Niles
		Rafat Ansari, MD, FACP	Ph:  574-234-5123
	Pontiac
	St. Joseph Mercy Oakland
		Philip Stella, MD	Ph:  734-712-1000
	Port Huron
	Mercy Regional Cancer Center at Mercy Hospital
		Philip Stella, MD	Ph:  734-712-1000
	Saginaw
	Seton Cancer Institute at Saint Mary's - Saginaw
		Clinical Trials Office - Seton Cancer Institute - Saginaw	Ph:  989-776-8411
	Saint Joseph
	Lakeside Cancer Specialists, PLLC
		Rafat Ansari, MD, FACP	Ph:  574-234-5123
	St. Joseph
	Lakeland Regional Cancer Care Center - St. Joseph
		Rafat Ansari, MD, FACP	Ph:  574-234-5123
	Traverse City
	Munson Medical Center
		Martin Bury	Ph:  231-935-6202
	Warren
	St. John Macomb Hospital
		Philip Stella, MD	Ph:  734-712-1000
Minnesota
	Alexandria
		Donald Jurgens
	Burnsville
	Fairview Ridges Hospital
		Patrick Flynn, MD	Ph:  612-863-8585
	Coon Rapids
	Mercy and Unity Cancer Center at Mercy Hospital
		Patrick Flynn, MD	Ph:  612-863-8585
	Edina
	Fairview Southdale Hospital
		Clinical Trials Office - Fairview Southdale Hospital	Ph:  612-625-3650
	Fridley
	Mercy and Unity Cancer Center at Unity Hospital
		Patrick Flynn, MD	Ph:  612-863-8585
	Hutchinson
	Hutchinson Area Health Care
		Patrick Flynn, MD	Ph:  612-863-8585
	Maplewood
	HealthEast Cancer Care at St. John's Hospital
		Patrick Flynn, MD	Ph:  612-863-8585
	Minnesota Oncology Hematology, PA - Maplewood
		Patrick Flynn, MD	Ph:  612-863-8585
	Minneapolis
	Hennepin County Medical Center - Minneapolis
		Clinical Trials Office - Hennepin County Medical Center - Minneapolis	Ph:  612-873-5911
	Masonic Cancer Center at University of Minnesota
		Clinical Trials Office - Masonic Cancer Center at University of Minnesota	Ph:  612-624-2620
	Virginia Piper Cancer Institute at Abbott - Northwestern Hospital
		Clinical Trials Office - Virginia Piper Cancer Institute	Ph:  612-863-5654
	Robbinsdale
	Humphrey Cancer Center at North Memorial Outpatient Center
		Clinical Trials Office - Humphrey Cancer Center at North Memorial Outpatient Center	Ph:  763-520-1893
	Saint Cloud
	CentraCare Clinic - River Campus
		Donald Jurgens	Ph:  320-252-5131
	Coborn Cancer Center
		Donald Jurgens	Ph:  320-229-4907 877-229-4907
	Saint Louis Park
	CCOP - Metro-Minnesota
		Patrick Flynn, MD	Ph:  612-863-8585
	Park Nicollet Cancer Center
		Patrick Flynn, MD	Ph:  612-863-8585
	Saint Paul
	United Hospital
		Patrick Flynn, MD	Ph:  612-863-8585
	Sartell
	Adult and Pediatric Urology, PLLP
		Donald Jurgens	Ph:  320-259-1411
	Shakopee
	St. Francis Cancer Center at St. Francis Medical Center
		Patrick Flynn, MD	Ph:  612-863-8585
	St. Paul
	Regions Hospital Cancer Care Center
		Clinical Trials Office - Regions Hospital Cancer Care Center	Ph:  651-254-1517
	Stillwater
	Lakeview Hospital
		Patrick Flynn, MD	Ph:  612-863-8585
	Waconia
	Ridgeview Medical Center
		Patrick Flynn, MD	Ph:  612-863-8585
	Willmar
	Willmar Cancer Center at Rice Memorial Hospital
		Patrick Flynn, MD	Ph:  612-863-8585
	Woodbury
	Minnesota Oncology Hematology, PA - Woodbury
		Patrick Flynn, MD	Ph:  612-863-8585
Mississippi
	Jackson
	University of Mississippi Cancer Clinic
		Charles Pound, MD	Ph:  601-984-5185
Missouri
	Kansas City
	Truman Medical Center - Hospital Hill
		Peter VanVeldhuizen, MD	Ph:  816-861-4700ext.56775
	Saint Louis
	Saint Louis University Cancer Center
		Clinical Trials Office - Saint Louis University Cancer Center	Ph:  314-977-4440
Montana
	Billings
	Billings Clinic - Downtown
		Clinical Trials Office - Billings Clinic - Downtown	Ph:  800-996-2663
			Email: research@billingsclinic.org
	CCOP - Montana Cancer Consortium
		Benjamin Marchello, MD	Ph:  406-238-6290
	Hematology-Oncology Centers of the Northern Rockies - Billings
		Benjamin Marchello, MD	Ph:  406-238-6290
	St. Vincent Healthcare Cancer Care Services
		Benjamin Marchello, MD	Ph:  406-238-6290
	Bozeman
	Bozeman Deaconess Cancer Center
		Benjamin Marchello, MD	Ph:  406-238-6290
	Butte
	St. James Healthcare Cancer Care
		Benjamin Marchello, MD	Ph:  406-238-6290
	Great Falls
	Big Sky Oncology
		Clinical Trial Office - Big Sky Oncology	Ph:  406-731-8217
	Great Falls Clinic - Main Facility
		Benjamin Marchello, MD	Ph:  406-238-6290
	Sletten Cancer Institute at Benefis Healthcare
		Grant Harrer, MD, FACP, CCTI	Ph:  406-731-8100
	Havre
	Northern Montana Hospital
		Benjamin Marchello, MD	Ph:  406-238-6290
	Helena
	St. Peter's Hospital
		Benjamin Marchello, MD	Ph:  406-238-6290
	Kalispell
	Glacier Oncology, PLLC
		Benjamin Marchello, MD	Ph:  406-238-6290
	Kalispell Medical Oncology at KRMC
		Benjamin Marchello, MD	Ph:  406-238-6290
	Kalispell Regional Medical Center
		Benjamin Marchello, MD	Ph:  406-238-6290
	Missoula
	Montana Cancer Center at St. Patrick Hospital and Health Sciences Center
		Clinical Trials Office - Montana Cancer Center at St. Patrick Hospital and Health Sciences Center	Ph:  406-329-7029
Nebraska
	Lincoln
	Cancer Resource Center - Lincoln
		Gamini Soori, MD, FACP, FRCP, MBA	Ph:  402-393-3110
	Omaha
	Alegant Health Cancer Center at Bergan Mercy Medical Center
		Clinical Trials Office - Alegant Health Cancer Center at Bergen Mercy Medical Center	Ph:  402-398-6060
	CCOP - Missouri Valley Cancer Consortium
		Gamini Soori, MD, FACP, FRCP, MBA	Ph:  402-393-3110
	Creighton University Medical Center
		Clinical Trials Office - Creighton University Medical Center	Ph:  402-280-4100
	Immanuel Medical Center
		Gamini Soori, MD, FACP, FRCP, MBA	Ph:  402-393-3110
	Methodist Estabrook Cancer Center
		Robert Langdon, MD	Ph:  402-399-8762
Nevada
	Las Vegas
	CCOP - Nevada Cancer Research Foundation
		John Ellerton, MD, CM	Ph:  702-384-0013
	University Medical Center of Southern Nevada
		John Ellerton, MD, CM	Ph:  702-384-0013
New Hampshire
	Concord
	New Hampshire Oncology - Hematology, PA at Payson Center for Cancer Care
		Douglas Weckstein, MD	Ph:  603-622-6484
	Exeter
	Center for Cancer Care at Exeter Hospital
		Michael Buff	Ph:  603-580-6636
	Hooksett
	New Hampshire Oncology - Hematology, PA - Hooksett
		Douglas Weckstein, MD	Ph:  603-622-6484
New Jersey
	Marlton
	Fox Chase Virtua Health Cancer Program at Virtua Memorial Hospital Marlton
		Clinical Trials Office - Fox Chase Virtua Health Cancer Program at Virtua Memorial Hospital Marlton	Ph:  888-847-8823
	Morristown
	Carol G. Simon Cancer Center at Morristown Memorial Hospital
		Stacey Leibowitz	Ph:  973-971-6100 800-247-9580
	Somerville
	Somerset Medical Center
		Clinical Trials Office - Somerset Medical Center	Ph:  908-685-2481
	Sparta
	Frederick R. and Betty M. Smith Cancer Treatment Center
		Edouard Trabulsi	Ph:  973-726-4180
	Summit
	Overlook Hospital
		Stacey Leibowitz	Ph:  908-522-2000
	Voorhees
	Cancer Institute of New Jersey at Cooper - Voorhees
		Clinical Trials Office - Cancer Institute of New Jersey at Cooper University Hospital - Voorhees	Ph:  856-325-6757
	Fox Chase Virtua Health Cancer Program at Virtua West Jersey
		Michael Entmacher, MD	Ph:  609-702-1900
New Mexico
	Albuquerque
	Hematology Oncology Associates, PC
		Richard Lauer	Ph:  505-938-5858
	Presbyterian Cancer Treatment Center at Presbyterian Kaseman Hospital
		Richard Lauer	Ph:  505-291-2462
	University of New Mexico Cancer Center
		Clinical Trials Office - University of New Mexico Cancer Center	Ph:  505-272-6972
New York
	Buffalo
	Roswell Park Cancer Institute
		Clinical Trials Office - Roswell Park Cancer Institute	Ph:  877-275-7724
	New York
	Memorial Sloan-Kettering Cancer Center
		James Eastham, MD	Ph:  646-422-4390
	New York Weill Cornell Cancer Center at Cornell University
		Clinical Trials Office - New York Weill Cornell Cancer Center at Cornell University	Ph:  212-746-1848
	Rochester
	James P. Wilmot Cancer Center at University of Rochester Medical Center
		Jonathan Friedberg	Ph:  585-275-5345
	Syracuse
	SUNY Upstate Medical University Hospital
		Clinical Trials Office - SUNY Upstate Medical University Hospital	Ph:  315-464-5476
	Veterans Affairs Medical Center - Syracuse
		Ajeet Gajra, MD	Ph:  315-425-4666
North Carolina
	Charlotte
	Blumenthal Cancer Center at Carolinas Medical Center
		Clinical Trials Office - Blumenthal Cancer Center at Carolinas Medical Center	Ph:  704-355-2884
	Presbyterian Cancer Center at Presbyterian Hospital
		Clinical Trials Office - Presbyterian Cancer Center at Presbyterian Hospital	Ph:  704-384-5369
	Durham
	Duke Cancer Institute
		Clinical Trials Office - Duke Cancer Institute	Ph:  888-275-3853
	Goldsboro
	Wayne Memorial Hospital, Incorporated
		James Atkins, MD	Ph:  919-580-0000
	Kinston
	Kinston Medical Specialists
		Peter Watson, MD	Ph:  252-559-2200ext.201
	Rutherfordton
	Rutherford Hospital
		Charles Bowers	Ph:  828-286-5000
	Statesville
	Iredell Memorial Hospital
		Ruby Grimm, MD	Ph:  704-873-2219
	Winston-Salem
	Forsyth Regional Cancer Center at Forsyth Medical Center
		Clinical Trials Office - Forsyth Regional Cancer Center at Forsyth Medical Center	Ph:  336-277-8887
	Wake Forest University Comprehensive Cancer Center
		Clinical Trials Office - Wake Forest University Comprehensive Cancer Center	Ph:  336-713-6771
Ohio
	Columbus
	Arthur G. James Cancer Hospital and Richard J. Solove Research Institute at Ohio State University Comprehensive Cancer Center
		Ohio State University Cancer Clinical Trial Matching Service	Ph:  866-627-7616
			Email: osu@emergingmed.com
	Lima
	St. Rita's Medical Center
		Clinical Trials Office - St. Rita's Medical Center	Ph:  419-226-9617
Oklahoma
	Oklahoma City
	Oklahoma University Cancer Institute
		Shubham Pant	Ph:  405-271-6822
Oregon
	Coos Bay
	Bay Area Hospital
		Bret Cook, MD	Ph:  541-267-5151
	Portland
	Kaiser Permanente Health Care - Portland
		Nagendra Tirumali, MD	Ph:  503-331-6500
Pennsylvania
	Darby
	Mercy Fitzgerald Hospital
		Clinical Trials Office - Mercy Fitzgerald Hospital	Ph:  610-237-4982
	Philadelphia
	Fox Chase Cancer Center - Philadelphia
		Clinical Trials Office - Fox Chase Cancer Center - Philadelphia	Ph:  215-728-4790
	Kimmel Cancer Center at Thomas Jefferson University - Philadelphia
		Clinical Trials Office - Kimmel Cancer Center at Thomas Jefferson University - Philadelphia	Ph:  215-955-6084
	Pittsburgh
	UPMC Cancer Centers
		Clinical Trials Office - UPMC Cancer Centers	Ph:  412-647-8073
South Carolina
	Anderson
	AnMed Cancer Center
		Clinical Trials Office - AnMed Cancer Center	Ph:  864-512-1000
	Charleston
	Roper St. Francis Cancer Center at Roper Hospital
		James Orcutt, MD	Ph:  843-577-2276
	Greenville
	Bon Secours St. Francis Health System
		Clinical Trails Office - Bon Secours St. Francis Health System	Ph:  864-255-1713
	CCOP - Greenville
		Jeffrey Giguere, MD, FACP	Ph:  864-987-7000
	Spartanburg
	CCOP - Upstate Carolina
		Clinical Trials Office - CCOP - Upstate Carolina	Ph:  800-486-5941
	Gibbs Regional Cancer Center at Spartanburg Regional Medical Center
		Clinical Trials Office - Gibbs Regional Cancer Center	Ph:  800-486-5941
Tennessee
	Kingsport
	Christine LaGuardia Phillips Cancer Center at Wellmont Holston Valley Medical Center
		Clinical Trials Office - Christine LaGuardia Phillips Cancer Center	Ph:  423-224-5593
Texas
	Austin
	Southwest Regional Cancer Center - Central
		Clinical Trials Office - Southwest Regional Cancer Center - Central	Ph:  512-421-4163
	Texas Oncology, PA - Austin North
		Beth Hellerstedt	Ph:  512-873-8900
	Texas Oncology, PA at South Austin Cancer Center
		Beth Hellerstedt	Ph:  512-447-2202
	Texas Oncology, PA at Texas Oncology Cancer Center - Central
		Beth Hellerstedt	Ph:  512-302-1771
	Cedar Park
	Texas Oncology, PA - Cedar Park
		Beth Hellerstedt	Ph:  512-260-6050
	Round Rock
	Texas Oncology, PA - Seton Williamson
		Beth Hellerstedt	Ph:  512-687-2300
	Texas Oncology, PA at Texas Cancer Center Round Rock
		Beth Hellerstedt	Ph:  512-341-8724
	San Marcos
	Texas Oncology, PA - San Marcos
		Beth Hellerstedt	Ph:  512-396-5199 888-340-9753
Vermont
	Berlin
	Mountainview Medical
		Steven Ades	Ph:  802-223-6196
	Burlington
	Fletcher Allen Health Care - University Health Center Campus
		Clinical Trials Office - Fletcher Allen Health Care	Ph:  802-656-8990
Virginia
	Lynchburg
	Lynchburg Hematology-Oncology Clinic
		John Leach MacNeill, MD	Ph:  434-947-5925
	Norton
	Southwest Virginia Regional Cancer Center at Wellmonth Health
		Asheesh Shipstone	Ph:  540-679-5874
Washington
	Centralia
	Providence Centralia Hospital
		Clinical Trials Office - Providence Centralia Hospital	Ph:  360-493-4300
	Federal Way
	St. Francis Hospital
		Lauren Colman, MD	Ph:  253-403-1677
	Kirkland
	Cascade Cancer Center at Evergreen Hospital Medical Center
		Craig Nichols, MD	Ph:  503-494-6346
	Olympia
	Providence St. Peter Hospital Regional Cancer Center
		Lauren Colman, MD	Ph:  253-403-1677
	Puyallup
	Good Samaritan Cancer Center
		Lauren Colman, MD	Ph:  253-403-1677
	Seattle
	CCOP - Virginia Mason Research Center
		Craig Nichols, MD	Ph:  503-494-6346
	Pacific Medical Center
		Craig Nichols, MD	Ph:  503-494-6346
	Virginia Mason Medical Center
		Craig Nichols, MD	Ph:  503-494-6346
	Spokane
	Rockwood Clinic Cancer Treatment Center
		Clinical Trials Office - Rockwood Clinic Cancer Treatment Center	Ph:  509-838-2531 ext. 6880
	Tacoma
	Allenmore Hospital
		Lauren Colman, MD	Ph:  253-403-1677
	CCOP - Northwest
		Lauren Colman, MD	Ph:  253-403-1677
	Franciscan Cancer Center at St. Joseph Medical Center
		Clinical Trials Office - Franciscan Cancer Center	Ph:  253-426-6914
	Madigan Army Medical Center - Tacoma
		Anthony Fadell	Ph:  206-968-1110
	MultiCare Regional Cancer Center at Tacoma General Hospital
		Clinical Trials Office - MultiCare Regional Cancer Center	Ph:  253-403-3229
	St. Clare Hospital
		Lauren Colman, MD	Ph:  253-403-1677
West Virginia
	Huntington
	Edwards Comprehensive Cancer Center at Cabell Huntington Hospital
		Oncology Research Supervisor	Ph:  304-399-6617
Wyoming
	Sheridan
	Welch Cancer Center at Sheridan Memorial Hospital
		Benjamin Marchello, MD	Ph:  406-238-6290
Canada
Alberta
	Calgary
	Tom Baker Cancer Centre - Calgary
		Joseph Ruether	Ph:  403-521-3723
British Columbia
	Vancouver
	University of British Columbia
		Martin Gleave, MD	Ph:  604-875-5003
Manitoba
	Winnipeg
	CancerCare Manitoba
		Darrel Drachenberg	Ph:  204-787-2241
Ontario
	London
	London Regional Cancer Program at London Health Sciences Centre
		Joseph Chin	Ph:  519-685-8615
	Toronto
	Princess Margaret Hospital
		Alexandre Zlotta	Ph:  416-946-2811
Quebec
	Montreal
	Hopital Notre-Dame du CHUM
		Fred Saad, MD, FRCS	Ph:  514-890-8000ext27466

Related Information

Featured trial article

Registry Information
Official Title		Randomized Phase III Study of Neo-Adjuvant Docetaxel and Androgen Deprivation Prior to Radical Prostatectomy Versus Immediate Radical Prostatectomy in Patients With High-Risk, Clinically Localized Prostate Cancer
Trial Start Date		2006-12-15
Trial Completion Date		2011-09-10 (estimated)
Registered in ClinicalTrials.gov		NCT00430183
Date Submitted to PDQ		2006-12-11
Information Last Verified		2012-02-08
NCI Grant/Contract Number		CA31946

Back to Top