Alternate Title
Basic Trial Information
Objectives
Entry Criteria
Expected Enrollment
Outcomes
Outline
Trial Contact Information
Related Information
Registry Information

Alternate Title

Paclitaxel, Cisplatin, and Radiation Therapy With or Without Cetuximab in Treating Patients With Locally Advanced Esophageal Cancer

Basic Trial Information

Special Category: NCI Web site featured trial, CTSU trial

Objectives

Primary

1. To evaluate whether the addition of cetuximab to chemotherapy comprising paclitaxel, cisplatin, and radiotherapy improves overall survival compared with paclitaxel, cisplatin, and radiotherapy alone in patients with esophageal cancer treated without surgery.

Secondary

1. To evaluate whether the addition of cetuximab to paclitaxel, cisplatin, and radiotherapy improves local control by increasing the clinical complete response and decreasing local recurrence in these patients.
2. To evaluate adverse events in these patients.
3. To evaluate endoscopic complete response rates in these patients.
4. To evaluate if the addition of cetuximab to paclitaxel, cisplatin, and radiotherapy improves the Esophageal Cancer Subscale score of the FACT-E quality of life tool.
5. To evaluate the quality-adjusted survival of each treatment arm using EQ-5D if the primary endpoint supports the primary hypothesis.

Entry Criteria

Disease Characteristics:

• Histologically confirmed primary squamous cell or adenocarcinoma* of the esophagus or gastroesophageal junction
  • Patients with involvement of the gastroesophageal junction with Siewert type I or II tumors (tumors arising from the distal esophagus and involving the esophagogastric junction or tumors starting at the esophagogastric junction and involving the cardia) are eligible
  • Patients with cervical esophageal carcinoma are eligible
  • Patients with celiac, perigastric, mediastinal, or supraclavicular adenopathy are eligible

   [Note: * The adenocarcinoma stratum is closed as of 5/3/2012.]

• Stage T1, N1, M0; T2-4, Any N, M0; or Any T, Any N, M1a disease based on history/physical examination, endoscopy with biopsy, AND PET/PET-CT scan or chest/abdominal CT scan within 6 weeks prior to registration

• Disease must be encompassed in a radiotherapy field

• No evidence of tracheoesophageal fistulas or invasion into the trachea or major bronchi
  • Patients with T3-4 proximal thoracic esophageal tumors (15-25 cm) must undergo bronchoscopy to exclude fistula

Prior/Concurrent Therapy:

• No prior systemic chemotherapy for esophageal cancer (prior chemotherapy for another cancer allowed)
• No prior therapy that specifically and directly targets the EGFR pathway
• No prior platinum-based and/or paclitaxel-based therapy
• No prior radiotherapy that would result in overlap of planned study radiotherapy fields
• No concurrent investigational agent
• No concurrent cytotoxic agent
• No other concurrent radiotherapy

Patient Characteristics:

• Zubrod performance status 0-2
• ANC ≥ 1,500/mm³
• Platelets ≥ 100,000 cells/mm³
• Hemoglobin ≥ 8.0 g/dL (transfusion or other intervention to achieve Hgb ≥ 8.0 g/dL allowed)
• Creatinine ≤ 1.5 mg/dL
• Bilirubin ≤ 1.5 times upper limit of normal (ULN)
• AST or ALT ≤ 3 times ULN
• Negative pregnancy test
• Not pregnant or nursing
• Fertile patients must use effective contraception
• Total intake (oral/enteral) must be ≥ 1,500 kCal/day
• No prior invasive malignancy except nonmelanomatous skin cancer (e.g., carcinoma in situ of the breast, oral cavity, or cervix) unless disease-free for ≥ 2 years
• No prior allergic reaction to the study drugs
• No prior severe infusion reaction to a monoclonal antibody
• No severe, active comorbidity, including any of the following:
  • Unstable angina and/or congestive heart failure requiring hospitalization within the past 3 months
  • Transmural myocardial infarction within the past 6 months
  • Acute bacterial or fungal infection requiring intravenous antibiotics
  • Chronic obstructive pulmonary disease exacerbation or other respiratory illness requiring hospitalization or precluding study therapy
  • Acquired immune deficiency syndrome based upon current CDC definition
    • HIV testing is not required for entry into this study

Expected Enrollment

Outcomes

Overall survival (failure: death due to any cause)

Local control (failure: residual cancer on post-treatment endoscopic biopsy or recurrent primary disease as defined in protocol)
Adverse events as assessed by NCI CTCAE v3.0
Endoscopic complete response rate
Health-related quality of life (FACT-E)
Quality-adjusted survival (using EQ-5D), if primary hypothesis is supported
Tissue handling/storage for future studies

Outline

This is a multicenter study. Patients are stratified according to histology (adenocarcinoma* vs squamous), cancer lesion size (< 5 cm vs ≥ 5 cm), and disease status of celiac nodes (present vs absent). Patients are randomized to 1 of 2 treatment arms.

 [Note: * The adenocarcinoma stratum is closed as of 5/3/2012.]

• Arm I: Patients receive cetuximab IV over 1-2 hours, paclitaxel IV over 1 hour, and cisplatin IV over 30-60 minutes on days 1, 8, 15, 22, 29, and 36. Patients also undergo radiotherapy once daily, 5 days a week, for 5½ weeks for a total dose of 50.4Gy.

• Arm II: Patients receive paclitaxel and cisplatin as in arm I. Patients also undergo radiotherapy as in arm I.

Patients undergo endoscopy 6 to 8 weeks after completion of chemoradiotherapy. Quality of life is assessed at baseline, within 1 week of post-treatment endoscopy, and at 1 and 2 years from beginning of study treatment.

After completion of study treatment, patients are followed periodically.

Trial Contact Information

Trial Lead Organizations

Radiation Therapy Oncology Group

Mohan Suntharalingam, MD, Protocol chair		Ph: 410-328-6080; 800-888-8823 Email: msuntha@umm.edu
David Ilson, MD, PhD, Protocol co-chair		Ph: 212-639-8306; 800-525-2225

U.S.A.
Alabama
	Mobile
	Providence Cancer Center at Providence Hospital
		Robert Gilbert	Ph:  251-633-1890
Arizona
	Tucson
	Arizona Oncology - Tucson
		Vivek Kavadi	Ph:  520-797-4468
California
	Auburn
	Auburn Radiation Oncology
		Christopher Jones, MD	Ph:  916-646-6600
	Cameron Park
	Radiation Oncology Centers - Cameron Park
		Christopher Jones, MD	Ph:  916-646-6600
	Carmichael
	Mercy Cancer Center at Mercy San Juan Medical Center
		Christopher Jones, MD	Ph:  916-646-6600
	Chico
	Enloe Cancer Center at Enloe Medical Center
		Clinical Trials Office - Enloe Cancer Center at Enloe Medical Center	Ph:  530-332-3808
	Fresno
	California Cancer Center - Woodward Park Office
		Brent Kane	Ph:  559-447-4050
	Saint Agnes Cancer Center at Saint Agnes Medical Center
		Clinical Trials Office - Saint Agnes Cancer Center	Ph:  559-450-7790
			Email: medresearch@samc.com
	Modesto
	Memorial Medical Center
		Clinical Trials Office - Memorial Medical Center	Ph:  209-572-7116
	Roseville
	Radiation Oncology Center - Roseville
		Christopher Jones, MD	Ph:  916-646-6600
	Sacramento
	Mercy General Hospital
		Christopher Jones, MD	Ph:  916-646-6600
	Radiological Associates of Sacramento Medical Group, Incorporated
		Christopher Jones, MD	Ph:  916-646-6600
	University of California Davis Cancer Center
		Clinical Trials Office - University of California Davis Cancer Center	Ph:  916-734-3089
	Stanford
	Stanford Cancer Center
		Clinical Trials Office - Stanford Cancer Center	Ph:  650-498-7061
			Email: cctoffice@stanford.edu
	Vacaville
	Solano Radiation Oncology Center
		Christopher Jones, MD	Ph:  916-646-6600
	Vallejo
	Sutter Solano Medical Center
		David Irwin, MD	Ph:  510-204-1591
Colorado
	Denver
	Porter Adventist Hospital
		Eduardo Pajon, MD	Ph:  303-399-8020ext2261
Connecticut
	New Britain
	George Bray Cancer Center at the Hospital of Central Connecticut - New Britain Campus
		Clinical Trials Office - George Bray Cancer Center	Ph:  860-224-5660
	Norwich
	William W. Backus Hospital
		Dennis Slater, MD	Ph:  860-886-8362
Delaware
	Newark
	CCOP - Christiana Care Health Services
		Clinical Trial Office - CCOP - Christiana Care Health Services	Ph:  302-623-4450
Florida
	Gainesville
	University of Florida Shands Cancer Center
		Clinical Trials Office - University of Florida Shands Cancer Center	Ph:  888-254-7581
	Jupiter
	Ella Milbank Foshay Cancer Center at Jupiter Medical Center
		Clinical Trials Office - Ella Milbank Foshay Cancer Center	Ph:  561-745-5768
	Lakeland
	Center for Cancer Care and Research at Watson Clinic, LLP
		Clinical Trials Office - Center for Cancer Care and Research	Ph:  863-680-7780
	Miami
	Baptist-South Miami Regional Cancer Program
		Andre Abitbol, MD	Ph:  786-596-6566
	Miami Beach
	CCOP - Mount Sinai Medical Center
		Michael Schwartz, MD	Ph:  305-535-3310
	Orlando
	M.D. Anderson Cancer Center at Orlando
		Omar Kayaleh, MD	Ph:  407-648-3800
Georgia
	Atlanta
	Winship Cancer Institute of Emory University
		Clinical Trials Office - Winship Cancer Institute	Ph:  404-778-1900
	Columbus
	John B. Amos Cancer Center
		Clinical Trials Office - John B. Amos Cancer Center	Ph:  706-660-6404
	Gainesville
	Northeast Georgia Medical Center
		Frank Lake, MD	Ph:  770-535-3393
	Savannah
	Nancy N. and J. C. Lewis Cancer and Research Pavilion at St. Joseph's/Candler
		John Pablo	Ph:  912-819-6000
Hawaii
	Honolulu
	Cancer Research Center of Hawaii
		Clinical Trials Office - Cancer Research Center of Hawaii	Ph:  808-586-2979
	Hawaii Medical Center - East
		Paul DeMare, MD, FACR	Ph:  808-547-4771
	Queen's Cancer Institute at Queen's Medical Center
		Paul DeMare, MD, FACR	Ph:  808-547-4771
Illinois
	Chicago
	John H. Stroger, Jr. Hospital of Cook County
		Thomas Lad, MD	Ph:  312-864-3200
	Robert H. Lurie Comprehensive Cancer Center at Northwestern University
		Clinical Trials Office - Robert H. Lurie Comprehensive Cancer Center at Northwestern University	Ph:  312-695-1301
			Email: cancer@northwestern.edu
	Rush University Medical Center
		Clinical Trials Office - Rush University Medical Center	Ph:  312-942-5498
			Email: clinical_trials@rush.edu
	University of Chicago Cancer Research Center
		Clinical Trials Office - University of Chicago Cancer Research Center	Ph:  773-834-7424
	Maywood
	Cardinal Bernardin Cancer Center at Loyola University Medical Center
		Clinical Trials Office - Cardinal Bernardin Cancer Center	Ph:  708-226-4357
	Moline
	Trinity Cancer Center at Trinity Medical Center - 7th Street Campus
		Costas Constantinou, MD	Ph:  563-359-9876
	Park Ridge
	Advocate Lutheran General Cancer Care Center
		Clinical Trials Office - Advocate Lutheran General Cancer Care Center	Ph:  847-384-3621
	Rockford
	Swedish-American Regional Cancer Center
		Clinical Trials Office - Swedish-American Regional Cancer Center	Ph:  815-489-4413
	Springfield
	Cancer Institute at St. John's Hospital
		Cathy Clausen, MD	Ph:  765-646-8358
Indiana
	Anderson
	Saint John's Cancer Center at Saint John's Medical Center
		Darrel Ross	Ph:  765-646-8459
	Bloomington
	Bloomington Hospital Regional Cancer Institute
		David Lee, MD	Ph:  812-353-2800
	Fort Wayne
	Parkview Regional Cancer Center at Parkview Health
		Brian Chang	Ph:  260-373-7850
	Radiation Oncology Associates Southwest
		Brian Chang	Ph:  260-436-4116
	Indianapolis
	Central Indiana Cancer Centers - East
		Vivek Kavadi	Ph:  317-964-5200
	Methodist Cancer Center at Methodist Hospital
		Alexander Yeh, MD	Ph:  317-962-3172
	St. Vincent Oncology Center
		Robert Liebross	Ph:  317-415-6789 888-415-6789
	Muncie
	Cancer Center at Ball Memorial Hospital
		Clinical Trials Office - Cancer Center at Ball Memorial Hospital	Ph:  765-281-2107
	South Bend
	Memorial Hospital of South Bend
		Clinical Trials Office - Memorial Hospital of South Bend	Ph:  800-284-7370
Iowa
	Ames
	McFarland Clinic, PC
		Clinical Trials Office - McFarland Clinic, PC	Ph:  515-239-2621
	Des Moines
	John Stoddard Cancer Center at Iowa Methodist Medical Center
		Clinical Trials Office - John Stoddard Cancer Center at Iowa Methodist Medical Center	Ph:  515-241-6727
	Mercy Cancer Center at Mercy Medical Center - Des Moines
		Robert Behrens	Ph:  515-643-8206 888-221-4849
	Mason City
	Mercy Cancer Center at Mercy Medical Center - North Iowa
		Clinical Trials Office - Mercy Cancer Center at Mercy Medical Center - North Iowa	Ph:  641-422-6304
	Sioux City
	Siouxland Hematology-Oncology Associates, LLP
		Donald Wender, MD, PhD	Ph:  712-252-0088
Kansas
	Topeka
	Cotton-O'Neil Cancer Center
		Clinical Trials Office - Cotton-O'Neil Cancer Center	Ph:  785-270-4963
Kentucky
	Louisville
	James Graham Brown Cancer Center at University of Louisville
		Shiao Woo	Ph:  502-562-4158 866-530-5516
Louisiana
	Baton Rouge
	Mary Bird Perkins Cancer Center - Baton Rouge
		Robert Veith	Ph:  225-767-0847
	New Orleans
	CCOP - Ochsner
		Troy Scroggins, MD	Ph:  504-842-3440
Maryland
	Baltimore
	Greater Baltimore Medical Center Cancer Center
		Clinical Trials Office - Greater Baltimore Medical Center Cancer Center	Ph:  443-849-3706
	Greenebaum Cancer Center at University of Maryland Medical Center
		Clinical Trials Office - Greenebaum Cancer Center at University of Maryladn Medical Center	Ph:  800-888-8823
Massachusetts
	Fall River
	Hudner Oncology Center at Saint Anne's Hospital - Fall River
		Clinical Trials Office - Hudner Oncology Center at Saint Anne's Hospital - Fall River	Ph:  508-674-5600 ext. 2019
Michigan
	Ann Arbor
	Saint Joseph Mercy Cancer Center
		Swati Dutta	Ph:  734-712-5658 888-474-4673
	Detroit
	Barbara Ann Karmanos Cancer Institute
		Clinical Trials Office - Barbara Ann Karmanos Cancer Institute	Ph:  313-576-9363
	Josephine Ford Cancer Center at Henry Ford Hospital
		Eleanor Walker, MD	Ph:  313-916-1021
	Flint
	Genesys Hurley Cancer Institute
		Clinical Trials Office - Genesys Hurley Cancer Institute	Ph:  810-762-8057
	Grand Rapids
	Lacks Cancer Center at Saint Mary's Health Care
		Gilbert Padula	Ph:  616-752-5222
	Grosse Pointe Woods
	Van Elslander Cancer Center at St. John Hospital and Medical Center
		Clincial Trials Office - Van Elslander Cancer Center at St. John Hospital and Medical Center	Ph:  313-343-3166
	Kalamazoo
	West Michigan Cancer Center
		Clinical Trials Office - West Michigan Cancer Center	Ph:  269-373-7458
	Port Huron
	Mercy Regional Cancer Center at Mercy Hospital
		Swati Dutta	Ph:  810-985-1484
	Saginaw
	Seton Cancer Institute at Saint Mary's - Saginaw
		Clinical Trials Office - Seton Cancer Institute - Saginaw	Ph:  989-776-8411
	Southfield
	Providence Cancer Institute at Providence Hospital - Southfield Campus
		Anibal Drelichman, MD, MPH, FACP	Ph:  313-552-0620
Minnesota
	Bemidji
	MeritCare Bemidji
		Preston Steen, MD	Ph:  701-234-2397
	Coon Rapids
	Mercy and Unity Cancer Center at Mercy Hospital
		Paul Sperduto, MD, MAPP	Ph:  952-442-6000
	Duluth
	Miller - Dwan Medical Center
		Daniel Nikcevich, MD, PhD	Ph:  218-786-3625
	Maplewood
	Minnesota Oncology - Maplewood
		Paul Sperduto, MD, MAPP	Ph:  952-442-6000
	Saint Paul
	United Hospital
		Paul Sperduto, MD, MAPP	Ph:  952-442-6000
	St. Paul
	Regions Hospital Cancer Care Center
		Clinical Trials Office - Regions Hospital Cancer Care Center	Ph:  651-254-1517
Mississippi
	Jackson
	University of Mississippi Cancer Clinic
		Richard Jennelle	Ph:  601-984-5590
Missouri
	Kansas City
	Kansas City Cancer Centers - North
		Vivek Kavadi	Ph:  816-746-4570
	Saint Louis
	David C. Pratt Cancer Center at St. John's Mercy
		Clinical Trials Office - David C. Pratt Cancer Center at St. John's Mercy	Ph:  314-251-6770
	Missouri Baptist Cancer Center
		Alan Lyss, MD	Ph:  314-996-5514
	Saint Louis University Cancer Center
		Clinical Trials Office - Saint Louis University Cancer Center	Ph:  314-977-4440
Montana
	Billings
	Billings Clinic - Downtown
		Clinical Trials Office - Billings Clinic - Downtown	Ph:  800-996-2663
			Email: research@billingsclinic.org
	Great Falls
	Sletten Cancer Institute at Benefis Healthcare
		Grant Harrer, MD, FACP, CCTI	Ph:  406-731-8100
Nebraska
	Omaha
	Lakeside Hospital
		Gamini Soori, MD, FACP, FRCP, MBA	Ph:  402-393-3110
	Methodist Estabrook Cancer Center
		Tien-Shew Huang	Ph:  402-354-5890 877-850-3212
Nevada
	Las Vegas
	CCOP - Nevada Cancer Research Foundation
		Raul Meoz	Ph:  702-384-0013
	Reno
	Renown Institute for Cancer at Renown Regional Medical Center
		Daniel Weed	Ph:  775-982-5050 866-559-0558
New Hampshire
	Concord
	Payson Center for Cancer Care at Concord Hospital
		Su Metcalfe	Ph:  603-225-2711 800-435-4464
	Dover
	Seacoast Cancer Center at Wentworth - Douglass Hospital
		Barbara Shea, MD	Ph:  603-740-2390
	Exeter
	Center for Cancer Care at Exeter Hospital
		Gary Proulx	Ph:  570-882-4048
	Keene
	Kingsbury Center for Cancer Care at Cheshire Medical Center
		Alan Hartford, MD, PhD	Ph:  603-650-6600
	Lebanon
	Norris Cotton Cancer Center at Dartmouth-Hitchcock Medical Center
		Clinical Trials Office - Norris Cotton Cancer Center	Ph:  603-650-7609
			Email: cancerhelp@dartmouth.edu
	Manchester
	Elliot Regional Cancer Center at Elliot Hospital
		Brian Knab	Ph:  603-663-4201
New Jersey
	Long Branch
	Monmouth Medical Center
		Clinical Trials Office - Monmouth Medical Center	Ph:  732-923-7689
	Marlton
	Fox Chase Virtua Health Cancer Program at Virtua Memorial Hospital Marlton
		Clinical Trials Office - Fox Chase Virtua Health Cancer Program at Virtua Memorial Hospital Marlton	Ph:  888-847-8823
	Sparta
	Frederick R. and Betty M. Smith Cancer Treatment Center
		Pramila Anne, MD	Ph:  215-955-6045
	Voorhees
	Cancer Institute of New Jersey at Cooper - Voorhees
		Clinical Trials Office - Cancer Institute of New Jersey at Cooper University Hospital - Voorhees	Ph:  856-325-6757
New Mexico
	Albuquerque
	University of New Mexico Cancer Center
		Clinical Trials Office - University of New Mexico Cancer Center	Ph:  505-272-6972
New York
	Albany
	New York Oncology Hematology, PC at Albany Regional Cancer Care
		Vivek Kavadi	Ph:  518-489-2607
	Binghamton
	Lourdes Regional Cancer Center
		Surjeet Pohar, MD	Ph:  757-388-2075
	Bronx
	Albert Einstein Cancer Center at Albert Einstein College of Medicine
		Clinical Trials Office - Albert Einstein Cancer Center at Albert Einstein College of Medicine	Ph:  718-904-2730
			Email: aecc@aecom.yu.edu
	Glens Falls
	Charles R. Wood Cancer Center at Glens Falls Hospital
		Clinical Trials Office - Charles R. Wood Cancer Center at Glens Falls Hospital	Ph:  518-926-6700
	New York
	Beth Israel Medical Center - Petrie Division
		Clinical Trials Office - Beth Israel Medical Center - Petrie Division	Ph:  212-844-6286
	Memorial Sloan-Kettering Cancer Center
		Karyn Goodman	Ph:  212-639-8895 800-525-2225
	St. Luke's - Roosevelt Hospital Center - St.Luke's Division
		Peter Kozuch, MD	Ph:  212-523-6769
	Sleepy Hollow
	Memorial Sloan-Kettering Cancer Center at Phelps Memorial Hospital Center
		Karyn Goodman	Ph:  914-366-3000
North Carolina
	Asheville
	Mission Hospitals - Memorial Campus
		Clinical Trials Office - Mission Hospitals - Memorial Campus	Ph:  828-213-4150
	Burlington
	Alamance Cancer Center at Alamance Regional Medical Center
		Janak Choksi, MD	Ph:  336-538-7737
	Charlotte
	Presbyterian Cancer Center at Presbyterian Hospital
		Clinical Trials Office - Presbyterian Cancer Center at Presbyterian Hospital	Ph:  704-384-5369
	Kinston
	Kinston Medical Specialists
		Peter Watson, MD	Ph:  252-559-2200ext.201
North Dakota
	Fargo
	CCOP - MeritCare Hospital
		Preston Steen, MD	Ph:  701-234-2397
	Minot
	Trinity CancerCare Center
		Kevin Collins, MD	Ph:  701-857-3535
Ohio
	Akron
	McDowell Cancer Center at Akron General Medical Center
		Mitchell Fromm, MD	Ph:  330-344-6448
	Summa Center for Cancer Care at Akron City Hospital
		Clinical Trials Office - Akron City Hospital	Ph:  330-375-6101
	Barberton
	Barberton Citizens Hospital
		William Demas, MD	Ph:  330-375-3557
	Canton
	Aultman Cancer Center at Aultman Hospital
		Clinical Trials Office - Aultman Cancer Center at Aultman Hospital	Ph:  330-363-6891
	Mercy Cancer Center at Mercy Medical Center
		Mitchell Haut, MD	Ph:  330-453-9993
	Cleveland
	Cleveland Clinic Cancer Center at Fairview Hospital
		Clinical Trials Office - Cleveland Clinic Cancer Center at Fairview Hospital	Ph:  216-476-9362
	Cleveland Clinic Taussig Cancer Center
		Clinical Trials Office - Cleveland Clinic Taussig Cancer Center	Ph:  866-223-8100
	MetroHealth Cancer Care Center at MetroHealth Medical Center
		Bruce Averbook, MD, FACS	Ph:  216-778-4795
	Mayfield Heights
	Hillcrest Cancer Center at Hillcrest Hospital
		David Adelstein	Ph:  440-312-4500
	Parma
	Parma Community General Hospital
		Clinical Trials Office - Parma Community General Hospital	Ph:  440-743-4747
	Ravenna
	Robinson Radiation Oncology
		Mitchell Fromm, MD	Ph:  330-344-6448
Oklahoma
	Oklahoma City
	Oklahoma University Cancer Institute
		Terence Herman	Ph:  405-271-6822
	Tulsa
	Natalie Warren Bryant Cancer Center at St. Francis Hospital
		Charles Stewart	Ph:  918-494-2273
Oregon
	Clackamas
	Clackamas Radiation Oncology Center
		Matthew Solhjem	Ph:  503-513-3300
	Eugene
	Willamette Valley Cancer Center - Eugene
		Vivek Kavadi	Ph:  541-683-5001
	Portland
	Providence Cancer Center at Providence Portland Medical Center
		Clinical Trials Office - Providence Cancer Center at Providence Portland Medical Center	Ph:  503-215-6412
	Providence St. Vincent Medical Center
		Clinical Trials Office - Providence St. Vincent Medical Center	Ph:  503-215-6412
Pennsylvania
	Beaver
	UPMC Cancer Center at Beaver Medical Center
		Michael Gibson	Ph:  724-773-7616
	Clairton
	UPMC Cancer Center at Jefferson Regional Medical Center
		Michael Gibson	Ph:  412-469-5500
	Danville
	Geisinger Cancer Institute at Geisinger Health
		Clinical Trials Office - Geisinger Cancer Institute	Ph:  570-271-5251
	Erie
	Regional Cancer Center - Erie
		Andrew Figura	Ph:  814-838-9000
	Gettysburg
	Adams Cancer Center
		Amit Shah	Ph:  717-741-8180
	Greensburg
	UPMC Cancer Center - Arnold Palmer Pavilion
		Michael Gibson	Ph:  724-838-1900 800-533-8762
	Philadelphia
	Albert Einstein Cancer Center
		Kenneth Zeitzer, MD	Ph:  215-456-6280
	Frankford Hospital Cancer Center - Torresdale Campus
		Pramila Anne, MD	Ph:  215-955-6045
	Pittsburgh
	Allegheny Cancer Center at Allegheny General Hospital
		David Parda	Ph:  412-359-8084
	UPMC - Shadyside
		Clinical Trials Office - UPMC - Shadyside	Ph:  412-621-2334
	UPMC Cancer Center at UPMC Passavant
		Clinical Trials Office - UPMC Cancer Center at UPMC Passavant	Ph:  412-367-6454
	UPMC Cancer Center at UPMC St. Margaret
		Michael Gibson	Ph:  412-781-3744
	Reading
	McGlinn Family Regional Cancer Center at Reading Hospital and Medical Center
		Clinical Trials Office - McGlinn Family Regional Cancer Center	Ph:  610-988-9323
	Seneca
	UPMC Cancer Center at UPMC Northwest
		Michael Gibson	Ph:  814-676-7900
	York
	York Cancer Center at Apple Hill Medical Center
		Amit Shah	Ph:  717-741-8180
Rhode Island
	Providence
	Rhode Island Hospital Comprehensive Cancer Center
		Clinical Trials Office - Rhode Island Hospital Comprehensive Cancer Center	Ph:  401-444-1488
South Carolina
	Charleston
	Hollings Cancer Center at Medical University of South Carolina
		Clinical Trials Office - Hollings Cancer Center at Medical University of South Carolina	Ph:  843-792-9321
	Greenville
	Cancer Centers of the Carolinas - Faris Road
		Jeffrey Giguere, MD, FACP	Ph:  864-987-7000
	CCOP - Greenville
		Jeffrey Giguere, MD, FACP	Ph:  864-987-7000
	Greer
	Cancer Centers of the Carolinas - Greer Radiation Oncology
		Jeffrey Giguere, MD, FACP	Ph:  864-987-7000
	Seneca
	Cancer Centers of the Carolinas - Seneca
		Jeffrey Giguere, MD, FACP	Ph:  864-987-7000
	Spartanburg
	Cancer Centers of the Carolinas - Spartanburg
		Jeffrey Giguere, MD, FACP	Ph:  864-987-7000
	CCOP - Upstate Carolina
		Clinical Trials Office - CCOP - Upstate Carolina	Ph:  800-486-5941
	Gibbs Regional Cancer Center at Spartanburg Regional Medical Center
		Clinical Trials Office - Gibbs Regional Cancer Center	Ph:  800-486-5941
South Dakota
	Rapid City
	Rapid City Regional Hospital
		Michael Swartz	Ph:  605-719-2360
	Sioux Falls
	Sanford Cancer Center at Sanford USD Medical Center
		Clinical Trials Office - Sanford Cancer Center	Ph:  605-328-1367
Tennessee
	Knoxville
	Thompson Cancer Survival Center
		Clinical Trials Office - Thompson Cancer Survival Center	Ph:  865-541-1812
Texas
	Amarillo
	Harrington Cancer Center
		Clinical Trials Officec - Harrington Cancer Center	Ph:  806-359-4673
			Email: ryokubaitis@harringtoncc.org
	Bedford
	Texas Oncology, PA at Harris Center HEB
		Vivek Kavadi	Ph:  817-359-9000
	Denton
	Texas Oncology, PA at Texas Cancer Center - Denton South
		Vivek Kavadi	Ph:  940-382-1022
	Fort Worth
	Klabzuba Cancer Center at Harris Methodist Fort Worth Hospital
		Vivek Kavadi	Ph:  817-820-4820
	Houston
	Memorial Hermann Hospital - Memorial City
		Vivek Kavadi	Ph:  713-242-3500
	Longview
	Longview Cancer Center
		Vivek Kavadi	Ph:  903-757-2122
	Lubbock
	Joe Arrington Cancer Research and Treatment Center
		Clinical Trials Office - Joe Arrington Cancer Research and Treatment Center	Ph:  806-725-8000
			Email: jaccresearch@covhs.org
	San Antonio
	Cancer Care Centers of South Texas - Northeast
		Vivek Kavadi	Ph:  210-656-7177
	Sherman
	Texas Oncology, PA at Texas Cancer Center - Sherman
		Vivek Kavadi	Ph:  903-892-9455
	Sugar Land
	Texas Oncology, PA at Texas Oncology Cancer Center Sugar Land
		Vivek Kavadi	Ph:  281-277-5200
	Tyler
	Tyler Cancer Center
		Vivek Kavadi	Ph:  903-579-9800
	Wichita Falls
	Texas Oncology, PA - Wichita Falls
		Vivek Kavadi	Ph:  940-767-4364
Utah
	Murray
	Jon and Karen Huntsman Cancer Center at Intermountain Medical Center
		R. Jeffrey Lee, MD	Ph:  801-408-1146
	Saint George
	Dixie Regional Medical Center - East Campus
		Clinical Trials Office - Dixie Regional Medical Center - East Campus	Ph:  435-688-4167
	Salt Lake City
	Utah Cancer Specialists at UCS Cancer Center
		R. Jeffrey Lee, MD	Ph:  801-408-1146
Virginia
	Danville
	Danville Regional Medical Center
		Clinical Trials Office - Danville Regional Medical Center	Ph:  434-799-3753
Washington
	Vancouver
	Northwest Cancer Specialists at Vancouver Cancer Center
		Matthew Solhjem	Ph:  360-944-9889
	Yakima
	North Star Lodge Cancer Center at Yakima Valley Memorial Hospital
		Clinical Trails Office - North Star Lodge Cancer Center	Ph:  509-574-3422
West Virginia
	Wheeling
	Schiffler Cancer Center at Wheeling Hospital
		Jon Pollock, MD	Ph:  304-243-3490
Wisconsin
	Green Bay
	St. Mary's Hospital Medical Center - Green Bay
		Gregory Cooley, MD	Ph:  414-433-8184
	St. Vincent Hospital Regional Cancer Center
		Clinical Trials Office - St. Vincent Hospital Regional Cancer Center	Ph:  920-433-8889
	La Crosse
	Gundersen Lutheran Center for Cancer and Blood
		Clinical Trials Office - Gundersen Lutheran Cancer Center	Ph:  608-775-2385
			Email: cancerctr@gundluth.org
	Marinette
	Bay Area Cancer Care Center at Bay Area Medical Center
		Gregory Cooley, MD	Ph:  414-433-8184
	Milwaukee
	Veterans Affairs Medical Center - Milwaukee
		Elizabeth Gore, MD	Ph:  414-805-4369
	Oconomowoc
	Regional Cancer Center at Oconomowoc Memorial Hospital
		Clinical Trials Office - Regional Cancer Center at Oconomowoc Memorial Hospital	Ph:  262-928-7878
	Sturgeon Bay
	Door County Cancer Center at Door County Memorial Hospital
		Gregory Cooley, MD	Ph:  414-433-8184
	Waukesha
	Waukesha Memorial Hospital Regional Cancer Center
		Clinical Trials Office - Waukesha Memorial Hospital Regional Cancer Center	Ph:  262-928-7632
	Wausau
	University of Wisconcin Cancer Center at Aspirus Wausau Hospital
		Clinical Trials Office - University of Wisconsin Cancer Center	Ph:  608-262-5223
Canada
New Brunswick
	Saint John
	Saint John Regional Hospital
		John Carson, MD	Ph:  506-648-6890
Ontario
	Toronto
	Princess Margaret Hospital
		Rebecca Wong	Ph:  416-946-2811

Related Information

Featured trial article

Registry Information
Official Title		A Phase III Trial Evaluating the Addition of Cetuximab to Paclitaxel, Cisplatin, and Radiation for Patients with Esophageal Cancer who are Treated without Surgery
Trial Start Date		2008-06-30
Trial Completion Date		2015-12-31 (estimated)
Registered in ClinicalTrials.gov		NCT00655876
Date Submitted to PDQ		2008-03-31
Information Last Verified		2012-05-25
NCI Grant/Contract Number		CA21661

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