Letrozole in Preventing Cancer in Postmenopausal Women Who Have Received 4-6 Years of Hormone Therapy for Hormone Receptor-Positive, Lymph Node-Positive, Early-Stage Breast Cancer
Trial Sites
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Basic Trial Information
Trial Description
Summary
Further Trial Information
Eligibility Criteria
Trial Contact Information
| Phase | Type | Status | Age | Sponsor | Protocol IDs |
|---|---|---|---|---|---|
| Phase III | Prevention | Active | Postmenopausal | Other | CDR0000574249 IBCSG 35-07, BIG 1-07 SOLE, 2007-001370-88, EUDRACT-2007-001370-88, EU-20772, NCT00553410 |
Summary
RATIONALE: Estrogen can cause the growth of breast cancer cells. Letrozole may fight breast cancer by lowering the amount of estrogen the body makes. It is not yet known which regimen of letrozole is more effective in postmenopausal women who have received hormone therapy for early-stage breast cancer.
PURPOSE: This randomized phase III trial is comparing two different regimens of letrozole in preventing cancer in postmenopausal women who have received 4-6 years of hormone therapy for hormone receptor-positive, lymph node-positive, early-stage breast cancer.
Further Study Information
OBJECTIVES:
Primary
- Compare the disease-free survival (DFS) of postmenopausal women treated with continuous letrozole for 5 years vs intermittent letrozole over a 5-year period.
Secondary
- Compare overall survival of patients treated with these two regimens.
- Compare distant DFS of these patients.
- Compare breast cancer-free interval of these patients.
- Compare sites of first DFS failure in these patients.
- Compare second (nonbreast) malignancies in these patients.
- Compare deaths without prior cancer events in these patients.
- Compare adverse events resulting from these two regimens.
OUTLINE: This is a multicenter study. Patients are stratified according to treatment center and type of prior endocrine therapy (selective estrogen receptor modulators [SERMs] alone vs aromatase inhibitors [AIs] alone vs both SERMs and AIs each for at least 1 month). Patients are randomized to 1 of 2 treatment arms.
- Arm I: Patients receive oral letrozole daily for 5 years.
- Arm II: Patients receive oral letrozole daily for the first 9 months of years 1 through 4, followed by 12 months in year 5.
After completion of study therapy, patients are followed annually.
Eligibility Criteria
DISEASE CHARACTERISTICS:
- Confirmed diagnosis of prior operable, noninflammatory breast cancer meeting the following criteria:
- Steroid hormone receptor-positive tumors (estrogen receptor and/or progesterone receptor), determined by immunohistochemistry, after primary surgery and before commencement of prior endocrine therapy
- Prior local treatment including surgery with or without radiotherapy for primary breast cancer with no known clinical residual loco-regional disease
- Following primary surgery, eligible patients must have had evidence of lymph node involvement either in the axillary or internal mammary nodes, but not supraclavicular nodes
- Clinically disease-free
- Must have completed 4-6 years of prior adjuvant selective estrogen receptor modulators (SERMs), aromatase inhibitors (AIs), or a sequential combination of both
- When calculating 4-6 years, neoadjuvant endocrine therapy should not be included
- No evidence of recurrent disease or distant metastatic disease
- No prior bilateral breast cancer
PATIENT CHARACTERISTICS:
- Female
- Must be postmenopausal by any of the following criteria:
- Patients of any age who have had a bilateral oophorectomy (including radiation castration AND amenorrheic for > 3 months)
- Patients 56 years old or older with any evidence of ovarian function must have biochemical evidence of definite postmenopausal status (defined as estradiol, luteinizing hormone [LH], and follicle-stimulating hormone [FSH] in the postmenopausal range)
- Patients 55 years old or younger must have biochemical evidence of definite postmenopausal status (defined as estradiol, LH, and FSH in the postmenopausal range)
- Patients who have received prior luteinizing-hormone releasing-hormone (LHRH) analogues within the last year are eligible if they have definite evidence of postmenopausal status as defined above
- Clinically adequate hepatic function
- No bone fracture due to osteoporosis at any time during the 4-6 years of prior therapy
- No prior or current malignancy except adequately treated basal cell or squamous cell carcinoma of the skin, in situ carcinoma of the cervix or bladder, or contra- or ipsilateral in situ breast carcinoma
- No other nonmalignant systemic diseases (cardiovascular, renal, lung, etc.) that would prevent prolonged follow-up
- No psychiatric, addictive, or any other disorder that compromises compliance with protocol requirements
PRIOR CONCURRENT THERAPY:
- See Disease Characteristics
- More than 12 months since prior and no other concurrent endocrine SERM/AI therapy
- Any type of prior adjuvant therapy allowed including, but not limited to, any of the following:
- Neoadjuvant chemotherapy
- Neoadjuvant endocrine therapy
- Adjuvant chemotherapy
- Trastuzumab (Herceptin®)
- Ovarian ablation
- Gonadotropin releasing hormone analogues
- Lapatinib ditosylate
- No concurrent hormone-replacement therapy, bisphosphonates (except for treatment of bone loss), or any other investigational agent
Trial Lead Organizations/Sponsors
International Breast Cancer Study Group
| Marco Colleoni |  | Study Chair |
Trial Sites
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| U.S.A. | |||
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| Massachusetts | |||
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| Boston | |||
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| Dana-Farber/Harvard Cancer Center at Dana-Farber Cancer Institute | |||
| Harold J. Burstein, MD, PhD | Ph: 617-632-2624 | ||
| Email: hburstein@partners.org | |||
| Faulkner Hospital | |||
| Harold J. Burstein, MD, PhD | Ph: 617-632-2624 | ||
| Australia | |||
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| Christchurch | |||
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| Christchurch Hospital | |||
| Contact Person | Ph: 61-2-4985-0166 | ||
| Perth | |||
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| Royal Perth Hospital | |||
| Contact Person | Ph: 61-2-4985-0166 | ||
| New South Wales | |||
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| Armidale | |||
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| Armidale Hospital | |||
| Contact Person | Ph: 61-2-4985-0166 | ||
| Bankstown | |||
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| Bankstown - Lidcombe Hospital | |||
| Contact Person | Ph: 61-2-4985-0166 | ||
| Bowral | |||
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| Southern Highlands Cancer Center | |||
| Contact Person | Ph: 61-2-4985-0166 | ||
| Concord | |||
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| Concord Repatriation General Hospital | |||
| Contact Person | Ph: 61-2-4985-0166 | ||
| Gateshead | |||
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| Breast Center | |||
| Contact Person | Ph: 61-2-4985-0166 | ||
| Port Macquarie | |||
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| Port Mcquarie Base Hospital | |||
| Contact Person | Ph: 61-2-4985-0166 | ||
| Randwick | |||
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| Prince of Wales Private Hospital | |||
| Contact Person | Ph: 61-2-4985-0166 | ||
| Tamworth | |||
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| Tamworth Base Hospital | |||
| Contact Person | Ph: 61-2-4985-0166 | ||
| Tweed Heads | |||
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| Tweed Heads Hospital | |||
| Contact Person | Ph: 61-2-4985-0166 | ||
| Waratah | |||
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| Newcastle Mater Misericordiae Hospital | |||
| Contact Person | Ph: 61-2-4985-0166 | ||
| Tasmania | |||
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| Burnie | |||
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| North West Regional Hospital | |||
| Contact Person | Ph: 61-2-4985-0166 | ||
| Hobart | |||
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| Royal Hobart Hospital | |||
| Contact Person | Ph: 61-2-4985-0166 | ||
| Victoria | |||
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| Box Hill | |||
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| Box Hill Hospital | |||
| Contact Person | Ph: 61-2-4985-0166 | ||
| East Melbourne | |||
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| Peter MacCallum Cancer Centre | |||
| Contact Person | Ph: 61-2-4985-0166 | ||
| East Ringwood | |||
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| Maroondah Hospital | |||
| Contact Person | Ph: 61-2-4985-0166 | ||
| Heidelberg | |||
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| Austin Health | |||
| Contact Person | Ph: 61-2-4985-0166 | ||
| Austria | |||
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| Feldkirch-Tisis | |||
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| Landeskrankenhaus Feldkirch | |||
| Contact Person | Ph: 43-1-408-9230 | ||
| Graz | |||
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| Landeskrankenhaus/Universitatskliniken Graz | |||
| Contact Person | Ph: 43-1-408-9230 | ||
| Innsbruck | |||
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| Innsbruck Universitaetsklinik | |||
| Contact Person | Ph: 43-1-408-9230 | ||
| Linz | |||
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| Allgemeines Krankenhaus Linz | |||
| Contact Person | Ph: 43-1-408-9230 | ||
| Linz Donau | |||
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| Krankenhaus BHS Linz | |||
| Contact Person | Ph: 43-1-408-9230 | ||
| Salzburg | |||
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| St. Johanns-Spital | |||
| Contact Person | Ph: 43-1-408-9230 | ||
| Vienna | |||
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| Allgemeines Krankenhaus - Universitatskliniken | |||
| Contact Person | Ph: 43-1-408-9230 | ||
| Contact Person | Ph: 43-1-408-9230 | ||
| Hanusch-Krankenhaus | |||
| Contact Person | Ph: 43-1-408-9230 | ||
| Krankenhaus Lainz | |||
| Contact Person | Ph: 43-1-408-9230 | ||
| Villach | |||
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| LKH Villach | |||
| Contact Person | Ph: 43-1-408-9230 | ||
| Wels | |||
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| Klinikum Kreuzschwestern Wels GmbH | |||
| Contact Person | Ph: 43-1-408-9230 | ||
| Belgium | |||
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| Antwerpen | |||
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| Ziekenhuis Netwerk Antwerpen Middelheim | |||
| Contact Person | Ph: 32-3-280-3111 | ||
| Arlon | |||
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| Cliniques du Sud Luxembourg | |||
| Contact Person | Ph: 32-63-23-1111 | ||
| Bonheiden | |||
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| Imelda vzw, Ziekenhuis | |||
| Contact Person | Ph: 32-15-505-011 | ||
| Brasschaat | |||
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| AZ Klina | |||
| Contact Person | Ph: 32-3-650- 5050 | ||
| Brussels | |||
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| Academisch Ziekenhuis der Vrije Universiteit Brussel | |||
| Contact Person | Ph: 32-02-477-6147 | ||
| Centre Hospitalier Universitaire Brugmann | |||
| Contact Person | Ph: 32-2-477-21-11 | ||
| Cliniques Universitaires Saint-Luc | |||
| Contact Person | Ph: 32-2-764-1111 | ||
| Institut Jules Bordet | |||
| Contact Person | Ph: 32-2-541-3082 | ||
| Duffel | |||
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| Algemeen Ziekenhuis Sint-Maarten - Campus Rooiberg | |||
| Contact Person | Ph: 32-15-30-3111 | ||
| Ghent | |||
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| Universitair Ziekenhuis Gent | |||
| Contact Person | Ph: 32-9-240-2111 | ||
| Haine Saint Paul | |||
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| Hopital de Jolimont | |||
| Contact Person | Ph: 32-6-423-4180 | ||
| Hasselt | |||
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| Virga Jesse Hospital | |||
| Contact Person | Ph: 32-11-309-960 | ||
| Huy | |||
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| Centre Hospitalier Hutois | |||
| Contact Person | Ph: 32-85-27-21-11 | ||
| Kortrijk | |||
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| AZ Groeninge - Oncologisch Centrum | |||
| Contact Person | Ph: 32-56-234-305 | ||
| Leuven | |||
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| U.Z. Gasthuisberg | |||
| Contact Person | Ph: 32-16-34-46-34 | ||
| Libramont | |||
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| Centre Hospitalier de l'Ardenne | |||
| Contact Person | Ph: 32-61-238-790 | ||
| Liege | |||
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| Centre Hospitalier Regional de la Citadelle | |||
| Contact Person | Ph: 32-4-225-6111 | ||
| CHU Liege - Domaine Universitaire du Sart Tilman | |||
| Contact Person | Ph: 32-43-667-111 | ||
| Clinique Saint-Joseph | |||
| Contact Person | Ph: 32-4-224-8990 | ||
| Merksem | |||
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| Jan Palfijn Hospital | |||
| Contact Person | Ph: 32-3-640-2020 | ||
| Oostende | |||
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| AZ Damiaan | |||
| Contact Person | Ph: 32-59-553-404 | ||
| Ottignies | |||
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| Clinique Saint-Pierre | |||
| Contact Person | Ph: 32-10-437-211 | ||
| Rocourt | |||
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| Clinique Saint Vincent | |||
| Contact Person | Ph: 32-4-239-4703 | ||
| Sint-Niklaas | |||
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| AZ Nikolaas - Sint-Niklaas | |||
| Contact Person | Ph: 32-3-760-2985 | ||
| Turnhout | |||
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| Sint-Elisabethziekenhuis | |||
| Contact Person | Ph: 32-14-40-69-02 | ||
| Verviers | |||
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| Centre Hospitalier Peltzer-La Tourelle | |||
| Contact Person | Ph: 32-87-212-171 | ||
| Chile | |||
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| Penalolen | |||
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| Hospital Santiago Oriente Dr. Luis Tisne Brousse | |||
| Contact Person | Ph: 56-2-235-7923 | ||
| Santiago | |||
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| Fundacion Arturo Lopez Perez | |||
| Contact Person | Ph: 56-2-235-7923 | ||
| Hospital Clinico San Borja Arriaran | |||
| Contract Person | Ph: 56-2-235-7923 | ||
| Instituto Nacional Del Cancer | |||
| Contact Person | Ph: 56-2-235-7923 | ||
| IRAM - Chile | |||
| Contact Person | Ph: 56-2-235-7923 | ||
| Valdivia | |||
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| Hospital Clinico Regional de Valdivia at University Austral de Chile | |||
| Contact Person | Ph: 56-2-235-7923 | ||
| Valparaiso | |||
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| Hospital Carlos Van Buren | |||
| Contact Person | Ph: 56-2-235-7923 | ||
| Denmark | |||
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| Aarhus C | |||
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| Aarhus Universitetshospital - Aarhus Sygehus | |||
| Contact Person | Ph: 45-89-49-44-44 | ||
| Copenhagen | |||
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| Copenhagen County Herlev University Hospital | |||
| Contact Person | Ph: 45-44-884-488 | ||
| Esbjerg | |||
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| Centralsygehus Esbjerg | |||
| Contact Person | Ph: 45-7918-2000 | ||
| Herning | |||
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| Herning Central Hospital | |||
| Contact Person | Ph: +45 44 88 44 88 | ||
| Hillerod | |||
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| Hillerod Hospital | |||
| Contact Person | Ph: 45-4-829-6100 | ||
| Naestved | |||
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| Naestved Hospital | |||
| Contact Person | Ph: 45-5651-2000 | ||
| Odense | |||
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| Odense University Hospital | |||
| Contact Person | Ph: 45-6611-3333 | ||
| Ronne | |||
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| Bornholms Hospital | |||
| Contact Person | Ph: 45-5695-1165 | ||
| Roskilde | |||
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| Roskilde Amtssygehuset | |||
| Contact Person | Ph: 45-4632-3200 | ||
| Sonderborg | |||
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| Sonderborg Sygehus | |||
| Contact Person | Ph: +45 44 88 44 88 | ||
| Vejle | |||
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| Vejle Sygehus | |||
| Contact Person | Ph: +45 44 88 44 88 | ||
| Viborg | |||
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| Viborg Sygehus | |||
| Contact Person | Ph: +45 44 88 44 88 | ||
| France | |||
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| Bordeaux | |||
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| Institut Bergonie | |||
| Contact Person | Ph: 33-5-5633-7817 | ||
| Germany | |||
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| Aalen | |||
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| Aalen Breast Center | |||
| Contact Person | Ph: 49-6102-7480-449 | ||
| Bielefeld | |||
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| Onkologische Schwerpunktpraxis Bielefeld | |||
| Contact Person | Ph: 49-6102-7480-449 | ||
| Celle | |||
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| Allgemeinen Krankenhaus Celle Kinderklinik | |||
| Contact Person | Ph: 49-6102-7480-449 | ||
| Deggendorf | |||
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| Klinikum Deggendorf | |||
| Contact Person | Ph: 49-6102-7480-449 | ||
| Fuerth | |||
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| Praxis Dr. Wilke - Onkologie am Klinikum Fuerth | |||
| Contact Person | Ph: 49-6102-7480-449 | ||
| Hannover | |||
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| Gynaekologisch-onkologische Praxis Hannover | |||
| Contact Person | Ph: 49-6102-7480-449 | ||
| Henriettenstiftung Krankenhaus | |||
| Contact Person | Ph: 49-6102-7480-449 | ||
| Vinzenzkrankenhaus Hannover gGmbH | |||
| Contact Person | Ph: 49-6102-7480-449 | ||
| Ilsede | |||
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| Frauenheilkunde u. Geburtshilfe | |||
| Contact Person | Ph: 49-6102-7480-449 | ||
| Lich | |||
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| Asklepios Klinik Lich | |||
| Contact Person | Ph: 49-6102-7480-449 | ||
| Mannheim | |||
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| Gemeinschaftspraxis Gynaekologie & Geburtshilfe | |||
| Contact Person | Ph: 49-6102-7480-449 | ||
| Meiningen | |||
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| Klinikum Meiningen GmbH | |||
| Contact Person | Ph: 49-6102-7480-449 | ||
| Memmingen | |||
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| Klinikum Memmingen | |||
| Contact Person | Ph: 49-6102-7480-449 | ||
| Offenbach | |||
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| Klinikum Offenback GmbH | |||
| Contact Person | Ph: 49-6102-7480-449 | ||
| Schwabisch Hall | |||
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| Deaconess Hospital | |||
| Contact Person | Ph: 49-6102-7480-449 | ||
| Stendal | |||
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| Johanniter Kankenhaus Stendal | |||
| Contact Person | Ph: 49-6102-7480-449 | ||
| Suhl | |||
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| SRH Zentralklinikum Suhl GmbH | |||
| Contact Person | Ph: 49-6102-7480-449 | ||
| Tuebingen | |||
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| Universitaetsklinikum Tuebingen | |||
| Contact Person | Ph: 49-6102-7480-449 | ||
| Hungary | |||
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| Budapest | |||
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| National Institute of Oncology - Budapest | |||
| Contact Person | Ph: 36-1-224-8763 | ||
| Szeged | |||
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| Szeged University | |||
| Contact Person | Ph: +36 1 22 48 763 | ||
| India | |||
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| Mumbai | |||
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| Tata Memorial Hospital | |||
| Contact Person | Ph: 91-22-2417-7144 | ||
| Italy | |||
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| Aviano | |||
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| Centro di Riferimento Oncologico - Aviano | |||
| Contact Person | Ph: 39-43-465-9653 | ||
| Biella | |||
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| Ospedale degli Infermi - ASL 12 | |||
| Contact Person | Ph: 39-015-35-031 | ||
| Bolzano | |||
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| Azienda Sanitaria di Bolzano | |||
| Contact Person | Ph: 39-471-908-572 | ||
| Brescia | |||
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| Spedali Civili di Brescia | |||
| Contact Person | Ph: 39-030-395-823 | ||
| Brindisi | |||
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| A. Perrino Hospital | |||
| Contact Person | Ph: 39-0831-537-508 | ||
| Cremona | |||
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| Azienda Istituti Ospitalieri | |||
| Contact Person | Ph: 372-405111 | ||
| Meldola | |||
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| Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori | |||
| Contact Person | Ph: +39 025 748 99 34 | ||
| Milan | |||
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| European Institute of Oncology | |||
| Contact Person | Ph: 39-02-5748-9934 | ||
| Pavia | |||
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| Fondazione Salvatore Maugeri | |||
| Contact Person | Ph: 39-0382-592-504 | ||
| Prato | |||
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| Misericordia e Dolce Hospital | |||
| Contact Person | Ph: 39-0574-43-4766 | ||
| Rimini | |||
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| Ospedale Civile Rimini | |||
| Contact Person | Ph: 39-0541-705-567 | ||
| Varese | |||
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| Ospedale di Circolo e Fondazione Macchi | |||
| Contact Person | Ph: 39-332-278-376 | ||
| Japan | |||
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| Kagoshima | |||
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| Sagara Hospital | |||
| Contact Person | Ph: 81-3-66659-7723 | ||
| Kumamoto | |||
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| Kumamoto University Faculty of Medical and Pharmaceutical Sciences | |||
| Contact Person | Ph: 81-3-66659-7723 | ||
| Kyoto | |||
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| Kyoto University Hospital | |||
| Contact Person | Ph: 81-3-66659-7723 | ||
| Niigata | |||
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| Niigata Cancer Center Hospital | |||
| Contact Person | Ph: 81-3-66659-7723 | ||
| Osaka | |||
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| Yao Municipal Hospital | |||
| Contact Person | Ph: 81-3-66659-7723 | ||
| Sakai | |||
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| Osaka Rosai Hospital | |||
| Contact Person | Ph: 81-3-66659-7723 | ||
| Tokyo | |||
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| Tokyo Metropolitan - Komagome Hospital | |||
| Contact Person | Ph: 81-3-66659-7723 | ||
| New Zealand | |||
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| Hamilton | |||
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| Waikato Hospital | |||
| Contact Person | Ph: 61-2-4985-0166 | ||
| Peru | |||
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| Lima | |||
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| Instituto Nacional de Enfermedades Neoplasicas | |||
| Contact Person | Ph: 511-710-6900 | ||
| Republic of South Africa | |||
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| Sandton | |||
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| Sandton Oncology Medical Research | |||
| Contact Person | Ph: 27-11-883-0900-4 | ||
| Tygerberg | |||
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| Tygerberg Hospital | |||
| Contact Person | Ph: 27-21-938-9277 | ||
| Russia | |||
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| Moscow | |||
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| Russian Academy of Medical Sciences Cancer Research Center | |||
| Contact Person | Ph: 7-903-597-7348 | ||
| Spain | |||
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| Barcelona | |||
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| Vall d'Hebron University Hospital | |||
| Contact Person | Ph: 34-93-715-6400 | ||
| Madrid | |||
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| Hospital Ramon y Cajal | |||
| Contact Person | Ph: 34-93-715-6400 | ||
| Hospital Universitario 12 de Octubre | |||
| Contact Person | Ph: 34-93-715-6400 | ||
| M. D. Anderson International Espana SA | |||
| Contact Person | Ph: 34-93-715-6400 | ||
| Palma De Mallorca | |||
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| Hospital Son Llatzer | |||
| Contact Person | Ph: 34-93-715-6400 | ||
| Reus | |||
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| Hospital Sant Joan de Reus | |||
| Contact Person | Ph: 34-93-715-6400 | ||
| Sevilla | |||
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| Hospital Universitario Virgen Macarena | |||
| Contact Person | Ph: 34-93-715-6400 | ||
| Torrevieja | |||
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| Hospital de Torrevieja | |||
| Contact Person | Ph: 34-93-715-6400 | ||
| Valencia | |||
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| Hospital Clinico Universitario de Valencia | |||
| Contact Person | Ph: 34-93-715-6400 | ||
| Instituto Valenciano De Oncologia | |||
| Contact Person | Ph: 34-93-715-6400 | ||
| Sweden | |||
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| Boras | |||
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| Lasarettet i Boras | |||
| Contact Person | Ph: 46-33-161-850 | ||
| Eskilstuna | |||
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| Malarsjukhuset Hospital | |||
| Contact Person | Ph: 46-73-822-8002 | ||
| Gothenburg | |||
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| Sahlgrenska University Hospital | |||
| Contact Person | Ph: 46-31-342-1000 | ||
| Lidkoping | |||
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| Lidkoping Hospital | |||
| Contact Person | Ph: +46 313 42 10 00 | ||
| Skovde | |||
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| Skaraborgs Hospital | |||
| Contact Person | Ph: 46-500-431-028 | ||
| Stockholm | |||
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| Karolinska University Hospital - Huddinge | |||
| Contact Person | Ph: 46-8-585-800-00 | ||
| Switzerland | |||
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| Aarau | |||
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| Kantonsspital Aarau | |||
| Contact Person | Ph: 41-62-838-6050 | ||
| Baden | |||
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| Kantonsspital Baden | |||
| Contact Person | Ph: 41-56-842-111 | ||
| Bellinzona | |||
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| Istituto Oncologico della Svizzera Italiana - Ospedale San Giovanni | |||
| Contact Person | Ph: 41-91-811-8666 | ||
| Bern | |||
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| Inselspital Bern | |||
| Contact Person | Ph: 41-31-632-4114 | ||
| Oncocare Sonnenhof-Klinik Engeriedspital | |||
| Contact Person | Ph: 41-31-309-9501 | ||
| Cham | |||
|
|||
| AndreasKlinik Cham Zug | |||
| Contact Person | Ph: 41-41-784-0784 | ||
| Chur | |||
|
|||
| Kantonsspital Graubuenden | |||
| Contact Person | Ph: 41-81-256-6111 | ||
| Frauenfeld | |||
|
|||
| Brustzentrum Thurgau at Kantonsspital Frauenfeld | |||
| Contact Person | Ph: 41-52-723-7711 | ||
| Freiburg | |||
|
|||
| Kantonsspital Freiburg | |||
| Contact Person | Ph: 41-26-426-7111 | ||
| Lausanne | |||
|
|||
| Centre Hospitalier Universitaire Vaudois | |||
| Contact Person | Ph: 41-21-314-0150 | ||
| Locarno | |||
|
|||
| Lago Maggiore Oncology Foundation | |||
| Contact Person | Ph: 41-91-751-8230 | ||
| Ospedale "la Carita", Locarno | |||
| Contact Person | Ph: 41-91-310-121 | ||
| Lugano | |||
|
|||
| Ospedale Civico | |||
| Contact Person | Ph: 41-91-811-6111 | ||
| Mendrisio | |||
|
|||
| Ospedale Beata Vergine | |||
| Contact Person | Ph: 41-91-811-3395 | ||
| Olten | |||
|
|||
| Kantonsspital Olten | |||
| Contact Person | Ph: 41-62-311-4111 | ||
| Sion | |||
|
|||
| Hopital Regional de Sion-Herens-Conthey | |||
| Contact Person | Ph: 41-27-603-4000 | ||
| St. Gallen | |||
|
|||
| Kantonsspital - St. Gallen | |||
| Contact Person | Ph: 41-71-494-1062 | ||
| Tumor Zentrum ZeTup St. Gallen und Chur | |||
| Contact Person | Ph: 41-71-243-0043 | ||
| Thun | |||
|
|||
| Regionalspital | |||
| Contact Person | Ph: 41-33-226-2645 | ||
| Winterthur | |||
|
|||
| Kantonsspital Winterthur | |||
| Contact Person | Ph: +41 31 632 41 14 | ||
| Zurich | |||
|
|||
| Breast Center | |||
| Contact Person | Ph: 41-44-380-7660 | ||
| City Hospital Triemli | |||
| Contact Person | Ph: 41-1-466-1111 | ||
| UniversitaetsSpital Zuerich | |||
| Contact Person | Ph: 41-44-255-1111 | ||
| United Kingdom | |||
|
|||
| England | |||
|
|||
| Melrose | |||
|
|||
| Borders General Hospital | |||
| Contact Person | Ph: 44-131-275-6544 | ||
| Scotland | |||
|
|||
| Dumfries | |||
|
|||
| Dumfries & Galloway Royal Infirmary | |||
| Contact Person | Ph: 44-131-275-6544 | ||
Link to the current ClinicalTrials.gov record.
NLM Identifer NCT00553410
Information obtained from ClinicalTrials.gov on March 04, 2012
Note: Information about this trial is from the ClinicalTrials.gov database. The versions designated for health professionals and patients contain
the same text. Minor
changes may be made to the ClinicalTrials.gov record to standardize the names of study sponsors, sites, and
contacts. Cancer.gov only lists sites that are recruiting patients for active trials, whereas ClinicalTrials.gov lists all sites for all trials. Questions and comments regarding the presented information should
be directed to ClinicalTrials.gov.
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