Alternate Title
Basic Trial Information
Objectives
Entry Criteria
Expected Enrollment
Outcomes
Outline
Trial Contact Information
Registry Information

Alternate Title

Prostate Radiation Therapy or Short-Term Androgen Deprivation Therapy and Pelvic Lymph Node Radiation Therapy With or Without Prostate Radiation Therapy in Treating Patients With a Rising PSA After Surgery for Prostate Cancer

Basic Trial Information

Special Category: CTSU trial

Objectives

Primary

1. To determine whether the addition of short-term androgen deprivation (STAD) to prostate bed radiotherapy (PBRT) improves freedom from progression (FFP) (i.e., maintenance of a prostate-specific antigen [PSA] less than the nadir+2 ng/mL, absence of clinical failure, and absence of death from any cause) for 5 years, over that of PBRT alone in men treated with salvage radiotherapy after radical prostatectomy.
2. To determine whether STAD, pelvic lymph node radiotherapy (PLNRT), and PBRT improves FFP over that of STAD+PBRT and PBRT alone in men treated with salvage radiotherapy after radical prostatectomy.

Secondary

1. To compare the rates of a PSA ≥ 0.4 ng/mL and rising at 5 years after randomization (secondary biochemical failure endpoint), the development of hormone-refractory disease (3 rises in PSA during treatment with salvage androgen-deprivation therapy), distant metastasis, cause-specific mortality, and overall mortality.
2. To compare acute and late morbidity based on CTCAE, v. 3.0.
3. To measure the expression of cell kinetic, apoptotic pathway, and angiogenesis-related genes in archival diagnostic tissue to better define the risk of FFP, distant failure, cause-specific mortality, and overall mortality after salvage radiotherapy for prostate cancer, independently of conventional clinical parameters now used.
4. To quantify blood product-based proteomic and genomic (single nucleotide polymorphisms) patterns and urine-based genomic patterns before and at different times after treatment to better define the risk of FFP, distant failure, cause-specific mortality, and overall mortality after salvage radiotherapy for prostate cancer, independently of conventional clinical parameters now used.
5. To assess the degree, duration, and significant differences of disease-specific health-related quality of life (HRQOL) decrements among treatment arms.
6. To assess whether mood is improved and depression is decreased with the more aggressive therapy if it improves FFP.
7. To collect paraffin-embedded tissue blocks, serum, plasma, urine, and buffy coat cells for future translational research analyses.

Tertiary

1. To assess whether an incremental gain in FFP and survival with more aggressive therapy outweighs decrements in the primary generic domains of HRQOL (i.e., mobility, self care, usual activities, pain/discomfort, and anxiety/depression).
2. To evaluate the cost-utility of the treatment arm demonstrating the most significant benefit (in terms of the primary outcome) in comparison with other widely accepted cancer and non-cancer therapies.
3. To assess associations between serum levels of beta-amyloid and measures of cognition and mood and depression.
4. An exploratory aim is to assess the relationship(s) between the American Urological Association Symptom Index (AUA SI) and urinary morbidity using the CTCAE v. 3.0 grading system.

Entry Criteria

Disease Characteristics:

• Adenocarcinoma of the prostate treated primarily with radical prostatectomy
  • Pathologically proven to be lymph node-negative by pelvic lymphadenectomy (N0) or lymph node status pathologically unknown (Nx [undissected pelvic lymph nodes because lymph node dissection is not required])
  • Any type of radical prostatectomy allowed, including retropubic, perineal, laparoscopic, or robotically assisted
  • Meets 1 of the following pathologic classifications:
    • T3 N0/Nx disease with or without positive prostatectomy margins
    • T2 N0/Nx disease with or without positive prostatectomy margins
  • N1 patients are ineligible, as are those with pelvic lymph node enlargement ≥ 1.5 cm in greatest dimension by CT scan or MRI of the pelvis, unless the enlarged lymph node is negative
  • Prostatectomy Gleason score of 9 or less

• A post-radical prostatectomy entry PSA of ≥ 0.1 and ≤ 1.0 ng/mL at least 6 weeks after prostatectomy and within 30 days of registration

• Serum total testosterone ≥ 40% of the lower limit of normal (patients who have had a unilateral orchiectomy are eligible as long as this requirement is met)

• No distant metastases based on history/physical examination, CT scan or MRI of the abdomen and pelvis, and bone scan

• No palpable prostatic fossa abnormality/mass suggestive of recurrence, unless shown by biopsy under ultrasound guidance not to contain cancer

Prior/Concurrent Therapy:

• See Disease Characteristics
• More than 5 years since prior chemotherapy for any other disease site
• No androgen-deprivation therapy started prior to prostatectomy for > 6 months duration
  • The use of finasteride or dutasteride (± tamsulosin) for longer periods prior to prostatectomy is acceptable
• No androgen-deprivation therapy started after prostatectomy and prior to registration
  • The use of finasteride or dutasteride (± tamsulosin) after prostatectomy is not acceptable, it must be stopped within 3 months after prostatectomy
• No neoadjuvant chemotherapy before or after prostatectomy
• No prior cyrosurgery or brachytherapy of the prostate (prostatectomy should be the primary treatment and not a salvage procedure)
• No prior pelvic radiotherapy

Patient Characteristics:

• Zubrod performance status 0-1
• Platelets ≥ 100,000/mm³
• Hemoglobin ≥ 10.0 g/dL (the use of transfusion or other intervention to achieve this is allowed)
• AST or ALT < 2 x upper limit of normal
• No prior invasive malignancy (except nonmelanoma skin cancer) or superficial bladder cancer unless disease free for a minimum of 5 years (e.g., carcinoma in situ of the oral cavity is permissible)
• No severe, active co-morbidity, including any of the following:
  • History of inflammatory bowel disease
  • History of hepatitis B or C
  • Unstable angina and/or congestive heart failure requiring hospitalization within the past 6 months
  • Transmural myocardial infarction within the past 6 months
  • Acute bacterial or fungal infection requiring intravenous antibiotics at the time of registration
  • Chronic obstructive pulmonary disease exacerbation or other respiratory illness requiring hospitalization or precluding study therapy at the time of registration
  • Hepatic insufficiency resulting in clinical jaundice and/or coagulation defects
  • Acquired immune deficiency syndrome (AIDS) based upon current CDC definition
    • HIV testing is not required for entry
• No prior allergic reaction to the study drug(s) involved in this protocol

Expected Enrollment

Outcomes

Freedom from progression (FFP)

Secondary biochemical failure
Hormone-refractory disease
Local failure
Distant metastasis
Cause-specific mortality
Overall mortality
Incidence of acute adverse events ≤ 90 days of the completion of radiotherapy (RT)
Time to late grade 2+ and 3+ adverse events assessed > 90 days from the completion of RT
Comparison of disease-specific health related quality of life (HRQOL) change by EPIC, HVLT-R, Trail Making Test, parts A & B, and COWAT
Assessment of mood and depression change using QOL measured by the HSCL-25
Assessment and comparison of Quality Adjusted Life Year (QALY) and Quality Adjusted FFP Year (QAFFPY)
Evaluation and comparison of the cost-utility using EQ-5D
Association between serum levels of beta-amyloid (Abeta) and measures of HSCL-25, the HVLT-R, Trail Making Test, parts A & B, or the COWAT
Prognostic value of genomic and proteomic markers for the primary and secondary clinical endpoints
Collection of paraffin-embedded tissue blocks, serum, plasma, urine, and buffy coat cells for future translational research analyses
Assessment of the relationship(s) between the American Urological Association Symptom Index (AUA SI) and urinary morbidity (Adverse Event terms: Urinary frequency/urgency) using the CTCAE v. 3.0 grading system

Outline

Patients are stratified according to seminal vesicle involvement (yes vs no), prostatectomy Gleason score (≤ 7 vs 8-9), pre-radiotherapy PSA (≥ 0.1 and ≤ 1.0 ng/mL vs > 1.0 and < 2.0 ng/mL), and pathology stage (pT2 and margin negative vs all others). Patients are randomized to 1 of 3 treatment arms.

• Arm I (prostate bed radiotherapy [PBRT] alone): Patients undergo PBRT once daily, 5 days a week, Monday through Friday, for approximately 7-8 weeks (36 to 39 fractions).

• Arm II (PBRT and short-term androgen-deprivation [STAD]): Beginning 2 months before the start of PBRT, patients undergo STAD, using a combination of antiandrogen and luteinizing hormone-releasing hormone (LHRH) agonist therapy, for a total of 4-6 months. Patients receive antiandrogen therapy comprising either oral flutamide 3 times daily or oral bicalutamide once daily for at least 4 months (started within 1-14 days prior to the LHRH agonist and ending the last day of radiotherapy ± 14 days). Patients receive LHRH agonist injection beginning concurrently with or 2 weeks after the start of antiandrogen therapy. LHRH agonist injection consists of analogs approved by the FDA (or by Health Canada for Canadian institutions) (e.g., leuprolide, goserelin, buserelin, or triptorelin) and may be given in any possible combination (may be given as a single 4-month injection and one to two 1-month injection[s], two 3-month injections, or a 6-month injection), such that the total LHRH agonist treatment time is 4-6 months. Approximately 2 months after beginning of STAD, patients undergo PBRT as in arm I.

• Arm III (Pelvic lymph node radiotherapy [PLNRT], PBRT, and STAD): Beginning 2 months before the start of radiotherapy, patients receive STAD therapy as in arm II. Approximately 2 months after beginning of STAD, patients undergo PBRT and PLNRT once daily, 5 days a week, Monday through Friday, for approximately 5 weeks (25 fractions) followed by PBRT only once daily, 5 days a week for approximately 2-3 weeks (11-14 fractions).

Patients complete the American Urological Association Symptom Index (AUA SI) questionnaire prior to protocol treatment, at week 6 of radiotherapy, and then periodically after completion of study therapy.

After completion of study therapy, patients are followed up every 3 months for 1 year, every 6 months for 4 years, and then annually thereafter.

Trial Contact Information

Trial Lead Organizations

Radiation Therapy Oncology Group

Alan Pollack, MD, PhD, Protocol chair		Ph: 215-728-2940; 888-369-2427 Email: alan.pollack@fccc.edu
Leonard Gomella, MD, Protocol co-chair		Ph: 215-955-6961 Email: leonard.gomella@mail.tju.edu

Cancer and Leukemia Group B

Joycelyn Speight, MD, PhD, Protocol chair		Ph: 415-353-7175; 800-888-8664

U.S.A.
Alabama
	Birmingham
	UAB Comprehensive Cancer Center
		Clinical Trials Office - UAB Comprehensive Cancer Center	Ph:  205-934-0309
Alaska
	Fairbanks
	Fairbanks Cancer Treatment Center at Fairbanks Memorial Hospital
		Huong Pham, MD	Ph:  206-223-6801
Arizona
	Peoria
	Arizona Center for Cancer Care - Peoria
		Terry Lee	Ph:  623-773-2873
	Phoenix
	Arizona Oncology Services Foundation
		David Brachman, MD, FACRO	Ph:  602-274-4484
	Tucson
	Arizona Cancer Center at University of Arizona Health Sciences Center
		Clinical Trials Office - Arizona Cancer Center at University of Arizona Health Sciences Center	Ph:  520-626-9008
	Arizona Oncology - Tucson
		Vivek Kavadi	Ph:  520-797-4468
California
	Auburn
	Auburn Radiation Oncology
		Christopher Jones, MD	Ph:  916-646-6600
	Berkeley
	Alta Bates Summit Comprehensive Cancer Center
		Clinical Trials Office - Alta Bates Summit Comprehensive Cancer Center	Ph:  510-204-3428
	Burlingame
	Peninsula Medical Center
		David Irwin, MD	Ph:  510-204-1591
	Cameron Park
	Radiation Oncology Centers - Cameron Park
		Christopher Jones, MD	Ph:  916-646-6600
	Carmichael
	Mercy Cancer Center at Mercy San Juan Medical Center
		Christopher Jones, MD	Ph:  916-646-6600
	Castro Valley
	East Bay Radiation Oncology Center
		James Feusner, MD	Ph:  510-428-3689
	Valley Medical Oncology Consultants - Castro Valley
		James Feusner, MD	Ph:  510-428-3689
	Chico
	Enloe Cancer Center at Enloe Medical Center
		Clinical Trials Office - Enloe Cancer Center at Enloe Medical Center	Ph:  530-332-3808
	Duarte
	City of Hope Comprehensive Cancer Center
		Clinical Trials Office - City of Hope Comprehensive Cancer Center	Ph:  800-826-4673
			Email: becomingapatient@coh.org
	Fremont
	Valley Medical Oncology
		James Feusner, MD	Ph:  510-428-3689
	Washington Township Hospital
		Vandana Sharma	Ph:  510-797-1111
	Fresno
	California Cancer Center - Woodward Park Office
		Brent Kane	Ph:  559-447-4050
	Long Beach
	Veterans Affairs Medical Center - Long Beach
		Samar Azawi, MD	Ph:  562-826-5606
	Los Angeles
	Samuel Oschin Comprehensive Cancer Institute at Cedars-Sinai Medical Center
		Howard Sandler, MD	Ph:  734-936-9338
	USC/Norris Comprehensive Cancer Center and Hospital
		Clinical Trials Office - USC/Norris Comprehensive Cancer Center and Hospital	Ph:  323-865-0451
	Martinez
	Contra Costa Regional Medical Center
		James Feusner, MD	Ph:  510-428-3689
	Mission Hills
	Providence Holy Cross Cancer Center
		Philip Beron	Ph:  818-898-4410
	Modesto
	Memorial Medical Center
		Clinical Trials Office - Memorial Medical Center	Ph:  209-572-7116
	Mountain View
	El Camino Hospital Cancer Center
		Clinical Trials Office - El Camino Hospital Cancer Center	Ph:  650-988-7623
	Novato
	Sutter Health - Western Division Cancer Research Group
		David Irwin, MD	Ph:  510-204-1591
	Oakland
	Alta Bates Summit Medical Center - Summit Campus
		Clinical Trials Office - Alta Bates Summit Medical Center - Summit Campus	Ph:  510-204-1414
	Bay Area Breast Surgeons, Incorporated
		James Feusner, MD	Ph:  510-428-3689
	CCOP - Bay Area Tumor Institute
		James Feusner, MD	Ph:  510-428-3689
	Larry G Strieff MD Medical Corporation
		James Feusner, MD	Ph:  510-428-3689
	Tom K Lee, Incorporated
		James Feusner, MD	Ph:  510-428-3689
	Orange
	St. Joseph Hospital Regional Cancer Center - Orange
		Robert Ash	Ph:  714-771-8999
	Palo Alto
	Palo Alto Medical Foundation
		David Irwin, MD	Ph:  510-204-1591
	Paradise
	Feather River Hospital Cancer Center
		Sam Mazj	Ph:  530-876-3144
	Pomona
	Robert and Beverly Lewis Family Cancer Care Center at Pomona Valley Hospital Medical Center
		Clinical Trials Office - Robert and Beverly Lewis Family Cancer Care Center	Ph:  909-865-9555
	Roseville
	Radiation Oncology Center - Roseville
		Christopher Jones, MD	Ph:  916-646-6600
	Sacramento
	Mercy General Hospital
		Christopher Jones, MD	Ph:  916-646-6600
	Radiological Associates of Sacramento Medical Group, Incorporated
		Christopher Jones, MD	Ph:  916-646-6600
	University of California Davis Cancer Center
		Clinical Trials Office - University of California Davis Cancer Center	Ph:  916-734-3089
	Saint Helena
	Saint Helena Hospital
		David Tate	Ph:  707-963-3611
	San Francisco
	California Pacific Medical Center - California Campus
		David Irwin, MD	Ph:  510-204-1591
	UCSF Helen Diller Family Comprehensive Cancer Center
		Clinical Trials Office - UCSF Helen Diller Family Comprehensive Cancer Center	Ph:  877-827-3222
	Vacaville
	Solano Radiation Oncology Center
		Christopher Jones, MD	Ph:  916-646-6600
	Vallejo
	Sutter Solano Medical Center
		David Irwin, MD	Ph:  510-204-1591
Colorado
	Aurora
	Aurora Presbyterian Hospital
		Eduardo Pajon, MD	Ph:  303-399-8020ext2261
	Boulder
	Boulder Community Hospital
		Clinical Trials Office - Boulder Community Hospital	Ph:  303-938-5253
	Denver
	Porter Adventist Hospital
		Eduardo Pajon, MD	Ph:  303-399-8020ext2261
	Presbyterian - St. Luke's Medical Center
		Clinical Trials Office - Presbyterian - St. Luke's Medical Center	Ph:  303-839-6000
	St. Joseph Hospital
		Eduardo Pajon, MD	Ph:  303-399-8020ext2261
	Englewood
	Swedish Medical Center
		Eduardo Pajon, MD	Ph:  303-399-8020ext2261
	Grand Junction
	St. Mary's Regional Cancer Center at St. Mary's Hospital and Medical Center
		Eduardo Pajon, MD	Ph:  303-399-8020ext2261
	Greeley
	North Colorado Medical Center
		Eduardo Pajon, MD	Ph:  303-399-8020ext2261
	Longmont
	Hope Cancer Care Center at Longmont United Hospital
		Eduardo Pajon, MD	Ph:  303-399-8020ext2261
	Loveland
	McKee Medical Center
		Eduardo Pajon, MD	Ph:  303-399-8020ext2261
	Pueblo
	St. Mary - Corwin Regional Medical Center
		Eduardo Pajon, MD	Ph:  303-399-8020ext2261
	Thornton
	North Suburban Medical Center
		Eduardo Pajon, MD	Ph:  303-399-8020ext2261
	Wheat Ridge
	Exempla Lutheran Medical Center
		Clinical Trials Office - Exempla Lutheran Medical Center	Ph:  303-403-3605
Connecticut
	Middletown
	Middlesex Hospital Cancer Center
		Joseph Weissberg, MD	Ph:  860-358-2100
	Norwich
	Eastern Connecticut Hematology and Oncology Associates
		Dennis Slater, MD	Ph:  860-886-8362
	William W. Backus Hospital
		Dennis Slater, MD	Ph:  860-886-8362
Delaware
	Newark
	CCOP - Christiana Care Health Services
		Clinical Trial Office - CCOP - Christiana Care Health Services	Ph:  302-623-4450
District of Columbia
	Washington
	Washington Cancer Institute at Washington Hospital Center
		Clinical Trials Office - Washington Cancer Institute	Ph:  202-877-8839
Florida
	Gainesville
	University of Florida Shands Cancer Center
		Clinical Trials Office - University of Florida Shands Cancer Center	Ph:  888-254-7581
	Jacksonville
	Baptist Cancer Institute - Jacksonville
		Clinical Trials Office - Baptist Cancer Institute - Jacksonville	Ph:  904-202-7051
	Integrated Community Oncology Network at Southside Cancer Center
		Douglas Johnson, MD	Ph:  904-202-2273
	Jacksonville Beach
	Integrated Community Oncology Network
		Douglas Johnson, MD	Ph:  904-202-2273
	Jascksonville
	Baptist Medical Center South
		Douglas Johnson, MD	Ph:  904-202-2273
	Orange Park
	Integrated Community Oncology Network - Orange Park
		Douglas Johnson, MD	Ph:  904-202-2273
	Orlando
	Florida Hospital Cancer Institute at Florida Hospital Orlando
		Clinical Trials Office - Florida Hospital Cancer Institute	Ph:  407-303-5623
	Palatka
	Florida Cancer Center - Palatka
		Douglas Johnson, MD	Ph:  904-202-2273
	Panama City
	Bay Medical
		Hasan Murshed	Ph:  850-747-6972
	Saint Augustine
	Flagler Cancer Center
		Douglas Johnson, MD	Ph:  904-202-2273
	Tampa
	Veterans Affairs Medical Center - Tampa
		Babu Zachariah, MD	Ph:  813-972-7667
Georgia
	Atlanta
	Emory Crawford Long Hospital
		Peter Rossi	Ph:  404-686-4411
	Georgia Cancer Center for Excellence at Grady Memorial Hospital
		Peter Rossi	Ph:  404-489-9000
	Piedmont Hospital
		Adam Nowlan	Ph:  404-605-5000 866-605-5111
	Winship Cancer Institute of Emory University
		Clinical Trials Office - Winship Cancer Institute	Ph:  404-778-1900
	Columbus
	John B. Amos Cancer Center
		Clinical Trials Office - John B. Amos Cancer Center	Ph:  706-660-6404
	Gainesville
	Northeast Georgia Medical Center
		Frank Lake, MD	Ph:  770-535-3393
	Savannah
	Nancy N. and J. C. Lewis Cancer and Research Pavilion at St. Joseph's/Candler
		John Pablo	Ph:  912-819-6000
Hawaii
	Aiea
	Kapiolani Medical Center at Pali Momi
		Paul DeMare, MD, FACR	Ph:  808-547-4771
	Honolulu
	Cancer Research Center of Hawaii
		Clinical Trials Office - Cancer Research Center of Hawaii	Ph:  808-586-2979
	Hawaii Medical Center - East
		Paul DeMare, MD, FACR	Ph:  808-547-4771
	Queen's Cancer Institute at Queen's Medical Center
		Paul DeMare, MD, FACR	Ph:  808-547-4771
	Straub Clinic and Hospital, Incorporated
		Paul DeMare, MD, FACR	Ph:  808-547-4771
	Wailuku
	Pacific Cancer Institute - Maui
		Paul DeMare, MD, FACR	Ph:  808-547-4771
Idaho
	Boise
	Saint Alphonsus Cancer Care Center at Saint Alphonsus Regional Medical Center
		Clinical Trials Office - Saint Alphonsus Cancer Care Center	Ph:  208-367-7954
Illinois
	Chicago
	Robert H. Lurie Comprehensive Cancer Center at Northwestern University
		Clinical Trials Office - Robert H. Lurie Comprehensive Cancer Center at Northwestern University	Ph:  312-695-1301
			Email: cancer@northwestern.edu
	Rush University Medical Center
		Clinical Trials Office - Rush University Medical Center	Ph:  312-942-5498
			Email: clinical_trials@rush.edu
	University of Chicago Cancer Research Center
		Clinical Trials Office - University of Chicago Cancer Research Center	Ph:  773-834-7424
	Decatur
	Decatur Memorial Hospital Cancer Care Institute
		Clinical Trials Office - Decatur Memorial Hospital Cancer Care Institute	Ph:  217-876-4750
	Freeport
	Leonard C. Ferguson Cancer Center
		Gregory Richards	Ph:  815-599-7000
	Harvey
	Ingalls Cancer Care Center at Ingalls Memorial Hospital
		Clinical Trials Office - Ingalls Cancer Care Center at Ingalls Memorial Hospital	Ph:  708-915-4673
	Hines
	Veterans Affairs Medical Center - Hines
		Nirmala Bhoopalam, MD	Ph:  708-202-2782
	Maywood
	Cardinal Bernardin Cancer Center at Loyola University Medical Center
		Clinical Trials Office - Cardinal Bernardin Cancer Center	Ph:  708-226-4357
	Moline
	Trinity Cancer Center at Trinity Medical Center - 7th Street Campus
		Costas Constantinou, MD	Ph:  563-359-9876
	Springfield
	Cancer Institute at St. John's Hospital
		Cathy Clausen, MD	Ph:  765-646-8358
	Regional Cancer Center at Memorial Medical Center
		Clinical Trials Office - Regional Cancer Center at Memorial Medical Center	Ph:  217-788-4233
Indiana
	Elkhart
	Elkhart General Hospital
		David Hornback, MD	Ph:  574-647-7461
	Fort Wayne
	Parkview Regional Cancer Center at Parkview Health
		Brian Chang	Ph:  260-373-7850
	Radiation Oncology Associates Southwest
		Brian Chang	Ph:  260-436-4116
	Goshen
	Center for Cancer Care at Goshen General Hospital
		Clinical Trials Office - Center for Cancer Care at Goshen General Hospital	Ph:  574-535-2858
	Indianapolis
	Central Indiana Cancer Centers - East
		Vivek Kavadi	Ph:  317-964-5200
	Indiana University Melvin and Bren Simon Cancer Center
		Clinical Trials Office - Indiana University Cancer Center	Ph:  317-274-2552
	Veterans Affairs Medical Center - Indianapolis
		Peter Johnstone, MD	Ph:  404-778-3473
	Kokomo
	Howard Community Hospital
		David Hornback, MD	Ph:  574-647-7461
	La Porte
	Center for Cancer Therapy at LaPorte Hospital and Health Services
		David Hornback, MD	Ph:  574-647-7461
	Mishawaka
	Saint Joseph Regional Medical Center
		David Hornback, MD	Ph:  574-647-7461
	Muncie
	Cancer Center at Ball Memorial Hospital
		Clinical Trials Office - Cancer Center at Ball Memorial Hospital	Ph:  765-281-2107
	South Bend
	CCOP - Northern Indiana CR Consortium
		David Hornback, MD	Ph:  574-647-7461
	Memorial Hospital of South Bend
		Clinical Trials Office - Memorial Hospital of South Bend	Ph:  800-284-7370
Iowa
	Des Moines
	CCOP - Iowa Oncology Research Association
		Robert Behrens	Ph:  515-244-7586 888-244-6061
	John Stoddard Cancer Center at Iowa Lutheran Hospital
		Clinical Trials Office - John Stoddard Cancer Center at Iowa Lutheran Hospital	Ph:  515-241-8704
	John Stoddard Cancer Center at Iowa Methodist Medical Center
		Clinical Trials Office - John Stoddard Cancer Center at Iowa Methodist Medical Center	Ph:  515-241-6727
	Medical Oncology and Hematology Associates at John Stoddard Cancer Center
		Robert Behrens	Ph:  515-282-2921
	Medical Oncology and Hematology Associates at Mercy Cancer Center
		Robert Behrens	Ph:  515-643-8740
	Mercy Cancer Center at Mercy Medical Center - Des Moines
		Robert Behrens	Ph:  515-643-8206 888-221-4849
	Dubuque
	Wendt Regional Cancer Center at Finley Hospital
		Nagendra (Bobby) Koneru	Ph:  563-589-2468 800-397-2467
	Sioux City
	Mercy Medical Center - Sioux City
		Donald Wender, MD, PhD	Ph:  712-252-0088
	Siouxland Hematology-Oncology Associates, LLP
		Donald Wender, MD, PhD	Ph:  712-252-0088
	St. Luke's Regional Medical Center
		Donald Wender, MD, PhD	Ph:  712-252-0088
Kansas
	Dodge City
	Cancer Center of Kansas, PA - Dodge City
		Shaker Dakhil, MD, FACP	Ph:  316-262-4467
	El Dorado
	Cancer Center of Kansas, PA - El Dorado
		Shaker Dakhil, MD, FACP	Ph:  316-262-4467
	Lawrence
	Lawrence Memorial Hospital
		Shaker Dakhil, MD, FACP	Ph:  316-262-4467
	Wellington
	Cancer Center of Kansas, PA - Wellington
		Shaker Dakhil, MD, FACP	Ph:  316-262-4467
	Wichita
	Associates in Womens Health, PA - North Review
		Shaker Dakhil, MD, FACP	Ph:  316-262-4467
	Cancer Center of Kansas, PA - Wichita
		Shaker Dakhil, MD, FACP	Ph:  316-262-4467
	Cancer Center of Kansas, PA - Medical Arts Tower
		Shaker Dakhil, MD, FACP	Ph:  316-262-4467
	CCOP - Wichita
		Shaker Dakhil, MD, FACP	Ph:  316-262-4467
	Via Christi Cancer Center at Via Christi Regional Medical Center
		Shaker Dakhil, MD, FACP	Ph:  316-262-4467
	Wesley Medical Center
		Shaker Dakhil, MD, FACP	Ph:  316-262-4467
	Winfield
	Cancer Center of Kansas, PA - Winfield
		Shaker Dakhil, MD, FACP	Ph:  316-262-4467
Kentucky
	Lexington
	Lucille P. Markey Cancer Center at University of Kentucky
		Clinical Trials Office - Markey Cancer Center at University of Kentucky Chandler Medical Center	Ph:  859-257-3379
	Louisville
	Norton Suburban Hospital
		Mark Cornett	Ph:  502-893-1000
Louisiana
	Alexandria
	Tulane Cancer Center Office of Clinical Research
		Clinical Trials Office - Tulane Cancer Center	Ph:  504-988-6121
	Baton Rouge
	Mary Bird Perkins Cancer Center - Baton Rouge
		Robert Veith	Ph:  225-767-0847
	New Orleans
	CCOP - Ochsner
		Troy Scroggins, MD	Ph:  504-842-3440
	MBCCOP - LSU Health Sciences Center
		Robert Veith	Ph:  504-568-5151
	Medical Center of Louisiana - New Orleans
		Robert Veith	Ph:  504-903-2311
Maryland
	Annapolis
	DeCesaris Cancer Institute at Anne Arundel Medical Center
		Angel Torano, MD	Ph:  443-481-5800
	Baltimore
	Greater Baltimore Medical Center Cancer Center
		Clinical Trials Office - Greater Baltimore Medical Center Cancer Center	Ph:  443-849-3706
	St. Agnes Hospital Cancer Center
		Richard Hudes, MD	Ph:  410-368-2965
	Silver Spring
	Holy Cross Hospital
		Clinical Trials Office - Holy Cross Hospital	Ph:  310-754-7552
Massachusetts
	Boston
	Beth Israel Deaconess Medical Center
		Clinical Trials Office - Beth Israel Deaconess Medical Center	Ph:  617-667-9925
	Boston University Cancer Research Center
		Clinical Trials Office - Boston University Cancer Research Center	Ph:  617-638-8265
	Dana-Farber/Brigham and Women's Cancer Center
		Clinical Trials Office	Ph:  617-724-5200
	Dana-Farber/Harvard Cancer Center at Dana-Farber Cancer Institute
		William Shipley, MD, FACR	Ph:  617-726-8146
	Massachusetts General Hospital
		Clinical Trials Office - Massachusetts General Hospital	Ph:  877-726-5130
	Fall River
	Hudner Oncology Center at Saint Anne's Hospital - Fall River
		Clinical Trials Office - Hudner Oncology Center at Saint Anne's Hospital - Fall River	Ph:  508-674-5600 ext. 2019
	Hyannis
	Cape Cod Hospital
		Daniel Canaday	Ph:  508-771-1800
	Mansfield
	Shields Radiation Oncology Center - Mansfield
		Bruce Bornstein	Ph:  617-376-6400
	Winchester
	Winchester Hospital Radiation Oncology Center
		Bruce Bornstein	Ph:  781-756-8300
Michigan
	Adrian
	Hickman Cancer Center at Bixby Medical Center
		Clinical Trials Office - Hickman Cancer Center at Bixby Medical Center	Ph:  517-265-0116
	Ann Arbor
	CCOP - Michigan Cancer Research Consortium
		Swati Dutta	Ph:  877-590-5995
	Saint Joseph Mercy Cancer Center
		Swati Dutta	Ph:  734-712-5658 888-474-4673
	University of Michigan Comprehensive Cancer Center
		Clinical Trials Office - University of Michigan Comprehensive Cancer Center	Ph:  800-865-1125
	Clinton Township
	Henry Ford Macomb Hospital
		Eleanor Walker, MD	Ph:  313-916-1021
	Commerce
	Charach Cancer Center at Huron Valley - Sinai Hospital
		Jordan Maier	Ph:  248-937-3300
	Dearborn
	Oakwood Cancer Center at Oakwood Hospital and Medical Center
		Clinical Trials Office - Oakwood Cancer Center at Oakwood Hospital and Medical Center	Ph:  313-593-8090
	Detroit
	Barbara Ann Karmanos Cancer Institute
		Clinical Trials Office - Barbara Ann Karmanos Cancer Institute	Ph:  313-576-9363
	Josephine Ford Cancer Center at Henry Ford Hospital
		Eleanor Walker, MD	Ph:  313-916-1021
	Flint
	Genesys Hurley Cancer Institute
		Clinical Trials Office - Genesys Hurley Cancer Institute	Ph:  810-762-8057
	Great Lakes Cancer Institute at McLaren Regional Medical Center
		Clinical Trials Office - Great Lakes Cancer Institute at McLaren Regional Medical Center	Ph:  810-342-4071
	Hurley Medical Center
		Clinical Trials Office - Hurley Medical Center	Ph:  810-762-8057
	Grosse Pointe Woods
	Van Elslander Cancer Center at St. John Hospital and Medical Center
		Clincial Trials Office - Van Elslander Cancer Center at St. John Hospital and Medical Center	Ph:  313-343-3166
	Jackson
	Foote Memorial Hospital
		Swati Dutta	Ph:  517-788-4800
	Kalamazoo
	Borgess Medical Center
		Raymond Lord, MD	Ph:  269-373-7458
	Bronson Methodist Hospital
		Raymond Lord, MD	Ph:  269-373-7458
	West Michigan Cancer Center
		Clinical Trials Office - West Michigan Cancer Center	Ph:  269-373-7458
	Lansing
	Sparrow Regional Cancer Center
		Clinical Trials Office - Sparrow Regional Cancer Center	Ph:  517-364-2890
	Livonia
	St. Mary Mercy Hospital
		Swati Dutta	Ph:  734-464-4800
	Pontiac
	St. Joseph Mercy Oakland
		Swati Dutta	Ph:  248-858-3612
	Port Huron
	Mercy Regional Cancer Center at Mercy Hospital
		Swati Dutta	Ph:  810-985-1484
	Royal Oak
	William Beaumont Hospital - Royal Oak Campus
		Clinical Trials Office - William Beaumont Hospital - Royal Oak Campus	Ph:  248-551-7695
	Saginaw
	Seton Cancer Institute at Saint Mary's - Saginaw
		Clinical Trials Office - Seton Cancer Institute - Saginaw	Ph:  989-776-8411
	St. Joseph
	Lakeland Regional Cancer Care Center - St. Joseph
		David Hornback, MD	Ph:  574-647-7461
	Warren
	St. John Macomb Hospital
		Swati Dutta	Ph:  586-573-5757 888-593-2237
Minnesota
	Bemidji
	MeritCare Bemidji
		Preston Steen, MD	Ph:  701-234-2397
	Duluth
	CCOP - Duluth
		Daniel Nikcevich, MD, PhD	Ph:  218-786-3625
	Duluth Clinic Cancer Center - Duluth
		Clinical Trials Office - Duluth Clinic Cancer Center - Duluth	Ph:  218-786-3308
	Miller - Dwan Medical Center
		Daniel Nikcevich, MD, PhD	Ph:  218-786-3625
	St. Luke's Hospital Cancer Care Center
		Steven Bonin	Ph:  218-249-7800 877-249-7800
	Mankato
	Immanuel St. Joseph's
		Ron Smith	Ph:  507-345-2929
	Rochester
	Mayo Clinic Cancer Center
		Clinical Trials Office - All Mayo Clinic Locations	Ph:  507-538-7623
Mississippi
	Pascagoula
	Regional Cancer Center at Singing River Hospital
		James Clarkson, MD	Ph:  228-374-6296
Missouri
	Cape Girardeau
	Cancer Institute of Cape Girardeau, LLC
		Tapan Roy, MD	Ph:  573-334-2230
	Saint Louis
	Barnes-Jewish West County Hospital
		Jeff Michalski, MD	Ph:  314-362-8566
	Siteman Cancer Center at Barnes-Jewish Hospital - Saint Louis
		Jeff Michalski, MD	Ph:  314-362-8566
	Saint Peters
	Siteman Cancer Center at Barnes-Jewish St. Peters Hospital - St. Peters
		Jeff Michalski, MD	Ph:  314-362-8566
Montana
	Billings
	Billings Clinic - Downtown
		Clinical Trials Office - Billings Clinic - Downtown	Ph:  800-996-2663
			Email: research@billingsclinic.org
	CCOP - Montana Cancer Consortium
		Benjamin Marchello, MD	Ph:  406-238-6290
	Bozeman
	Bozeman Deaconess Cancer Center
		Benjamin Marchello, MD	Ph:  406-238-6290
	Great Falls
	Great Falls Clinic - Main Facility
		Benjamin Marchello, MD	Ph:  406-238-6290
	Sletten Cancer Institute at Benefis Healthcare
		Grant Harrer, MD, FACP, CCTI	Ph:  406-731-8100
Nebraska
	Lincoln
	Cancer Resource Center - Lincoln
		Gamini Soori, MD, FACP, FRCP, MBA	Ph:  402-393-3110
	Saint Elizabeth Cancer Institute at Saint Elizabeth Regional Medical Center
		Clinical Trials Office - Saint Elizabeth Cancer Institute at Saint Elizabeth Regional Medical Center	Ph:  402-483-2827
	Omaha
	Alegant Health Cancer Center at Bergan Mercy Medical Center
		Clinical Trials Office - Alegant Health Cancer Center at Bergen Mercy Medical Center	Ph:  402-398-6060
	CCOP - Missouri Valley Cancer Consortium
		Gamini Soori, MD, FACP, FRCP, MBA	Ph:  402-393-3110
	Creighton University Medical Center
		Clinical Trials Office - Creighton University Medical Center	Ph:  402-280-4100
	Immanuel Medical Center
		Gamini Soori, MD, FACP, FRCP, MBA	Ph:  402-393-3110
	Lakeside Hospital
		Gamini Soori, MD, FACP, FRCP, MBA	Ph:  402-393-3110
	Methodist Estabrook Cancer Center
		Tien-Shew Huang	Ph:  402-354-5890 877-850-3212
Nevada
	Las Vegas
	CCOP - Nevada Cancer Research Foundation
		John Ellerton, MD, CM	Ph:  702-384-0013
New Hampshire
	Exeter
	Center for Cancer Care at Exeter Hospital
		Gary Proulx	Ph:  570-882-4048
	Keene
	Kingsbury Center for Cancer Care at Cheshire Medical Center
		Alan Hartford, MD, PhD	Ph:  603-650-6600
	Lebanon
	Norris Cotton Cancer Center at Dartmouth-Hitchcock Medical Center
		Clinical Trials Office - Norris Cotton Cancer Center	Ph:  603-650-7609
			Email: cancerhelp@dartmouth.edu
New Jersey
	Basking Ridge
	Memorial Sloan-Kettering Cancer Center - Basking Ridge
		Michael Zelefsky	Ph:  908-542-3000
	Freehold
	CentraState Medical Center
		Edward Soffen, MD	Ph:  609-497-4304
	Marlton
	Fox Chase Virtua Health Cancer Program at Virtua Memorial Hospital Marlton
		Clinical Trials Office - Fox Chase Virtua Health Cancer Program at Virtua Memorial Hospital Marlton	Ph:  888-847-8823
	Pennington
	Capital Health Regional Cancer Center
		Shirnett Williamson, MD	Ph:  340-775-5433
	Pomona
	AtlantiCare Cancer Care Institute at AtlantiCare Regional Medical Center - Mainland Campus
		James Wurzer	Ph:  609-652-1000
	Ridgewood
	Valley Hospital - Ridgewood
		Michael Wesson	Ph:  201-634-5339
	Somerville
	Somerset Medical Center
		Clinical Trials Office - Somerset Medical Center	Ph:  908-685-2481
	Sparta
	Frederick R. and Betty M. Smith Cancer Treatment Center
		Adam Dicker, MD, PhD	Ph:  215-955-6527
	Vineland
	Franklin & Edith Scarpa Regional Cancer Center at South Jersey Healthcare
		Clinical Trials Office - Franklin & Edith Scarpa Regional Cancer Center at South Jersey Healthcare	Ph:  856-641-7933
	Voorhees
	Cancer Institute of New Jersey at Cooper - Voorhees
		Clinical Trials Office - Cancer Institute of New Jersey at Cooper University Hospital - Voorhees	Ph:  856-325-6757
	Fox Chase Virtua Health Cancer Program at Virtua West Jersey
		Lemuel Ariaratnam, MD	Ph:  609-261-7074
New Mexico
	Albuquerque
	Lovelace Medical Center - Downtown
		Ian Rabinowitz, MD	Ph:  505-272-4551
	Radiation Oncology Associates, PA
		Ian Rabinowitz, MD	Ph:  505-272-4551
	University of New Mexico Cancer Center
		Clinical Trials Office - University of New Mexico Cancer Center	Ph:  505-272-6972
	Las Cruces
	University of New Mexico Cancer Center - South
		Ian Rabinowitz, MD	Ph:  505-272-4551
New York
	Albany
	New York Oncology Hematology, PC at Albany Regional Cancer Care
		Vivek Kavadi	Ph:  518-489-2607
	Bronx
	Lincoln Medical and Mental Health Center
		Aubrey Freiberg	Ph:  718-579-5000
	Brooklyn
	Kings County Hospital Center
		Marvin Rotman, MD	Ph:  718-270-2181
	Long Island College Hospital
		Marvin Rotman, MD	Ph:  718-270-2181
	SUNY Downstate Medical Center
		Marvin Rotman, MD	Ph:  718-270-2181
	Veterans Affairs Medical Center - Brooklyn
		David Schwartz	Ph:  718-630-3574
	Buffalo
	Roswell Park Cancer Institute
		Clinical Trials Office - Roswell Park Cancer Institute	Ph:  877-275-7724
	Canandiaqua
	Sands Cancer Center
		Yuhchyau Chen	Ph:  585-396-6161 877-620-6161
	Commack
	Memorial Sloan-Kettering Cancer Center
		Michael Zelefsky	Ph:  212-639-8895 800-525-2225
	New York
	Herbert Irving Comprehensive Cancer Center at Columbia University Medical Center
		Clinical Trials Office - Herbert Irving Comprehensive Cancer Center at Columbia University Medical Center	Ph:  212-305-8615
	Memorial Sloan-Kettering Cancer Center
		Michael Zelefsky	Ph:  212-639-8895 800-525-2225
	St. Luke's - Roosevelt Hospital Center - St.Luke's Division
		Ronald Ennis	Ph:  212-523-4000
	Stich Radiation Center at NewYork-Presbyterian Hospital/Weill Cornell Medical Center
		Michael Smith	Ph:  212-746-3610
	Poughkeepsie
	Hudson Valley Oncology Associates
		Adam Dicker, MD, PhD	Ph:  215-955-6527
	Rochester
	Highland Hospital of Rochester
		Yuhchyau Chen	Ph:  585-473-2200
	James P. Wilmot Cancer Center at University of Rochester Medical Center
		Yuhchyau Chen	Ph:  585-275-5345
	Lipson Cancer and Blood Center at Rochester General Hospital
		Meri Atanas	Ph:  585-922-4020
	University Radiation Oncology at Parkridge Hospital
		Yuhchyau Chen	Ph:  585-225-3989
	Rockville Centre
	Memorial Sloan-Kettering Cancer Center - Rockville Centre
		Michael Zelefsky	Ph:  516-256-3651
	Sleepy Hollow
	Memorial Sloan-Kettering Cancer Center at Phelps Memorial Hospital Center
		Michael Zelefsky	Ph:  914-366-3000
North Carolina
	Asheboro
	Randolph Hospital
		Clinical Trails Office - Randolph Hospital	Ph:  336-832-0821
	Asheville
	Mission Hospitals - Memorial Campus
		Clinical Trials Office - Mission Hospitals - Memorial Campus	Ph:  828-213-4150
	Charlotte
	Blumenthal Cancer Center at Carolinas Medical Center
		Clinical Trials Office - Blumenthal Cancer Center at Carolinas Medical Center	Ph:  704-355-2884
	Greensboro
	Moses Cone Regional Cancer Center at Wesley Long Community Hospital
		Clinical Trials Office - Moses Cone Regional Cancer Center at Wesley Long Community Hospital	Ph:  336-621-8374
	Morehead City
	Coleman Radiation Oncology Center at Carter General Hospital
		Michael Papagikos	Ph:  252-808-6191
	New Bern
	CarolinaEast Cancer Care
		Michael Papagikos	Ph:  252-633-8790
	Pinehurst
	FirstHealth Moore Regional Community Hospital Comprehensive Cancer Center
		Clinical Trials Office - FirstHealth Moore Regional Community Hospital Comprehensive Cancer Center	Ph:  910-715-2200
	Raleigh
	Cancer Centers of North Carolina - Raleigh
		Vivek Kavadi	Ph:  919-781-7070
	Rex Cancer Center at Rex Hospital
		Clinical Trials Office - Rex Cancer Center	Ph:  919-784-7209
	Reidsville
	Annie Penn Cancer Center
		Clinical Trials Office - Annie Penn Cancer Center	Ph:  336-621-8374
	Supply
	South Atlantic Radiation Oncology, LLC
		Michael Papagikos	Ph:  910-754-4716
	Wilmington
	Coastal Carolina Radiation Oncology Center
		Michael Papagikos	Ph:  910-251-1839
	Zimmer Cancer Center at New Hanover Regional Medical Center
		Michael Papagikos	Ph:  910-342-3000 877-228-8135
	Winston-Salem
	Wake Forest University Comprehensive Cancer Center
		Clinical Trials Office - Wake Forest University Comprehensive Cancer Center	Ph:  336-713-6771
North Dakota
	Fargo
	CCOP - MeritCare Hospital
		Preston Steen, MD	Ph:  701-234-2397
	MeritCare Broadway
		Preston Steen, MD	Ph:  701-234-2397
	Roger Maris Cancer Center at MeritCare Hospital
		Preston Steen, MD	Ph:  701-234-2397
	Grand Forks
	Altru Cancer Center at Altru Hospital
		Clinical Trails Office - Altru Cancer Center at Altru Hospital	Ph:  701-780-6520
Ohio
	Akron
	McDowell Cancer Center at Akron General Medical Center
		Mitchell Fromm, MD	Ph:  330-344-6448
	Summa Center for Cancer Care at Akron City Hospital
		Clinical Trials Office - Akron City Hospital	Ph:  330-375-6101
	Barberton
	Barberton Citizens Hospital
		William Demas, MD	Ph:  330-375-3557
	Canton
	Aultman Cancer Center at Aultman Hospital
		Clinical Trials Office - Aultman Cancer Center at Aultman Hospital	Ph:  330-363-6891
	Chillicothe
	Adena Regional Medical Center
		Clinical Trials Office - Adena Regional Medical Center	Ph:  877-779-7585
	Cincinnati
	Charles M. Barrett Cancer Center at University Hospital
		Kevin Redmond, MD	Ph:  513-584-9089
	Cleveland
	Case Comprehensive Cancer Center
		Clinical Trials Office - Case Comprehensive Cancer Center	Ph:  800-641-2422
	Cleveland Clinic Cancer Center at Fairview Hospital
		Clinical Trials Office - Cleveland Clinic Cancer Center at Fairview Hospital	Ph:  216-476-9362
	Cleveland Clinic Taussig Cancer Center
		Clinical Trials Office - Cleveland Clinic Taussig Cancer Center	Ph:  866-223-8100
	Columbus
	Arthur G. James Cancer Hospital and Richard J. Solove Research Institute at Ohio State University Comprehensive Cancer Center
		Ohio State University Cancer Clinical Trial Matching Service	Ph:  866-627-7616
			Email: osu@emergingmed.com
	CCOP - Columbus
		J. Philip Kuebler, MD, PhD	Ph:  614-442-3130
	Doctors Hospital at Ohio Health
		Clinical Trials Office - Doctors Hospital at Ohio Health	Ph:  614-566-3275
	Grant Medical Center Cancer Care
		Clinical Trials Office - Grant Medical Center Cancer Care	Ph:  614-566-4475
	Mount Carmel Health - West Hospital
		J. Philip Kuebler, MD, PhD	Ph:  614-442-3130
	Riverside Methodist Hospital Cancer Care
		Clinical Trials Office - Riverside Methodist Hospital Cancer Care	Ph:  614-566-4475
	Delaware
	Grady Memorial Hospital
		J. Philip Kuebler, MD, PhD	Ph:  614-442-3130
	Elyria
	Community Cancer Center
		Rex Mowat	Ph:  440-324-0400
	Hematology Oncology Center
		Rex Mowat	Ph:  440-324-0401
	Independence
	Cleveland Clinic Cancer Center
		Rahul Tendulkar	Ph:  216-524-7979
	Lima
	Lima Memorial Hospital
		Rex Mowat	Ph:  419-228-3335
	Marietta
	Strecker Cancer Center at Marietta Memorial Hospital
		J. Philip Kuebler, MD, PhD	Ph:  614-442-3130
	Maumee
	Northwest Ohio Oncology Center
		Rex Mowat	Ph:  419-891-5600
	Mayfield Heights
	Hillcrest Cancer Center at Hillcrest Hospital
		Rahul Tendulkar	Ph:  440-312-4500
	Mentor
	Lake/University Ireland Cancer Center
		Robert Fine	Ph:  440-205-5755
	Middleburg Heights
	Southwest General Health Center
		Robert Fine	Ph:  440-816-8000
	Newark
	Licking Memorial Cancer Care Program at Licking Memorial Hospital
		J. Philip Kuebler, MD, PhD	Ph:  614-442-3130
	Orange Village
	UHHS Chagrin Highlands Medical Center
		Robert Fine	Ph:  216-292-1783
	Oregon
	St. Charles Mercy Hospital
		Rex Mowat	Ph:  419-696-7200
	Parma
	Parma Community General Hospital
		Clinical Trials Office - Parma Community General Hospital	Ph:  440-743-4747
	Salem
	Cancer Care Center, Incorporated
		William Demas, MD	Ph:  330-375-3557
	Sandusky
	North Coast Cancer Care, Incorporated
		Rex Mowat	Ph:  419-626-9090
	Springfield
	Community Hospital of Springfield and Clark County
		J. Philip Kuebler, MD, PhD	Ph:  614-442-3130
	Sylvania
	Flower Hospital Cancer Center
		Clinical Trials Office - Flower Hospital Cancer Center	Ph:  419-824-1842
	Tiffin
	Mercy Hospital of Tiffin
		Rex Mowat	Ph:  419-447-3130
	Toledo
	CCOP - Toledo Community Hospital
		Rex Mowat	Ph:  419-843-6147
	Medical University of Ohio Cancer Center
		Clinical Trials Office - Medical University of Ohio Cancer Center	Ph:  419-383-6583
	St. Anne Mercy Hospital
		Rex Mowat	Ph:  419-407-2663
	St. Vincent Mercy Medical Center
		Rex Mowat	Ph:  419-251-4515
	Toledo Clinic, Incorporated - Main Clinic
		Rex Mowat	Ph:  419-479-5605
	Toledo Hospital
		Clinical Trials Office - Toledo Hospital	Ph:  419-824-1842
	West Chester
	Precision Radiotherapy at University Pointe
		Kevin Redmond, MD	Ph:  513-584-9089
	Westerville
	Mount Carmel St. Ann's Cancer Center
		J. Philip Kuebler, MD, PhD	Ph:  614-442-3130
	Westlake
	UHHS Westlake Medical Center
		Robert Fine	Ph:  440-250-2001
	Wooster
	Cancer Treatment Center
		Clinical Trials Office - Cancer Treatment Center	Ph:  330-375-4221
	Cleveland Clinic - Wooster
		Clinical Trials Office - Cleveland Clinic - Wooster	Ph:  800-862-7798
	Zanesville
	Genesis - Good Samaritan Hospital
		Clinical Trials Office - Genesis - Good Samaritan Hospital	Ph:  740-454-5232
Oklahoma
	Oklahoma City
	Oklahoma University Cancer Institute
		Terence Herman	Ph:  405-271-6822
	Tulsa
	Natalie Warren Bryant Cancer Center at St. Francis Hospital
		Charles Stewart	Ph:  918-494-2273
Oregon
	Eugene
	Willamette Valley Cancer Center - Eugene
		Vivek Kavadi	Ph:  541-683-5001
	Grants Pass
	Three Rivers Community Hospital
		Gordon Metz, MD	Ph:  541-608-4263
	Medford
	Dubs Cancer Center at Rogue Valley Medical Center
		Gordon Metz, MD	Ph:  541-608-4263
	Providence Cancer Center at PMCC
		Gordon Metz, MD	Ph:  541-608-4263
	Salem
	Salem Hospital Regional Cancer Care Services
		Clinical Trials Office - Salem Hospital Regional Cancer Care Services	Ph:  503-561-2618
Pennsylvania
	Abington
	Rosenfeld Cancer Center at Abington Memorial Hospital
		Clinical Trials Office - Rosenfeld Cancer Center at Abington Memorial Hospital	Ph:  215-481-2402
	Beaver
	UPMC Cancer Center at Beaver Medical Center
		Ryan Smith, MD	Ph:  412-623-3205
	Bethlehem
	St. Luke's Cancer Network at St. Luke's Hospital
		Nimisha Deb, MD	Ph:  610-954-4300
	Clairton
	UPMC Cancer Center at Jefferson Regional Medical Center
		Ryan Smith, MD	Ph:  412-623-3205
	Danville
	Geisinger Cancer Institute at Geisinger Health
		Clinical Trials Office - Geisinger Cancer Institute	Ph:  570-271-5251
	Drexel Hill
	Delaware County Regional Cancer Center at Delaware County Memorial Hospital
		Rachelle Lanciano, MD	Ph:  610-284-8240
	Dunmore
	Northeast Radiation Oncology Center
		Adam Dicker, MD, PhD	Ph:  215-955-6527
	Gettysburg
	Adams Cancer Center
		Amit Shah	Ph:  717-741-8180
	Greensburg
	UPMC Cancer Center - Arnold Palmer Pavilion
		Ryan Smith, MD	Ph:  412-623-3205
	Hershey
	Penn State Hershey Cancer Institute at Milton S. Hershey Medical Center
		Clinical Trials Office - Penn State Hershey Cancer Institute at Milton S. Hershey Medical Center	Ph:  717-531-3779
			Email: CTO@hmc.psu.edu
	Johnstown
	UPMC Cancer Center at the John P. Murtha Pavilion
		Ryan Smith, MD	Ph:  412-623-3205
	Lancaster
	Lancaster General Hospital
		Jeffery Eshleman	Ph:  717-544-5511
	Langhorne
	St. Mary Regional Cancer Center
		Clinical Trials Office - St. Mary Regional Cancer Center	Ph:  215-710-4585
	McKeesport
	UPMC Cancer Center at UPMC McKeesport
		Clinical Trials Office - UPMC Cancer Center at UPMC McKeesport	Ph:  412-647-8073
	Milford
	Upper Delaware Valley Cancer Center
		Adam Dicker, MD, PhD	Ph:  215-955-6527
	Moon Township
	UPMC - Moon
		Ryan Smith, MD	Ph:  412-623-3205
	Natrona Heights
	UPMC Cancer Center - Natrona Heights
		Ryan Smith, MD	Ph:  412-623-3205
	New Castle
	Jameson Memorial Hospital - North Campus
		Ryan Smith, MD	Ph:  412-623-3205
	Philadelphia
	Fox Chase Cancer Center - Philadelphia
		Clinical Trials Office - Fox Chase Cancer Center - Philadelphia	Ph:  215-728-4790
	Frankford Hospital Cancer Center - Torresdale Campus
		Adam Dicker, MD, PhD	Ph:  215-955-6527
	Kimmel Cancer Center at Thomas Jefferson University - Philadelphia
		Clinical Trials Office - Kimmel Cancer Center at Thomas Jefferson University - Philadelphia	Ph:  215-955-6084
	Pittsburgh
	UPMC - Shadyside
		Clinical Trials Office - UPMC - Shadyside	Ph:  412-621-2334
	UPMC Cancer Center - Upper St. Clair
		Ryan Smith, MD	Ph:  412-623-3205
	UPMC Cancer Center at Magee-Womens Hospital
		Clinical Trials Office - UPMC Cancer Center at Magee-Womens Hospital	Ph:  412-647-2811
	UPMC Cancer Center at UPMC Passavant
		Clinical Trials Office - UPMC Cancer Center at UPMC Passavant	Ph:  412-367-6454
	UPMC Cancer Center at UPMC Presbyterian
		Clinical Trial Office - UPMC Cancer Center at UPMC Presbyterian	Ph:  412-647-2811
	UPMC Cancer Center at UPMC St. Margaret
		Ryan Smith, MD	Ph:  412-623-3205
	Reading
	McGlinn Family Regional Cancer Center at Reading Hospital and Medical Center
		Clinical Trials Office - McGlinn Family Regional Cancer Center	Ph:  610-988-9323
	St. Joseph Medical Center
		Leonard Tuanquin	Ph:  610-378-2000
	Uniontown
	UPMC Cancer Center - Uniontown
		Ryan Smith, MD	Ph:  412-623-3205
	Upland
	Crozer-Chester Medical Center
		Stephen Arrigo	Ph:  610-447-2000
	Washington
	Washington Hospital Cancer Center
		Ryan Smith, MD	Ph:  412-623-3205
	Wilkes-Barre
	Frank M. and Dorothea Henry Cancer Center at Geisinger Wyoming Valley Medical Center
		Clinical Trials Office - Frank M. and Dorothea Henry Cancer Center at Geisinger Wyoming Valley Medical Center	Ph:  570-271-5251
	York
	York Cancer Center at Apple Hill Medical Center
		Amit Shah	Ph:  717-741-8180
South Carolina
	Anderson
	AnMed Cancer Center
		Clinical Trials Office - AnMed Cancer Center	Ph:  864-512-1000
	Charleston
	Hollings Cancer Center at Medical University of South Carolina
		Clinical Trials Office - Hollings Cancer Center at Medical University of South Carolina	Ph:  843-792-9321
	Greenville
	Cancer Centers of the Carolinas - Eastside
		Clinical Trials Office - Cancer Centers of the Carolinas	Ph:  864-241-6251
	Cancer Centers of the Carolinas - Faris Road
		Jeffrey Giguere, MD, FACP	Ph:  864-987-7000
	Cancer Centers of the Carolinas - Grove Commons
		Clinical Trials Office - Cancer Centers of the Carolinas	Ph:  864-241-6251
	CCOP - Greenville
		Jeffrey Giguere, MD, FACP	Ph:  864-987-7000
	Greer
	Cancer Centers of the Carolinas - Greer Medical Oncology
		Jeffrey Giguere, MD, FACP	Ph:  864-987-7000
	Seneca
	Cancer Centers of the Carolinas - Seneca
		Jeffrey Giguere, MD, FACP	Ph:  864-987-7000
	Spartanburg
	Cancer Centers of the Carolinas - Spartanburg
		Jeffrey Giguere, MD, FACP	Ph:  864-987-7000
	CCOP - Upstate Carolina
		Clinical Trials Office - CCOP - Upstate Carolina	Ph:  800-486-5941
	Gibbs Regional Cancer Center at Spartanburg Regional Medical Center
		Clinical Trials Office - Gibbs Regional Cancer Center	Ph:  800-486-5941
South Dakota
	Rapid City
	Rapid City Regional Hospital
		Michael Swartz	Ph:  605-719-2360
Texas
	Bedford
	Texas Oncology, PA at Harris Center HEB
		Vivek Kavadi	Ph:  817-359-9000
	Dallas
	Simmons Comprehensive Cancer Center at University of Texas Southwestern Medical Center - Dallas
		Clinical Trials Office - Simmons Comprehensive Cancer Center at University of Texas Southwestern Medical Center - Dallas	Ph:  866-460-4673; 214-648-7097
	Denton
	Texas Oncology, PA at Texas Cancer Center - Denton South
		Vivek Kavadi	Ph:  940-382-1022
	Fort Worth
	Klabzuba Cancer Center at Harris Methodist Fort Worth Hospital
		Vivek Kavadi	Ph:  817-820-4820
	Galveston
	University of Texas Medical Branch
		Clinical Trials Office - University of Texas Medical Branch	Ph:  409-772-1950
	Longview
	Longview Cancer Center
		Vivek Kavadi	Ph:  903-757-2122
	Odessa
	West Texas Cancer Center
		Vivek Kavadi	Ph:  432-335-8275
	San Antonio
	Cancer Care Centers of South Texas - Northeast
		Vivek Kavadi	Ph:  210-656-7177
	Sherman
	Texas Oncology, PA at Texas Cancer Center - Sherman
		Vivek Kavadi	Ph:  903-892-9455
	Sugar Land
	Texas Oncology, PA at Texas Oncology Cancer Center Sugar Land
		Vivek Kavadi	Ph:  281-277-5200
	Tyler
	Tyler Cancer Center
		Vivek Kavadi	Ph:  903-579-9800
	Wichita Falls
	Texas Oncology, PA - Wichita Falls
		Vivek Kavadi	Ph:  940-767-4364
Utah
	Cedar City
	Sandra L. Maxwell Cancer Center
		R. Jeffrey Lee, MD	Ph:  801-408-1146
	Logan
	Logan Regional Hospital
		R. Jeffrey Lee, MD	Ph:  801-408-1146
	Murray
	Jon and Karen Huntsman Cancer Center at Intermountain Medical Center
		R. Jeffrey Lee, MD	Ph:  801-408-1146
	Ogden
	Val and Ann Browning Cancer Center at McKay-Dee Hospital Center
		Clinical Trials Office - McKay-Dee Hospital Center	Ph:  801 387-7426
	Provo
	Utah Valley Regional Medical Center - Provo
		Clinical Trials Office - Utah Valley Regional Medical Center - Provo	Ph:  801-357-7965
	Saint George
	Dixie Regional Medical Center - East Campus
		Clinical Trials Office - Dixie Regional Medical Center - East Campus	Ph:  435-688-4167
	Salt Lake City
	Huntsman Cancer Institute at University of Utah
		Clinical Trials Office - Huntsman Cancer Institute at University of Utah	Ph:  801-581-4477
			Email: clinical.trials@hci.utah.edu
	LDS Hospital
		R. Jeffrey Lee, MD	Ph:  801-408-1146
	Utah Cancer Specialists at UCS Cancer Center
		R. Jeffrey Lee, MD	Ph:  801-408-1146
Vermont
	Burlington
	Fletcher Allen Health Care - University Health Center Campus
		Clinical Trials Office - Fletcher Allen Health Care	Ph:  802-656-8990
	Saint Johnsbury
	Norris Cotton Cancer Center - North
		Alan Hartford, MD, PhD	Ph:  603-650-6600
Virginia
	Alexandria
	INOVA Alexandria Hospital
		Matthew Poggi	Ph:  703-504-3000
	Charlottesville
	Martha Jefferson Hospital Cancer Care Center
		Sylvia Hendrix, MD	Ph:  434-982-8125
	Danville
	Danville Regional Medical Center
		Clinical Trials Office - Danville Regional Medical Center	Ph:  434-799-3753
	Portsmouth
	Naval Medical Center - Portsmouth
		Clinical Trials Office - Naval Medical Center - Portsmouth	Ph:  757-953-5939
	Richmond
	Veterans Affairs Medical Center - Richmond
		Clinical Trials Office - Veterans Affairs Medical Center - Richmond	Ph:  804-675-5646
Washington
	Bellingham
	St. Joseph Cancer Center
		Michael Taylor, MD	Ph:  360-715-4144
	Bremerton
	Harrison Medical Center
		Stephen Springate	Ph:  360-792-6605
	Federal Way
	St. Francis Hospital
		Yoshio Inoue	Ph:  253-944-7997
	Puyallup
	Good Samaritan Cancer Center
		Yoshio Inoue	Ph:  253-697-4000
	Seattle
	CCOP - Virginia Mason Research Center
		Huong Pham, MD	Ph:  206-223-6801
	Seattle Cancer Care Alliance
		Clinical Trials Office - Seattle Cancer Care Alliance	Ph:  800-804-8824
	University Cancer Center at University of Washington Medical Center
		George Laramore, PhD, MD, FACR	Ph:  206-598-4110
	Virginia Mason Medical Center
		Huong Pham, MD	Ph:  206-223-6801
	Spokane
	Cancer Care Northwest - Spokane South
		Clinical Trials Office - Cancer Care Northwest - Spokane South	Ph:  509-228-1083
	Tacoma
	CCOP - Northwest
		Yoshio Inoue	Ph:  253-403-1461
	Franciscan Cancer Center at St. Joseph Medical Center
		Clinical Trials Office - Franciscan Cancer Center	Ph:  253-426-6914
	MultiCare Regional Cancer Center at Tacoma General Hospital
		Clinical Trials Office - MultiCare Regional Cancer Center	Ph:  253-403-3229
	Wenatchee
	Wenatchee Valley Medical Center
		Clinical Trials Office - Wenatchee Valley Medical Center	Ph:  509-665-5800
	Yakima
	North Star Lodge Cancer Center at Yakima Valley Memorial Hospital
		Clinical Trails Office - North Star Lodge Cancer Center	Ph:  509-574-3422
West Virginia
	Charleston
	West Virginia University Health Sciences Center - Charleston
		Steven Jubelirer, MD	Ph:  304-388-8380
Wisconsin
	Antigo
	Langlade Memorial Hospital
		Darryl Barton, MD	Ph:  715-847-2866
	Appleton
	Theda Care Cancer Institute
		Clinical Trials Office - Theda Care Cancer Institute	Ph:  920-380-1500
	Beloit
	Beloit Memorial Hospital
		Mark Ritter	Ph:  608-364-5011
	Fond du Lac
	Central Wisconsin Cancer Program at Agnesian HealthCare
		Clinical Trials Office - Central Wisconsin Cancer Program at Agnesian HealthCare	Ph:  800-494-2927
	Green Bay
	Bellin Memorial Hospital
		Charlie Pan	Ph:  920-433-3500
	St. Vincent Hospital Regional Cancer Center
		Clinical Trials Office - St. Vincent Hospital Regional Cancer Center	Ph:  920-433-8889
	Johnson Creek
	UW Cancer Center Johnson Creek
		Mark Ritter	Ph:  920-699-3500
	La Crosse
	Franciscan Skemp Healthcare - La Crosse Campus
		Kernan Minehan, MD	Ph:  608-791-9510
	Gundersen Lutheran Center for Cancer and Blood
		Clinical Trials Office - Gundersen Lutheran Cancer Center	Ph:  608-775-2385
			Email: cancerctr@gundluth.org
	Madison
	University of Wisconsin Paul P. Carbone Comprehensive Cancer Center
		Clinical Trials Office - University of Wisconsin Paul P. Carbone Comprehensive Cancer Center	Ph:  608-262-5223
	Marinette
	Bay Area Cancer Care Center at Bay Area Medical Center
		Gregory Cooley, MD	Ph:  414-433-8184
	Menomonee Falls
	Community Memorial Hospital Cancer Care Center
		Colleen Lawton, MD	Ph:  414-805-4472
	Mequon
	Columbia Saint Mary's Hospital - Ozaukee
		Carl Olson, MD	Ph:  414-291-1556
	Milwaukee
	Columbia-Saint Mary's Cancer Care Center
		Clinical Trials Office - Columbia-St. Mary's Cancer Care Center	Ph:  414-326-1739
	Medical College of Wisconsin Cancer Center
		Clinical Trials Office - Medical College of Wisconsin Cancer Center	Ph:  414-805-4380
	Veterans Affairs Medical Center - Milwaukee
		Elizabeth Gore, MD	Ph:  414-805-4369
	Vince Lombardi Cancer Clinic at Aurora St. Luke's Medical Center
		Clinical Trials Office - Vince Lombardi Cancer Clinic	Ph:  414-649-5717
	Mukwonago
	D.N. Greenwald Center
		Wingate Clapper, MD	Ph:  262-928-2439
	Oconomowoc
	Regional Cancer Center at Oconomowoc Memorial Hospital
		Clinical Trials Office - Regional Cancer Center at Oconomowoc Memorial Hospital	Ph:  262-928-7878
	Racine
	All Saints Cancer Center at Wheaton Franciscan Healthcare
		James Taylor, MD	Ph:  262-687-5000
	Sturgeon Bay
	Door County Cancer Center at Door County Memorial Hospital
		Gregory Cooley, MD	Ph:  414-433-8184
	Summit
	Aurora Medical Center
		Ellen Ziaja	Ph:  262-434-1000
	Waukesha
	Waukesha Memorial Hospital Regional Cancer Center
		Clinical Trials Office - Waukesha Memorial Hospital Regional Cancer Center	Ph:  262-928-7632
	Wausau
	University of Wisconcin Cancer Center at Aspirus Wausau Hospital
		Clinical Trials Office - University of Wisconsin Cancer Center	Ph:  608-262-5223
	West Allis
	West Allis Memorial Hospital
		Clinical Trials Office - West Allis Memorial Hospital	Ph:  414-649-5717
	Wisconsin Rapids
	Riverview UW Cancer Center at Riverview Hospital
		Mark Ritter	Ph:  715-421-7442
Wyoming
	Sheridan
	Welch Cancer Center at Sheridan Memorial Hospital
		Benjamin Marchello, MD	Ph:  406-238-6290
Canada
Alberta
	Calgary
	Tom Baker Cancer Centre - Calgary
		Alexander Balogh	Ph:  403-521-3723
	Edmonton
	Cross Cancer Institute at University of Alberta
		Nawaid Usmani	Ph:  780-432-8771
New Brunswick
	Saint John
	Saint John Regional Hospital
		John Carson, MD	Ph:  506-648-6890
Newfoundland and Labrador
	Saint John's
	Doctor H. Bliss Murphy Cancer Centre
		Jonathan Greenland	Ph:  709-777-7589
Ontario
	Hamilton
	Margaret and Charles Juravinski Cancer Centre
		Himanshu Lukka	Ph:  905-387-9495
	Thunder Bay
	Cancer Care Program at Thunder Bay Regional Health Sciences
		Sunil Premial Gulavita	Ph:  807-684-7200
Quebec
	Montreal
	Hopital Notre-Dame du CHUM
		Marie-Claude Beauchemin	Ph:  514-281-6000
	Maisonneuve-Rosemont Hospital
		Nader Khaouam	Ph:  514-252-3400
	McGill Cancer Centre at McGill University
		Luis Souhami	Ph:  514-398-1444
	Quebec City
	Centre Hospitalier Universitaire de Quebec
		Andre-Guy Martin	Ph:  418-525-4444
	Sherbrooke
	CHUS-Hopital Fleurimont
		Abdenour Nabid, MD, FRCPC	Ph:  819-346-1110ext.14602
Saskatchewan
	Regina
	Allan Blair Cancer Centre at Pasqua Hospital
		Evgeny Sadikov	Ph:  306-766-2203
	Saskatoon
	Saskatoon Cancer Centre at the University of Saskatchewan
		Ali El-Gayed	Ph:  306-655-2662