Alternate Title
Basic Trial Information
Objectives
Entry Criteria
Expected Enrollment
Outcomes
Outline
Published Results
Trial Contact Information
Registry Information

Alternate Title

Vorinostat and Bortezomib in Treating Patients With Progressive, Recurrent Glioblastoma Multiforme

Basic Trial Information

Objectives

Primary

1. To determine the clinical efficacy of vorinostat (SAHA) and bortezomib, in terms of progression-free survival (PFS) at 6 months, in patients with progressive, recurrent glioblastoma multiforme.

Secondary

1. To determine the clinical efficacy of this regimen, in terms of overall survival, PFS at 12 months, time to progression, and objective response rate, in these patients.
2. To identify molecular predictors of response in baseline tumor specimens from these patients.
3. To determine molecular changes in response to this regimen in tumor specimens from patients undergoing surgery.

Entry Criteria

Disease Characteristics:

• Histologically confirmed glioblastoma multiforme
  • Gliosarcoma or other grade 4 astrocytoma variant (e.g., giant cell glioblastoma) allowed
  • Recurrent disease

• Must have evidence of tumor progression by MRI or CT scan after radiotherapy or after the most recent antitumor therapy

• Bidimensionally measurable or evaluable disease by MRI or CT scan
  • Patients receiving corticosteroids must be on a fixed dose for at least 1 week prior to baseline scan

Prior/Concurrent Therapy:

• See Disease Characteristics
• At least 8 weeks since prior radiotherapy
• More than 6 weeks since prior stereotactic radiosurgery or interstitial brachytherapy, unless there is a separate lesion on MRI that is not part of the prior treatment field
• More than 4 weeks since prior chemotherapy (6 weeks for nitrosoureas)
• No more than 1 prior chemotherapy regimen* for progressive/recurrent disease (stratum 1)
  • Patients in stratum 2 may have received any number of prior chemotherapy regimens* for progressive/recurrent disease
• More than 2 weeks since prior small molecule cell cycle inhibitors
• More than 7 days since prior valproic acid
• More than 7 days since prior category I drugs that are generally accepted to have a risk of causing Torsades de Pointes including:
  • Quinidine, procainamide, disopyramide
  • Amiodarone, sotalol, ibutilide, dofetilide
  • Erythromycin, clarithromycin
  • Chlorpromazine, haloperidol, mesoridazine, thioridazine, pimozide
  • Cisapride, bepridil, droperidol, methadone, arsenic, chloroquine, domperidone, halofantrine, levomethadyl, pentamidine, sparfloxacin, lidoflazine
• More than 4 weeks since prior bevacizumab
• No prior treatment with vorinostat or bortezomib
• No concurrent enzyme-inducing antiepileptic drugs (e.g., phenytoin, fosphenytoin, carbamazepine, phenobarbital, or primidone)
• No other concurrent potent CYP3A4 inducer (e.g., rifampin or St. John’s wort)
• No other concurrent investigational therapy for the primary neoplasm
• No other concurrent anticancer therapy (other than hormonal therapy)

 [Note: *Prior adjuvant therapy allowed; adjuvant therapy does not count towards the number of prior chemotherapy regimens for progressive/recurrent disease]

Patient Characteristics:

• ECOG performance status 0-2
• WBC ≥ 3,000/mm³
• ANC ≥ 1,500/mm³
• Platelet count ≥ 100,000/mm³
• Hemoglobin ≥ 9 g/dL
• Total bilirubin ≤ 1.5 times upper limit of normal (ULN)
• AST ≤ 3 times ULN
• Creatinine normal
• Not pregnant or nursing
• Negative pregnancy test
• Fertile patients must use effective contraception during and for 6 months after the last dose of vorinostat
• Willing to provide mandatory correlative laboratory tissue samples
• Able to take oral medications
• No uncontrolled infection
• No known hypersensitivity to any of the components of vorinostat or bortezomib
• No myocardial infarction or unstable angina within the past 6 months
• No congestive heart failure requiring use of ongoing maintenance therapy or history of life-threatening ventricular arrhythmias
• No concurrent uncontrolled illness including, but not limited to, any of the following:
  • Ongoing or active infection
  • Psychiatric illness or social situation that would limit compliance with study requirements
• No other active malignancy within the past 3 years except nonmelanoma skin cancer or carcinoma in situ of the cervix
• No comorbid systemic illness or other severe concurrent disease that, in the judgment of the investigator, would preclude study entry or significantly interfere with proper assessment of safety and toxicity of the prescribed study regimens
• Not immunocompromised
  • Patients known to be HIV positive are eligible provided there is no clinical evidence of an immunocompromised state
• No peripheral neuropathy ≥ grade 2
• No peripheral neuropathy with pain ≥ grade 1
• No congenital long QT syndrome
• No prolonged OTC interval (> 450 msec)

Expected Enrollment

Outcomes

Progression-free survival at 6 months

Overall survival
Progression-free survival at 12 and 18 months
Confirmed tumor response (complete response, partial response, or regular response on two consecutive evaluations over at least 6 weeks)

Outline

This is a multicenter study. Patients are stratified according to planned surgery (no [stratum 1] vs yes [stratum 2]).

• Stratum 1 (not undergoing surgery): Patients receive oral vorinostat (SAHA) once daily on days 1-14 and bortezomib IV on days 1, 4, 8, and 11. Courses repeat every 21 days in the absence of disease progression or unacceptable toxicity.

• Stratum 2 (undergoing surgery): Patients receive oral SAHA once daily for 2 days prior to surgery and then on the day of surgery. Patients also receive bortezomib IV on the day of surgery. After receiving the 3rd dose of SAHA, patients undergo surgery to remove the tumor. Beginning at least 7 days after surgery, patients receive SAHA and bortezomib as in stratum 1.

Tumor tissue samples are collected at baseline and during surgery (stratum 2) for correlative laboratory studies. Tissue samples are analyzed for baseline total and phosphorylated AKT and p27^KIp1 expression by IHC. Tissue samples from patients in stratum 2 are also analyzed for histone acetylation status; markers of proteasome inhibition; total and phosphorylated Bax expression by IHC; and gene expression profiles.

After completion of study therapy, patients are followed every 3 months for 2 years and then every 6 months thereafter.

Friday BB, Anderson SK, Buckner J, et al.: Phase II trial of vorinostat in combination with bortezomib in recurrent glioblastoma: a north central cancer treatment group study. Neuro Oncol 14 (2): 215-21, 2012.[PUBMED Abstract]

Trial Contact Information

Trial Lead Organizations

North Central Cancer Treatment Group

Evanthia Galanis, MD, Protocol chair		Ph: 507-284-3559

Registry Information
Official Title		Phase II Study of Vorinostat (SAHA) in Combination with Bortezomib (PS-341) in Patients with Recurrent Glioblastoma Multiforme
Trial Start Date		2008-07-04
Trial Completion Date		2010-11-09
Registered in ClinicalTrials.gov		NCT00641706
Date Submitted to PDQ		2008-03-13
Information Last Verified		2010-01-29
NCI Grant/Contract Number		CA25224

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