Clinical Trials (PDQ®)
Phase III Randomized Study of Adjuvant Chemotherapy With L-leucovorin and Fluorouracil Versus Observation in Patients With Resected Colorectal Cancer. Note: The information about this trial has not been updated by the sponsor/principal investigator/lead organization. Cancer.gov cannot verify the accuracy of the information.
|Phase III||Treatment||Closed||18 and over||Other||NCRI-QUASAR1|
EU-99053, UKCCCR-QUASAR1, NCT00005586, ISRCTN82375386
Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells. It is not yet known whether chemotherapy is more effective than observation in patients who have had surgery to remove colorectal cancer.
Eligibility criteria include the following:
- At least 18 years old
- No distant metastases
- No residual disease following surgery
- No more than 12 weeks since surgery
- For more information about the eligibility criteria for this trial, refer to the Health Professional version.
Final eligibility for a clinical trial is determined by the health professionals conducting the trial.
Patients will be randomly assigned to one of two groups. Some patients in group one will receive infusions of leucovorin and fluorouracil for 5 days every 4 weeks for six courses. Other patients will receive infusions of leucovorin and fluorouracil once a week for 30 weeks. Patients in group two will receive observation. All patients will be evaluated once a year.
For more details about this trial, refer to the Health Professional version of the trial summary.
If you are interested in participating in a clinical trial, contact your doctor for a referral or call a trial contact person listed below. You may see the same contact person listed at more than one site, however, if you call the number listed you can ask to speak to the study coordinator or person involved with the specific trial you are interested in. If you have questions about cancer or clinical trials, call the Cancer Information Service at 1-800-4-CANCER (1-800-422-6237). General information about clinical trials, including risks, benefits, and costs, can be found on NCI's Web site.
Trial Lead Organizations
National Cancer Research Institute
|Norman Williams, MD, Protocol chair|
|Official Title||A UKCCCR Study of Adjuvant Chemotherapy for Colorectal Cancer|
|Trial Start Date||1997-10-26|
|Registered in ClinicalTrials.gov||NCT00005586|
|Date Submitted to PDQ||2000-01-13|
|Information Last Verified||2007-03-26|