Alternate Title
Basic Trial Information
Objectives
Entry Criteria
Expected Enrollment
Outcomes
Outline
Trial Contact Information
Registry Information
CT Scans in Guiding the Treatment of Patients With Prostate Cancer Who are Undergoing Radiation Therapy
| Phase | Type | Status | Age | Sponsor | Protocol IDs |
|---|---|---|---|---|---|
| Phase II | Diagnostic, Treatment | Completed | Not specified | NCI | MSKCC-01022 NCI-G01-1968, NCT00020891 |
Objectives
- Compare the accuracy of radiotherapy delivery using multiple CT scans to guide patient positioning vs the standard portal image guided procedure in patients with prostate cancer undergoing external beam radiotherapy.
- Determine the reduction in the proportion of patients with large target positioning errors using the CT-guided procedure.
- Determine organ motion and setup errors over the course of radiotherapy in order to develop efficient clinical intervention strategies in these patients.
Entry Criteria
Disease Characteristics:
- Undergoing external beam intensity-modulated radiotherapy for prostate cancer
- Able to maintain treatment position for about 40 minutes
Prior/Concurrent Therapy:
Biologic therapy:
- Not specified
Chemotherapy:
- Not specified
Endocrine therapy:
- Not specified
Radiotherapy:
- See Disease Characteristics
Surgery:
- Not specified
Patient Characteristics:
Age:
- Not specified
Performance status:
- Not specified
Life expectancy:
- Not specified
Hematopoietic:
- Not specified
Hepatic:
- Not specified
Renal:
- Not specified
Expected Enrollment
25A total of 25 patients will be accrued for this study within 2 years.
Outcomes
Primary Outcome(s)Treatment accuracy
Reduction in the proportion of patients with large target positioning errors using CT guided procedure
Organ motion and setup errors
Outline
Patients undergo radiotherapy over 9 weeks. Patients undergo a CT scan immediately prior to receiving radiotherapy on treatment days 3-8 and then weekly thereafter. On 3 different days, patients also undergo CT scan immediately after radiotherapy. If the CT scans indicate a correction that exceeds the action level currently in effect, then beginning with the next treatment, the patient's position with respect to the radiation field is adjusted.
Trial Lead Organizations
Memorial Sloan-Kettering Cancer Center
 | | | |
| Michael Lovelock, PhD, Protocol chair | |
| |
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| Registry Information | ||
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| Official Title | The Use Of Multiple CT Scans To Reduce Target Positioning Errors In Patients Undergoing External Beam Radiotherapy Treatment For Prostate Cancer | |
| ||
| Trial Start Date | 2001-03-13 | |
| ||
| Registered in ClinicalTrials.gov | NCT00020891 | |
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| Date Submitted to PDQ | 2001-05-07 | |
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| Information Last Verified | 2006-08-15 | |
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| NCI Grant/Contract Number | CA08748 | |
Note: The purpose of most clinical trials listed in this database is to test new cancer treatments, or new methods of diagnosing, screening, or preventing cancer. Because all potentially harmful side effects are not known before a trial is conducted, dose and schedule modifications may be required for participants if they develop side effects from the treatment or test. The therapy or test described in this clinical trial is intended for use by clinical oncologists in carefully structured settings, and may not prove to be more effective than standard treatment. A responsible investigator associated with this clinical trial should be consulted before using this protocol.
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