Basic Trial Information
Trial Description
     Summary
     Further Trial Information
     Eligibility Criteria
Trial Contact Information

Basic Trial Information

Trial Description

Summary

This phase III clinical trial is studying ipilimumab or high-dose interferon alfa-2b in treating patients with high-risk stage III or stage IV melanoma that has been removed by surgery. Monoclonal antibodies, such as ipilimumab, can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread. Others find tumor cells and help kill them or carry tumor-killing substances to them. Interferon alfa-2b may interfere with the growth of tumor cells and slow the growth of melanoma and other cancers. It is not yet known whether ipilimumab is more effective then interferon alfa-2b in treating patients with melanoma.

Further Study Information

PRIMARY OBJECTIVES:

I. To evaluate recurrence-free survival (RFS) between patients randomized to receive post-operative adjuvant ipilimumab given at either 10 mg/kg (high dose ipilimumab; HIP) or 3 mg/kg (low dose ipilimumab: LIP) versus those randomized to receive HDI utilizing a hierarchical design assessing HIP versus HDI first and LIP versus HDI second (if the first comparison is significant).

II. To evaluate overall survival (OS) between patients randomized to receive post-operative adjuvant ipilimumab given at either 10 mg/kg (HIP) or 3 mg/kg (LIP) versus those randomized to receive HDI utilizing a hierarchical design assessing HIP versus HDI first and LIP versus HDI second (if the first comparison is significant).

SECONDARY OBJECTIVES:

I. To evaluate safety and tolerability of post-operative adjuvant ipilimumab therapy given at either 10 mg/kg (HIP) or 3 mg/kg (LIP).

II. Among patients enrolled by CCOPs, to compare the global QOL between the ipilimumab arms versus HDI using FACT-G form and to evaluate the effect of treatment-related side effects that may have an impact on the health-related domains of QOL using FACIT-D and FACT-BRM.

OUTLINE: Patients are randomized to 1 of 2 treatment arms.

ARM I: Patients receive induction ipilimumab IV over 90 minutes on day 1. Treatment repeats every 21 days for a total of 4 courses in the absence of disease progression or unacceptable toxicity. Beginning on week 24, patients receive maintenance ipilimumab IV over 90 minutes on day 1. Treatment repeats every 90 days for a maximum of 4 courses in the absence of disease progression or unacceptable toxicity.

ARM II: Patients receive induction high-dose recombinant interferon alfa-2b IV on days 1-5, 8-12, 15-19, and 22-26 in the absence of disease progression or unacceptable toxicity. Patients then receive maintenance high-dose recombinant interferon alfa-2b subcutaneously on days 1, 3, and 5. Treatment repeats every week for 48 weeks in the absence of disease progression or unacceptable toxicity.

After completion of study therapy, patients are followed up every 3 months for 2 years, every 6 months for 3 years, and then yearly for 15 years.

Eligibility Criteria

Inclusion Criteria:

• Diagnosis of melanoma of a cutaneous origin or unknown primary

• No ocular melanoma or melanoma of mucosal origin

• Stage IIIB, IIIC, or IV (M1a or M1b) disease

• Patients with stage IV melanoma must have normal LDH and distant skin, subcutaneous, lymph node, or lung metastases

• No other visceral metastases allowed

• Disease that has been completely resected with negative margins on resected specimens within the past 12 weeks

• Disease-free status documented by a complete physical examination and imaging studies within 4 weeks prior to randomization

• Imaging studies must include a total body PET-CT scan (with or without brain) and brain MRI or CT (if MRI is contraindicated) (if PET-CT cannot be done, CT scan of neck, chest, abdomen, and pelvis should be done)

• Patients rendered free of disease by non-surgical means not allowed

• Disease recurrence after adequate surgical excision of original primary cutaneous melanoma allowed provided one of the following criteria are met:

• Recurrence in a regional lymph node basin after a prior complete lymph node dissection

• Relapsed disease must be completely surgically resected with free margins

• Recurrence in the form of in-transit or satellite metastases or distant skin/subcutaneous, nodal, or lung metastases that are completely surgically resected with free margins

• Recurrence in a regional lymph node basin

• Relapsed disease must be completely surgically resected with free margins

• Patients must be randomized within 84 days (12 weeks) of surgical resection; if more than one surgical procedure is required to render the patient disease-free, the patient must be randomized within 12 weeks of the last surgery

• NOTE: patients with clinically positive lymph nodes for melanoma involvement or those with positive lymph nodes identified through lymphoscintigraphic and/or dye lymphographic techniques in the groin, axilla, or neck should have additional lymphadenectomy in those sites; the complete lymph node dissection procedure would be considered as the last surgery in counting the 84 days unless a subsequent surgical procedure(s) was clinically required to ensure the disease free status

• ECOG performance status 0-1

• WBC ≥ 3,000/μL

• ANC ≥ 1,500/μL

• Platelet count ≥ 100,000/μL

• Hemoglobin ≥ 10 g/dL

• Serum creatinine ≤ 1.8 mg/dL

• AST and ALT ≤ 2.5 times upper limit of normal (ULN)

• Serum bilirubin < 2 times ULN (< 3 mg/dL in case of Gilbert syndrome)

• Not pregnant or nursing

• Negative pregnancy test

• Fertile patients must use adequate method of contraception throughout the study and for up to 26 weeks after the last dose of high-dose recombinant interferon alpha-2b (HDI)

• No active infection requiring concurrent treatment with parenteral antibiotics

• None of the following:

• Other significant medical, surgical, or psychiatric conditions

• Requirement for any medication or treatment that, in the opinion of the investigator, may interfere with compliance, make the administration of ipilimumab or HDI hazardous, or obscure the interpretation of adverse events, such as a condition associated with frequent diarrhea

• Patients should be carefully screened for depression at baseline and if there are indications or a history of depression it is strongly recommended that these patients be closely followed together with behavioral health or psychiatric medical support; patients with an established diagnosis of depression that, in the assessment of the investigator may make the administration of IFNα or ipilimumab hazardous, should not be enrolled on this protocol; the risks and benefits of being treated with standard adjuvant IFNα should be weighed very carefully in consultation with behavioral health or psychiatry

• No documented history of inflammatory bowel disease, including ulcerative colitis and Crohn disease, or diverticulitis

• History of diverticulosis allowed

• No autoimmune disorders or conditions of immunosuppression that require current ongoing treatment with systemic corticosteroids (or other systemic immunosuppressants), including oral steroids or continuous use of topical steroid creams or ointments or ophthalmologic steroids

• History of occasional (but not continuous) use of steroid inhalers allowed

• None of the following:

• History of symptomatic autoimmune disease

• Rheumatoid arthritis

• Systemic progressive sclerosis (scleroderma)

• Systemic lupus erythematosus

• Sjögren syndrome

• Autoimmune vasculitis (e.g., Wegener granulomatosis)

• Motor neuropathy considered of autoimmune origin (e.g., Guillain-Barre syndrome and myasthenia gravis)

• Other CNS autoimmune disease (e.g., poliomyelitis, multiple sclerosis)

• Autoimmune hypothyroid disease or type 1 diabetes allowed provided replacement therapy is administered

• Not incarcerated or compulsorily detained (involuntarily incarcerated) for treatment of either a psychiatric or physical (e.g., infectious) illness

• No other current malignancies except any prior in situ cancer, lobular carcinoma of the breast in situ, cervical cancer in situ, atypical melanocytic hyperplasia or melanoma in situ, multiple primary melanomas, basal or squamous skin cancer, or other malignancies for which the patient has been disease free for > 5 years

• No active or chronic infection with HIV, hepatitis B virus (HBV), or hepatitis C virus (HCV)

• Patients must have negative testing for HIV, hepatitis B antigen, and HCV within the past 4 weeks

• No other concurrent anticancer or investigational agent

• No prior adjuvant treatment (chemotherapy, biotherapy, or limb perfusion) after resection

• At least 30 days since prior radiotherapy, including after surgical resection

• No prior or concurrent anti-CTLA4 monoclonal antibodies, CTLA-4 inhibitor or agonist, CD137 agonist, or prior interferon-α

• At least 4 weeks since prior aldesleukin (IL-2), anti-tumor vaccine, or chemotherapy given before randomization

• No infectious disease vaccination (e.g., standard influenza, H1N1 influenza, pneumococcal, meningococcal, or tetanus toxoid) within the past 4 weeks

• No concurrent systemic corticosteroids (or other systemic immunosuppressants), including oral steroids (i.e., prednisone, dexamethasone), continuous use of topical steroid creams or ointments, or ophthalmologic steroids

• Occasional but not continuous use of steroid inhalers allowed

• Systemic corticosteroids (or other systemic immunosuppressants), including oral steroids (i.e., prednisone, dexamethasone), continuous use of topical steroid creams or ointments, or ophthalmologic steroids within the past 2 weeks allowed provided, in judgment of the treating physician investigator, that the patient is not likely to require resumption of treatment with these classes of drugs during the study

• Replacement doses of steroids for patients with adrenal insufficiency allowed

• No concurrent chemotherapy or radiotherapy

Trial Contact Information

Trial Lead Organizations/Sponsors

National Cancer Institute

Ahmad Tarhini

Principal Investigator

U.S.A.
Alabama
	Birmingham
	UAB Comprehensive Cancer Center
		Carla I. Falkson	Ph: 205-934-0309
Arizona
	Tucson
	Arizona Cancer Center at University Medical Center North
		Joanne M Jeter	Ph: 520-626-9008
	Arizona Cancer Center at University of Arizona Health Sciences Center
		Joanne M Jeter	Ph: 520-626-9008
Arkansas
	Ft. Smith
	Hembree Mercy Cancer Center at St. Edward Mercy Medical Center
		John Dalie Wells	Ph: 800-378-9373
	Little Rock
	Arkansas Cancer Research Center at University of Arkansas for Medical Sciences
		Rangaswamy Govindarajan	Ph: 501-686-8274
	Veterans Affairs Medical Center - Little Rock
		Rangaswamy Govindarajan	Ph: 501-686-8274
California
	Antioch
	Kaiser Permanente - Deer Valley
		Louis Fehrenbacher	Ph: 626-564-3455
	Greenbrae
	Sutter Health Western Division Cancer Research Group
		David H. Irwin	Ph: 510-204-3428
	Hayward
	Kaiser Permanente Medical Center - Hayward
		Louis Fehrenbacher	Ph: 626-564-3455
	LA Jolla
	Rebecca and John Moores UCSD Cancer Center
		Gregory A Daniels	Ph: 858-822-5354
			Email: cancercto@ucsd.edu
	Los Angeles
	Angeles Clinic and Research Institute - Los Angeles
		Omid Hamid	Ph: 323-865-0451
	Monterey
	Community Hospital of the Monterey Peninsula Comprehensive Cancer Center
		John Hausdorff	Ph: 831-625-4753
	Oakland
	Kaiser Permanente-Oakland
		Louis Fehrenbacher	Ph: 626-564-3455
	Orange
	St. Joseph Hospital Regional Cancer Center - Orange
		Timothy E Byun	Ph: 714-734-6220
	Rancho Mirage
	Lucy Curci Cancer Center at Eisenhower Memorial Hospital and Medical Center
		Henry T Tsai	Ph: 760-834-3798
	Roseville
	Kaiser Permanente Medical Center - Roseville
		Louis Fehrenbacher	Ph: 626-564-3455
	Sacramento
	Kaiser Permanente Medical Center - Sacramento
		Louis Fehrenbacher	Ph: 626-564-3455
	South Sacramento Kaiser-Permanente Medical Center
		Louis Fehrenbacher	Ph: 626-564-3455
	San Diego
	Sharp Memorial Hospital Cancer Center
		Robert M. Barone	Ph: 858-939-5015
	San Francisco
	California Pacific Medical Center - California Campus
		David H. Irwin	Ph: 510-204-3428
	San Jose
	Kaiser Permanente Medical Center - Santa Teresa
		Louis Fehrenbacher	Ph: 626-564-3455
	Santa Clara
	Kaiser Permanente Medical Center - Santa Clara Homestead Campus
		Louis Fehrenbacher	Ph: 626-564-3455
	Santa Rosa
	Kaiser Permanente Medical Center - Santa Rosa
		Louis Fehrenbacher	Ph: 626-564-3455
	Stanford
	Stanford Cancer Center
		Harlan A. Pinto	Ph: 800-455-0057
	Vallejo
	Kaiser Permanente Medical Center - Vallejo
		Louis Fehrenbacher	Ph: 626-564-3455
	Walnut Creek
	Kaiser Permanente Medical Center - Walnut Creek
		Louis Fehrenbacher	Ph: 626-564-3455
	Whittier
	Ruby L. Golleher Cancer Program at Presbyterian Intercommunity Hospital
		Jack H. Freimann	Ph: 562-698-0811
			Email: cdelferraro@pih.net
Colorado
	Aurora
	Medical Center of Aurora - South Campus
		Eduardo R. Pajon	Ph: 888-785-6789
	University of Colorado Cancer Center at UC Health Sciences Center
		Karl D Lewis	Ph: 720-848-0650
	Boulder
	Boulder Community Hospital
		Eduardo R. Pajon	Ph: 888-785-6789
	Colorado Springs
	Penrose Cancer Center at Penrose Hospital
		Eduardo R. Pajon	Ph: 888-785-6789
	Denver
	CCOP - Colorado Cancer Research Program
		Eduardo R. Pajon	Ph: 888-785-6789
	Kaiser Permanente of Colorado
		Alexander Menter	Ph: 303-614-1300
	Porter Adventist Hospital
		Eduardo R. Pajon	Ph: 888-785-6789
	Presbyterian - St. Luke's Medical Center
		Eduardo R. Pajon	Ph: 888-785-6789
	Rose Medical Center
		Eduardo R. Pajon	Ph: 888-785-6789
	St. Anthony Central Hospital
		Eduardo R. Pajon	Ph: 888-785-6789
	St. Joseph Hospital
		Eduardo R. Pajon	Ph: 888-785-6789
	Englewood
	Swedish Medical Center
		Eduardo R. Pajon	Ph: 888-785-6789
	Fort Collins
	Front Range Cancer Specialists
		Diana C. Medgyesy	Ph: 970-212-7600
	Poudre Valley Hospital
		Paolo Romero	Ph: 970-495-8226
	Grand Junction
	St. Mary's Regional Cancer Center at St. Mary's Hospital and Medical Center
		Karl D Lewis	Ph: 720-848-0650
	Greeley
	North Colorado Medical Center
		Eduardo R. Pajon	Ph: 888-785-6789
	Lafayette
	Kaiser Permanente - Lafayette
		Alexander Menter	Ph: 303-614-1300
	Littleton
	Littleton Adventist Hospital
		Eduardo R. Pajon	Ph: 888-785-6789
	Lone Tree
	Sky Ridge Medical Center
		Eduardo R. Pajon	Ph: 888-785-6789
	Longmont
	Hope Cancer Care Center at Longmont United Hospital
		Eduardo R. Pajon	Ph: 888-785-6789
	Loveland
	McKee Medical Center
		Eduardo R. Pajon	Ph: 888-785-6789
	Parker
	Parker Adventist Hospital
		Eduardo R. Pajon	Ph: 888-785-6789
	Pueblo
	St. Mary - Corwin Regional Medical Center
		Eduardo R. Pajon	Ph: 888-785-6789
	Thornton
	North Suburban Medical Center
		Eduardo R. Pajon	Ph: 888-785-6789
	Wheat Ridge
	Exempla Lutheran Medical Center
		Eduardo R. Pajon	Ph: 888-785-6789
Connecticut
	Hartford
	Helen and Harry Gray Cancer Center at Hartford Hospital
		Robert D. Siegel	Ph: 860-545-5363
	Saint Francis/Mount Sinai Regional Cancer Center at Saint Francis Hospital and Medical Center
		Philip J. Stella	Ph: 734-712-3456
	New Haven
	Yale Cancer Center
		Harriet Kluger	Ph: 203-785-5702
	Norwich
	Eastern Connecticut Hematology and Oncology Associates
		Dennis E. Slater	Ph: 860-886-8362
	Stamford
	Carl and Dorothy Bennett Cancer Center at Stamford Hospital
		Salvatore A. Del Prete	Ph: 203-323-8944
Delaware
	Lewes
	Tunnell Cancer Center at Beebe Medical Center
		Gregory A. Masters	Ph: 302-733-6227
	Newark
	Helen F. Graham Cancer Center at Christiana Hospital
		Gregory A. Masters	Ph: 302-733-6227
District of Columbia
	Washington
	Washington Cancer Institute at Washington Hospital Center
		Sekwon Jang	Ph: 202-877-8839
Florida
	Boca Raton
	Eugene M. and Christine E. Lynn Cancer Institute at Boca Raton Community Hospital - Main Campus
		Lloyd D Berkowitz	Ph: 561-955-6400
	Fort Lauderdale
	Michael and Dianne Bienes Comprehensive Cancer Center at Holy Cross Hospital
		Michael Schwartz	Ph: 305-674-2625
			Email: info@msccop.com
	Jacksonville
	Baptist Cancer Institute - Jacksonville
		Troy Hancil Guthrie	Ph: 904-202-7051
	Mayo Clinic - Jacksonville
		Richard W Joseph	Ph: 507-538-7623
	Jupiter
	Ella Milbank Foshay Cancer Center at Jupiter Medical Center
		Michael Schwartz	Ph: 305-674-2625
			Email: info@msccop.com
	Lakeland
	Lakeland Regional Cancer Center at Lakeland Regional Medical Center
		Sushma S Nakka	Ph: 863-904-1900
	Miami Beach
	CCOP - Mount Sinai Medical Center
		Michael Schwartz	Ph: 305-674-2625
			Email: info@msccop.com
	Orlando
	Florida Hospital Cancer Institute at Florida Hospital Orlando
		Lee M. Zehngebot	Ph: 407-303-5623
	M.D. Anderson Cancer Center at Orlando
		Gregory K Pennock	Ph: 321-841-7246
	Tampa
	H. Lee Moffitt Cancer Center and Research Institute at University of South Florida
		Ragini R Kudchadkar	Ph: 800-456-7121
			Email: canceranswers@moffitt.org
Georgia
	Atlanta
	Winship Cancer Institute of Emory University
		David H. Lawson	Ph: 404-778-1868
	Augusta
	Medical College of Georgia Cancer Center
		Anand P. Jillella	Ph: 706-721-1663
			Email: cancer@georgiahealth.edu
	Savannah
	Curtis and Elizabeth Anderson Cancer Institute at Memorial Health University Medical Center
		Harvey C. Lebos	Ph: 912-350-8568
	Nancy N. and J. C. Lewis Cancer and Research Pavilion at St. Joseph's/Candler
		Howard A. Zaren	Ph: 312-864-6000
Idaho
	Boise
	Mountain States Tumor Institute at St. Luke's Regional Medical Center
		Paul G. Montgomery	Ph: 800-845-4624
Illinois
	Bloomington
	St. Joseph Medical Center
		Nguyet A Le-Lindqwister	Ph: 800-793-2262
	Bloomington%
	Illinois CancerCare - Bloomington
		Nguyet A Le-Lindqwister	Ph: 800-793-2262
	Canton
	Illinois CancerCare - Canton
		Nguyet A Le-Lindqwister	Ph: 800-793-2262
	Carthage
	Illinois CancerCare - Carthage
		Nguyet A Le-Lindqwister	Ph: 800-793-2262
	Chicago
	Resurrection Medical Center
		Christopher G. Rose	Ph: 773-792-5116
	Robert H. Lurie Comprehensive Cancer Center at Northwestern University
		Timothy M. Kuzel	Ph: 312-695-1301
			Email: cancer@northwestern.edu
	Rush Cancer Institute at Rush University Medical Center
		Howard L Kaufman	Ph: 312-942-5498
			Email: clinical_trials@rush.edu
	Saint Joseph Hospital
		Ira Oliff	Ph: 312-695-1301
			Email: cancer@northwestern.edu
	University of Chicago Cancer Research Center
		Thomas F. Gajewski	Ph: 773-834-7424
	Decatur
	Decatur Memorial Hospital Cancer Care Institute
		James L. Wade	Ph: 217-876-4740
			Email: kcheek@dmhhs.org
	Elgin
	Sherman Hospital
		James L. Wade	Ph: 217-876-4740
			Email: kcheek@dmhhs.org
	Eureka
	Eureka Community Hospital
		Nguyet A Le-Lindqwister	Ph: 800-793-2262
	Illinois CancerCare - Eureka
		Nguyet A Le-Lindqwister	Ph: 800-793-2262
	Galesburg
	Galesburg Clinic, PC
		Nguyet A Le-Lindqwister	Ph: 800-793-2262
	Havana
	Illinois CancerCare - Havana
		Nguyet A Le-Lindqwister	Ph: 800-793-2262
	Highland Park
	Hematology Oncology Associates of Illinois-Highland Park
		Timothy M. Kuzel	Ph: 312-695-1301
			Email: cancer@northwestern.edu
	Hinsdale
	Hinsdale Hematology Oncology Associates
		Elyse Cheryl Schneiderman	Ph: 630-654-1790
			Email: info@hhoaltd.com
	Kewanee
	Illinois CancerCare - Kewanee Clinic
		Nguyet A Le-Lindqwister	Ph: 800-793-2262
	Libertyville
	North Shore Oncology and Hematology Associates, Limited - Libertyville
		Timothy M. Kuzel	Ph: 312-695-1301
			Email: cancer@northwestern.edu
	Macomb
	Illinois CancerCare - Macomb
		Nguyet A Le-Lindqwister	Ph: 800-793-2262
	Maywood
	Cardinal Bernardin Cancer Center at Loyola University Medical Center
		Joseph I. Clark	Ph: 708-226-4357
	Moline
	Garneau, Stewart C MD (UIA Investigator)
		Costas L. Constantinou	Ph: 319-363-2690
	Trinity Cancer Center at Trinity Medical Center - 7th Street Campus
		Costas L. Constantinou	Ph: 319-363-2690
	Monmouth
	Illinois CancerCare - Monmouth
		Nguyet A Le-Lindqwister	Ph: 800-793-2262
	OSF Holy Family Medical Center
		Nguyet A Le-Lindqwister	Ph: 800-793-2262
	Mt. Vernon
	Good Samaritan Regional Health Center
		Bethany G. Sleckman	Ph: 913-948-5588
	Normal
	BroMenn Regional Medical Center
		Nguyet A Le-Lindqwister	Ph: 800-793-2262
	Community Cancer Center
		Nguyet A Le-Lindqwister	Ph: 800-793-2262
	Illinois CancerCare - Community Cancer Center
		Nguyet A Le-Lindqwister	Ph: 800-793-2262
	Ottawa
	Community Hospital of Ottawa
		Nguyet A Le-Lindqwister	Ph: 800-793-2262
	Illinois CancerCare - Ottawa
		Nguyet A Le-Lindqwister	Ph: 800-793-2262
	Pekin
	Cancer Treatment Center at Pekin Hospital
		Nguyet A Le-Lindqwister	Ph: 800-793-2262
	Illinois CancerCare - Pekin
		Nguyet A Le-Lindqwister	Ph: 800-793-2262
	Peoria
	CCOP - Illinois Oncology Research Association
		Nguyet A Le-Lindqwister	Ph: 800-793-2262
	Illinois CancerCare - Peoria
		Nguyet A Le-Lindqwister	Ph: 800-793-2262
	Methodist Medical Center of Illinois
		Nguyet A Le-Lindqwister	Ph: 800-793-2262
	OSF St. Francis Medical Center
		Nguyet A Le-Lindqwister	Ph: 800-793-2262
	Proctor Hospital
		Nguyet A Le-Lindqwister	Ph: 800-793-2262
	Peru
	Illinois CancerCare - Princeton
		Nguyet A Le-Lindqwister	Ph: 800-793-2262
	Illinois Valley Community Hospital
		Nguyet A Le-Lindqwister	Ph: 800-793-2262
	Princeton
	Illinois CancerCare - Princeton
		Nguyet A Le-Lindqwister	Ph: 800-793-2262
	Rockford
	Swedish-American Regional Cancer Center
		Harvey Eric Einhorn	Ph: 815-489-4413
	Skokie
	Hematology Oncology Associates - Skokie
		Timothy M. Kuzel	Ph: 312-695-1301
			Email: cancer@northwestern.edu
	Spring Valley
	Illinois CancerCare - Spring Valley
		Nguyet A Le-Lindqwister	Ph: 800-793-2262
	Springfield
	Regional Cancer Center at Memorial Medical Center
		James L. Wade	Ph: 217-876-4740
			Email: kcheek@dmhhs.org
	Urbana
	Carle Cancer Center at Carle Foundation Hospital
		Patricia A. Johnson	Ph: 800-446-5532
Indiana
	Elkhart
	Elkhart Clinic, LLC
		Jose A. Bufill	Ph: 574-237-1328
	Elkhart General Hospital
		Jose A. Bufill	Ph: 574-237-1328
	Michiana Hematology-Oncology, PC - Elkhart
		Jose A. Bufill	Ph: 574-237-1328
	Indianapolis
	Indiana University Melvin and Bren Simon Cancer Center
		Theodore F. Logan	Ph: 317-274-2552
	Kokomo
	Community Cancer Care at Howard Regional Health System
		Jose A. Bufill	Ph: 574-237-1328
	La Porte
	Center for Cancer Therapy at LaPorte Hospital and Health Services
		Jose A. Bufill	Ph: 574-237-1328
	Mishawaka
	Michiana Hematology-Oncology, PC - Mishawaka
		Jose A. Bufill	Ph: 574-237-1328
	Saint Joseph's Medical Center
		Jose A. Bufill	Ph: 574-237-1328
	Plymouth
	Michiana Hematology Oncology PC - Plymouth
		Jose A. Bufill	Ph: 574-237-1328
	South Bend
	CCOP - Northern Indiana CR Consortium
		Jose A. Bufill	Ph: 574-237-1328
	Memorial Hospital of South Bend
		Jose A. Bufill	Ph: 574-237-1328
	Michiana Hematology-Oncology, PC - South Bend
		Jose A. Bufill	Ph: 574-237-1328
	Westville
	Michiana Hematology Oncology-PC Westville
		Jose A. Bufill	Ph: 574-237-1328
Iowa
	Ames
	McFarland Clinic, PC
		Joseph James Merchant	Ph: 515-239-2621
	Cedar Rapids
	Cedar Rapids Oncology Associates
		Deborah W Wilbur	Ph: 319-363-2690
	Iowa Blood and Cancer Care
		David O. Zenk	Ph: 319-297-2900
			Email: cetscheidt@pcofiowa.com
	Clive
	Medical Oncology and Hematology Associates-West Des Moines
		Robert J Behrens	Ph: 888-244-6061
			Email: sherrijr@iora.org
	Mercy Cancer Center - West Lakes
		Robert J Behrens	Ph: 888-244-6061
			Email: sherrijr@iora.org
	Des Moines
	CCOP - Iowa Oncology Research Association
		Robert J Behrens	Ph: 888-244-6061
			Email: sherrijr@iora.org
	John Stoddard Cancer Center at Iowa Lutheran Hospital
		Robert J Behrens	Ph: 888-244-6061
			Email: sherrijr@iora.org
	John Stoddard Cancer Center at Iowa Methodist Medical Center
		Robert J Behrens	Ph: 888-244-6061
			Email: sherrijr@iora.org
	Medical Oncology and Hematology Associates at John Stoddard Cancer Center
		Robert J Behrens	Ph: 888-244-6061
			Email: sherrijr@iora.org
	Medical Oncology and Hematology Associates at Mercy Cancer Center
		Robert J Behrens	Ph: 888-244-6061
			Email: sherrijr@iora.org
	Mercy Cancer Center at Mercy Medical Center - Des Moines
		Robert J Behrens	Ph: 888-244-6061
			Email: sherrijr@iora.org
	Iowa City
	Holden Comprehensive Cancer Center at University of Iowa
		Mohammed M Milhem	Ph: 800-237-1225
	Sioux City
	Mercy Medical Center - Sioux City
		Donald Bruce Wender	Ph: 712-252-0088
	Siouxland Hematology-Oncology Associates, LLP
		Donald Bruce Wender	Ph: 712-252-0088
	St. Luke's Regional Medical Center
		Donald Bruce Wender	Ph: 712-252-0088
	Waterloo
	Covenant Cancer Treatment Center
		Mohammed T. Masri	Ph: 319-272-2070
	West Des Moines
	Methodist West Hospital
		Robert J Behrens	Ph: 888-244-6061
			Email: sherrijr@iora.org
		Robert J Behrens	Ph: 888-244-6061
			Email: sherrijr@iora.org
Kansas
	Chanute
	Cancer Center of Kansas, PA - Chanute
		Shaker R. Dakhil	Ph: 316-262-4467
	Dodge City
	Cancer Center of Kansas, PA - Dodge City
		Shaker R. Dakhil	Ph: 316-262-4467
	El Dorado
	Cancer Center of Kansas, PA - El Dorado
		Shaker R. Dakhil	Ph: 316-262-4467
	Fort Scott
	Cancer Center of Kansas - Fort Scott
		Shaker R. Dakhil	Ph: 316-262-4467
	Independence
	Cancer Center of Kansas-Independence
		Shaker R. Dakhil	Ph: 316-262-4467
	Kingman
	Cancer Center of Kansas, PA - Kingman
		Shaker R. Dakhil	Ph: 316-262-4467
	Lawrence
	Lawrence Memorial Hospital
		Shaker R. Dakhil	Ph: 316-262-4467
	Liberal
	Cancer Center of Kansas, PA - Liberal
		Shaker R. Dakhil	Ph: 316-262-4467
	McPherson
	Cancer Center of Kansas, PA - McPherson
		Shaker R. Dakhil	Ph: 316-262-4467
	Newton
	Cancer Center of Kansas, PA - Newton
		Shaker R. Dakhil	Ph: 316-262-4467
	Parsons
	Cancer Center of Kansas, PA - Parsons
		Shaker R. Dakhil	Ph: 316-262-4467
	Pratt
	Cancer Center of Kansas, PA - Pratt
		Shaker R. Dakhil	Ph: 316-262-4467
	Salina
	Cancer Center of Kansas, PA - Salina
		Shaker R. Dakhil	Ph: 316-262-4467
	Wellington
	Cancer Center of Kansas, PA - Wellington
		Shaker R. Dakhil	Ph: 316-262-4467
	Wichita
	Associates in Women's Health, PA - North Hillside
		Shaker R. Dakhil	Ph: 316-262-4467
	Cancer Center of Kansas, PA - Medical Arts Tower
		Shaker R. Dakhil	Ph: 316-262-4467
	Cancer Center of Kansas, PA - Wichita
		Shaker R. Dakhil	Ph: 316-262-4467
	CCOP - Wichita
		Shaker R. Dakhil	Ph: 316-262-4467
	Via Christi Cancer Center at Via Christi Regional Medical Center
		Shaker R. Dakhil	Ph: 316-262-4467
	Winfield
	Cancer Center of Kansas, PA - Winfield
		Shaker R. Dakhil	Ph: 316-262-4467
Kentucky
	Owensboro
	Mitchell Memorial Cancer Center at Owensboro Medical Health System
		Kevin P Ridenhour	Ph: 270-688-3691
			Email: shawns@omhs.org
Louisiana
	New Orleans
	Ochsner Cancer Institute at Ochsner Clinic Foundation
		Jyotsna Fuloria	Ph: 888-562-4763
Maine
	Augusta
	Harold Alfond Center for Cancer Care
		Thomas Henry Openshaw	Ph: 207-973-4274
	Bangor
	CancerCare of Maine at Eastern Maine Medical Center
		Thomas Henry Openshaw	Ph: 207-973-4274
	Scarborough
	Maine Center for Cancer Medicine and Blood Disorders - Scarborough
		Frederick R. Aronson	Ph: 207-396-7600
	York
	York Hospital's Oncology Treatment Center
		Jonathan D Eneman	Ph: 207-351-3777
Maryland
	Baltimore
	Alvin and Lois Lapidus Cancer Institute at Sinai Hospital
		Mukund S. Didolkar	Ph: 410-601-6120
			Email: pridgely@lifebridgehealth.org
	Greater Baltimore Medical Center Cancer Center
		Gary I. Cohen	Ph: 443-849-3706
	Harry and Jeanette Weinberg Cancer Institute at Franklin Square Hospital Center
		Michael Benjamin Atkins	Ph: 202-444-0381
	St. Agnes Hospital Cancer Center
		Carole Miller	Ph: 410-368-2910
	Elkton MD
	Union Hospital of Cecil County
		Gregory A. Masters	Ph: 302-733-6227
	Frederick
	Frederick Memorial Hospital Regional Cancer Therapy Center
		Mark G Goldstein	Ph: 240-566-3584
			Email: clinicaltrials@fmh.org
Massachusetts
	Boston
	Beth Israel Deaconess Medical Center
		F. Stephen Hodi	Ph: 866-790-4500
	Dana-Farber/Harvard Cancer Center at Dana-Farber Cancer Institute
		F. Stephen Hodi	Ph: 866-790-4500
	Massachusetts General Hospital
		F. Stephen Hodi	Ph: 866-790-4500
	Burlington
	Lahey Clinic Medical Center - Burlington
		Christopher P Tretter	Ph: 781-744-8027
	Worcester
	UMASS Memorial Cancer Center - University Campus
		Ahmad D Siddiqui	Ph: 508-856-2464
			Email: laura.lefko@umassmed.edu
Michigan
	Adrian
	Hickman Cancer Center at Bixby Medical Center
		Rex B Mowat	Ph: 517-265-0116
	Ann Arbor
	CCOP - Michigan Cancer Research Consortium
		Philip J. Stella	Ph: 734-712-3456
	Saint Joseph Mercy Cancer Center
		Philip J. Stella	Ph: 734-712-3456
	University of Michigan Comprehensive Cancer Center
		Christopher D Lao	Ph: 800-865-1125
	Battle Creek
	Battle Creek Health System Cancer Care Center
		Gilbert D Padula	Ph: 616-685-5225
	Big Rapids
	Mecosta County Medical Center
		Gilbert D Padula	Ph: 616-685-5225
	Escanaba
	Green Bay Oncology, Limited - Escanaba
		Gerald K. Bayer	Ph: 800-432-6049
	Flint
	Hurley Medical Center
		Philip J. Stella	Ph: 734-712-3456
	Grand Blanc
	Genesys Regional Medical Center
		Philip J. Stella	Ph: 734-712-3456
	Grand Rapids
	Butterworth Hospital at Spectrum Health
		Gilbert D Padula	Ph: 616-685-5225
	CCOP - Grand Rapids
		Gilbert D Padula	Ph: 616-685-5225
	Lacks Cancer Center at Saint Mary's Health Care
		Gilbert D Padula	Ph: 616-685-5225
	Iron Mountain
	Green Bay Oncology - Iron Mountain
		Gerald K. Bayer	Ph: 800-432-6049
	Jackson
	Gayle M. Jacob Cancer Center at Allegiance Health
		Philip J. Stella	Ph: 734-712-3456
	Kalamazoo
	West Michigan Cancer Center
		Raymond Sterling Lord	Ph: 269-373-7458
	Lansing
	Sparrow Regional Cancer Center
		Philip J. Stella	Ph: 734-712-3456
	Livonia
	St. Mary Mercy Hospital
		Philip J. Stella	Ph: 734-712-3456
	Monroe
	Community Cancer Center of Monroe
		Rex B Mowat	Ph: 517-265-0116
	Mercy Memorial Hospital - Monroe
		Rex B Mowat	Ph: 517-265-0116
	Muskegon
	Mercy General Health Partners
		Gilbert D Padula	Ph: 616-685-5225
	Port Huron
	Mercy Regional Cancer Center at Mercy Hospital
		Philip J. Stella	Ph: 734-712-3456
	Saginaw
	Seton Cancer Institute at Saint Mary's - Saginaw
		Philip J. Stella	Ph: 734-712-3456
	Saint Joseph
	Lakeside Cancer Specialists, PLLC
		Jose A. Bufill	Ph: 574-237-1328
	St. Joseph
	Lakeland Regional Cancer Care Center - St. Joseph
		Jose A. Bufill	Ph: 574-237-1328
	Traverse City
	Munson Medical Center
		Gilbert D Padula	Ph: 616-685-5225
Minnesota
	Coon Rapids
	Mercy and Unity Cancer Center at Mercy Hospital
		Joseph W Leach	Ph: 952-993-1517
			Email: MMCCOP@parknicollet.com
	Duluth
	CCOP - Duluth
		Daniel Nikcevich	Ph: 888-203-7267
	Essentia Health - Duluth Clinic
		Daniel Nikcevich	Ph: 888-203-7267
	Miller - Dwan Medical Center
		Daniel Nikcevich	Ph: 888-203-7267
	Edina
	Fairview Southdale Hospital
		Joseph W Leach	Ph: 952-993-1517
			Email: MMCCOP@parknicollet.com
	Fridley
	Mercy and Unity Cancer Center at Unity Hospital
		Joseph W Leach	Ph: 952-993-1517
			Email: MMCCOP@parknicollet.com
	Hutchinson
	Hutchinson Area Health Care
		Joseph W Leach	Ph: 952-993-1517
			Email: MMCCOP@parknicollet.com
	Maplewood
	HealthEast Cancer Care at St. John's Hospital
		Joseph W Leach	Ph: 952-993-1517
			Email: MMCCOP@parknicollet.com
	Minnesota Oncology - Maplewood
		Joseph W Leach	Ph: 952-993-1517
			Email: MMCCOP@parknicollet.com
	Minneapolis
	Hennepin County Medical Center - Minneapolis
		Joseph W Leach	Ph: 952-993-1517
			Email: MMCCOP@parknicollet.com
	Virginia Piper Cancer Institute at Abbott - Northwestern Hospital
		Joseph W Leach	Ph: 952-993-1517
			Email: MMCCOP@parknicollet.com
	Robbinsdale
	Humphrey Cancer Center at North Memorial Outpatient Center
		Joseph W Leach	Ph: 952-993-1517
			Email: MMCCOP@parknicollet.com
	Saint Cloud
	CentraCare Clinic - Women and Children
		Donald J Jurgens	Ph: 877-229-4907
			Email: coborncancercenter@centracare.com
	Coborn Cancer Center
		Donald J Jurgens	Ph: 877-229-4907
			Email: coborncancercenter@centracare.com
	Saint Louis Park
	Park Nicollet Cancer Center
		Joseph W Leach	Ph: 952-993-1517
			Email: MMCCOP@parknicollet.com
	Saint Paul
	Regions Hospital Cancer Care Center
		Joseph W Leach	Ph: 952-993-1517
			Email: MMCCOP@parknicollet.com
	United Hospital
		Joseph W Leach	Ph: 952-993-1517
			Email: MMCCOP@parknicollet.com
	Shakopee
	St. Francis Cancer Center at St. Francis Medical Center
		Joseph W Leach	Ph: 952-993-1517
			Email: MMCCOP@parknicollet.com
	Stillwater
	Lakeview Hospital
		Joseph W Leach	Ph: 952-993-1517
			Email: MMCCOP@parknicollet.com
	Woodbury
	Minnesota Oncology - Woodbury
		Joseph W Leach	Ph: 952-993-1517
			Email: MMCCOP@parknicollet.com
Missouri
	Cape Girardeau
	Saint Francis Medical Center
		Bethany G. Sleckman	Ph: 913-948-5588
	Saint Louis
	CCOP - St. Louis-Cape Girardeau
		Bethany G. Sleckman	Ph: 913-948-5588
	David C. Pratt Cancer Center at St. John's Mercy
		Bethany G. Sleckman	Ph: 913-948-5588
	Mercy Clinic St. Louis Cancer and Breast Institute
		Bethany G. Sleckman	Ph: 913-948-5588
	Siteman Cancer Center at Barnes-Jewish Hospital - Saint Louis
		Gerald P. Linette	Ph: 800-600-3606
			Email: info@siteman.wustl.edu
	Springfield
	Cancer Research for the Ozarks
		Robert L Carolla	Ph: 417-269-4520
	St. John's Regional Health Center
		Robert L Carolla	Ph: 417-269-4520
Montana
	Billings
	Billings Clinic Cancer Center - 801 N 29th Street
		Benjamin Thomas Marchello	Ph: 800-648-6274
	CCOP - Montana Cancer Consortium
		Benjamin Thomas Marchello	Ph: 800-648-6274
	Great Falls
	Benefis Sletten Cancer Institute
		Benjamin Thomas Marchello	Ph: 800-648-6274
Nebraska
	Lincoln
	Cancer Resource Center - Lincoln
		Gamini S. Soori	Ph: 800-253-4368
	Omaha
	Alegant Health Cancer Center at Bergan Mercy Medical Center
		Gamini S. Soori	Ph: 800-253-4368
	CCOP - Missouri Valley Cancer Consortium
		Gamini S. Soori	Ph: 800-253-4368
	Creighton University Medical Center
		Gamini S. Soori	Ph: 800-253-4368
	Immanuel Medical Center
		Gamini S. Soori	Ph: 800-253-4368
	Methodist Estabrook Cancer Center
		Ralph Hauke	Ph: 402-354-5144
Nevada
	Las Vegas
	CCOP - Nevada Cancer Research Foundation
		John Allan Ellerton	Ph: 702-731-8274
New Jersey
	Camden
	Cancer Institute of New Jersey at Cooper University Hospital - Camden
		Gregory A. Masters	Ph: 302-733-6227
	Flemington
	Hunterdon Regional Cancer Center at Hunterdon Medical Center
		Kenneth B. Blankstein	Ph: 888-788-1260
	Morristown
	Carol G. Simon Cancer Center at Morristown Memorial Hospital
		Eric D Whitman	Ph: 973-971-5900
New Mexico
	Albuquerque
	University of New Mexico Cancer Center
		Montaser Shaheen	Ph: 505-272-6972
New York
	Albany
	New York Oncology Hematology, PC - Albany
		Charles H Weissman	Ph: 518-489-3612ext1342
			Email: sharon.krause@usoncology.com
	New York Oncology Hematology, PC at Albany Medical Center
		Charles H Weissman	Ph: 518-489-3612ext1342
			Email: sharon.krause@usoncology.com
	Amsterdam
	New York Oncology Hematology, PC - Amsterdam
		Charles H Weissman	Ph: 518-489-3612ext1342
			Email: sharon.krause@usoncology.com
	Hudson
	New York Oncology Hematology, PC - Hudson
		Charles H Weissman	Ph: 518-489-3612ext1342
			Email: sharon.krause@usoncology.com
	Lake Success
	Monter Cancer Center of the North Shore-LIJ Health System
		Craig E DeVoe	Ph: 516-562-3467
	Latham
	New York Oncology Hematology, PC - Latham
		Charles H Weissman	Ph: 518-489-3612ext1342
			Email: sharon.krause@usoncology.com
	Manhasset
	Don Monti Comprehensive Cancer Center at North Shore University Hospital
		Craig E DeVoe	Ph: 516-562-3467
	New Hyde Park
	Long Island Jewish Medical Center
		Craig E DeVoe	Ph: 516-562-3467
	Poughkeepsie
	Saint Francis Hospital Cancer Center
		Theodora S. Budnik	Ph: 845-483-5997
			Email: Cancer@sfhhc.org
	Rexford
	Riverview Cancer Care Medical Associates, PC
		Charles H Weissman	Ph: 518-489-3612ext1342
			Email: sharon.krause@usoncology.com
	Rochester
	James P. Wilmot Cancer Center at University of Rochester Medical Center
		Jonathan W Friedberg	Ph: 585-275-5830
	Stony Brook
	Stony Brook University Cancer Center
		Andrzej P Kudelka	Ph: 800-862-2215
	Syracuse
	SUNY Upstate Medical University Hospital
		Teresa C. Gentile	Ph: 315-464-5476
	Troy
	New York Oncology Hematology, PC - Troy
		Charles H Weissman	Ph: 518-489-3612ext1342
			Email: sharon.krause@usoncology.com
North Carolina
	Charlotte
	Blumenthal Cancer Center at Carolinas Medical Center
		Asim Amin	Ph: 704-355-2884
	Concord
	Batte Cancer Center at Northeast Medical Center
		Asim Amin	Ph: 704-355-2884
	Greensboro
	Moses Cone Regional Cancer Center at Wesley Long Community Hospital
		Peter Rubin	Ph: 336-832-0821
	Kinston
	Kinston Medical Specialists
		Peter R. Watson	Ph: 252-559-2200
North Dakota
	Bismarck
	Medcenter One Hospital Cancer Care Center
		Edward J. Wos	Ph: 701-323-5760
			Email: tfischer@mohs.org
	Mid Dakota Clinic, PC
		Edward J. Wos	Ph: 701-323-5760
			Email: tfischer@mohs.org
	St. Alexius Medical Center Cancer Center
		Edward J. Wos	Ph: 701-323-5760
			Email: tfischer@mohs.org
Ohio
	Akron
	Summa Center for Cancer Care at Akron City Hospital
		Jennifer E Payne	Ph: 330-375-6101
	Barberton
	Barberton Citizens Hospital
		Jennifer E Payne	Ph: 330-375-6101
	Canton
	Aultman Cancer Center at Aultman Hospital
		Kisa E Weeman	Ph: 330-363-6891
	Cincinnati
	Christ Hospital Cancer Center
		Philip D. Leming	Ph: 513-585-2859
	Cleveland
	MetroHealth Cancer Care Center at MetroHealth Medical Center
		Bruce J. Averbook	Ph: 216-778-8526
			Email: kbauchens@metrohealth.org
	Columbus
	CCOP - Columbus
		J. Philip Kuebler	Ph: 502-361-8496
	Grant Medical Center Cancer Care
		J. Philip Kuebler	Ph: 502-361-8496
	Mount Carmel Health - West Hospital
		J. Philip Kuebler	Ph: 502-361-8496
	Riverside Methodist Hospital Cancer Care
		J. Philip Kuebler	Ph: 502-361-8496
	Dayton
	CCOP - Dayton
		Howard M. Gross	Ph: 317-783-8918
	Delaware
	Grady Memorial Hospital
		J. Philip Kuebler	Ph: 614-566-3275
	Franklin
	Atrium Medical Center
		Howard M. Gross	Ph: 317-783-8918
	Maumee
	Northwest Ohio Oncology Center
		Rex B Mowat	Ph: 517-265-0116
	Oregon
	St. Charles Mercy Hospital
		Rex B Mowat	Ph: 517-265-0116
	Toledo Clinic - Oregon
		Rex B Mowat	Ph: 517-265-0116
	Sylvania
	Flower Hospital Cancer Center
		Rex B Mowat	Ph: 517-265-0116
	Toledo
	CCOP - Toledo Community Hospital
		Rex B Mowat	Ph: 517-265-0116
	St. Vincent Mercy Medical Center
		Rex B Mowat	Ph: 517-265-0116
	Toledo Clinic, Incorporated - Main Clinic
		Rex B Mowat	Ph: 517-265-0116
	Toledo Hospital
		Rex B Mowat	Ph: 517-265-0116
	Westerville
	Mount Carmel St. Ann's Cancer Center
		J. Philip Kuebler	Ph: 502-361-8496
Oklahoma
	Norman
	Cancer Care Associates - Norman
		Vikki Ann Canfield	Ph: 888-823-5923
			Email: ctsucontact@westat.com
	Oklahoma City
	Cancer Care Associates - Mercy Campus
		Vikki Ann Canfield	Ph: 888-823-5923
			Email: ctsucontact@westat.com
	Oklahoma University Cancer Institute
		Carla Kurkjian	Ph: 405-271-4272
			Email: julie-traylor@ouhsc.edu
Oregon
	Milwaukie
	Providence Milwaukie Hospital
		Alison K Conlin	Ph: 503-215-6412
	Portland
	CCOP - Columbia River Oncology Program
		Alison K Conlin	Ph: 503-215-6412
	Providence Cancer Center at Providence Portland Medical Center
		Alison K Conlin	Ph: 503-215-6412
	Providence St. Vincent Medical Center
		Alison K Conlin	Ph: 503-215-6412
Pennsylvania
	Bethlehem
	St. Luke's Cancer Network at St. Luke's Hospital
		Sanjiv S. Agarwala	Ph: 610-954-3582
			Email: infolink@slhn.org
	Danville
	Geisinger Cancer Institute at Geisinger Health
		Maged F Khalil	Ph: 570-271-5251
	Hazleton
	Geisinger Hazleton Cancer Center
		Maged F Khalil	Ph: 570-271-5251
	Hershey
	Penn State Hershey Cancer Institute at Milton S. Hershey Medical Center
		Joseph Drabick	Ph: 717-531-3779
			Email: CTO@hmc.psu.edu
	Paoli
	Cancer Center of Paoli Memorial Hospital
		Paul B. Gilman	Ph: 484-476-2649
			Email: wellenbachj@mlhs.org
	Philadelphia
	Abramson Cancer Center of the University of Pennsylvania
		Tara C Gangadhar	Ph: 800-474-9892
	Fox Chase Cancer Center - Philadelphia
		Anthony J Olszanski	Ph: 215-728-4790
	Pittsburgh
	UPMC Cancer Centers
		Ahmad A. Tarhini	Ph: 412-647-8073
	Scranton
	Mercy Hospital Cancer Center - Scranton
		Martin B. Hyzinski	Ph: 570-558-3020
	Scranton Hematology Oncology
		Martin B. Hyzinski	Ph: 570-558-3020
	State College
	Mount Nittany Medical Center
		Joseph Drabick	Ph: 717-531-3779
			Email: CTO@hmc.psu.edu
	West Reading
	McGlinn Family Regional Cancer Center at Reading Hospital and Medical Center
		Terrence P. Cescon	Ph: 610-988-9323
	Wilkes-Barre
	Frank M. and Dorothea Henry Cancer Center at Geisinger Wyoming Valley Medical Center
		Maged F Khalil	Ph: 570-271-5251
	Williamsport
	Susquehanna Cancer Center at Divine Providence Hospital
		Warren L Robinson	Ph: 800-598-4282
	Wynnewood
	CCOP - Main Line Health
		Paul B. Gilman	Ph: 484-476-2649
			Email: wellenbachj@mlhs.org
Rhode Island
	Providence
	Rhode Island Hospital Comprehensive Cancer Center
		Maria Constantinou	Ph: 401-444-1488
South Carolina
	Charleston
	Roper St. Francis Cancer Center at Roper Hospital
		James Michael Orcutt	Ph: 843-720-8386
			Email: elizabeth.strojny@roperstfrancis.com
	Easley
	Cancer Centers of the Carolinas - Easley
		Jeffrey Kent Giguere	Ph: 864-241-6251
	Greenville
	Cancer Centers of the Carolinas - Faris Road
		Jeffrey Kent Giguere	Ph: 864-241-6251
	Cancer Centers of the Carolinas - Grove Commons
		Jeffrey Kent Giguere	Ph: 864-241-6251
	CCOP - Greenville
		Jeffrey Kent Giguere	Ph: 864-241-6251
	Greenville Memorial Hospital
		Jeffrey Kent Giguere	Ph: 864-241-6251
	Greer
	Cancer Centers of the Carolinas - Greer Medical Oncology
		Jeffrey Kent Giguere	Ph: 864-241-6251
	Seneca
	Cancer Centers of the Carolinas - Seneca
		Jeffrey Kent Giguere	Ph: 864-241-6251
	Spartanburg
	Cancer Centers of the Carolinas - Spartanburg
		Jeffrey Kent Giguere	Ph: 864-241-6251
South Dakota
	Sioux Falls
	Avera Cancer Institute
		Addison R Tolentino	Ph: 800-657-4377
			Email: Jan.Healy@avera.org
Tennessee
	Jackson
	West Tennessee Cancer Center at Jackson-Madison County General Hospital
		Brion V Randolph	Ph: 731-425-6865
	Kingsport
	Christine LaGuardia Phillips Cancer Center at Wellmont Holston Valley Medical Center
		Asheesh Shipstone	Ph: 423-578-8538
	Knoxville
	Thompson Cancer Survival Center
		Samuel Spence McCachren	Ph: 865-541-1812
	Nashville
	Vanderbilt-Ingram Cancer Center
		Jeffrey A. Sosman	Ph: 800-811-8480
Texas
	Dallas
	Baylor University Medical Center - Dallas
		Charles L Cowey	Ph: 800-422-9567
	Parkland Memorial Hospital
		James F Huth	Ph: 214-648-7097
	Simmons Comprehensive Cancer Center at University of Texas Southwestern Medical Center - Dallas
		James F Huth	Ph: 214-648-7097
Utah
	Cedar City
	Sandra L. Maxwell Cancer Center
		R. Dirk Noyes	Ph: 801-507-3950
	Murray
	Jon and Karen Huntsman Cancer Center at Intermountain Medical Center
		R. Dirk Noyes	Ph: 801-507-3950
	Ogden
	Val and Ann Browning Cancer Center at McKay-Dee Hospital Center
		R. Dirk Noyes	Ph: 801-507-3950
	Saint George
	Dixie Regional Medical Center - East Campus
		R. Dirk Noyes	Ph: 801-507-3950
	Salt Lake City
	Huntsman Cancer Institute at University of Utah
		Kenneth F Grossmann	Ph: 801-581-4477
			Email: clinical.trials@hci.utah.edu
	LDS Hospital
		R. Dirk Noyes	Ph: 801-507-3950
	Utah Cancer Specialists at UCS Cancer Center
		R. Dirk Noyes	Ph: 801-507-3950
Virginia
	Fredericksburg
	Hematology Oncology Associates of Fredericksburg Inc
		Christopher N Vaughn	Ph: 540-371-0079
Washington
	Seattle
	CCOP - Virginia Mason Research Center
		Craig R. Nichols	Ph: 503-215-6412
	Group Health Central Hospital
		Gary E Goodman	Ph: 206-386-2323
			Email: patra.grevstad@swedish.org
	University Cancer Center at University of Washington Medical Center
		Gary E Goodman	Ph: 206-386-2323
			Email: patra.grevstad@swedish.org
	Virginia Mason Medical Center
		Craig R. Nichols	Ph: 503-215-6412
West Virginia
	Charleston
	West Virginia University Medical School - Charleston
		Steven J. Jubelirer	Ph: 304-388-9944
Wisconsin
	Antigo
	Langlade Memorial Hospital
		Hamied R. Rezazadeh	Ph: 877-405-6866
	Appleton
	Fox Valley Hematology and Oncology - East Grant Street
		Avi Bar-Lev	Ph: 920-749-1171
	Green Bay
	Bellin Memorial Hospital
		Patrick J Mansky	Ph: 920-435-8326
	Green Bay Oncology, Limited at St. Mary's Hospital
		Gerald K. Bayer	Ph: 800-432-6049
	Green Bay Oncology, Limited at St. Vincent Hospital Regional Cancer Center
		Gerald K. Bayer	Ph: 800-432-6049
	St. Mary's Hospital Medical Center - Green Bay
		Gerald K. Bayer	Ph: 800-432-6049
	St. Vincent Hospital Regional Cancer Center
		Gerald K. Bayer	Ph: 800-432-6049
	Vince Lombardi Cancer Clinic - Green Bay at Aurora BayCare Medical Center
		Dhimant R. Patel	Ph: 800-252-2990
	La Crosse
	Gundersen Lutheran Center for Cancer and Blood
		Kurt Oettel	Ph: 608-775-2385
			Email: cancerctr@gundluth.org
	Madison
	Dean Hematology & Oncology Clinic
		Amit Sanyal	Ph: 608-410-2700
	Manitowoc
	Holy Family Memorial Medical Center Cancer Care Center
		Gerald K. Bayer	Ph: 800-432-6049
	Marinette
	Vince Lombardi Cancer Clinic - Marinette
		Dhimant R. Patel	Ph: 800-252-2990
	Marshfield
	Marshfield Clinic - Marshfield Center
		Seth Olusegun Fagbemi	Ph: 715-389-4457
	Saint Joseph's Hospital
		Seth Olusegun Fagbemi	Ph: 715-389-4457
	Minocqua
	Marshfield Clinic - Lakeland Center
		Seth Olusegun Fagbemi	Ph: 715-389-4457
	Oconomowoc
	Regional Cancer Center at Oconomowoc Memorial Hospital
		Michael A Thompson	Ph: 262-928-7632
	Oconto Falls
	Green Bay Oncology, Limited - Oconto Falls
		Gerald K. Bayer	Ph: 800-432-6049
	Rhinelander
	Ministry Medical Group at Saint Mary's Hospital
		Seth Olusegun Fagbemi	Ph: 715-389-4457
	Sheboygan
	Vince Lombardi Cancer Clinic - Sheboygan
		Dhimant R. Patel	Ph: 800-252-2990
	Stevens Point
	Marshfield Clinic at Saint Michael's Hospital
		Seth Olusegun Fagbemi	Ph: 715-389-4457
	Saint Michael's Hospital Cancer Center
		Seth Olusegun Fagbemi	Ph: 715-389-4457
	Sturgeon Bay
	Green Bay Oncology, Limited - Sturgeon Bay
		Gerald K. Bayer	Ph: 800-432-6049
	Summit
	Aurora Medical Center
		Dhimant R. Patel	Ph: 800-252-2990
	Two Rivers
	Vince Lombardi Cancer Clinic - Two Rivers
		Dhimant R. Patel	Ph: 800-252-2990
	Waukesha
	Waukesha Memorial Hospital Regional Cancer Center
		Michael A Thompson	Ph: 262-928-7632
	Wausau
	University of Wisconcin Cancer Center at Aspirus Wausau Hospital
		Hamied R. Rezazadeh	Ph: 877-405-6866
	Wauwatosa
	Oncology Alliance, SC - Milwaukee - West
		Rubina Qamar	Ph: 888-709-2080
	Weston
	Marshfield Clinic - Weston Center
		Seth Olusegun Fagbemi	Ph: 715-389-4457
Canada
Ontario
	Ottawa
	Ottawa Hospital Regional Cancer Centre - General Campus
		Vincent P Young	Ph: 613-761-4395
			Email: info@ohri.ca
	Toronto
	Odette Cancer Centre at Sunnybrook
		Teresa M. Petrella	Ph: 416-480-5000